Standard name
Human Ortholog
Description Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.07 0 0.06 0 0 0 0 0.05 0 0 0.1 0.12 0.1 0.05 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.16 0 0 0 0 0.12 0.23 0.22 0.39 0.34 0.52 0.27 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Nucleus 0.93 0.93 0.96 0.92 0.95 0.89 0.83 0.85 0.81 0.85 0.75 0.85 0.94 0.88 0.85 0.81 0.87 0.87 0.9 0.87 0.89 0.84 0.78 0.73
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.17 0.18 0.06 0 0 0.05 0.12 0.07 0.15 0.12 0.19 0.09 0 0 0 0 0 0.08 0.07 0.07 0.05 0 0.09 0.11
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.1 0 0 0 0 0.05 0.08 0.1
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 1 0 0 0 3 0 3 3 4 1 0 0 0 0 0 0 0 1 1 0 2 1
Bud Neck 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 3 4 6 12 7 14 13 10 0 0 0 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 3 3 2 14 13 21 23 16 5 5 15 6 12 35 61 13 3 4 0 0 1 1 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 1 0 0 2 2 5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 1
Mitochondria 43 2 8 2 4 47 120 95 135 121 153 123 2 0 0 1 3 4 1 0 0 1 8 7
Nucleus 257 92 183 180 315 338 433 364 283 298 219 389 261 305 416 110 54 72 245 90 184 172 327 322
Nuclear Periphery 0 0 0 3 0 2 7 2 6 1 5 2 0 3 3 1 0 0 0 0 0 1 0 1
Nucleolus 46 18 12 6 10 18 62 32 54 42 56 41 9 7 22 6 2 7 19 6 9 8 37 50
Peroxisomes 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 3 0 5 3 1 2 1 6 2 5 5 0 0 0 0 0 1 1 2 3
Vac/Vac Membrane 0 0 1 1 2 0 0 6 0 3 2 1 1 1 7 8 6 3 3 3 5 10 31 44
Unique Cell Count 276 99 191 196 333 379 521 429 349 351 292 457 279 345 489 135 62 83 273 104 207 204 419 442
Labelled Cell Count 349 115 207 207 350 430 661 530 494 489 469 579 288 356 518 143 68 92 273 104 207 204 419 442


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 8.5 6.8 6.5 6.8 5.7 5.1 5.4 4.6 4.6 4.1 4.9 7.3 7.5 7.5 11.2 10.1 10.0 7.0 7.2 7.9
Std Deviation (1e-4) 0.8 1.5 1.3 1.4 1.4 1.7 1.4 1.3 1.3 1.1 1.3 1.0 1.2 1.6 1.8 2.8 3.0 2.8 1.8 1.4 1.4
Intensity Change (Log2) – – – -0.06 -0.0 -0.25 -0.4 -0.32 -0.58 -0.55 -0.73 -0.45 0.1 0.15 0.15 0.72 0.58 0.56 0.04 0.09 0.22


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3.0 1.9 2.6 2.2 1.8 0 0 2.4 0 2.0 4.0 4.6 3.6 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.1 5.8 5.5 0 0 0 6.6 0 0 0 0 0 0
Nucleus -1.6 -0.6 -2.7 -4.4 -3.9 -4.8 -3.8 -6.0 -3.9 -1.1 -2.9 -3.9 -4.2 -2.4 -2.7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -1.5 -1.8 -0.8 2.2 0.5 0 0 0 1.1 -1.6 -2.6 -1.0 -0.7 0 0.6
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8721 2.0785 1.7458 1.7031 1.337 1.7228 2.2002 2.3918 2.1661 1.7903 1.7657 2.1888 1.6236 1.819 1.2025 0.8518 0.8613 1.548
Actin 0.0016 0 0.0008 0.0002 0 0 0.0426 0 0.0001 0.0008 0 0 0.0408 0 0.0085 0 0.1503 0.0001
Bud 0.0006 0 0.0001 0.0001 0 0 0.0009 0 0.0001 0.0001 0 0 0.0006 0 0.0001 0 0.0014 0
Bud Neck 0.0006 0 0.0004 0.0004 0.0001 0.0004 0.008 0 0.0002 0.0008 0.0003 0.0005 0.0012 0 0.0001 0 0.0014 0.0007
Bud Periphery 0.0006 0 0.0004 0.0002 0 0 0.0014 0 0 0.0002 0.0002 0 0.0018 0 0.0001 0 0.0029 0
Bud Site 0.0004 0 0.0003 0.0003 0 0 0.0206 0 0.0011 0.0006 0.0001 0 0.0011 0 0.0005 0 0.0023 0
Cell Periphery 0.0003 0 0.0002 0.0002 0 0 0.0004 0 0 0.0001 0 0 0.0003 0 0 0 0.0003 0
Cytoplasm 0.0045 0 0.0007 0.0029 0 0.0002 0.0049 0 0.008 0.0036 0.0001 0 0.0153 0 0.0026 0 0.005 0
Cytoplasmic Foci 0.0016 0 0.0023 0.0045 0 0 0.023 0 0.0078 0.008 0 0 0.0072 0 0.0069 0 0.0165 0.0035
Eisosomes 0 0 0 0 0 0 0.0004 0 0 0 0 0 0.0002 0 0.0001 0 0.001 0
Endoplasmic Reticulum 0.0016 0 0.0024 0.0022 0 0 0.0042 0 0.0003 0.0014 0 0 0.0043 0 0.0003 0 0.0074 0
Endosome 0.0078 0 0.004 0.0071 0 0 0.0292 0 0.0073 0.0349 0 0 0.0069 0 0.0009 0 0.0523 0.0002
Golgi 0.0013 0 0.0003 0.0004 0 0 0.0102 0 0.0009 0.0125 0 0 0.0032 0 0.0005 0 0.0165 0.0001
Lipid Particles 0.0087 0 0.004 0.0037 0 0 0.0178 0 0.0077 0.0101 0 0 0.0152 0 0.001 0 0.0619 0.0009
Mitochondria 0.0036 0 0.002 0.0005 0.0004 0 0.0083 0.0001 0.0011 0.005 0.0011 0.0001 0.0017 0.0001 0.0034 0.0001 0.0135 0.0001
None 0.0014 0 0.0002 0.0018 0 0 0.0144 0 0.0005 0.0029 0.0001 0 0.0014 0 0.0067 0 0.0111 0.0001
Nuclear Periphery 0.0147 0.0004 0.007 0.0128 0.0025 0.0004 0.0143 0.0004 0.0016 0.0138 0.0027 0.0002 0.0094 0.0003 0.0008 0.0002 0.0338 0.0002
Nucleolus 0.0216 0.0211 0.0141 0.0145 0.0652 0.0537 0.028 0.0178 0.006 0.0162 0.1141 0.0645 0.0179 0.0174 0.0097 0.0136 0.0432 0.0532
Nucleus 0.9152 0.9734 0.9502 0.9116 0.9284 0.9432 0.7492 0.9812 0.9545 0.8718 0.88 0.934 0.8514 0.982 0.9481 0.9859 0.5229 0.9295
Peroxisomes 0.0025 0 0.0001 0.0003 0 0 0.007 0 0.0008 0.0017 0 0 0.0111 0 0.0073 0 0.0367 0.0016
Punctate Nuclear 0.0068 0.0049 0.0074 0.0328 0.0029 0.0018 0.0087 0.0002 0.0006 0.0121 0.0008 0.0004 0.0067 0.0001 0.0019 0.0002 0.0116 0.0095
Vacuole 0.003 0 0.0021 0.0024 0.0001 0.0001 0.0039 0.0001 0.0008 0.0025 0.0002 0.0001 0.0015 0 0.0002 0 0.0033 0.0001
Vacuole Periphery 0.0016 0 0.001 0.0009 0.0001 0 0.0025 0 0.0003 0.001 0.0002 0 0.0007 0 0.0001 0 0.0046 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.362 14.9938 10.3313 14.7997 20.9699 13.1713 18.4088 16.4445 15.451 19.9363
Translational Efficiency 0.788 1.0961 1.13 0.7187 0.7407 1.5788 1.0078 0.9797 1.0359 1.0299

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1989 394 164 125 1761 1821 293 1403 3750 2215 457 1528

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 858.89 974.10 1095.09 1154.96 852.33 943.45 1123.54 1017.21 855.81 948.90 1113.33 1028.48
Standard Deviation 133.20 159.91 125.38 171.19 123.00 138.22 144.99 155.27 128.55 142.80 138.95 161.12
Intensity Change Log 2 — 0.181597 0.350504 0.427298 — 0.146534 0.398567 0.255134 — 0.164239 0.374644 0.344112

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000383 0.000728 0.001545 0.001690 0.000274 0.000686 0.001226 0.001429 0.000332 0.000693 0.001341 0.001450
Bud Neck 0.005137 0.008661 0.008797 0.011117 0.005505 0.007974 0.008117 0.035276 0.005310 0.008096 0.008361 0.033300
Bud Site 0.000664 0.000714 0.001266 0.001280 0.000421 0.000928 0.000907 0.008873 0.000550 0.000890 0.001036 0.008252
Cell Periphery 0.000090 0.000042 0.000050 0.000053 0.000052 0.000080 0.000031 0.000246 0.000072 0.000073 0.000038 0.000230
Cytoplasm 0.001812 0.000154 0.000318 0.000730 0.000159 0.000586 0.000103 0.013827 0.001036 0.000509 0.000180 0.012756
Cytoplasmic Foci 0.000235 0.000254 0.000029 0.000035 0.000021 0.000915 0.000026 0.004486 0.000135 0.000797 0.000027 0.004122
Eisosomes 0.000027 0.000035 0.000064 0.000051 0.000029 0.000047 0.000057 0.000042 0.000028 0.000045 0.000059 0.000043
Endoplasmic Reticulum 0.003423 0.003083 0.004586 0.004687 0.002768 0.003574 0.003711 0.005196 0.003115 0.003487 0.004025 0.005154
Endosome 0.000198 0.000166 0.000115 0.000125 0.000088 0.000710 0.000079 0.005911 0.000146 0.000613 0.000092 0.005437
Golgi 0.000126 0.000264 0.000150 0.000126 0.000046 0.000701 0.000104 0.005845 0.000089 0.000623 0.000121 0.005377
Lipid Particles 0.000108 0.000196 0.000112 0.000124 0.000061 0.000410 0.000089 0.000465 0.000086 0.000372 0.000097 0.000437
Mitochondria 0.000740 0.003495 0.001218 0.002385 0.000526 0.001981 0.001020 0.007785 0.000639 0.002250 0.001091 0.007343
Mitotic Spindle 0.001737 0.003827 0.000512 0.000589 0.002502 0.004043 0.000228 0.058130 0.002096 0.004004 0.000330 0.053423
None 0.004349 0.001566 0.003199 0.005913 0.000998 0.001618 0.002064 0.007174 0.002775 0.001609 0.002471 0.007071
Nuclear Periphery 0.000180 0.000243 0.000161 0.000389 0.000173 0.000357 0.000120 0.004297 0.000176 0.000337 0.000135 0.003978
Nuclear Periphery Foci 0.000437 0.001122 0.000107 0.000064 0.000130 0.000425 0.000063 0.004230 0.000293 0.000549 0.000079 0.003889
Nucleolus 0.035869 0.037281 0.038395 0.018920 0.035160 0.034712 0.035078 0.017921 0.035536 0.035169 0.036268 0.018003
Nucleus 0.943649* 0.936716* 0.936736* 0.948716* 0.950497* 0.938588* 0.945067* 0.797678* 0.946865* 0.938255* 0.942077* 0.810034*
Peroxisomes 0.000322 0.000851 0.001435 0.001010 0.000268 0.000769 0.001060 0.000763 0.000297 0.000784 0.001195 0.000784
Vacuole 0.000278 0.000217 0.001049 0.001803 0.000190 0.000549 0.000737 0.013818 0.000236 0.000490 0.000849 0.012835
Vacuole Periphery 0.000235 0.000385 0.000154 0.000193 0.000131 0.000348 0.000113 0.006609 0.000186 0.000355 0.000128 0.006084

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.01 -9.97 -10.07 -7.09 -1.16 -3.43 -13.10 -18.20 -7.65 -3.29 -3.51 -15.64 -18.43 -8.95 -2.36
Bud Neck -3.14 -5.32 -7.31 -3.35 -3.19 -4.30 -4.56 -17.49 -16.18 -14.16 -5.66 -6.72 -18.09 -16.23 -14.64
Bud Site -0.54 -5.15 -5.01 -3.83 -1.00 -2.85 -5.28 -9.80 -8.89 -8.81 -2.48 -7.06 -9.84 -9.09 -8.54
Cell Periphery 3.12 2.53 1.81 -1.97 -1.11 -1.16 0.74 -3.87 -3.40 -5.65 -0.04 2.47 -3.68 -3.70 -5.46
Cytoplasm 3.12 2.85 1.89 -2.01 -1.46 -2.08 0.63 -7.47 -7.00 -7.50 1.47 3.00 -6.57 -7.09 -7.47
Cytoplasmic Foci 0.04 2.12 2.04 1.49 -1.29 -2.60 -0.94 -3.38 -1.52 -3.37 -2.22 2.08 -3.10 -1.64 -3.37
Eisosomes -3.09 -9.53 -6.53 -4.68 1.14 -4.31 -9.75 -9.14 -0.22 3.64 -4.95 -13.66 -11.48 -1.14 4.95
Endoplasmic Reticulum 0.93 -3.36 -3.35 -3.79 -0.20 -3.90 -4.38 -8.81 -6.30 -4.28 -1.99 -4.93 -8.20 -6.93 -3.73
Endosome 0.24 1.51 0.22 -0.13 -1.80 -2.77 -1.03 -6.17 -4.29 -6.14 -2.52 1.52 -6.03 -4.49 -6.11
Golgi -1.21 -1.15 -1.33 0.70 -0.41 -1.93 -7.59 -2.86 -1.98 -2.76 -1.90 -2.33 -2.82 -2.05 -2.74
Lipid Particles -0.91 -0.55 -1.01 0.53 -0.66 -2.43 -1.52 -6.14 -0.06 -5.78 -2.37 -1.01 -5.70 -0.17 -5.62
Mitochondria -1.41 -3.74 -4.61 0.19 -3.44 -2.45 -7.83 -6.56 -3.65 -5.67 -2.68 -6.43 -6.66 -3.33 -5.79
Mitotic Spindle -1.04 1.53 0.34 1.20 -1.39 -0.75 2.13 -8.88 -8.52 -9.82 -1.43 2.71 -9.17 -8.48 -9.79
None 4.00 1.20 0.24 -0.88 -0.40 -1.56 -1.89 -8.38 -5.32 -5.15 2.00 0.93 -4.30 -5.58 -4.26
Nuclear Periphery -0.44 -1.03 -4.82 -2.16 -3.98 -0.96 0.24 -6.86 -5.92 -6.89 -1.03 -0.45 -6.95 -6.10 -6.92
Nuclear Periphery Foci -0.83 1.73 2.11 1.13 0.80 -1.71 0.67 -3.22 -2.65 -3.28 -1.14 2.04 -2.88 -2.20 -3.23
Nucleolus -0.40 -1.16 2.93 2.69 2.82 0.25 -0.71 6.49 6.59 4.45 0.27 -1.25 8.23 7.24 5.58
Nucleus 1.24 2.16 0.96 -0.20 -0.86 3.29 2.53 16.50 14.27 13.70 2.85 2.99 16.20 14.11 13.30
Peroxisomes -2.66 -6.86 -4.69 -0.96 1.83 -2.77 -8.01 -4.97 0.79 4.18 -3.16 -10.22 -5.25 0.79 5.66
Vacuole 0.46 -4.58 -5.42 -5.54 -2.78 -2.63 -5.35 -7.58 -7.34 -7.09 -2.39 -6.95 -7.69 -7.50 -7.08
Vacuole Periphery -0.57 0.85 0.06 0.61 -1.99 -3.38 0.09 -4.39 -4.04 -4.40 -2.21 1.08 -4.30 -4.01 -4.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Kin28

Kin28


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kin28-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available