Standard name
Human Ortholog
Description Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.07 0.08 0.07 0 – 0 0 0 0 – 0.2 0.21 0.05 0.12 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0.05 0 0.05 0 0 0 0.05 0 0
Endosome 0.1 0.12 0.08 0.17 0.18 0.2 0.18 – 0.15 0.07 0 0.06 – 0.28 0.12 0.25 0.21 0.24 0.18 0.13 0.13 0.28 0.34 0.44
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0
Mitochondria 0.2 0.05 0 0.05 0 0.12 0.14 – 0.3 0.21 0.54 0.3 – 0 0 0.16 0.09 0.11 0 0 0 0 0.05 0.09
Nucleus 0.31 0.3 0.42 0.23 0.21 0.2 0.3 – 0.21 0.23 0.15 0.19 – 0.1 0.23 0.23 0.2 0.27 0.11 0.15 0.11 0.05 0.05 0
Nuclear Periphery 0.24 0.3 0.29 0.12 0.24 0.18 0.1 – 0.13 0.16 0.13 0.16 – 0.12 0.08 0.28 0.23 0.17 0.34 0.34 0.34 0.18 0.13 0.07
Nucleolus 0.39 0.32 0.22 0.48 0.4 0.4 0.41 – 0.39 0.4 0.49 0.46 – 0.6 0.44 0.24 0.2 0.2 0.16 0.19 0.23 0.18 0.11 0.17
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0.08 0 0
SpindlePole 0 0 0.06 0.12 0.14 0.1 0.12 – 0.12 0.11 0.05 0.1 – 0.1 0.17 0.12 0.1 0.1 0.12 0.05 0.07 0.14 0.15 0.07
Vac/Vac Membrane 0.06 0.14 0.09 0 0.07 0 0 – 0 0 0 0 – 0.05 0.06 0.18 0.26 0.15 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 0 – 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0
Bud 0 0 0 0 1 0 2 – 4 6 4 6 – 0 0 0 0 0 2 1 1 0 0 0
Bud Neck 0 0 0 0 1 0 3 – 0 1 0 3 – 0 0 0 0 0 0 0 1 0 0 0
Bud Site 0 0 0 0 0 0 8 – 7 9 17 9 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 5 2 13 22 22 17 – 12 21 16 10 – 8 10 5 13 14 0 1 0 0 0 0
Endoplasmic Reticulum 1 0 0 0 1 1 0 – 0 1 0 0 – 0 0 5 3 8 0 0 0 0 0 0
Endosome 27 18 11 31 50 66 81 – 47 34 12 25 – 11 6 24 23 41 57 28 29 3 12 16
Golgi 0 0 0 0 1 0 0 – 0 0 0 0 – 0 0 1 2 0 2 1 0 0 1 1
Mitochondria 55 7 0 10 4 41 63 – 95 101 235 123 – 0 0 15 10 19 8 7 7 0 1 3
Nucleus 86 47 58 42 57 69 137 – 67 107 67 80 – 4 11 22 21 46 35 32 24 0 1 0
Nuclear Periphery 65 47 40 22 66 60 46 – 43 76 57 65 – 5 4 27 25 29 109 72 75 2 5 2
Nucleolus 108 49 31 87 110 136 189 – 126 190 217 192 – 24 21 23 21 34 50 41 50 2 4 6
Peroxisomes 1 1 0 3 1 3 7 – 1 0 0 0 – 0 0 1 0 0 2 0 1 0 0 0
SpindlePole 9 2 8 22 39 35 54 – 39 52 20 41 – 4 8 11 11 17 37 11 15 1 5 2
Vac/Vac Membrane 16 22 13 7 18 13 16 – 13 16 11 8 – 2 3 17 28 25 11 13 9 0 0 0
Unique Cell Count 276 155 139 182 275 338 456 320 470 439 414 40 48 95 107 168 323 213 224 13 38 38
Labelled Cell Count 372 198 164 237 372 446 623 454 614 656 562 58 63 151 157 233 323 213 224 13 38 38


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.9 8.3 7.9 7.6 7.5 6.5 6.2 – 5.6 5.7 5.0 5.3 – 8.1 7.3 7.9 8.0 7.5 – – –
Std Deviation (1e-4) 1.0 1.8 1.1 1.5 1.5 1.5 1.3 – 1.3 1.1 1.2 1.2 – 1.8 1.7 1.6 1.8 1.5 – – –
Intensity Change (Log2) – – – -0.05 -0.07 -0.28 -0.34 – -0.49 -0.47 -0.65 -0.56 – 0.04 -0.12 0.0 0.02 -0.08 – – –

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT102468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Cytoplasm 2.4 2.7 2.3 0 – 0 1.6 0 0 – 0 0 0 3.5 2.7
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Endosome 2.4 2.8 3.1 2.8 – 2.0 -0.3 -2.7 -0.8 – 0 0 3.7 3.1 3.8
Golgi 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Mitochondria 0 0 4.3 4.6 – 7.2 6.0 11.2 7.3 – 0 0 4.8 0 4.1
Nucleus -3.6 -4.5 -4.8 -2.6 – -4.6 -4.4 -6.6 -5.3 – -3.7 -2.3 -2.9 -3.7 -2.6
Nuclear Periphery -3.8 -1.1 -2.7 -5.5 – -3.9 -3.3 -4.3 -3.4 – -2.1 -2.9 -0.1 -1.0 -2.4
Nucleolus 4.7 3.6 3.7 4.1 – 3.5 3.9 5.6 5.0 – 4.6 2.9 0.3 -0.5 -0.4
Peroxisomes 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
SpindlePole 1.9 2.6 1.6 2.1 – 2.1 1.8 -0.6 1.5 – 0 0 1.6 1.3 1.4
Vacuole -2.0 -1.0 -2.4 -2.8 – -2.3 -2.9 -3.5 -4.0 – 0 0 1.9 3.5 1.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5362 2.8258 2.3163 1.9202 2.0623 2.0628 2.083 2.4921 2.303 1.9217 1.6821 2.0754 1.6931 1.9363 1.9098 1.9239 1.4529 1.2913
Actin 0.0094 0.0001 0.0068 0.0005 0.0008 0.0005 0.0125 0.0003 0.0093 0.0016 0.0045 0.0005 0.0287 0.0003 0.043 0.0048 0.0004 0.0031
Bud 0.0003 0 0.0003 0 0.0001 0 0.0001 0 0.0003 0 0.0001 0 0.0006 0.0001 0.0003 0.0002 0 0
Bud Neck 0.0014 0.0006 0.0005 0.0004 0.0005 0.0015 0.0005 0.0003 0.0005 0.0003 0.0009 0.0005 0.0013 0.0006 0.0008 0.0008 0.0006 0.0013
Bud Periphery 0.0007 0.0001 0.0009 0.0002 0.0003 0.0002 0.0004 0.0001 0.0004 0.0001 0.0002 0.0001 0.0011 0.0001 0.0006 0.0004 0.0001 0.0002
Bud Site 0.0018 0.0002 0.0009 0.0003 0.0002 0.0002 0.0006 0.0002 0.0114 0.0002 0.0003 0.0001 0.0021 0.0005 0.0022 0.0007 0.0002 0.0002
Cell Periphery 0.0002 0 0.0002 0.0001 0.0001 0.0001 0.0001 0 0.0002 0.0001 0.0001 0 0.0002 0.0001 0.0002 0.0002 0 0.0001
Cytoplasm 0.0024 0.0003 0.0018 0.0002 0.0032 0.0002 0.0041 0.0001 0.0016 0.0018 0.0015 0.0003 0.0027 0.0006 0.0011 0.0241 0.0021 0.0003
Cytoplasmic Foci 0.0121 0.006 0.0166 0.0072 0.0081 0.0056 0.0161 0.0037 0.021 0.0147 0.0217 0.004 0.0302 0.0083 0.0176 0.0192 0.0053 0.0037
Eisosomes 0.0002 0 0.0002 0 0.0001 0 0.0002 0 0.0002 0.0001 0.0003 0 0.0002 0 0.0011 0.0001 0 0.0001
Endoplasmic Reticulum 0.0013 0.0002 0.0022 0.0002 0.0014 0.0002 0.0012 0.0002 0.0011 0.0007 0.0009 0.0006 0.0041 0.0002 0.0009 0.0031 0.0005 0.0004
Endosome 0.0152 0.0013 0.0202 0.002 0.0169 0.004 0.0134 0.0012 0.0184 0.0048 0.0164 0.0079 0.0306 0.0021 0.0057 0.0128 0.0022 0.0019
Golgi 0.0055 0.0016 0.0063 0.0024 0.0029 0.003 0.0074 0.002 0.0103 0.0051 0.009 0.0039 0.017 0.0022 0.0062 0.009 0.0022 0.0025
Lipid Particles 0.083 0.0752 0.0907 0.0605 0.0634 0.0743 0.1372 0.0538 0.0877 0.1221 0.0921 0.0643 0.1041 0.0554 0.0839 0.1003 0.0524 0.0458
Mitochondria 0.0095 0.0002 0.0176 0.0003 0.003 0.0007 0.0028 0.0002 0.0071 0.0203 0.0081 0.0013 0.0086 0.0003 0.0144 0.0038 0.0004 0.0024
None 0.0038 0.0002 0.0016 0.0004 0.0012 0.0002 0.0053 0.0003 0.0031 0.0011 0.0058 0.0003 0.0016 0.0003 0.0018 0.0116 0.0012 0.0002
Nuclear Periphery 0.3672 0.2324 0.3092 0.2858 0.3908 0.2435 0.3751 0.3298 0.3148 0.2449 0.2165 0.2685 0.2833 0.1492 0.2232 0.1151 0.2526 0.1841
Nucleolus 0.1354 0.2669 0.1592 0.1568 0.1897 0.2308 0.1324 0.2275 0.1652 0.1639 0.1701 0.2115 0.1637 0.3444 0.2557 0.3301 0.1704 0.3068
Nucleus 0.044 0.0647 0.0762 0.0531 0.0791 0.0554 0.0409 0.0413 0.0323 0.0232 0.0474 0.0539 0.0446 0.1228 0.0875 0.0801 0.1083 0.0982
Peroxisomes 0.0074 0.0006 0.0035 0.0012 0.0018 0.0019 0.0097 0.0008 0.013 0.0184 0.0182 0.0007 0.0195 0.0013 0.0114 0.0106 0.0007 0.001
Punctate Nuclear 0.2925 0.3471 0.272 0.4262 0.2318 0.3754 0.2335 0.3349 0.2972 0.3704 0.384 0.3785 0.2492 0.309 0.237 0.2695 0.3979 0.3454
Vacuole 0.0022 0.0005 0.0067 0.0003 0.0021 0.0007 0.0013 0.0002 0.0013 0.0007 0.0007 0.0004 0.0022 0.0007 0.0013 0.0012 0.0005 0.0005
Vacuole Periphery 0.0045 0.0017 0.0063 0.0017 0.0027 0.0016 0.0051 0.0032 0.0038 0.0051 0.0014 0.0024 0.0046 0.0017 0.0041 0.0025 0.0018 0.0018

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.6789 2.336 4.3335 8.7158 11.8582 17.629 6.4953 4.9817 5.6169 12.191
Translational Efficiency 1.1143 2.5116 1.2559 0.6084 0.7719 0.8972 0.781 0.788 0.9721 0.9785

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
373 1335 365 801 1633 1706 1636 2172 2006 3041 2001 2973

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 693.24 834.64 1056.19 884.36 800.05 820.93 923.22 943.09 780.19 826.95 947.47 927.27
Standard Deviation 106.13 140.43 147.65 114.33 109.79 121.33 148.42 126.43 116.77 130.24 156.92 126.01
Intensity Change Log 2 — 0.267799 0.607443 0.351279 — 0.037169 0.206584 0.237305 — 0.148834 0.406576 0.291338

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000222 0.000504 0.000853 0.000530 0.000432 0.000443 0.000619 0.000475 0.000393 0.000470 0.000662 0.000490
Bud Neck 0.000663 0.001012 0.003114 0.001173 0.000739 0.000958 0.003199 0.003467 0.000725 0.000982 0.003183 0.002849
Bud Site 0.000146 0.000362 0.000472 0.000296 0.000919 0.000277 0.000569 0.000453 0.000776 0.000314 0.000552 0.000411
Cell Periphery 0.000059 0.000047 0.000046 0.000032 0.000055 0.000041 0.000145 0.000033 0.000055 0.000044 0.000126 0.000033
Cytoplasm 0.004160 0.001425 0.000232 0.000369 0.002978 0.001163 0.017164 0.000739 0.003198 0.001278 0.014076 0.000640
Cytoplasmic Foci 0.003286 0.001256 0.000319 0.000274 0.002141 0.002602 0.002685 0.000362 0.002354 0.002011 0.002253 0.000338
Eisosomes 0.000029 0.000027 0.000029 0.000031 0.000034 0.000035 0.000048 0.000028 0.000033 0.000032 0.000045 0.000029
Endoplasmic Reticulum 0.001792 0.003395 0.004055 0.003059 0.002624 0.003115 0.002636 0.002292 0.002469 0.003238 0.002895 0.002498
Endosome 0.001707 0.001474 0.000472 0.000420 0.001172 0.005922 0.000697 0.001319 0.001272 0.003970 0.000656 0.001077
Golgi 0.001015 0.000906 0.000491 0.000358 0.000773 0.002730 0.000347 0.000412 0.000818 0.001929 0.000373 0.000397
Lipid Particles 0.046614 0.009201 0.000617 0.000657 0.016797 0.012091 0.001373 0.000501 0.022341 0.010822 0.001235 0.000543
Mitochondria 0.001800 0.001423 0.000969 0.001232 0.001837 0.005502 0.001702 0.002038 0.001831 0.003711 0.001569 0.001821
Mitotic Spindle 0.065994 0.094597 0.327566 0.129755 0.067520 0.119530 0.199425 0.210063 0.067236 0.108585 0.222799 0.188426
None 0.016093 0.004062 0.000712 0.001361 0.004702 0.002819 0.021539 0.001128 0.006820 0.003365 0.017740 0.001191
Nuclear Periphery 0.014029 0.016166 0.035215 0.017378 0.011739 0.016943 0.017928 0.027064 0.012165 0.016602 0.021082 0.024455
Nuclear Periphery Foci 0.731976 0.576346 0.227055 0.364851 0.639601 0.524900 0.154796 0.307862 0.656777 0.547485 0.167977 0.323216
Nucleolus 0.069147 0.151958 0.222486 0.275343 0.147594 0.167075 0.250841 0.259309 0.133007 0.160438 0.245669 0.263629
Nucleus 0.039744 0.133831 0.171778 0.201500 0.096801 0.129183 0.322054 0.179923 0.086192 0.131223 0.294642 0.185736
Peroxisomes 0.001180 0.001017 0.002485 0.000899 0.001117 0.001444 0.001212 0.000696 0.001129 0.001257 0.001444 0.000750
Vacuole 0.000253 0.000741 0.000722 0.000367 0.000272 0.001845 0.000833 0.001112 0.000268 0.001360 0.000813 0.000912
Vacuole Periphery 0.000091 0.000249 0.000312 0.000114 0.000152 0.001383 0.000187 0.000723 0.000141 0.000885 0.000210 0.000559

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.88 -7.60 -5.39 -0.52 4.13 -0.21 -6.04 -1.84 -2.61 6.15 -1.64 -7.93 -3.06 -1.76 7.21
Bud Neck -1.59 -5.43 -2.18 -0.92 4.30 -1.31 -9.47 -9.76 -9.60 1.33 -2.15 -10.65 -9.91 -9.15 2.97
Bud Site -1.53 -4.84 -1.42 -0.05 0.50 1.06 -0.72 0.14 -3.60 2.73 0.76 -0.92 0.04 -2.15 2.87
Cell Periphery 0.99 0.99 2.40 2.73 2.89 2.76 -6.26 3.27 0.99 8.47 2.50 -5.91 4.04 2.38 8.77
Cytoplasm 1.44 2.55 2.42 3.58 -1.80 2.76 -6.59 3.70 1.01 8.32 3.03 -5.96 4.54 2.50 8.31
Cytoplasmic Foci 1.42 2.37 2.39 3.55 0.30 0.59 0.40 3.74 5.22 4.09 1.48 1.22 4.43 6.18 4.13
Eisosomes 1.54 1.10 1.15 -0.93 -0.03 1.02 -4.99 4.92 3.90 8.01 2.54 -4.43 4.78 2.69 7.83
Endoplasmic Reticulum -4.80 -5.69 -4.40 0.63 2.60 -1.93 -2.70 0.90 3.70 4.47 -3.59 -4.46 -0.83 3.79 4.74
Endosome 0.46 3.62 3.80 2.44 0.90 -3.75 1.85 0.01 3.74 -1.58 -3.54 3.20 1.67 4.06 -1.11
Golgi 0.38 1.23 1.46 4.54 4.19 -3.06 6.54 6.36 3.90 0.68 -2.78 3.81 4.17 4.71 1.74
Lipid Particles 6.37 8.10 8.11 6.31 0.03 2.36 8.81 9.52 7.52 3.72 5.77 11.77 12.34 9.82 3.64
Mitochondria 0.97 2.59 1.68 1.38 -1.08 -4.10 -0.33 -1.39 3.73 -1.27 -3.68 0.70 -0.28 3.58 -1.04
Mitotic Spindle -3.43 -13.28 -6.28 -4.04 9.38 -8.11 -15.66 -20.09 -11.77 -1.47 -8.33 -19.78 -20.44 -13.45 3.28
None 2.49 3.50 3.36 4.60 -3.90 2.68 -6.08 6.56 3.35 8.48 3.19 -3.89 6.28 5.66 8.37
Nuclear Periphery -1.41 -5.79 -1.90 -0.67 4.84 -5.33 -3.75 -11.56 -6.94 -6.78 -5.46 -6.20 -11.40 -6.82 -3.43
Nuclear Periphery Foci 7.09 21.90 16.41 12.93 -7.46 8.46 45.30 29.93 20.75 -16.41 9.81 50.11 33.34 25.83 -18.73
Nucleolus -5.95 -8.81 -13.83 -10.86 -3.04 -1.79 -12.21 -14.05 -12.70 -0.66 -3.34 -14.62 -18.31 -16.99 -1.85
Nucleus -11.40 -11.53 -16.06 -7.01 -1.79 -5.16 -25.42 -13.46 -8.33 15.34 -8.93 -27.28 -18.47 -10.58 13.77
Peroxisomes 0.93 -2.76 2.02 1.87 7.18 -0.16 -0.04 3.09 4.01 7.13 0.40 -0.95 3.47 4.59 9.50
Vacuole -1.65 -3.24 -0.86 0.99 1.48 -3.50 -3.03 -3.94 1.12 1.37 -3.94 -3.22 -4.05 1.09 1.60
Vacuole Periphery -2.36 -7.35 -0.96 2.14 7.58 -2.91 -2.68 -1.74 1.29 -1.56 -3.14 -4.91 -1.74 1.06 -1.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy
Localization
Cell Percentages nuclear periphery (63%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sir2

Sir2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sir2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available