Standard name
Human Ortholog
Description NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 0 0 0 0 0.05 0.05 0.08 0.08 0.11 0.12 0 0.07 0.07 0.06 0.08 0.09 0 – 0.17 0.1 0.11 0.1
Bud – – 0 0 0 0.06 0.08 0.06 0.09 0.1 0.13 0.08 0 0 0 0 0 0.05 0 – 0 0 0 0
Bud Neck – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0.06 0
Bud Site – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – – 0 0.06 0.05 0 0 0.06 0.07 0.07 0.08 0.1 0.05 0.12 0.14 0.07 0.06 0.05 0 – 0.07 0.06 0.1 0.1
Cytoplasm – – 0.93 0.88 0.76 0.5 0.35 0.38 0.3 0.21 0.2 0.22 0.91 0.8 0.72 0.79 0.82 0.78 0 – 0.28 0.53 0.45 0.54
Endoplasmic Reticulum – – 0 0 0 0.06 0.08 0.07 0.1 0.12 0.09 0.13 0 0.06 0.13 0.05 0.09 0.1 0 – 0 0 0.05 0
Endosome – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0
Golgi – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0
Mitochondria – – 0 0.11 0.2 0.57 0.64 0.5 0.59 0.69 0.67 0.61 0 0 0 0 0.07 0 0.08 – 0.3 0.16 0.12 0.12
Nucleus – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0
Nuclear Periphery – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0
Nucleolus – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0
Peroxisomes – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0
SpindlePole – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0
Vac/Vac Membrane – – 0 0 0 0 0 0.08 0.05 0 0 0.05 0 0 0 0 0 0 0 – 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 2 0 8 9 34 29 44 47 74 89 15 30 30 22 25 20 0 – 67 29 28 40
Bud – – 6 6 15 33 54 34 45 56 85 63 4 4 5 7 4 11 0 – 8 4 3 11
Bud Neck – – 10 4 4 2 2 0 2 0 0 1 2 3 3 3 4 3 0 – 11 9 15 11
Bud Site – – 0 2 2 3 2 3 4 7 10 13 0 1 0 0 0 0 – – – – – –
Cell Periphery – – 10 23 21 21 27 36 36 37 56 78 22 51 57 26 19 10 0 – 28 16 26 39
Cytoplasm – – 337 332 344 278 238 225 156 114 138 163 371 344 291 278 261 171 0 – 109 159 122 224
Endoplasmic Reticulum – – 1 2 9 32 54 40 51 65 60 100 11 25 52 19 28 21 0 – 13 12 13 15
Endosome – – 3 0 8 2 3 18 7 2 12 10 1 2 2 4 3 2 0 – 8 2 4 5
Golgi – – 0 0 1 1 0 6 8 6 13 18 2 2 6 1 1 2 0 – 0 1 1 3
Mitochondria – – 12 41 91 320 431 298 312 383 454 463 2 4 3 11 21 6 0 – 114 47 31 48
Nucleus – – 1 1 0 2 3 4 1 2 4 3 0 0 3 6 3 0 0 – 0 1 1 0
Nuclear Periphery – – 0 1 0 2 6 16 12 14 9 19 0 0 0 0 0 1 0 – 1 1 0 1
Nucleolus – – 0 0 1 1 2 3 1 3 5 4 0 0 0 0 0 0 0 – 0 0 0 0
Peroxisomes – – 2 14 12 2 0 17 5 6 10 14 0 4 1 5 0 1 0 – 1 0 0 0
SpindlePole – – 7 11 12 2 12 17 16 9 20 14 2 6 13 13 2 5 0 – 4 1 2 4
Vac/Vac Membrane – – 1 3 6 7 27 46 28 23 30 41 1 4 3 8 2 1 0 – 4 7 9 5
Unique Cell Count 364 376 452 561 677 597 528 555 678 755 406 429 403 353 319 218 1 387 300 271 418
Labelled Cell Count 392 440 534 717 895 792 728 774 980 1093 433 480 469 403 373 254 1 387 300 271 418


Peroxisomes

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – – 4.0 4.1 4.9 3.6 4.1 5.0 5.3 6.1 6.7 7.2 5.8 6.7 7.3 5.9 5.7 5.4 5.5 5.7 5.9
Std Deviation (1e-4) – – 1.5 3.3 5.5 2.1 1.9 3.2 3.6 4.6 5.9 6.4 2.1 3.0 3.7 1.4 1.6 1.9 1.5 1.6 1.8
Intensity Change (Log2) – – – 0.04 0.31 -0.13 0.04 0.33 0.43 0.62 0.76 0.87 0.54 0.76 0.88 0.57 0.53 0.44 0.48 0.52 0.58

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 3.7 5.2 5.2 6.1 6.4 3.0 4.6 4.8 4.2 4.9 5.3
Bud 0 1.5 0 0 3.0 4.3 5.0 5.9 4.4 0 0 -0.5 0.3 0 2.4
Bud Neck 0 -2.0 0 0 0 0 0 0 0 -2.5 -2.3 -2.1 -1.9 -1.4 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 1.4 0 0 2.3 2.7 2.6 3.5 4.4 1.9 4.8 5.6 2.8 2.1 1.2
Cytoplasm -2.0 -6.3 -13.5 -17.8 -16.8 -18.6 -21.4 -22.3 -22.4 -0.6 -5.0 -7.3 -5.3 -4.3 -5.0
Endoplasmic Reticulum 0 0 0 0 4.8 5.9 6.6 5.6 7.1 2.7 4.4 6.9 4.2 5.5 5.7
Endosome 0 0 0 0 2.3 0 0 1.2 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 3.0 0 0 0 0 0 0
Mitochondria 0 7.2 0 0 15.0 17.0 19.7 19.7 18.4 -2.9 -2.4 -2.5 -0.1 2.0 -0.4
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 3.1 0 3.1 0 3.1 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 2.3 0 0 2.5 0 0 0 1.7 0 0 0 0 0 0
SpindlePole 0 0.7 0 0 0.9 1.0 -0.3 1.0 -0.1 0 -0.6 1.1 1.4 0 0
Vacuole 0 0 0 3.5 5.2 4.2 3.6 3.8 4.3 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.2799 1.4244 1.3159 1.2886 1.8413 1.6422 1.8073 2.2596 2.4736 2.477 1.9809 2.0146 1.2076 1.2442 0.6223 0.6779 0.7571 0.5248
Actin 0.0437 0.0339 0.0529 0.0171 0.0112 0.0391 0.1085 0.0583 0.1439 0.0611 0.0997 0.0763 0.0901 0.0622 0.0971 0.1239 0.1336 0.0942
Bud 0.0046 0.0081 0.0124 0.0056 0.0021 0.0028 0.0064 0.0113 0.0152 0.017 0.0138 0.0096 0.0058 0.0092 0.0154 0.0179 0.0089 0.004
Bud Neck 0.0082 0.0054 0.0072 0.0026 0.0098 0.0382 0.0117 0.0075 0.0179 0.013 0.0077 0.1221 0.0162 0.0065 0.0088 0.0095 0.0374 0.0928
Bud Periphery 0.0296 0.0156 0.0533 0.0486 0.0329 0.0267 0.0314 0.0323 0.0832 0.1392 0.0728 0.0613 0.0328 0.0228 0.0707 0.1401 0.0419 0.0335
Bud Site 0.0251 0.1489 0.0475 0.012 0.0032 0.0067 0.0402 0.1935 0.081 0.032 0.0204 0.0071 0.0404 0.2586 0.0695 0.0218 0.0104 0.0048
Cell Periphery 0.0497 0.0358 0.0391 0.045 0.1389 0.0711 0.0904 0.0904 0.1221 0.1319 0.0391 0.0987 0.144 0.0724 0.1044 0.1301 0.0866 0.0965
Cytoplasm 0.2104 0.1743 0.1904 0.2805 0.3396 0.2555 0.2888 0.3407 0.2537 0.3061 0.2525 0.4294 0.2756 0.2877 0.2458 0.239 0.2741 0.3375
Cytoplasmic Foci 0.0151 0.011 0.0187 0.0132 0.0229 0.0191 0.0425 0.0122 0.0195 0.0068 0.0367 0.0176 0.0309 0.0063 0.0211 0.0349 0.0168 0.0197
Eisosomes 0.0064 0.0023 0.0038 0.0021 0.0052 0.0026 0.0155 0.0063 0.0096 0.0089 0.0033 0.0059 0.0201 0.0073 0.01 0.0058 0.0047 0.0063
Endoplasmic Reticulum 0.0239 0.0028 0.0047 0.0089 0.0054 0.0068 0.0219 0.0203 0.0115 0.0244 0.0089 0.019 0.0225 0.0063 0.0115 0.013 0.0113 0.0118
Endosome 0.0043 0.0021 0.0047 0.0036 0.0061 0.0089 0.03 0.0049 0.0153 0.0087 0.0625 0.0108 0.026 0.0023 0.0135 0.0064 0.0384 0.0119
Golgi 0.0038 0.0013 0.0041 0.0017 0.0027 0.0055 0.018 0.0064 0.0147 0.0136 0.0315 0.0071 0.0172 0.0033 0.0107 0.0094 0.0292 0.0116
Lipid Particles 0.0043 0.0012 0.0013 0.0014 0.0027 0.0021 0.0166 0.0036 0.0076 0.0058 0.0219 0.0059 0.0177 0.001 0.0115 0.0101 0.0475 0.0105
Mitochondria 0.0033 0.0012 0.0038 0.0039 0.0111 0.0035 0.0214 0.0008 0.0063 0.0156 0.0426 0.0022 0.0064 0.0016 0.0054 0.0148 0.0392 0.007
None 0.5578 0.5378 0.5389 0.5475 0.3941 0.5041 0.2065 0.2046 0.1751 0.2049 0.2472 0.1136 0.2184 0.2479 0.2853 0.2027 0.1797 0.2331
Nuclear Periphery 0.0014 0.0009 0.0007 0.0006 0.0004 0.0006 0.0148 0.0009 0.004 0.0021 0.0062 0.0033 0.0085 0.0004 0.0017 0.001 0.0088 0.0034
Nucleolus 0.0006 0.0006 0.0024 0.0005 0.0003 0.0003 0.0017 0.0004 0.0007 0.0005 0.002 0.0005 0.0009 0.0003 0.0012 0.0003 0.0008 0.0004
Nucleus 0.0012 0.0047 0.0031 0.0013 0.0006 0.0016 0.0054 0.001 0.0016 0.0012 0.0032 0.0018 0.0041 0.0007 0.0014 0.0008 0.0014 0.0043
Peroxisomes 0.001 0.0026 0.0022 0.0012 0.0084 0.0013 0.0084 0.0005 0.0047 0.0021 0.0068 0.0007 0.0092 0.0003 0.0063 0.0146 0.0099 0.0132
Punctate Nuclear 0.0008 0.0036 0.0043 0.0008 0.0004 0.0013 0.0101 0.0005 0.0081 0.0005 0.0057 0.0012 0.0049 0.0002 0.0022 0.0008 0.0074 0.0012
Vacuole 0.0044 0.0057 0.0039 0.0017 0.0018 0.0017 0.0075 0.0035 0.0038 0.0041 0.0129 0.0054 0.0073 0.0025 0.0058 0.0025 0.007 0.0019
Vacuole Periphery 0.0005 0.0002 0.0004 0.0002 0.0004 0.0003 0.0022 0.0002 0.0006 0.0008 0.0026 0.0006 0.001 0.0002 0.0006 0.0004 0.0049 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 68.4936 52.8416 82.1558 129.0559 60.8253 128.4717 99.8596 125.3526 197.7931 84.452
Translational Efficiency 1.7246 1.5433 1.2882 1.891 1.9835 1.4559 1.6743 1.782 1.7372 1.8498

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1696 229 1394 1073 1904 1463 88 881 3600 1692 1482 1954

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 665.53 741.74 797.66 792.15 674.89 695.53 897.62 799.56 670.48 701.78 803.60 795.49
Standard Deviation 70.35 87.12 100.44 130.68 72.44 79.20 120.94 242.97 71.61 81.86 104.48 189.76
Intensity Change Log 2 — 0.156410 0.261270 0.251270 — 0.043460 0.411452 0.244554 — 0.100646 0.338838 0.247892

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000124 0.000905 0.002909 0.020017 0.000713 0.000184 0.006507 0.037736 0.000436 0.000281 0.003122 0.028006
Bud Neck 0.018596 0.041285 0.006656 0.014096 0.013598 0.028190 0.005137 0.013710 0.015953 0.029963 0.006566 0.013922
Bud Site 0.004320 0.021556 0.013094 0.078270 0.006166 0.006316 0.015769 0.093335 0.005297 0.008378 0.013253 0.085062
Cell Periphery 0.000132 0.000213 0.002378 0.019498 0.001194 0.000171 0.009201 0.046341 0.000694 0.000176 0.002783 0.031601
Cytoplasm 0.441785 0.303818 0.395050 0.382417 0.542586 0.447513 0.285151 0.400189 0.495098 0.428065 0.388525 0.390430
Cytoplasmic Foci 0.261088 0.314630 0.027440 0.050477 0.185486 0.231769 0.029710 0.056305 0.221102 0.242984 0.027575 0.053104
Eisosomes 0.000228 0.000259 0.000301 0.004079 0.000594 0.000201 0.005791 0.008069 0.000421 0.000209 0.000627 0.005878
Endoplasmic Reticulum 0.000694 0.000714 0.003523 0.013485 0.001097 0.000489 0.015064 0.018352 0.000908 0.000519 0.004208 0.015679
Endosome 0.009670 0.042550 0.002754 0.004153 0.005285 0.016360 0.004869 0.003079 0.007351 0.019904 0.002879 0.003668
Golgi 0.002804 0.004511 0.000361 0.002331 0.002195 0.003318 0.000633 0.003048 0.002482 0.003480 0.000377 0.002654
Lipid Particles 0.010906 0.008991 0.003768 0.004850 0.007296 0.008301 0.007028 0.005328 0.008997 0.008394 0.003962 0.005065
Mitochondria 0.006618 0.009310 0.000416 0.002178 0.003418 0.008756 0.000210 0.001282 0.004926 0.008831 0.000403 0.001774
Mitotic Spindle 0.001875 0.002709 0.000926 0.009467 0.000141 0.004644 0.000169 0.002876 0.000958 0.004382 0.000881 0.006496
None 0.002059 0.000985 0.005225 0.001766 0.002416 0.002608 0.027693 0.001873 0.002248 0.002388 0.006559 0.001814
Nuclear Periphery 0.000460 0.000349 0.001172 0.000651 0.000279 0.000481 0.001521 0.000350 0.000364 0.000463 0.001192 0.000515
Nuclear Periphery Foci 0.000203 0.000435 0.000836 0.002040 0.000202 0.000227 0.002079 0.001598 0.000203 0.000255 0.000910 0.001841
Nucleolus 0.001191 0.002098 0.000542 0.000225 0.000592 0.001401 0.001138 0.000204 0.000874 0.001496 0.000577 0.000215
Nucleus 0.186564 0.104772 0.488916 0.208939 0.192834 0.159306 0.430158 0.173739 0.189880 0.151925 0.485427 0.193069
Peroxisomes 0.007777 0.042752 0.000456 0.003073 0.002886 0.010604 0.000685 0.005607 0.005190 0.014955 0.000470 0.004215
Vacuole 0.041947 0.094485 0.043083 0.176724 0.030336 0.067642 0.151330 0.126639 0.035806 0.071275 0.049510 0.154142
Vacuole Periphery 0.000957 0.002672 0.000196 0.001265 0.000685 0.001519 0.000156 0.000340 0.000813 0.001675 0.000193 0.000848

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.86 -3.33 -7.74 -7.15 -5.93 2.49 -1.65 -8.36 -8.53 -6.29 1.24 -3.14 -11.16 -11.26 -9.30
Bud Neck -3.74 7.42 4.31 4.97 -3.48 -6.79 6.93 1.34 7.47 -4.85 -7.02 7.57 3.95 9.28 -4.15
Bud Site -3.91 -3.68 -11.03 -5.82 -8.92 -0.12 -0.92 -11.58 -11.61 -8.30 -2.90 -3.40 -15.92 -14.95 -12.93
Cell Periphery -2.14 -2.83 -5.24 -5.20 -4.29 3.14 -1.33 -7.31 -7.55 -5.74 2.99 -2.25 -8.91 -9.14 -8.02
Cytoplasm 7.66 6.70 8.80 -2.51 2.20 10.96 11.69 15.05 5.92 -5.56 8.74 15.20 17.61 7.23 0.33
Cytoplasmic Foci -3.25 41.46 36.81 18.54 -7.12 -6.70 25.52 26.03 29.44 -4.31 -3.37 51.96 44.48 36.26 -9.50
Eisosomes -0.79 -0.59 -5.49 -5.42 -5.32 3.34 -1.04 -6.40 -6.91 -1.40 3.34 -0.05 -8.27 -8.79 -7.93
Endoplasmic Reticulum -0.18 -8.14 -8.00 -7.98 -5.39 2.43 -2.60 -7.09 -7.43 -1.13 2.54 -7.69 -10.48 -10.86 -7.19
Endosome -5.67 8.75 7.33 6.81 -1.70 -9.87 -0.23 5.65 12.54 2.71 -9.76 9.32 8.89 13.53 -0.67
Golgi -1.72 6.63 1.76 2.69 -2.17 -2.36 5.73 -0.16 1.28 -2.83 -2.23 9.86 1.19 2.65 -3.62
Lipid Particles 1.22 6.40 7.15 2.76 -0.60 -1.26 0.71 3.68 4.68 1.46 0.98 5.81 7.88 6.06 -0.74
Mitochondria -0.83 5.95 4.07 2.67 -1.91 -4.11 5.01 3.32 6.62 -2.54 -3.20 7.57 5.03 6.74 -2.54
Mitotic Spindle -0.83 1.30 -3.30 -2.27 -3.89 -4.18 -1.03 -2.19 1.63 -2.02 -3.52 0.18 -4.03 -0.82 -4.04
None 3.66 -3.98 1.33 -1.61 4.59 -0.63 -1.26 2.36 2.71 1.34 -0.46 -3.68 2.48 2.41 4.43
Nuclear Periphery 1.26 -6.76 -4.81 -6.41 2.20 -2.80 -8.87 -6.38 0.02 7.83 -1.48 -9.27 -6.59 -3.78 5.16
Nuclear Periphery Foci -2.48 -8.12 -8.84 -7.35 -5.27 -0.49 -3.92 -12.16 -11.38 1.37 -0.95 -9.39 -13.25 -12.44 -5.96
Nucleolus -1.35 2.41 3.42 2.62 6.88 -4.42 -1.13 4.65 7.52 2.61 -2.76 2.35 4.69 7.40 7.83
Nucleus 7.11 -33.87 -4.73 -9.49 25.85 5.53 -7.46 -0.75 -4.42 7.13 7.37 -36.17 -3.98 -9.22 29.99
Peroxisomes -4.91 10.46 5.89 5.72 -2.74 -6.81 9.24 -1.52 4.05 -3.79 -6.79 13.29 2.96 7.82 -4.79
Vacuole -6.41 -3.25 -25.40 -12.08 -23.07 -12.72 -7.31 -19.51 -13.82 2.07 -12.89 -8.01 -31.99 -23.22 -23.28
Vacuole Periphery -2.64 3.74 0.17 2.54 -2.18 -3.79 4.24 2.85 6.38 -1.54 -4.04 5.22 0.94 4.18 -2.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import
Localization
Cell Percentages cytoplasm (19%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Gpd1

Gpd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gpd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available