Standard name
Human Ortholog
Description Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0.1 0.08 0.06 0.05 0.08 – 0.08 0.06 0.09 0 0 0 0.05 0.05 0.07 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0.05 0.06 0.05 0.05 0.1 0.16 0.22 0.24 0.23 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.07 0.1 0.11 0.07 0.08 – 0.08 0.12 0.11 0 0 0 0.17 0.22 0.2 0 0 0 0 0 0
Endoplasmic Reticulum 0.73 0.92 0.92 0.7 0.75 0.7 0.72 0.62 – 0.66 0.55 0.52 0.87 0.9 0.9 0 0 0 0.92 0.94 0.92 0.89 0.85 0.83
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.19 0 0.05 0.22 0.09 0 0 0 – 0 0 0 0 0.07 0.05 0.53 0.37 0.44 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.09 0.09 0.08 – 0.08 0.22 0.25 0 0 0 0.09 0.1 0.07 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.05 0 0.26 0.15 0.08 0 0.11 0.08 – 0.07 0.09 0.09 0 0 0 0 0.05 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0 0 0.06 0.1 0.12 0.12 0.22 – 0.16 0.12 0.14 0.06 0 0 0 0.05 0 0 0 0 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 4 18 27 23 32 43 – 47 26 56 6 13 13 9 5 6 5 0 2 2 8 4
Bud 0 0 0 0 0 4 1 3 – 10 11 12 0 0 1 0 0 1 0 0 0 0 1 2
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 12 5 5 3 11 9 17 20 – 32 26 32 11 32 49 36 25 20 0 0 0 1 0 1
Cytoplasm 5 8 9 12 32 41 43 47 – 49 57 64 7 13 11 28 23 18 0 1 1 2 2 3
Endoplasmic Reticulum 209 166 174 126 244 257 433 352 – 402 258 312 187 282 273 1 1 1 340 179 194 123 232 221
Endosome 0 0 0 0 0 1 0 0 – 1 0 3 0 0 0 1 0 0 0 1 0 1 0 0
Golgi 56 3 10 40 30 2 17 18 – 12 2 4 9 21 15 88 38 39 2 0 1 2 6 7
Mitochondria 0 1 0 5 14 33 56 47 – 50 102 151 0 0 0 15 10 6 3 0 1 0 5 2
Nucleus 1 0 0 0 0 4 2 3 – 1 2 0 0 0 0 1 1 2 0 0 0 0 0 0
Nuclear Periphery 13 1 50 26 26 16 63 43 – 43 40 55 9 14 3 3 5 2 7 1 3 0 4 2
Nucleolus 1 0 0 0 2 1 1 3 – 5 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 45 8 2 10 31 42 74 126 – 99 58 84 13 3 2 5 5 3 5 3 2 2 6 15
Unique Cell Count 288 180 189 179 325 365 599 568 605 467 601 216 315 305 167 104 88 371 190 210 139 272 268
Labelled Cell Count 342 193 254 240 417 433 739 705 751 583 774 242 378 367 187 113 98 371 190 210 139 272 268


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 45.5 44.3 25.3 24.9 21.0 16.4 15.3 14.9 – 13.7 11.9 12.0 35.5 35.9 34.2 38.9 39.3 38.6 39.5 39.4 39.2
Std Deviation (1e-4) 11.5 8.5 5.6 6.2 4.7 3.4 3.3 3.1 – 3.0 2.7 2.7 7.0 7.3 6.4 9.1 9.5 9.6 8.1 11.0 9.1
Intensity Change (Log2) – – – -0.02 -0.27 -0.62 -0.72 -0.77 – -0.88 -1.09 -1.07 0.49 0.51 0.44 0.62 0.64 0.61 0.64 0.64 0.63

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 3.2 2.8 2.2 1.9 2.7 – 2.8 1.9 3.3 0 1.2 1.3 1.6 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0.5 0 0.1 0.6 – 1.5 1.6 1.5 1.3 3.1 4.6 5.6 5.8 5.4
Cytoplasm 0.8 2.1 2.5 1.2 1.6 – 1.5 2.9 2.4 -0.8 -0.3 -0.6 3.7 4.6 4.1
Endoplasmic Reticulum -5.4 -4.8 -5.8 -5.6 -7.8 – -6.9 -9.0 -9.9 -1.8 -0.9 -0.9 -17.2 -15.2 -14.6
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 4.8 1.6 0 -1.6 -1.3 – -2.4 0 0 -0.5 0.6 -0.2 10.0 6.9 7.9
Mitochondria 0 2.9 4.3 4.4 4.1 – 4.1 7.0 7.7 0 0 0 4.2 0 0
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery -2.8 -5.7 -7.6 -5.5 -6.9 – -7.2 -6.0 -6.1 -6.3 -7.2 -8.9 -6.5 -4.5 -4.8
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 2.4 3.8 4.3 4.6 6.7 – 5.5 4.6 5.0 2.6 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 29.5099 31.0632 32.4347 31.3991 27.1744 32.0477 32.2277 35.2529 33.7784 30.3407 31.1972 34.3377 35.9884 32.9853 36.498 34.6155 32.2418 33.3491
Actin 0.0122 0.001 0.0014 0.0001 0.0182 0.0003 0.0148 0.0003 0.0155 0.0018 0.0036 0.0001 0.0019 0.0002 0.0001 0 0.0298 0.0017
Bud 0.0003 0 0.0002 0 0.0003 0 0.0003 0 0.0002 0.0001 0 0 0.0003 0 0 0 0.0001 0
Bud Neck 0.0004 0.0003 0.0002 0.0003 0.0006 0.0002 0.0003 0.0002 0.0007 0.0001 0.0002 0.0002 0.0002 0.0004 0.0002 0.0002 0.0005 0.0007
Bud Periphery 0.001 0.0001 0.0003 0 0.0003 0.0001 0.0005 0.0001 0.0002 0.0004 0.0001 0.0001 0.0004 0.0002 0 0 0.0004 0
Bud Site 0.0011 0.0004 0.0002 0 0.0006 0 0.0009 0 0.0015 0.0001 0.0001 0 0.0005 0.0001 0 0 0.0001 0
Cell Periphery 0.0033 0.0081 0.0054 0.0024 0.0011 0.0009 0.0055 0.0054 0.003 0.0042 0.004 0.0009 0.0045 0.0096 0.0042 0.0014 0.0068 0.0007
Cytoplasm 0.0302 0.0663 0.0161 0.0062 0.0017 0.0019 0.0025 0.0032 0.0036 0.002 0.001 0.0005 0.0042 0.0149 0.0052 0.0007 0.0014 0.0008
Cytoplasmic Foci 0.0236 0.0005 0.0109 0.0001 0.0398 0.0021 0.013 0.0002 0.0094 0.0016 0.0248 0 0.0015 0.0003 0 0 0.0008 0.0018
Eisosomes 0.0004 0.0002 0.0006 0.0001 0.0001 0 0.0007 0 0.0002 0.0007 0.0002 0 0.0005 0.0001 0 0.0001 0.0006 0
Endoplasmic Reticulum 0.7099 0.8299 0.8941 0.9079 0.809 0.8855 0.6932 0.9335 0.9012 0.8158 0.8124 0.8501 0.7807 0.9041 0.9539 0.9832 0.867 0.8809
Endosome 0.0152 0.0007 0.0097 0.0022 0.019 0.0031 0.0143 0.0007 0.0024 0.0106 0.0045 0.0005 0.0041 0.001 0.0002 0.0003 0.002 0.0007
Golgi 0.0036 0.0003 0.0018 0.0003 0.0338 0.0012 0.0117 0.0005 0.0018 0.0105 0.0039 0.0004 0.001 0.0013 0.0002 0.0004 0.0017 0.0003
Lipid Particles 0.0058 0.0023 0.0103 0.0001 0.0154 0.01 0.0147 0.007 0.0056 0.0174 0.0346 0.0006 0.0036 0.0139 0.0005 0.0004 0.004 0.0006
Mitochondria 0.004 0.0003 0.0027 0.0001 0.01 0.0081 0.021 0.0001 0.0058 0.0389 0.0072 0.0001 0.003 0.0001 0 0 0.0084 0.0001
None 0.0062 0.0003 0.0015 0 0.0002 0.0005 0.0022 0 0.0091 0.0006 0.0005 0 0.0011 0.0001 0 0 0.0024 0.0035
Nuclear Periphery 0.1448 0.0626 0.0296 0.0687 0.0391 0.0747 0.1668 0.0427 0.031 0.0769 0.0531 0.1382 0.1709 0.0405 0.0305 0.0106 0.0479 0.1012
Nucleolus 0.001 0.0002 0.0003 0 0 0.0007 0.0007 0 0.0003 0.0002 0.0004 0 0.0006 0.0001 0 0 0.0024 0
Nucleus 0.0113 0.0127 0.0026 0.0084 0.0008 0.0031 0.0074 0.0007 0.0014 0.001 0.0011 0.0009 0.0071 0.0028 0.0012 0.0002 0.0027 0.0018
Peroxisomes 0.0029 0 0.0016 0 0.0028 0.0004 0.0047 0 0.0018 0.0003 0.0306 0 0.0001 0 0 0 0.0013 0.0006
Punctate Nuclear 0.0033 0.0006 0.0008 0 0.0006 0.0002 0.009 0.0001 0.001 0.0001 0.0008 0 0.0011 0.0001 0 0 0.0009 0.0006
Vacuole 0.0103 0.0124 0.0077 0.0022 0.0049 0.0046 0.0065 0.004 0.0028 0.0079 0.0071 0.0035 0.0069 0.0092 0.003 0.002 0.0117 0.0017
Vacuole Periphery 0.0092 0.0007 0.0021 0.0007 0.0016 0.0023 0.0093 0.0012 0.0016 0.0086 0.0097 0.004 0.006 0.001 0.0007 0.0004 0.0069 0.0022

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 172.2748 132.2727 112.1737 154.204 168.5491 100.35 136.3678 119.9248 88.0099 176.4932
Translational Efficiency 1.2463 1.6145 1.5533 0.8056 1.1085 2.0816 1.4205 1.1684 1.5095 1.1662

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1650 571 1132 1340 1574 1178 2242 1993 3224 1749 3374 3333

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2085.61 2626.97 3137.95 3292.39 2210.52 2460.05 3618.80 3343.57 2146.59 2514.54 3457.47 3322.99
Standard Deviation 402.05 534.98 532.19 726.51 481.89 505.62 614.67 799.57 447.21 521.30 630.58 771.44
Intensity Change Log 2 — 0.332930 0.589353 0.658666 — 0.154302 0.711126 0.597004 — 0.243783 0.653292 0.627268

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000494 0.003203 0.000296 0.000676 0.001074 0.001173 0.000098 0.001631 0.000777 0.001836 0.000165 0.001247
Bud Neck 0.000227 0.000875 0.004324 0.002579 0.000686 0.000911 0.000199 0.005623 0.000451 0.000900 0.001583 0.004399
Bud Site 0.000543 0.002007 0.000791 0.003271 0.001199 0.001127 0.000173 0.008643 0.000863 0.001414 0.000380 0.006483
Cell Periphery 0.000875 0.001471 0.003496 0.009492 0.001943 0.001937 0.001977 0.005970 0.001396 0.001785 0.002486 0.007386
Cytoplasm 0.000258 0.000727 0.000713 0.001318 0.001322 0.000889 0.000335 0.008785 0.000777 0.000836 0.000462 0.005783
Cytoplasmic Foci 0.000368 0.000578 0.000108 0.000373 0.000400 0.000419 0.000047 0.001672 0.000384 0.000471 0.000067 0.001150
Eisosomes 0.000177 0.000123 0.000193 0.000223 0.000169 0.000263 0.000187 0.000179 0.000173 0.000218 0.000189 0.000196
Endoplasmic Reticulum 0.968089 0.945148 0.887497 0.905451 0.946985 0.964878 0.978141 0.825172 0.957786 0.958437 0.947730 0.857447
Endosome 0.005061 0.007004 0.006085 0.008916 0.006849 0.005962 0.002365 0.018373 0.005934 0.006302 0.003613 0.014571
Golgi 0.002134 0.004110 0.002151 0.007733 0.006404 0.002412 0.001556 0.005440 0.004218 0.002967 0.001756 0.006362
Lipid Particles 0.002692 0.004513 0.003543 0.009530 0.006586 0.002891 0.001733 0.016415 0.004593 0.003421 0.002340 0.013647
Mitochondria 0.000549 0.001330 0.001189 0.001519 0.001984 0.000820 0.000300 0.002518 0.001249 0.000987 0.000599 0.002117
Mitotic Spindle 0.000091 0.000268 0.000134 0.001055 0.000036 0.000158 0.000015 0.002632 0.000064 0.000194 0.000055 0.001998
None 0.000700 0.000243 0.000164 0.000838 0.001677 0.000441 0.000909 0.002232 0.001177 0.000377 0.000659 0.001671
Nuclear Periphery 0.009855 0.010794 0.057242 0.011739 0.006673 0.003794 0.005405 0.019780 0.008301 0.006079 0.022796 0.016547
Nuclear Periphery Foci 0.003094 0.007967 0.014405 0.014089 0.005084 0.004661 0.001827 0.044898 0.004065 0.005740 0.006047 0.032512
Nucleolus 0.000018 0.000034 0.000063 0.000034 0.000056 0.000210 0.000005 0.000219 0.000037 0.000153 0.000025 0.000145
Nucleus 0.000089 0.000261 0.000579 0.000248 0.000763 0.001202 0.000033 0.001343 0.000418 0.000895 0.000216 0.000903
Peroxisomes 0.000037 0.000238 0.000012 0.000033 0.000019 0.000019 0.000047 0.000261 0.000029 0.000091 0.000035 0.000169
Vacuole 0.002931 0.005904 0.012378 0.014415 0.006101 0.003762 0.003362 0.022283 0.004478 0.004461 0.006387 0.019120
Vacuole Periphery 0.001719 0.003202 0.004637 0.006467 0.003990 0.002068 0.001286 0.005932 0.002828 0.002438 0.002410 0.006147

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.94 0.87 -1.13 1.76 -2.30 -0.18 2.42 -1.16 -0.61 -3.78 -1.59 2.76 -1.70 0.77 -4.32
Bud Neck -3.91 -7.55 -6.15 -4.34 2.17 -0.89 2.96 -8.59 -7.79 -9.34 -2.30 -5.68 -10.33 -8.69 -7.46
Bud Site -1.66 -1.10 -3.27 -1.33 -2.87 -0.15 2.93 -7.48 -7.29 -8.64 -1.52 1.93 -8.24 -6.83 -8.95
Cell Periphery -2.82 -8.22 -9.33 -8.40 -6.12 -0.06 -0.16 -6.18 -5.77 -5.72 -1.80 -4.52 -11.08 -9.71 -8.46
Cytoplasm -1.35 -2.84 -2.74 -1.40 -1.60 0.45 1.73 -7.11 -7.54 -8.72 -0.30 1.01 -7.91 -7.45 -8.81
Cytoplasmic Foci -0.60 1.76 -0.28 0.47 -2.56 -0.06 3.98 -4.70 -3.66 -6.07 -0.39 3.71 -4.44 -2.96 -6.53
Eisosomes 0.39 -0.13 -0.35 -2.36 -0.61 -0.71 -0.18 -0.13 0.60 0.06 -0.41 -0.17 -0.30 0.21 -0.12
Endoplasmic Reticulum 3.56 13.99 11.36 5.08 -1.97 -3.42 -7.82 18.08 20.31 24.11 0.11 3.64 21.86 19.75 19.43
Endosome -2.11 -2.50 -6.70 -1.99 -4.88 1.26 9.98 -12.35 -12.60 -18.39 -0.79 7.46 -14.33 -11.81 -19.08
Golgi -1.92 -0.10 -4.74 -2.49 -4.96 5.31 6.91 1.12 -5.62 -8.25 2.28 5.97 -3.30 -5.33 -8.65
Lipid Particles -1.93 -1.14 -6.90 -4.04 -5.26 3.52 4.97 -5.80 -8.36 -9.21 1.72 3.76 -8.33 -9.43 -10.71
Mitochondria -2.16 -3.06 -2.53 -0.40 -0.84 1.81 2.77 -0.88 -3.52 -4.87 0.62 2.01 -2.24 -3.23 -4.77
Mitotic Spindle -0.95 -0.47 -1.50 -1.19 -1.41 -1.38 2.28 -5.72 -5.38 -5.76 -1.50 0.11 -5.32 -4.89 -5.32
None 2.22 3.19 -0.52 -2.09 -2.59 2.39 1.49 -0.84 -3.37 -2.51 2.87 1.87 -1.28 -3.82 -3.02
Nuclear Periphery -0.55 -13.74 -1.45 -0.55 13.36 2.99 1.15 -7.88 -10.50 -9.07 2.28 -10.18 -7.11 -9.29 3.92
Nuclear Periphery Foci -2.45 -10.59 -7.03 -2.62 -0.16 0.33 4.26 -14.09 -13.84 -15.54 -1.70 -3.58 -15.71 -13.54 -14.64
Nucleolus -1.10 -2.17 -1.98 -0.24 1.33 -1.32 2.61 -1.91 -0.14 -2.51 -1.47 0.89 -2.13 -0.01 -2.35
Nucleus -1.71 -1.41 -2.38 -0.46 0.87 -0.55 1.47 -2.14 -1.09 -4.92 -0.94 0.42 -2.86 -0.91 -3.66
Peroxisomes -0.94 2.65 0.20 0.96 -1.04 -0.06 -2.07 -2.10 -2.10 -1.85 -0.90 -0.71 -2.03 -0.79 -1.92
Vacuole -2.59 -9.36 -8.45 -5.11 -1.51 2.14 2.24 -10.18 -11.65 -11.71 -0.27 -3.43 -13.28 -12.81 -11.33
Vacuole Periphery -1.90 -4.78 -5.60 -2.85 -1.85 2.88 4.68 -2.45 -5.26 -7.02 0.71 0.95 -5.90 -5.97 -6.71
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7
Localization
Cell Percentages ER (100%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Elo2

Elo2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Elo2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available