Standard name
Human Ortholog
Description Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0.05 0 0 0 0 0 0.06 0.11 0.15 0.19 0.2 0.25 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0.08 0.12 0.05 0.16 0.16 0.16 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.84 0.89 0.95 0.97 0.95 0.9 0.85 0.9 0.82 0.83 0.82 0.82 0.94 0.87 0.81 0.53 0.45 0.44 0.82 0.86 0.89 0.81 0.79 0.7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.06 0.11 0.12 0.17 0.18 0.23 0.22 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.08 0.16 0 0 0 0 0 0 0 0 0 0 0 0 0 0.35 0.39 0.35 0.05 0.08 0 0.07 0.08 0.14
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 1
Bud 0 0 0 0 0 0 3 1 2 2 1 2 0 0 0 0 0 0 7 1 3 4 11 17
Bud Neck 0 0 0 0 0 0 0 2 2 0 1 2 0 0 0 0 0 0 0 0 0 0 2 2
Bud Site 0 0 0 0 1 3 6 12 10 15 20 23 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0
Cytoplasm 9 2 6 7 12 10 25 10 7 9 8 13 20 56 78 25 36 26 7 2 2 9 12 11
Endoplasmic Reticulum 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 7 11 8 0 0 1 0 0 2
Endosome 7 0 1 0 0 1 1 1 0 1 0 0 0 2 2 3 2 5 4 0 1 0 9 5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 0 2 0 0 0 2 0
Mitochondria 24 4 1 4 2 29 66 26 66 80 97 82 0 0 0 3 7 3 6 0 2 0 7 7
Nucleus 265 103 271 235 336 326 466 456 343 417 504 701 339 444 409 68 81 47 283 108 264 176 441 358
Nuclear Periphery 5 0 2 2 2 1 10 11 3 4 3 14 0 0 0 0 0 1 0 0 0 0 0 2
Nucleolus 4 0 3 2 4 20 61 62 70 91 138 193 0 4 4 1 0 1 4 1 2 0 10 15
Peroxisomes 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 1 0 0 1 1 2 1 2 6 0 0 0 5 0 4 4 11 12
Vac/Vac Membrane 26 18 5 0 2 1 1 1 1 1 2 2 5 2 8 45 70 37 17 9 10 14 43 72
Unique Cell Count 316 116 286 242 355 363 547 504 419 504 613 858 362 508 504 129 179 106 344 126 298 217 557 513
Labelled Cell Count 341 127 290 250 360 391 641 582 504 621 775 1034 365 512 509 153 209 128 344 126 298 217 557 513


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.6 6.6 6.6 6.2 6.7 5.9 5.8 5.9 5.6 5.4 5.3 5.6 7.9 7.9 7.5 8.9 8.6 9.9 7.2 7.3 7.9
Std Deviation (1e-4) 0.8 1.2 1.5 1.5 1.7 1.3 1.5 1.5 1.2 1.2 1.2 1.2 1.3 1.7 1.7 1.9 2.1 16.2 1.0 1.5 1.6
Intensity Change (Log2) – – – -0.11 0.02 -0.18 -0.19 -0.17 -0.26 -0.3 -0.32 -0.24 0.24 0.26 0.18 0.42 0.37 0.57 0.11 0.15 0.26

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 2.9 3.1 2.8 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.6 1.0 0.5 1.8 -0.1 -0.4 -0.3 0 0 2.2 4.5 5.9 6.2 6.6 7.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.6 5.9 3.6 6.8 6.9 6.9 5.2 0 0 0 0 0 0
Nucleus 1.3 -0.1 -2.3 -4.1 -2.1 -5.0 -4.8 -5.1 -5.3 -0.6 -3.3 -5.3 -10.2 -12.1 -11.3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 3.1 5.2 5.5 6.7 7.1 8.2 8.3 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 9.6 10.7 9.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.5021 3.5295 3.1633 3.0757 2.7628 3.1076 2.3644 2.8514 2.2194 2.296 2.2443 2.3399 2.0357 2.192 1.6561 1.8468 1.5036 1.4524
Actin 0.0201 0.0002 0 0 0.0001 0.0001 0.0631 0 0.0006 0.0038 0.0001 0.0007 0.0381 0.0001 0.0033 0.0114 0.0183 0.0001
Bud 0.0001 0.0001 0 0 0 0 0.0015 0 0.0004 0.0011 0.0001 0.0004 0.0008 0.0001 0.0001 0.0014 0.0001 0.0002
Bud Neck 0.0004 0.0005 0.0001 0.0001 0.0003 0.0024 0.0107 0.0001 0.0001 0.0005 0.0006 0.0015 0.0078 0.0001 0.0018 0.0023 0.0007 0.0012
Bud Periphery 0.0001 0 0 0 0 0.0001 0.0024 0 0.0004 0.0036 0.0001 0.0006 0.0019 0.0001 0.0001 0.0014 0.0002 0.0001
Bud Site 0.0001 0.0007 0.0001 0 0.0001 0.0001 0.0257 0.0001 0.0016 0.0011 0.0001 0.0011 0.0035 0.0001 0.0055 0.0141 0.0002 0.0004
Cell Periphery 0 0 0 0 0 0 0.0011 0 0 0.0002 0 0.0001 0.0004 0 0.0001 0.0003 0 0
Cytoplasm 0.0049 0.0949 0.0344 0.0259 0.0247 0.012 0.007 0.0359 0.0122 0.0125 0.0027 0.0085 0.0026 0.0142 0.0052 0.002 0.0033 0.0051
Cytoplasmic Foci 0.0008 0.0009 0.0002 0.0001 0.0003 0.0003 0.0451 0.0001 0.0026 0.0007 0 0.0023 0.0273 0.0001 0.0013 0.0032 0.0033 0.0026
Eisosomes 0.0002 0 0 0 0 0 0.0006 0 0 0.0001 0 0 0.0003 0 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.0003 0.0007 0.001 0.0004 0.0016 0.0003 0.0086 0.0005 0.0002 0.0007 0.0003 0.0005 0.0041 0.0004 0.0002 0.0011 0.0005 0.0001
Endosome 0.0012 0.0004 0.0002 0.0005 0.0019 0.0004 0.0664 0.0002 0.0029 0.0106 0.0001 0.0069 0.0218 0.0002 0.0011 0.0082 0.0049 0.0021
Golgi 0.0011 0 0 0 0 0 0.0186 0 0.0023 0.0052 0 0.0061 0.0105 0 0.0013 0.0044 0.0074 0.0006
Lipid Particles 0.0008 0 0 0 0.0001 0 0.0199 0 0.0027 0.0022 0 0.0115 0.0167 0 0.0007 0.0075 0.0129 0.0003
Mitochondria 0.0003 0.0002 0.0001 0.0003 0.0003 0.0001 0.0127 0.0002 0.0026 0.0073 0.0006 0.0043 0.013 0.001 0.0015 0.0073 0.0013 0.0006
None 0.0166 0.0165 0.0124 0.0017 0.0149 0.0068 0.0041 0.0021 0.0007 0.0003 0.0002 0.0003 0.0019 0.0001 0.0007 0.0003 0.0004 0.0001
Nuclear Periphery 0.0027 0.0042 0.0049 0.0032 0.0291 0.0033 0.0204 0.0043 0.0045 0.0042 0.0099 0.0091 0.0188 0.0048 0.0013 0.0033 0.0029 0.0012
Nucleolus 0.0048 0.004 0.0033 0.0018 0.0069 0.0103 0.0113 0.0026 0.0025 0.0025 0.0091 0.0071 0.0046 0.0031 0.0025 0.0033 0.0086 0.0065
Nucleus 0.929 0.8644 0.9389 0.9634 0.905 0.9504 0.6142 0.9504 0.9557 0.9355 0.974 0.9321 0.7953 0.9675 0.9705 0.923 0.929 0.976
Peroxisomes 0.0004 0 0 0 0 0 0.0239 0 0.0044 0.0004 0 0.0016 0.0138 0 0.0002 0.0017 0.0034 0.0008
Punctate Nuclear 0.0159 0.0117 0.0038 0.0022 0.0135 0.0128 0.0114 0.0028 0.0029 0.0022 0.001 0.0033 0.0107 0.0066 0.0021 0.0015 0.0021 0.0017
Vacuole 0.0001 0.0005 0.0003 0.0003 0.0007 0.0004 0.0209 0.0003 0.0005 0.0033 0.0006 0.0012 0.0041 0.0007 0.0002 0.0015 0.0002 0.0003
Vacuole Periphery 0.0001 0.0001 0.0001 0.0002 0.0004 0.0001 0.0105 0.0001 0.0002 0.0021 0.0003 0.0007 0.0022 0.0006 0.0001 0.0006 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.0402 23.2479 12.9382 18.3993 19.2675 14.8524 17.6295 23.5141 20.4077 23.702
Translational Efficiency 0.9579 0.7359 1.1812 0.8098 0.8919 1.6515 1.3839 0.9421 1.0256 1.0396

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1626 673 1702 95 848 1831 271 2634 2474 2504 1973 2729

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 837.89 903.94 991.39 1049.14 779.14 844.28 1112.71 1038.99 817.75 860.31 1008.05 1039.34
Standard Deviation 116.12 138.69 134.41 146.78 120.02 114.51 128.75 151.83 120.73 124.33 140.02 151.67
Intensity Change Log 2 — 0.109466 0.242692 0.324374 — 0.115839 0.514123 0.415227 — 0.112540 0.379857 0.368865

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000200 0.000584 0.000539 0.001278 0.000331 0.000216 0.001310 0.001066 0.000245 0.000315 0.000645 0.001073
Bud Neck 0.005948 0.006593 0.010371 0.008204 0.004158 0.007236 0.004525 0.037977 0.005334 0.007063 0.009568 0.036941
Bud Site 0.000868 0.002441 0.002127 0.002149 0.000850 0.001983 0.001381 0.018003 0.000862 0.002106 0.002025 0.017451
Cell Periphery 0.000104 0.000149 0.000102 0.000131 0.000244 0.000138 0.000105 0.000165 0.000152 0.000141 0.000102 0.000163
Cytoplasm 0.006598 0.029569 0.013707 0.021538 0.008084 0.028839 0.010527 0.109566 0.007107 0.029035 0.013270 0.106501
Cytoplasmic Foci 0.001186 0.004863 0.000396 0.000158 0.001304 0.003884 0.000489 0.000614 0.001227 0.004147 0.000409 0.000598
Eisosomes 0.000017 0.000026 0.000020 0.000043 0.000019 0.000017 0.000065 0.000017 0.000017 0.000020 0.000026 0.000018
Endoplasmic Reticulum 0.004419 0.007884 0.004928 0.014328 0.004569 0.004174 0.013805 0.002457 0.004471 0.005171 0.006147 0.002871
Endosome 0.000433 0.000868 0.000380 0.000538 0.000371 0.001288 0.000566 0.002475 0.000412 0.001175 0.000406 0.002408
Golgi 0.000219 0.000699 0.000103 0.000072 0.000104 0.000570 0.000065 0.000368 0.000179 0.000605 0.000098 0.000358
Lipid Particles 0.000232 0.001519 0.000128 0.000361 0.000185 0.000647 0.000711 0.000224 0.000216 0.000881 0.000208 0.000229
Mitochondria 0.000956 0.002323 0.001332 0.001127 0.000930 0.003269 0.000865 0.005703 0.000947 0.003015 0.001268 0.005543
Mitotic Spindle 0.004251 0.006161 0.002466 0.000437 0.001857 0.009445 0.000213 0.030042 0.003431 0.008562 0.002156 0.029011
None 0.001518 0.003231 0.003883 0.002822 0.005211 0.003480 0.002890 0.013894 0.002784 0.003413 0.003747 0.013508
Nuclear Periphery 0.000641 0.001510 0.000837 0.001196 0.000412 0.001844 0.000946 0.002245 0.000563 0.001754 0.000852 0.002208
Nuclear Periphery Foci 0.000415 0.000632 0.000148 0.000316 0.000297 0.000886 0.000271 0.000174 0.000375 0.000817 0.000165 0.000179
Nucleolus 0.004811 0.003219 0.001068 0.001024 0.008270 0.004569 0.001899 0.001266 0.005996 0.004206 0.001182 0.001258
Nucleus 0.965542 0.919795 0.954229 0.926986 0.961222 0.921225 0.941780 0.762203 0.964061 0.920840 0.952519 0.767939
Peroxisomes 0.000519 0.002083 0.000095 0.000110 0.000278 0.000852 0.000202 0.000565 0.000436 0.001183 0.000109 0.000549
Vacuole 0.000985 0.005520 0.003050 0.017068 0.000894 0.004731 0.017276 0.010381 0.000954 0.004943 0.005004 0.010614
Vacuole Periphery 0.000137 0.000332 0.000089 0.000113 0.000410 0.000706 0.000109 0.000595 0.000231 0.000605 0.000092 0.000578

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.22 -11.42 -9.93 -5.24 -6.42 1.20 -7.38 -1.25 -2.06 5.17 -2.22 -11.67 -2.21 -1.53 1.66
Bud Neck -1.56 -6.61 -3.50 -2.54 0.74 -3.45 -3.83 -14.89 -12.09 -13.33 -2.74 -7.85 -14.43 -12.66 -8.91
Bud Site -3.21 -3.92 -6.44 -0.98 -2.94 -2.29 -2.74 -7.02 -5.62 -4.45 -3.94 -4.46 -7.38 -5.37 -5.30
Cell Periphery -2.20 -0.00 -3.59 -0.89 -3.84 1.17 1.23 1.62 2.31 2.42 0.34 1.36 1.63 2.93 1.01
Cytoplasm -5.84 -3.41 -3.59 -0.27 -2.79 -7.50 -0.08 -25.89 -17.84 -25.90 -10.41 -3.21 -29.24 -18.31 -27.07
Cytoplasmic Foci -3.18 1.92 1.79 4.03 -0.49 -2.06 1.36 1.47 5.43 0.42 -4.10 2.38 2.31 6.76 -0.57
Eisosomes -5.02 -6.93 -8.00 -5.93 -6.77 0.24 -10.60 -1.19 -1.51 10.52 -2.88 -11.18 -4.78 -0.70 7.77
Endoplasmic Reticulum -6.40 -4.58 -6.84 -4.23 -5.76 0.80 -10.27 4.96 4.83 12.24 -2.93 -8.38 4.93 7.15 12.10
Endosome -3.41 0.29 -3.41 0.11 -3.80 -4.03 -2.83 -1.71 1.34 -0.24 -4.90 -0.41 -1.75 1.26 -1.61
Golgi -1.34 1.21 0.78 1.66 -1.29 -2.71 0.39 -0.91 2.40 -1.42 -2.46 1.22 0.44 2.87 -1.19
Lipid Particles -1.99 1.30 -4.58 1.15 -6.03 -3.50 -5.47 -2.05 2.79 4.85 -3.34 -0.47 -1.83 2.93 -2.23
Mitochondria -1.47 -2.20 -2.29 0.94 0.32 -3.78 -0.83 -6.39 -0.65 -7.52 -4.12 -2.45 -7.43 -1.03 -5.98
Mitotic Spindle -0.97 0.43 -1.03 -0.42 -1.20 -3.73 0.47 -10.11 -6.36 -10.60 -3.05 0.12 -9.60 -6.88 -9.80
None -3.02 -2.30 -2.09 -1.54 -1.51 1.71 3.02 -6.06 -11.18 -13.24 -1.12 -0.34 -13.14 -12.21 -10.55
Nuclear Periphery -1.47 -3.54 -7.35 -1.62 -6.06 -4.45 -8.33 -20.53 -5.32 -13.49 -4.11 -5.96 -19.47 -5.89 -16.66
Nuclear Periphery Foci -0.94 1.75 -0.97 0.31 -2.71 -1.61 -0.07 1.81 2.64 2.52 -1.81 1.89 2.55 3.09 1.10
Nucleolus 1.96 6.20 6.20 4.84 0.74 2.97 6.25 6.29 4.77 -0.15 2.45 8.89 8.45 5.66 -1.59
Nucleus 6.85 4.21 6.97 3.85 6.12 6.75 4.51 26.57 19.18 15.31 10.31 5.33 32.15 20.10 28.39
Peroxisomes -1.73 2.25 2.14 2.15 -0.82 -2.54 0.68 0.90 3.08 0.52 -2.43 2.52 1.83 3.38 -0.44
Vacuole -4.58 -7.52 -5.48 -4.84 -5.18 -5.40 -5.62 -15.67 -11.47 0.81 -7.14 -8.68 -16.66 -11.90 -10.71
Vacuole Periphery -1.71 1.44 -0.21 1.69 -3.17 -1.06 1.37 0.87 2.73 -2.55 -2.50 1.76 0.11 2.85 -3.22
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Maf1

Maf1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Maf1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available