Standard name
Human Ortholog
Description Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.14 0.26 0.17 0.21 0 0.15 0.19 0.24 0.15 0.14 0.12 0.18 0.15 0.18 0.12 0.11 0.09 0.12 0.15 0.16 0.13 0.3 0.26 0.31
Bud 0.09 0.1 0.08 0.09 0.07 0.1 0.15 0.13 0.15 0.12 0.14 0.15 0.07 0 0 0 0 0 0.32 0.29 0.23 0.34 0.35 0.28
Bud Neck 0.15 0.12 0.21 0.19 0.28 0.19 0.16 0.17 0.19 0.2 0.18 0.19 0.2 0.24 0.24 0.11 0.19 0.08 0.35 0.33 0.39 0.24 0.19 0.18
Bud Site 0.23 0.12 0.1 0.18 0.17 0.12 0.07 0 0.07 0.05 0 0.05 0.1 0 0 0.05 0.08 0.1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.09 0.07 0.09 0.09 0.15 0.11 0.12 0.16 0.12 0.13 0.15 0.17 0.1 0.09 0.09 0.15 0.13 0.1 0 0 0 0 0 0.05
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0.09 0.09 0.11 0.06 0 0 0 0 0 0
Mitochondria 0.06 0.07 0 0 0 0.09 0.14 0.09 0.19 0.16 0.25 0.14 0 0 0 0.18 0.06 0.14 0 0 0 0 0 0
Nucleus 0 0.06 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.32 0.38 0.32 0.23 0.29 0.34 0.36 0.35 0.31 0.32 0.32 0.33 0.18 0.21 0.21 0.34 0.36 0.43 0 0 0 0 0 0
Peroxisomes 0 0 0.07 0.06 0 0.07 0 0 0 0 0 0 0.09 0.1 0.07 0.06 0.08 0.08 0 0 0 0 0 0
SpindlePole 0 0.05 0.14 0.14 0.13 0.09 0.08 0.07 0.07 0.08 0 0.08 0.12 0.16 0.17 0.05 0.05 0.05 0 0 0.05 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0.08 0 0.05 0.06 0.07 0.06 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 13 21 20 29 5 27 37 48 35 21 26 28 21 34 25 17 10 19 24 27 21 112 78 84
Bud 8 8 9 12 9 18 30 26 35 19 29 23 10 7 7 3 3 6 51 50 37 125 107 78
Bud Neck 14 10 25 26 38 35 32 35 45 30 37 30 29 45 49 16 20 12 56 57 62 89 57 49
Bud Site 22 10 12 25 23 21 14 9 16 8 7 8 14 8 6 8 9 16 – – – – – –
Cell Periphery 4 1 2 2 1 0 2 8 9 4 3 3 2 7 4 2 0 0 2 0 0 2 2 6
Cytoplasm 8 6 11 13 21 20 23 32 28 20 32 26 15 16 18 22 14 15 4 3 3 9 12 15
Endoplasmic Reticulum 1 0 0 1 0 4 2 3 3 1 9 5 3 4 0 2 0 1 1 0 0 4 6 5
Endosome 4 1 3 3 6 5 6 4 6 2 9 6 4 13 7 4 3 3 1 3 2 1 5 5
Golgi 2 3 4 3 0 1 2 10 2 2 1 1 3 1 18 13 12 10 0 0 0 1 1 3
Mitochondria 6 6 1 5 4 17 28 18 45 25 52 21 2 1 4 27 6 22 1 6 1 4 12 11
Nucleus 2 5 2 1 6 12 4 8 6 5 3 1 3 2 5 7 3 1 0 0 0 0 0 0
Nuclear Periphery 0 2 0 1 0 1 0 0 1 1 1 0 0 0 0 0 0 0 0 2 3 3 3 2
Nucleolus 30 30 37 32 40 61 70 71 73 49 68 51 26 38 43 51 39 66 1 7 4 1 0 0
Peroxisomes 4 2 8 8 1 12 8 5 3 3 5 3 13 19 13 9 9 12 3 2 5 4 5 3
SpindlePole 3 4 16 20 18 16 15 15 16 12 6 12 17 29 35 7 5 8 4 4 8 2 4 3
Vac/Vac Membrane 1 0 2 1 3 4 1 3 9 13 7 7 9 13 11 5 3 6 0 2 0 1 0 2
Unique Cell Count 94 80 117 139 136 180 194 202 232 153 210 154 143 184 200 148 107 154 160 174 160 369 305 277
Labelled Cell Count 122 109 152 182 175 254 274 295 332 215 295 225 171 237 245 193 136 197 160 174 160 369 305 277


Bud Neck, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.7 22.9 15.3 15.5 16.3 15.0 14.6 15.3 13.2 13.7 11.8 13.9 18.7 17.5 18.6 27.5 26.3 25.7 17.6 18.4 18.7
Std Deviation (1e-4) 5.9 10.2 5.8 5.0 6.5 7.5 7.0 6.8 5.6 6.0 5.2 6.7 9.7 7.2 8.7 23.7 12.3 13.6 6.9 5.7 7.0
Intensity Change (Log2) – – – 0.02 0.09 -0.03 -0.07 -0.0 -0.22 -0.16 -0.38 -0.14 0.29 0.19 0.28 0.85 0.78 0.75 0.2 0.26 0.29

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.8 -3.6 -0.5 0.4 1.4 -0.5 -0.8 -1.2 0.2 -0.5 0.3 -1.1 -1.3 -1.7 -1.1
Bud 0.3 -0.3 0.7 2.0 1.4 2.0 1.3 1.7 1.8 -0.2 -1.5 -1.6 -2.2 -1.6 -1.4
Bud Neck -0.5 1.2 -0.4 -1.1 -0.9 -0.4 -0.4 -0.8 -0.4 -0.2 0.6 0.6 -2.4 -0.5 -3.2
Bud Site 1.8 1.5 0.4 -0.9 -2.0 -1.1 -1.6 -2.6 -1.6 -0.1 -2.0 -2.7 -1.5 -0.5 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 1.4 0.5 0.7 1.6 0.7 0.9 1.5 1.8 0.3 -0.2 -0.1 1.3 0.9 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 1.7 0 0 0 0
Golgi 0 0 0 0 0.6 0 0 0 0 0 0 1.9 1.8 2.3 1.1
Mitochondria 0 0 3.0 4.0 2.9 4.8 4.3 5.6 3.8 0 0 0 4.6 0 3.9
Nucleus 0 0 2.0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -1.5 -0.4 0.4 0.8 0.6 0 0.1 0.1 0.3 -2.5 -2.1 -2.0 0.5 0.8 1.9
Peroxisomes -0.4 0 -0.1 -1.0 0 0 0 0 0 0.7 1.0 -0.1 -0.2 0.4 0.3
SpindlePole 0.2 -0.1 -1.3 -1.7 -1.8 -2.1 -1.6 -3.7 -1.6 -0.4 0.5 0.9 -2.6 -2.3 -2.4
Vacuole 0 0 0 0 0 0 2.4 0 0 0 2.1 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.368 10.3606 12.7014 9.9131 10.9153 11.4126 15.3707 12.3434 13.2009 13.0762 13.1433 13.7896 16.5855 13.2855 14.9946 14.8206 15.0386 15.957
Actin 0.0888 0.0566 0.0387 0.0285 0.0381 0.1486 0.0628 0.0319 0.0188 0.0293 0.028 0.0697 0.0778 0.0454 0.0261 0.0088 0.0063 0.1535
Bud 0.0104 0.037 0.0185 0.0058 0.0013 0.0074 0.0129 0.0243 0.0093 0.0012 0.0056 0.0052 0.0082 0.0296 0.0141 0.0017 0.0037 0.0054
Bud Neck 0.1111 0.036 0.5255 0.7639 0.6395 0.6616 0.2286 0.0525 0.5166 0.7622 0.6891 0.8233 0.1746 0.0456 0.5314 0.7792 0.7913 0.753
Bud Periphery 0.016 0.0438 0.0215 0.0128 0.0016 0.0164 0.0212 0.0192 0.0138 0.0017 0.01 0.0154 0.0091 0.0227 0.0152 0.002 0.0055 0.015
Bud Site 0.3028 0.7462 0.2874 0.0235 0.0046 0.0396 0.4268 0.8188 0.2662 0.021 0.0161 0.0172 0.5031 0.7659 0.2997 0.0118 0.0141 0.0209
Cell Periphery 0.0108 0.0132 0.0122 0.0063 0.0028 0.0093 0.0125 0.0073 0.0108 0.004 0.007 0.0054 0.0086 0.0128 0.0135 0.0091 0.0072 0.0078
Cytoplasm 0.0308 0.0137 0.0038 0.0035 0.0016 0.0016 0.0033 0.0006 0.0016 0.001 0.0025 0.001 0.0044 0.0009 0.0021 0.001 0.001 0.0008
Cytoplasmic Foci 0.1206 0.0127 0.0106 0.0177 0.0664 0.0375 0.0752 0.0137 0.0261 0.0094 0.015 0.0177 0.0599 0.0298 0.0192 0.0281 0.0174 0.0087
Eisosomes 0.0025 0.0011 0.0013 0.0007 0.0007 0.0029 0.0036 0.0008 0.0011 0.0005 0.0031 0.0009 0.0053 0.0007 0.0011 0.0011 0.0009 0.0022
Endoplasmic Reticulum 0.0058 0.001 0.0008 0.0018 0.0026 0.0004 0.0026 0 0.0004 0.0019 0.0026 0.0001 0.0042 0.0001 0.0007 0.0004 0.0006 0.0005
Endosome 0.049 0.0011 0.0077 0.0232 0.0339 0.0054 0.0068 0.0001 0.0168 0.0351 0.0526 0.0008 0.0162 0.0001 0.0017 0.0079 0.0175 0.0016
Golgi 0.0182 0.0007 0.0097 0.0163 0.0198 0.0021 0.0025 0.0002 0.0043 0.0166 0.0109 0.0013 0.0056 0.0008 0.0014 0.0074 0.0042 0.0016
Lipid Particles 0.0339 0.0021 0.0085 0.0343 0.0413 0.0063 0.0168 0.0017 0.0272 0.0536 0.0164 0.0024 0.0119 0.0022 0.0025 0.0228 0.0164 0.0017
Mitochondria 0.0471 0.0026 0.0074 0.0078 0.0334 0.0083 0.0196 0.0023 0.0066 0.0114 0.034 0.0066 0.0334 0.0106 0.0107 0.0263 0.0301 0.0027
None 0.0138 0.0007 0.0004 0.002 0.0016 0.0005 0.0044 0.0003 0.0025 0.0014 0.0021 0.0001 0.0027 0.0004 0.003 0.0035 0.0007 0.0004
Nuclear Periphery 0.0237 0.0007 0.0006 0.0062 0.0302 0.001 0.0017 0.0001 0.001 0.0061 0.0094 0.0002 0.0075 0.0001 0.0003 0.0012 0.001 0.0015
Nucleolus 0.0389 0.0093 0.0252 0.0163 0.0461 0.0156 0.0439 0.0078 0.042 0.0223 0.0487 0.013 0.0207 0.0156 0.0331 0.0591 0.0349 0.0094
Nucleus 0.0112 0.0032 0.0043 0.0046 0.0051 0.0069 0.0074 0.0021 0.006 0.0047 0.0084 0.0025 0.0043 0.0033 0.0062 0.0073 0.0047 0.0019
Peroxisomes 0.0311 0.0021 0.011 0.015 0.0158 0.0083 0.0302 0.0028 0.0121 0.0087 0.0215 0.0083 0.0274 0.0063 0.0063 0.0108 0.03 0.0026
Punctate Nuclear 0.0157 0.001 0.0019 0.0076 0.008 0.0005 0.0068 0.0089 0.0032 0.0039 0.0098 0.0024 0.0044 0.0015 0.0008 0.006 0.0023 0.002
Vacuole 0.0132 0.0132 0.0026 0.0014 0.0023 0.0144 0.0091 0.0034 0.0121 0.0029 0.0048 0.0049 0.0091 0.0048 0.009 0.0024 0.008 0.0059
Vacuole Periphery 0.0045 0.0021 0.0004 0.0009 0.0033 0.0053 0.0014 0.001 0.0016 0.0012 0.0025 0.0014 0.0018 0.0008 0.0019 0.0019 0.0022 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 55.7965 67.1835 62.694 65.1667 53.1497 54.6275 75.9057 72.9394 62.0059 65.3218
Translational Efficiency 1.6275 1.7313 1.5755 1.5897 1.3275 1.6136 1.691 1.2401 1.4801 1.3318

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
187 1067 1250 773 1654 2051 599 1411 1841 3118 1849 2184

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1343.01 1474.43 1536.28 1908.84 1237.08 1445.80 1656.97 1842.85 1247.84 1455.60 1575.38 1866.21
Standard Deviation 269.85 345.01 370.92 446.82 288.09 329.99 403.40 500.03 288.07 335.48 385.90 482.90
Intensity Change Log 2 — 0.134687 0.193971 0.507226 — 0.224929 0.421609 0.575000 — 0.178661 0.307604 0.540119

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.019171 0.015310 0.006574 0.006608 0.009247 0.008578 0.005448 0.016374 0.010255 0.010882 0.006209 0.012918
Bud Neck 0.179052 0.193326 0.245642 0.225342 0.209502 0.229468 0.236931 0.201143 0.206409 0.217100 0.242820 0.209708
Bud Site 0.646323 0.563067 0.614228 0.619985 0.586873 0.604901 0.614074 0.657199 0.592912 0.590585 0.614178 0.644027
Cell Periphery 0.011222 0.012651 0.007262 0.007275 0.016277 0.016266 0.006521 0.007886 0.015764 0.015029 0.007022 0.007670
Cytoplasm 0.035354 0.027375 0.028091 0.022037 0.034061 0.032660 0.029105 0.029878 0.034192 0.030851 0.028419 0.027103
Cytoplasmic Foci 0.048013 0.079704 0.044173 0.048111 0.074115 0.047906 0.057793 0.035975 0.071464 0.058788 0.048585 0.040271
Eisosomes 0.005614 0.009606 0.005339 0.006078 0.010809 0.013076 0.005086 0.003725 0.010281 0.011889 0.005257 0.004558
Endoplasmic Reticulum 0.000387 0.000545 0.000270 0.000157 0.001345 0.000313 0.000367 0.000408 0.001248 0.000392 0.000302 0.000319
Endosome 0.002341 0.004108 0.001455 0.001060 0.002402 0.002168 0.001540 0.002779 0.002396 0.002832 0.001482 0.002170
Golgi 0.001451 0.002507 0.000695 0.000580 0.001047 0.000950 0.000673 0.002434 0.001088 0.001483 0.000688 0.001778
Lipid Particles 0.000379 0.001572 0.000192 0.000212 0.000339 0.000226 0.000705 0.001024 0.000343 0.000687 0.000358 0.000737
Mitochondria 0.015292 0.024241 0.010493 0.015696 0.011498 0.010227 0.003505 0.005557 0.011883 0.015023 0.008229 0.009146
Mitotic Spindle 0.001401 0.003420 0.003078 0.002916 0.001958 0.002062 0.001694 0.005029 0.001901 0.002527 0.002630 0.004281
None 0.000320 0.000962 0.000461 0.000439 0.001485 0.000826 0.000403 0.000374 0.001367 0.000873 0.000442 0.000397
Nuclear Periphery 0.000065 0.000084 0.000070 0.000082 0.000050 0.000033 0.000055 0.000237 0.000051 0.000050 0.000065 0.000182
Nuclear Periphery Foci 0.000493 0.000672 0.000703 0.000422 0.000726 0.000626 0.000645 0.001923 0.000702 0.000642 0.000684 0.001391
Nucleolus 0.001484 0.004628 0.002656 0.005497 0.002663 0.001721 0.002940 0.002021 0.002543 0.002716 0.002748 0.003252
Nucleus 0.001497 0.004465 0.002663 0.002613 0.004280 0.002385 0.003610 0.003747 0.003997 0.003097 0.002969 0.003346
Peroxisomes 0.021712 0.033210 0.011110 0.015308 0.020173 0.016591 0.009664 0.006359 0.020329 0.022278 0.010641 0.009526
Vacuole 0.007798 0.016103 0.013931 0.016912 0.010106 0.008084 0.017478 0.013218 0.009871 0.010828 0.015080 0.014525
Vacuole Periphery 0.000631 0.002445 0.000914 0.002670 0.001045 0.000934 0.001765 0.002710 0.001003 0.001451 0.001190 0.002696

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.69 2.37 2.37 3.78 0.00 0.44 2.16 -2.89 -3.16 -4.20 -0.41 2.87 -1.44 -1.15 -3.90
Bud Neck -0.81 -3.72 -2.54 -3.17 1.97 -2.56 -2.26 1.34 3.93 3.28 -1.58 -4.55 -0.20 1.51 4.71
Bud Site 3.60 1.49 1.10 -4.35 -0.64 -1.96 -1.65 -6.99 -5.45 -3.68 0.24 -2.04 -5.79 -6.90 -3.79
Cell Periphery -0.55 1.74 1.62 3.28 0.03 0.02 7.27 6.01 5.76 -1.22 0.59 8.24 6.76 6.64 -0.89
Cytoplasm 0.91 0.69 1.47 1.66 2.12 0.35 0.62 0.83 0.54 0.05 1.18 1.42 2.15 1.30 0.69
Cytoplasmic Foci -2.98 0.25 0.01 5.02 -0.47 5.47 1.93 7.87 2.97 3.97 2.89 4.60 7.26 5.44 2.67
Eisosomes -2.14 0.20 -0.25 2.56 -0.75 -1.51 4.76 6.89 7.99 1.65 -1.31 5.04 6.01 8.09 1.17
Endoplasmic Reticulum -1.48 1.27 3.02 4.83 2.84 2.24 2.03 2.00 -1.33 -0.23 2.06 2.25 2.22 1.18 -0.17
Endosome -2.22 1.50 2.36 4.93 1.86 0.49 1.89 -0.57 -0.88 -1.74 -1.03 2.63 0.42 1.26 -1.49
Golgi -2.09 2.38 2.85 4.58 1.06 0.59 2.47 -2.08 -2.22 -2.63 -2.03 3.01 -1.56 -0.61 -2.49
Lipid Particles -1.33 0.66 0.73 1.55 0.24 1.43 -0.99 -1.65 -1.85 -0.62 -1.13 -0.43 -1.50 -0.39 -1.21
Mitochondria -1.60 0.93 -0.08 2.41 -1.89 0.69 4.60 3.60 3.28 -1.72 -1.70 2.08 1.59 3.78 -0.68
Mitotic Spindle -1.88 -2.99 -1.40 0.25 0.26 -0.12 -0.44 -2.75 -2.67 -2.23 -1.08 -1.96 -2.82 -2.03 -1.48
None -4.96 -1.55 -1.58 4.30 0.45 1.56 2.60 2.90 2.18 0.18 1.37 2.64 2.84 3.38 0.60
Nuclear Periphery -0.51 -0.53 -0.62 0.06 -0.14 2.82 -1.54 -2.21 -2.43 -1.99 0.25 -2.29 -2.36 -2.39 -1.93
Nuclear Periphery Foci -1.07 -1.40 0.55 2.76 3.21 0.54 0.41 -1.73 -1.86 -1.83 0.43 -0.03 -1.51 -1.65 -1.53
Nucleolus -2.90 -1.61 -3.61 -0.69 -2.73 1.59 -0.36 1.09 -0.64 1.13 -0.27 -0.39 -1.20 -0.99 -0.87
Nucleus -3.45 -1.75 -1.83 2.20 0.08 3.13 -0.07 0.35 -2.77 0.35 1.72 1.23 0.77 -1.09 -0.56
Peroxisomes -1.90 1.93 1.15 5.57 -2.05 1.67 5.05 7.69 6.85 2.28 -0.92 5.34 6.14 8.56 0.97
Vacuole -3.83 -3.54 -4.16 -0.48 -1.12 2.35 -3.63 -2.92 -5.05 1.97 -0.94 -4.58 -4.47 -3.89 0.70
Vacuole Periphery -3.62 -1.25 -2.63 -0.24 -2.26 0.38 -1.14 -2.22 -2.43 -0.95 -1.53 -0.68 -2.96 -2.19 -2.56
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Cdc10

Cdc10


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cdc10-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available