Standard name
Human Ortholog
Description Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0.05 0 0 0 0 0 0
Cytoplasm 0.97 0.97 0.97 0.98 0.9 0.86 0.81 0.66 0.74 0.68 0.55 0.54 1.0 0.99 0.99 0.97 0.96 0.96 0.94 0.95 0.95 0.9 0.92 0.9
Endoplasmic Reticulum 0 0 0 0 0.07 0.08 0.13 0.05 0.05 0.09 0.06 0.05 0 0 0 0.07 0 0 0 0 0 0.06 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.07 0 0.12 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.25 0.14 0.17 0.28 0.36 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 12 8 7 14 9 10 12 0 0 0 0 0 0 1 0 0 0 0 0
Bud 2 1 1 0 0 1 5 2 7 11 5 4 0 1 0 0 0 0 1 1 1 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 7 7 23 19 21 18 18 13 13 8 15 19 0 0 1 9 13 6 0 0 0 0 0 0
Cytoplasm 335 364 519 515 406 482 532 378 419 361 260 350 251 268 302 189 156 110 324 364 531 129 223 197
Endoplasmic Reticulum 0 5 7 5 30 44 83 31 29 46 27 30 0 3 3 13 4 1 1 0 2 7 5 4
Endosome 0 1 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 2 0 4 0 1 0
Golgi 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0
Mitochondria 4 0 1 1 1 5 6 5 39 21 55 33 1 0 0 0 0 0 1 0 3 0 1 2
Nucleus 5 3 3 3 1 3 5 15 4 11 8 13 1 3 0 1 1 1 0 6 2 0 0 1
Nuclear Periphery 0 0 0 0 0 0 0 7 0 5 0 5 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 2 0 0 0 0 1 0 2 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0
Vac/Vac Membrane 3 2 6 4 10 18 26 141 77 90 131 232 0 0 0 1 2 5 3 7 9 2 3 4
Unique Cell Count 345 374 533 525 451 561 656 571 566 530 473 651 252 272 305 195 162 115 344 385 559 144 243 219
Labelled Cell Count 358 383 560 547 471 585 683 602 602 562 511 704 253 275 306 213 176 123 344 385 559 144 243 219


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.5 13.1 12.2 11.5 13.8 12.1 12.0 11.7 10.3 9.7 9.1 10.3 16.4 17.7 17.1 29.3 30.6 29.6 12.9 14.0 15.7
Std Deviation (1e-4) 2.7 2.6 1.9 1.5 2.0 1.9 1.9 2.3 1.8 1.7 1.6 2.0 3.1 3.5 3.1 7.9 8.4 8.8 2.1 2.3 3.0
Intensity Change (Log2) – – – -0.09 0.17 -0.01 -0.02 -0.06 -0.25 -0.33 -0.42 -0.24 0.42 0.53 0.48 1.26 1.32 1.28 0.08 0.19 0.36

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 3.4 0 0 3.7 0 0 3.2 0 0 0 0 0 0
Bud 0 0 0 0 0 0 2.9 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.6 0.3 -1.0 -1.5 -1.9 -1.9 -2.7 -0.9 -1.3 -3.3 -3.5 -3.3 0.2 1.9 0.4
Cytoplasm 0.8 -4.8 -6.8 -8.7 -13.3 -10.9 -12.6 -16.1 -16.9 2.1 1.0 1.6 -0.3 -0.7 -1.0
Endoplasmic Reticulum -0.6 4.4 5.1 7.4 3.7 3.5 5.5 3.9 3.2 0 0 0 3.9 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 5.9 4.3 7.9 5.0 0 0 0 0 0 0
Nucleus 0 0 0 0 2.7 0 2.2 1.7 2.1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 1.3 2.4 3.0 11.5 7.8 9.0 12.3 14.7 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.8103 11.7449 10.5655 9.9365 8.7588 10.9399 11.5339 15.3121 13.5841 13.3926 11.7885 13.5329 10.9742 14.4862 12.9749 12.5494 12.4672 12.789
Actin 0.0236 0.0012 0.0088 0.0024 0.0241 0.0012 0.01 0.0015 0.0063 0.0007 0.0044 0.0023 0.0143 0.0006 0.0066 0.0042 0.0014 0.0025
Bud 0.0017 0.0003 0.0003 0.004 0.0006 0.0003 0.0007 0.0029 0.0005 0.0013 0.001 0.0008 0.0006 0.0002 0.0008 0.0011 0.0014 0.0008
Bud Neck 0.0058 0.0003 0.0005 0.0006 0.0019 0.0021 0.0013 0.0004 0.0009 0.0048 0.0026 0.0018 0.0013 0.0003 0.001 0.0011 0.0013 0.0077
Bud Periphery 0.002 0.0001 0.0001 0.0072 0.001 0.0002 0.0004 0.0006 0.0003 0.0004 0.0005 0.0011 0.0004 0 0.0004 0.0011 0.0014 0.0004
Bud Site 0.0033 0.0003 0.0004 0.0001 0.0008 0.0001 0.0011 0.0045 0.0007 0.0287 0.0007 0.0002 0.001 0.0003 0.0009 0.0009 0.0003 0.0005
Cell Periphery 0.0007 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.0004 0.0002 0.0002 0.0001 0.0001 0.0002 0 0.0001 0.0001 0.0002 0.0001
Cytoplasm 0.7811 0.9663 0.9503 0.9702 0.8595 0.9376 0.8734 0.9676 0.9355 0.9344 0.8305 0.9429 0.8864 0.9811 0.9415 0.941 0.9587 0.9417
Cytoplasmic Foci 0.0238 0.0059 0.0046 0.0021 0.0075 0.0071 0.0218 0.0082 0.0119 0.0124 0.0248 0.0109 0.0146 0.0044 0.0143 0.0046 0.0107 0.014
Eisosomes 0.0002 0 0 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0163 0.0047 0.0025 0.0018 0.0028 0.0068 0.005 0.0025 0.002 0.0011 0.0039 0.0059 0.0078 0.0011 0.0028 0.0057 0.0009 0.0074
Endosome 0.0415 0.0064 0.0128 0.0021 0.0339 0.015 0.026 0.0059 0.0105 0.0064 0.0364 0.011 0.0247 0.0027 0.0092 0.0043 0.007 0.0088
Golgi 0.0082 0.0011 0.0016 0.0003 0.006 0.004 0.0096 0.0012 0.0025 0.0017 0.013 0.0028 0.0054 0.0003 0.005 0.0015 0.0051 0.0011
Lipid Particles 0.0148 0.0001 0.0017 0 0.0059 0.0015 0.0108 0 0.002 0.0003 0.0257 0.0013 0.0049 0 0.0036 0.0003 0.005 0.0001
Mitochondria 0.0095 0.0003 0.003 0.0009 0.0061 0.0055 0.0108 0.0004 0.0186 0.0016 0.0157 0.006 0.0064 0.0003 0.0027 0.0255 0.0013 0.0019
None 0.0033 0.0005 0.001 0.0006 0.0011 0.0007 0.0044 0.0005 0.0006 0.0003 0.0026 0.0008 0.0036 0.0004 0.0009 0.0011 0.0003 0.0008
Nuclear Periphery 0.0169 0.0034 0.002 0.0014 0.0063 0.0045 0.0044 0.0006 0.0013 0.0003 0.0115 0.003 0.0072 0.0008 0.0013 0.0012 0.0004 0.0015
Nucleolus 0.0059 0 0.0001 0 0.0003 0.0001 0.0002 0 0.0001 0.0002 0.0005 0 0.0003 0 0 0.0001 0 0.0002
Nucleus 0.0132 0.0052 0.0046 0.0037 0.0067 0.0081 0.0045 0.0014 0.0026 0.0017 0.0075 0.0029 0.0116 0.0055 0.003 0.0038 0.0022 0.0045
Peroxisomes 0.0066 0.0002 0.0009 0.0001 0.021 0.0005 0.0045 0.0003 0.0008 0.0025 0.0035 0.0034 0.0024 0.0001 0.0027 0.0007 0.0019 0.0005
Punctate Nuclear 0.0099 0.0002 0.0003 0.0001 0.001 0.0019 0.0059 0.0001 0.0014 0.0001 0.0096 0.0009 0.0012 0.0001 0.0017 0.0002 0.0001 0.0034
Vacuole 0.0087 0.0028 0.0031 0.0018 0.0083 0.0018 0.0036 0.0008 0.001 0.0007 0.0038 0.0011 0.004 0.0013 0.001 0.001 0.0004 0.0015
Vacuole Periphery 0.0029 0.0005 0.0013 0.0007 0.005 0.0009 0.0013 0.0002 0.0003 0.0003 0.0017 0.0006 0.0014 0.0002 0.0003 0.0005 0.0002 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 95.9482 74.2434 87.9415 98.6214 72.2329 78.3659 99.1962 101.4882 110.223 87.6235
Translational Efficiency 0.9865 1.0953 1.0434 0.9578 0.9747 1.1843 0.9159 0.8303 0.881 0.8648

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
426 947 1645 1203 1556 1124 1347 172 1982 2071 2992 1375

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1168.14 1306.21 2259.96 1872.92 1182.70 1284.25 1877.13 1818.06 1179.57 1294.29 2087.61 1866.06
Standard Deviation 723.56 222.23 394.58 318.53 185.36 537.55 287.22 325.62 373.55 423.71 398.77 319.94
Intensity Change Log 2 — 0.161174 0.952084 0.681076 — 0.118842 0.666444 0.620316 — 0.140032 0.815440 0.650828

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000180 0.000812 0.000238 0.004686 0.000270 0.001126 0.000599 0.000805 0.000251 0.000982 0.000401 0.004201
Bud Neck 0.000913 0.001426 0.001115 0.004427 0.001271 0.001592 0.001433 0.009221 0.001194 0.001516 0.001258 0.005026
Bud Site 0.008832 0.023117 0.001737 0.069833 0.016952 0.041967 0.007669 0.051010 0.015207 0.033348 0.004407 0.067478
Cell Periphery 0.000114 0.000095 0.000207 0.000505 0.000069 0.000140 0.000182 0.000467 0.000078 0.000119 0.000196 0.000500
Cytoplasm 0.824820 0.835497 0.764375 0.751596 0.826351 0.756090 0.828813 0.555522 0.826022 0.792401 0.793385 0.727069
Cytoplasmic Foci 0.102818 0.056373 0.005199 0.039731 0.081889 0.111508 0.011630 0.076598 0.086388 0.086297 0.008094 0.044343
Eisosomes 0.000010 0.000007 0.000001 0.000014 0.000005 0.000011 0.000002 0.000013 0.000006 0.000009 0.000002 0.000014
Endoplasmic Reticulum 0.000790 0.000970 0.000076 0.000798 0.000962 0.001646 0.000177 0.000762 0.000925 0.001337 0.000121 0.000793
Endosome 0.003964 0.003352 0.000235 0.006750 0.004445 0.009280 0.001017 0.014484 0.004342 0.006570 0.000587 0.007718
Golgi 0.001367 0.003087 0.000888 0.014637 0.005131 0.008626 0.000651 0.003794 0.004322 0.006093 0.000781 0.013281
Lipid Particles 0.000554 0.001044 0.000583 0.005278 0.000757 0.001660 0.001325 0.005632 0.000714 0.001378 0.000917 0.005322
Mitochondria 0.000060 0.000619 0.000162 0.002213 0.000713 0.001479 0.000143 0.000734 0.000573 0.001086 0.000153 0.002028
Mitotic Spindle 0.000904 0.009837 0.003802 0.017077 0.003501 0.006655 0.009134 0.018536 0.002943 0.008110 0.006203 0.017259
None 0.002685 0.001992 0.006603 0.001059 0.001505 0.000868 0.003556 0.000489 0.001759 0.001382 0.005231 0.000988
Nuclear Periphery 0.000038 0.000085 0.000185 0.000174 0.000073 0.000053 0.000213 0.000150 0.000066 0.000068 0.000198 0.000171
Nuclear Periphery Foci 0.003135 0.003793 0.001025 0.002474 0.001811 0.003315 0.002279 0.005424 0.002095 0.003533 0.001590 0.002843
Nucleolus 0.000167 0.000369 0.000107 0.000143 0.000206 0.000195 0.000128 0.000473 0.000198 0.000274 0.000117 0.000184
Nucleus 0.022424 0.025076 0.205599 0.024547 0.022233 0.017203 0.108532 0.014564 0.022274 0.020803 0.161899 0.023298
Peroxisomes 0.000493 0.001434 0.000018 0.003196 0.000747 0.002103 0.000211 0.005939 0.000693 0.001797 0.000105 0.003540
Vacuole 0.025270 0.029141 0.007639 0.047314 0.027622 0.030447 0.022052 0.225059 0.027117 0.029850 0.014127 0.069549
Vacuole Periphery 0.000461 0.001874 0.000206 0.003546 0.003486 0.004036 0.000255 0.010323 0.002836 0.003047 0.000228 0.004394

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.98 -2.17 -6.13 -4.47 -5.61 -6.83 -3.09 -3.92 2.32 -0.18 -6.06 -3.33 -6.11 -4.33 -5.40
Bud Neck -2.95 -6.60 -12.46 -10.71 -6.43 -1.90 -5.73 -6.92 -6.65 -5.88 -2.68 -7.88 -13.82 -12.77 -9.05
Bud Site -6.44 5.58 -13.01 -7.51 -15.56 -7.49 4.57 -4.70 0.47 -6.48 -8.28 7.73 -11.55 -4.70 -15.72
Cell Periphery 1.29 -9.36 -9.53 -10.17 -2.42 -5.14 -7.17 -3.98 -2.86 -1.49 -4.52 -13.13 -11.54 -10.00 -4.10
Cytoplasm -0.34 11.16 8.74 10.70 -1.65 7.24 8.92 13.74 10.34 10.91 5.18 16.06 15.26 10.34 4.47
Cytoplasmic Foci 6.09 14.02 9.36 5.04 -14.80 -4.93 18.66 2.22 5.38 -6.68 0.02 23.98 12.55 12.60 -15.04
Eisosomes 1.52 7.40 -1.87 -3.20 -8.18 -6.21 1.33 -5.00 -1.06 -5.39 -4.69 7.21 -5.74 -2.37 -8.41
Endoplasmic Reticulum -0.55 4.65 2.08 1.87 -2.47 -1.42 6.16 2.00 2.34 -0.97 -1.35 7.67 3.58 3.11 -2.32
Endosome 0.68 5.31 0.24 -0.52 -6.75 -4.77 7.79 -2.91 0.00 -5.14 -3.50 10.51 -0.06 3.03 -7.64
Golgi -5.28 1.73 -3.79 -2.54 -4.06 -3.64 11.25 5.28 6.96 -2.16 -2.90 10.63 -1.28 0.07 -4.29
Lipid Particles -1.89 -6.56 -10.43 -8.90 -8.81 -2.06 -7.40 -5.25 -4.47 -4.06 -2.51 -9.11 -11.30 -9.40 -9.14
Mitochondria -2.04 -11.52 -1.75 -0.61 -1.43 -1.54 3.48 1.90 2.49 -0.47 -1.61 3.01 -0.59 0.41 -1.51
Mitotic Spindle -2.53 -1.95 -3.36 -0.45 -2.16 -1.80 -4.66 -2.17 -1.62 -0.88 -3.25 -4.87 -4.90 -1.78 -1.58
None 1.37 -6.92 3.19 2.91 21.97 3.36 -8.80 4.96 2.12 15.79 1.88 -15.28 3.81 1.90 24.45
Nuclear Periphery -2.87 -16.66 -9.05 -4.66 8.24 1.65 -15.53 -6.63 -7.50 2.67 -0.20 -20.28 -8.33 -8.23 9.70
Nuclear Periphery Foci -1.78 3.31 -0.51 1.60 -5.38 -3.85 -5.75 -4.07 -2.29 -2.47 -4.79 -2.72 -5.63 0.50 -3.90
Nucleolus -1.94 0.29 0.43 2.35 0.57 0.46 0.97 -1.18 -1.68 -2.36 -0.93 1.16 0.97 2.06 -0.60
Nucleus -1.31 -41.81 -5.56 -5.97 41.02 2.31 -31.55 0.79 -0.78 26.18 0.40 -52.92 -7.85 -7.99 42.97
Peroxisomes -3.57 3.28 -5.39 -1.87 -7.79 -4.94 6.24 -1.69 -0.59 -2.15 -5.85 8.53 -5.23 -1.18 -7.48
Vacuole -2.50 0.89 -15.84 -13.69 -17.94 -1.60 -9.75 -13.68 -13.40 -11.84 -2.60 -6.01 -19.98 -18.33 -16.96
Vacuole Periphery -3.01 2.73 -3.14 0.40 -3.89 -0.50 7.07 0.01 0.25 -1.99 -0.21 7.17 1.98 1.92 -4.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Prd1

Prd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Prd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available