Standard name
Human Ortholog
Description Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0.08 0.05 0.09 0.08 0.07 0 0.05 0.09 0.14 0.2 0.13 0.11 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.06 0 0 0.15 0.11 0.17 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.92 0.85 0.85 0.83 0.47 0.45 0.48 0.44 0.47 0.46 0.43 0.4 0.81 0.69 0.58 0.55 0.52 0.49 0.83 0.81 0.62 0.82 0.71 0.51
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0.06 0 0 0 0.05 0 0 0.06 0.05 0.13 0.08 0 0 0 0 0 0 0.09 0.1 0.24 0.05 0.08 0.14
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0.11 0.1 0.12 0.49 0.4 0.38 0.38 0.33 0.27 0.3 0.31 0.09 0.2 0.21 0.29 0.32 0.35 0.05 0.05 0.08 0.08 0.14 0.26
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 1 0 1 1 1 1 0 1 0 1 0 0 0 0 0 0
Bud 0 0 0 0 1 1 4 0 2 3 1 2 0 0 1 0 1 0 0 2 7 2 5 9
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 1 1 4 1 5 4 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 0 6 10 7 8 15 15 26 18 17 8 10 23 36 71 31 29 22 0 0 0 4 3 5
Endoplasmic Reticulum 0 0 0 0 0 1 0 2 1 2 0 1 0 0 1 6 11 6 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 1 1 1 1 0 2 1 5 0 0 0 0 1 1 3 2 8
Golgi 0 0 0 0 0 3 0 5 5 1 1 0 1 2 4 9 6 4 0 0 2 0 0 3
Mitochondria 0 0 0 0 0 7 16 9 9 37 22 33 1 0 0 2 6 2 0 1 0 1 1 4
Nucleus 33 257 233 150 100 89 134 121 101 118 87 78 219 181 208 132 132 91 56 264 209 261 223 237
Nuclear Periphery 0 0 4 4 4 3 9 5 2 6 4 7 1 3 2 2 2 0 0 0 4 0 2 5
Nucleolus 1 18 5 3 5 9 9 12 12 13 27 16 3 1 3 6 10 5 5 33 81 15 24 63
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 2 2
Vac/Vac Membrane 4 34 27 22 103 79 106 105 71 70 60 62 23 52 76 69 82 64 3 15 26 25 44 118
Unique Cell Count 36 301 274 181 211 196 278 274 213 255 201 197 269 261 356 241 255 184 68 325 339 318 315 462
Labelled Cell Count 38 315 279 186 221 208 294 290 224 273 216 214 274 278 373 258 279 195 68 325 339 318 315 462


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 17.3 29.0 23.2 21.1 21.2 20.0 19.5 18.9 18.5 17.4 16.4 14.6 24.6 25.4 22.1 27.5 23.0 26.6 24.9 23.8 26.0
Std Deviation (1e-4) 3.4 6.0 5.8 4.5 4.5 4.2 4.2 5.1 5.1 5.2 4.7 4.9 6.9 7.8 6.7 8.8 7.6 8.7 6.2 6.6 7.7
Intensity Change (Log2) – – – -0.14 -0.13 -0.22 -0.25 -0.3 -0.32 -0.42 -0.5 -0.66 0.08 0.13 -0.07 0.25 -0.01 0.2 0.1 0.04 0.17


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 0.1 1.9 1.0 2.8 2.3 1.6 0.2 0.8 2.4 4.2 6.1 3.9 3.4 3.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 3.5 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 4.0 0 0 6.5 5.6 7.0 0 0 0 0 0 0
Nucleus -0.6 -8.9 -9.1 -9.2 -10.0 -8.9 -9.4 -9.6 -10.3 -1.1 -4.3 -7.2 -7.5 -8.3 -8.2
Nuclear Periphery 0 0 0 1.4 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1.7 1.1 1.7 2.3 2.1 5.0 3.3 0 0 0 0.5 1.5 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.8 9.6 7.8 7.8 7.8 6.4 5.2 5.6 5.9 -0.5 3.3 3.9 5.5 6.3 6.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 24.2761 26.1751 24.4194 23.6228 24.1004 24.0111 17.7138 29.5056 25.6913 23.1221 21.4815 23.4922 23.816 31.4337 28.933 27.6683 27.8896 28.6116
Actin 0.0001 0 0 0 0.0001 0.0001 0.0348 0.0001 0.0146 0.0018 0.0001 0.0033 0.0065 0.0016 0.0027 0.0005 0.0001 0.0046
Bud 0.0001 0 0 0 0.0001 0.0002 0.0012 0.0001 0.0004 0.0001 0.0003 0.0011 0.0005 0.002 0.0005 0.0001 0.0001 0.0001
Bud Neck 0 0 0.0001 0.0001 0.0003 0.0005 0.0007 0 0.0001 0.0001 0.0003 0.0021 0.0004 0.0001 0.0001 0.0001 0.0002 0.0006
Bud Periphery 0.0001 0 0 0 0.0001 0.0004 0.0017 0 0.0004 0.0001 0.0003 0.0026 0.0007 0.001 0.0005 0.0001 0.0001 0.0003
Bud Site 0 0 0 0 0 0.0001 0.0027 0.0001 0.0005 0.0002 0.0001 0.0007 0.0012 0.0014 0.0011 0.0001 0 0.0001
Cell Periphery 0.0001 0 0.0001 0 0 0.0003 0.0007 0.0001 0.0003 0 0.0002 0.0012 0.0005 0.0001 0.0002 0.0002 0 0.0002
Cytoplasm 0.0007 0.001 0.0004 0.0002 0.0003 0.0008 0.0369 0.0029 0.0018 0.0027 0.0011 0.0086 0.0219 0.0026 0.0071 0.0051 0.0003 0.0018
Cytoplasmic Foci 0 0.0008 0.0007 0 0 0 0.0217 0 0.0061 0.0005 0 0.0021 0.0185 0.0012 0.004 0.0072 0 0.0003
Eisosomes 0 0 0.0001 0 0 0 0.0004 0 0 0 0 0 0.0001 0 0 0.0001 0 0
Endoplasmic Reticulum 0 0 0 0 0 0.0002 0.0101 0 0.0002 0.0008 0.0001 0.0041 0.0032 0.0003 0.0005 0.0007 0 0.0004
Endosome 0 0 0.0002 0 0.0001 0.0002 0.0261 0 0.0006 0.0018 0.0001 0.031 0.0243 0.0014 0.0036 0.0006 0 0.0015
Golgi 0 0 0 0 0 0 0.0063 0 0.0005 0.0001 0 0.0037 0.0026 0.0002 0.0005 0.0003 0 0.0009
Lipid Particles 0 0.0002 0.0007 0 0 0.0001 0.0092 0 0.0016 0.0001 0 0.0024 0.0083 0.0002 0.0006 0.0026 0 0.0005
Mitochondria 0.0009 0.0005 0.0005 0.0004 0.0012 0.0004 0.0121 0.0007 0.0028 0.0015 0.0007 0.0043 0.0046 0.0007 0.0052 0.0016 0.0006 0.0061
None 0 0.0001 0.0101 0 0 0 0.0114 0.0001 0.0012 0.0005 0.0001 0.0005 0.0039 0.0002 0.0005 0.0041 0 0.0002
Nuclear Periphery 0.0148 0.0157 0.0079 0.0041 0.0071 0.0062 0.0749 0.0065 0.004 0.0377 0.0035 0.0137 0.0407 0.0202 0.0101 0.018 0.0148 0.0116
Nucleolus 0.0073 0.0147 0.0099 0.0061 0.0407 0.0172 0.0158 0.004 0.0172 0.0024 0.0352 0.0334 0.0545 0.0078 0.0077 0.0379 0.0232 0.0176
Nucleus 0.9732 0.9656 0.9619 0.9887 0.9484 0.9697 0.6492 0.9848 0.9358 0.9392 0.9543 0.8651 0.7598 0.9561 0.9482 0.9047 0.9595 0.9481
Peroxisomes 0 0 0 0 0 0 0.0075 0 0.0031 0.0001 0 0.0002 0.0024 0.0001 0.0006 0.0001 0 0.0001
Punctate Nuclear 0.0002 0.0006 0.0014 0.0001 0.0006 0.0002 0.0632 0.0001 0.0047 0.0097 0.0005 0.0051 0.029 0.0021 0.0032 0.0132 0.0003 0.0008
Vacuole 0.0009 0.0002 0.0046 0.0001 0.0003 0.0026 0.0072 0.0002 0.0021 0.0003 0.0018 0.0081 0.0077 0.0003 0.0015 0.0007 0.0003 0.0016
Vacuole Periphery 0.0015 0.0003 0.0012 0.0001 0.0006 0.0009 0.0065 0.0002 0.0022 0.0005 0.0012 0.0069 0.0086 0.0005 0.0015 0.002 0.0005 0.0027

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 99.3487 92.2129 88.0564 116.6405 89.3447 109.8568 100.3056 118.6353 118.603 107.4355
Translational Efficiency 2.4868 1.9371 2.3097 1.8437 2.199 2.414 1.9612 1.7047 1.8751 1.7421

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1913 769 2298 1522 1932 934 1621 1488 3845 1703 3919 3010

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1686.92 2025.22 1969.79 1990.22 1629.13 1813.98 1989.98 1851.32 1657.88 1909.37 1978.14 1921.55
Standard Deviation 295.35 369.47 358.04 398.49 298.08 319.71 424.84 430.78 298.13 358.82 387.20 420.54
Intensity Change Log 2 — 0.263687 0.223650 0.238536 — 0.155057 0.288652 0.184453 — 0.211340 0.255951 0.212219

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000912 0.001082 0.000841 0.001523 0.000911 0.000892 0.001021 0.001280 0.000911 0.000978 0.000916 0.001403
Bud Neck 0.012718 0.009429 0.025145 0.040919 0.012533 0.011575 0.023170 0.037212 0.012625 0.010606 0.024328 0.039086
Bud Site 0.000469 0.000496 0.000692 0.005485 0.000475 0.000643 0.001943 0.006129 0.000472 0.000576 0.001210 0.005804
Cell Periphery 0.000056 0.000043 0.000052 0.000274 0.000082 0.000085 0.000115 0.000221 0.000069 0.000066 0.000078 0.000248
Cytoplasm 0.000642 0.001316 0.000526 0.004085 0.000591 0.000414 0.002063 0.018137 0.000616 0.000821 0.001162 0.011032
Cytoplasmic Foci 0.000042 0.000650 0.000044 0.001524 0.000060 0.000417 0.000338 0.002171 0.000051 0.000522 0.000166 0.001844
Eisosomes 0.000024 0.000030 0.000024 0.000021 0.000026 0.000029 0.000030 0.000013 0.000025 0.000029 0.000027 0.000017
Endoplasmic Reticulum 0.002980 0.001457 0.001451 0.002279 0.003708 0.001859 0.001132 0.002266 0.003346 0.001677 0.001319 0.002273
Endosome 0.000112 0.000363 0.000393 0.001790 0.000152 0.000183 0.000741 0.003019 0.000132 0.000264 0.000537 0.002397
Golgi 0.000084 0.000428 0.000096 0.002448 0.000093 0.000578 0.000444 0.002382 0.000089 0.000510 0.000240 0.002415
Lipid Particles 0.000023 0.000594 0.000050 0.000202 0.000028 0.000130 0.000084 0.000479 0.000025 0.000340 0.000064 0.000339
Mitochondria 0.002193 0.002437 0.003289 0.009242 0.002325 0.002293 0.004002 0.010991 0.002259 0.002358 0.003584 0.010107
Mitotic Spindle 0.000240 0.003014 0.000854 0.028809 0.000756 0.001784 0.004900 0.047518 0.000500 0.002340 0.002528 0.038058
None 0.000740 0.001061 0.001167 0.002186 0.000745 0.002073 0.002491 0.004753 0.000742 0.001616 0.001714 0.003455
Nuclear Periphery 0.002410 0.000893 0.002967 0.015416 0.004315 0.001423 0.002695 0.045822 0.003367 0.001183 0.002854 0.030447
Nuclear Periphery Foci 0.000615 0.001023 0.000250 0.002128 0.000660 0.000254 0.000335 0.010333 0.000638 0.000602 0.000285 0.006185
Nucleolus 0.061262 0.075310 0.033868 0.042245 0.077285 0.055121 0.041888 0.028323 0.069313 0.064237 0.037185 0.035363
Nucleus 0.912723* 0.897948* 0.927006* 0.832144* 0.892837* 0.918346* 0.909752* 0.770744* 0.902731* 0.909135* 0.919869* 0.801791*
Peroxisomes 0.000386 0.001072 0.000532 0.000480 0.000426 0.000495 0.000929 0.000671 0.000406 0.000756 0.000696 0.000574
Vacuole 0.000622 0.000659 0.000372 0.004470 0.000850 0.000711 0.001302 0.004945 0.000737 0.000687 0.000756 0.004704
Vacuole Periphery 0.000746 0.000696 0.000382 0.002329 0.001140 0.000696 0.000622 0.002591 0.000944 0.000696 0.000481 0.002459

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.35 -0.05 -4.43 -2.17 -4.58 -0.03 -4.52 -7.74 -5.66 -4.55 -1.13 -2.67 -7.53 -4.77 -6.47
Bud Neck 4.33 -14.85 -17.35 -19.11 -8.75 0.87 -12.18 -19.03 -18.79 -10.37 3.03 -19.20 -25.72 -26.53 -13.58
Bud Site -0.14 -2.47 -6.03 -6.05 -5.62 -1.33 -5.19 -5.72 -5.25 -3.52 -1.18 -5.87 -8.27 -7.85 -6.50
Cell Periphery 1.42 -0.03 -3.94 -4.29 -3.99 -0.31 -1.79 -5.41 -4.20 -4.73 -0.04 -1.24 -6.11 -5.68 -5.91
Cytoplasm -0.64 -0.22 -5.69 -3.21 -5.77 0.69 -4.88 -10.83 -11.01 -9.74 -0.43 -3.31 -12.14 -10.73 -11.38
Cytoplasmic Foci -1.66 -0.16 -3.20 -0.80 -3.19 -1.06 -2.36 -4.09 -2.43 -3.50 -1.90 -2.25 -5.19 -2.36 -4.81
Eisosomes -3.77 -2.40 1.45 4.47 3.36 -1.36 -4.36 8.00 9.36 13.92 -3.59 -4.32 6.69 9.27 11.09
Endoplasmic Reticulum 8.77 11.69 4.62 -3.89 -5.13 8.09 14.91 6.31 -2.93 -10.02 11.46 18.66 7.79 -4.55 -10.16
Endosome -1.14 -0.81 -4.88 -2.75 -2.54 -0.93 -1.30 -4.63 -4.40 -3.09 -1.42 -1.40 -6.43 -5.28 -4.03
Golgi -1.49 -0.59 -2.57 -1.81 -2.53 -0.98 -1.72 -3.15 -1.49 -2.48 -1.46 -1.81 -3.98 -2.25 -3.61
Lipid Particles -1.46 -0.62 -5.36 0.99 -3.42 -1.17 -1.28 -5.28 -2.98 -4.64 -1.73 -1.21 -6.74 -0.17 -5.66
Mitochondria -1.46 -10.72 -8.18 -7.71 -6.28 0.03 -6.33 -8.06 -7.92 -6.00 -0.80 -11.01 -11.41 -11.00 -8.71
Mitotic Spindle -1.93 -2.56 -8.08 -6.50 -7.65 -1.50 -3.55 -11.40 -10.38 -9.61 -2.40 -4.07 -13.91 -12.15 -12.48
None -0.92 -2.42 -7.56 -4.04 -4.53 -1.26 -7.81 -8.89 -2.39 -4.02 -1.46 -6.77 -11.51 -3.36 -6.26
Nuclear Periphery 4.61 -0.67 -8.43 -9.68 -7.95 4.74 2.56 -12.71 -13.80 -13.35 6.21 1.57 -14.93 -16.42 -15.31
Nuclear Periphery Foci -0.80 1.46 -3.52 -1.73 -5.61 1.14 2.04 -9.51 -9.82 -10.05 -0.17 2.39 -10.04 -9.46 -11.22
Nucleolus -2.69 7.15 5.01 6.18 -1.78 4.38 9.25 11.27 4.33 1.32 1.24 11.92 11.47 7.29 -0.43
Nucleus 2.34 -1.33 12.08 7.86 13.26 -3.80 -2.16 17.16 18.33 18.19 -1.07 -2.98 20.67 18.79 22.69
Peroxisomes -5.35 -1.30 -1.87 4.72 0.85 -1.67 -2.75 -1.05 -0.15 1.25 -5.31 -2.53 -1.52 2.67 1.33
Vacuole -0.06 0.07 -5.80 -5.78 -5.61 0.20 -1.21 -7.06 -7.02 -6.08 0.07 -0.68 -9.08 -9.00 -8.40
Vacuole Periphery 0.37 3.90 -2.80 -2.92 -4.00 1.94 2.86 -1.88 -3.16 -3.73 1.82 4.45 -3.26 -4.28 -5.56
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (96%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-5

Rpn6

Rpn6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rpn6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available