Standard name
Human Ortholog
Description Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.07 0.06 0 0 0 – 0 0 0 0 0 0.05 0 0 0.08 0 0 0.06 0.06 0 0 0.06 0.06
Bud 0 0 0 0 0 0 – 0 0.06 0.06 0.09 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0 0.11 0 0.11 0.12 0.08 0.08
Golgi 0.11 0.27 0 0 0 0 – 0 0 0 0 0 0.12 0.09 0.12 0.58 0.51 0.56 0.58 0.7 0.55 0.62 0.67 0.71
Mitochondria 0.93 0.92 0.96 0.92 0.88 0.9 – 0.73 0.86 0.87 0.82 0.84 0.95 0.92 0.88 0.07 0.08 0.08 0.08 0.08 0.09 0.09 0.09 0.06
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.13 0 0 0.06 0 0.07 – 0.13 0.12 0.07 0.11 0.09 0 0 0 0.07 0.14 0.09 0 0 0 0 0 0
Peroxisomes 0 0 0 0.11 0.14 0.16 – 0.19 0.08 0.16 0.15 0.17 0 0.08 0.1 0.08 0.21 0.08 0.13 0.07 0.2 0.1 0.07 0.05
SpindlePole 0 0 0 0 0 0 – 0.05 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0.05 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 6 9 8 9 12 5 – 8 4 17 3 11 26 27 21 6 2 4 11 7 4 1 29 36
Bud 1 1 3 12 21 18 – 23 32 40 41 44 6 6 8 1 1 1 0 0 0 0 1 2
Bud Neck 0 0 0 1 0 0 – 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 1 3 – 4 5 18 4 19 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 0 1 – 0 2 0 2 3 2 0 1 1 1 0 0 0 0 0 0 0
Cytoplasm 0 1 0 7 8 7 – 9 4 18 13 10 13 17 21 5 4 8 0 0 0 0 1 2
Endoplasmic Reticulum 1 0 5 2 1 1 – 1 0 0 1 0 2 2 0 3 0 2 0 0 0 0 0 0
Endosome 7 1 0 2 20 14 – 29 5 2 4 4 6 24 28 5 3 2 21 5 15 13 42 48
Golgi 20 33 4 1 12 2 – 16 1 1 0 1 66 70 104 41 51 54 111 85 74 69 348 448
Mitochondria 175 111 130 310 427 434 – 543 423 545 370 549 499 683 765 5 8 8 15 9 12 10 48 36
Nucleus 1 0 0 0 2 0 – 5 2 2 2 1 0 0 0 0 0 0 0 0 0 0 0 1
Nuclear Periphery 5 0 3 1 3 7 – 11 11 6 10 11 8 6 5 1 0 3 0 0 0 0 0 1
Nucleolus 25 3 4 21 21 34 – 97 59 42 48 57 14 24 32 5 14 9 0 0 0 0 0 1
Peroxisomes 2 2 2 37 67 79 – 142 41 99 68 112 18 59 89 6 21 8 25 8 27 11 36 34
SpindlePole 1 0 0 5 12 11 – 35 21 28 25 27 1 2 4 3 4 4 3 0 0 0 1 1
Vac/Vac Membrane 3 5 4 5 5 1 – 11 5 2 4 5 21 11 26 5 5 6 2 3 0 3 6 10
Unique Cell Count 188 121 135 336 483 481 740 493 628 449 655 528 745 871 71 100 97 193 122 135 112 519 627
Labelled Cell Count 247 167 163 413 612 617 935 615 821 595 854 682 931 1104 87 114 109 193 122 135 112 519 627


Late Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.8 13.1 8.9 8.9 9.8 9.5 – 10.2 9.1 8.6 8.5 8.7 12.9 14.0 13.8 15.7 17.0 16.0 10.6 12.5 13.1
Std Deviation (1e-4) 2.1 2.5 1.7 1.6 1.7 2.2 – 2.3 2.5 2.4 2.5 2.6 2.7 3.0 3.3 4.1 4.0 4.0 2.4 2.4 2.4
Intensity Change (Log2) – – – 0.0 0.13 0.09 – 0.19 0.04 -0.04 -0.07 -0.03 0.54 0.65 0.64 0.82 0.93 0.84 0.25 0.49 0.56


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 -0.5 -1.3 0 0 0 -0.6
Bud 0 1.1 0 – 0 1.9 1.9 2.7 2.0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 3.2 2.5 3.1 9.0 8.6 9.1
Mitochondria -1.6 -2.7 -2.2 – -5.8 -3.3 -3.1 -4.0 -3.8 -0.8 -1.9 -2.9 -12.8 -13.6 -13.5
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.4 0.7 1.8 – 3.4 3.1 1.6 2.8 2.3 0 0 0 0 3.1 2.1
Peroxisomes 3.4 4.0 4.5 – 5.1 2.8 4.4 4.3 4.7 0 2.7 3.3 0 5.0 0
SpindlePole 0 0 0 – 2.6 0 0 2.8 0 0 0 0 0 0 0
Vacuole 0 0 0 – 0 0 0 0 0 0.6 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.8693 13.667 12.4424 11.5491 10.9191 13.3282 10.3568 12.6692 12.7521 12.0034 12.2834 12.7999 13.0089 15.4662 14.9417 12.9915 15.065 16.4676
Actin 0.0256 0.0387 0.0351 0.015 0.0158 0.0257 0.0895 0.0289 0.0321 0.0241 0.0414 0.0529 0.0914 0.049 0.0472 0.0185 0.0044 0.0088
Bud 0.0003 0.0003 0.0003 0.0003 0.0002 0.0001 0.0006 0.0003 0.0004 0.0001 0.0002 0.0001 0.0004 0.0029 0.0011 0.0002 0.0001 0.0005
Bud Neck 0.0024 0.0003 0.0002 0.0003 0.0003 0.0002 0.0008 0.0007 0.0005 0.0003 0.0003 0.0005 0.0005 0.0006 0.0015 0.0002 0.0001 0.0015
Bud Periphery 0.0004 0.0003 0.0003 0.0004 0.0002 0.0001 0.0009 0.0002 0.0005 0.0001 0.0002 0.0002 0.0006 0.0025 0.0014 0.0004 0.0001 0.0009
Bud Site 0.003 0.0008 0.0011 0.0017 0.0006 0.0001 0.0022 0.0044 0.0013 0.0002 0.0002 0.0002 0.002 0.0121 0.0184 0.0008 0.0001 0.001
Cell Periphery 0.0003 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0002 0.0003 0.0002 0.0001 0.0001 0.0002 0.0005 0.0002 0.0002 0.0001 0.0003
Cytoplasm 0.002 0.0003 0.0004 0.0004 0.0122 0.0005 0.0009 0.0093 0.0115 0.0062 0.0004 0.0001 0.0072 0.0013 0.0005 0.0002 0.0001 0.0001
Cytoplasmic Foci 0.0621 0.0551 0.0474 0.0516 0.0585 0.0323 0.0457 0.0612 0.0424 0.0524 0.0377 0.0202 0.046 0.0456 0.0279 0.0151 0.0292 0.0174
Eisosomes 0.0002 0.0001 0.0002 0.0002 0.0001 0.0001 0.0004 0.0001 0.0002 0.0001 0.0002 0.0002 0.0005 0.0002 0.0004 0.0006 0.0001 0.0002
Endoplasmic Reticulum 0.0027 0.0001 0.0003 0.0009 0.0017 0.0006 0.0025 0.0002 0.0024 0.0048 0.0007 0.0002 0.0014 0.0003 0.0009 0.0003 0.0001 0.0001
Endosome 0.0948 0.0796 0.0711 0.0809 0.0741 0.0524 0.0673 0.1027 0.0913 0.1077 0.1238 0.0462 0.0752 0.112 0.0666 0.1101 0.0526 0.0343
Golgi 0.5992 0.7021 0.6386 0.7479 0.6661 0.7426 0.4551 0.6198 0.6031 0.4925 0.7065 0.6559 0.4394 0.5309 0.5952 0.4676 0.7225 0.6542
Lipid Particles 0.0754 0.0333 0.0926 0.0519 0.0287 0.0507 0.13 0.0853 0.0756 0.1895 0.0277 0.08 0.1137 0.0643 0.0747 0.0182 0.0382 0.1031
Mitochondria 0.0691 0.049 0.074 0.018 0.0898 0.0534 0.1022 0.0392 0.0785 0.0729 0.0361 0.0972 0.1113 0.1217 0.0957 0.3343 0.1392 0.1458
None 0.0019 0 0.0003 0.0004 0.0005 0.0003 0.0017 0.0001 0.0009 0.0002 0 0 0.0067 0.0001 0.0005 0.0005 0 0
Nuclear Periphery 0.005 0.0001 0.0008 0.0009 0.0045 0.0013 0.0228 0.0002 0.0011 0.0035 0.0002 0.0001 0.0159 0.0003 0.0008 0.0004 0.0001 0.0001
Nucleolus 0.0021 0.0004 0.0004 0.0002 0.0013 0.0005 0.0006 0.0021 0.0009 0.0004 0 0 0.0008 0.0011 0.0002 0.0005 0 0.0002
Nucleus 0.0012 0.0001 0.0003 0.0003 0.0032 0.0005 0.0016 0.0003 0.0003 0.0002 0 0 0.0088 0.0004 0.0002 0.0003 0 0.0001
Peroxisomes 0.0381 0.034 0.0314 0.0234 0.0219 0.0326 0.0578 0.0341 0.0402 0.0332 0.0205 0.0427 0.046 0.0264 0.0566 0.0109 0.0087 0.0249
Punctate Nuclear 0.0054 0.0001 0.001 0.0014 0.002 0.0034 0.0011 0.0004 0.0002 0.0004 0.0001 0.0001 0.0229 0.0002 0.0006 0.0001 0 0.0001
Vacuole 0.0042 0.0018 0.0014 0.0016 0.007 0.0006 0.0055 0.005 0.0086 0.0031 0.0011 0.0005 0.0024 0.0154 0.0017 0.004 0.0008 0.0015
Vacuole Periphery 0.0045 0.0033 0.0027 0.002 0.0111 0.002 0.0104 0.0054 0.0077 0.0078 0.0025 0.0023 0.0066 0.0124 0.0078 0.0165 0.0033 0.0047

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 103.4785 100.437 101.1112 108.9456 88.9684 88.8819 111.4753 103.4806 97.3105 109.5617
Translational Efficiency 0.989 1.0446 0.9238 0.8321 0.8836 0.9623 0.7823 0.6808 0.7526 0.6938

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
85 1546 1135 949 214 220 1696 953 299 1766 2831 1902

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1077.91 1163.75 1341.15 1342.59 1152.46 1200.27 1439.55 1286.50 1131.27 1168.30 1400.10 1314.49
Standard Deviation 217.48 201.06 183.62 195.05 164.82 197.08 201.67 185.34 184.44 200.93 200.52 192.30
Intensity Change Log 2 — 0.110544 0.315234 0.316782 — 0.058642 0.320901 0.158735 — 0.083959 0.318165 0.237280

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.079547 0.043205 0.036474 0.030714 0.022790 0.012347 0.081939 0.033196 0.038925 0.039360 0.063711 0.031958
Bud Neck 0.002364 0.000611 0.001574 0.002240 0.001389 0.000984 0.001314 0.001204 0.001666 0.000657 0.001418 0.001721
Bud Site 0.000687 0.000575 0.001151 0.003238 0.000673 0.001061 0.000746 0.002180 0.000677 0.000636 0.000909 0.002708
Cell Periphery 0.000150 0.000091 0.000089 0.000154 0.000142 0.000092 0.000081 0.000114 0.000145 0.000091 0.000084 0.000134
Cytoplasm 0.000768 0.000820 0.000672 0.001206 0.000704 0.000745 0.000698 0.001103 0.000722 0.000811 0.000687 0.001154
Cytoplasmic Foci 0.157347 0.144043 0.192772* 0.170326 0.172576 0.231653* 0.105812 0.189737* 0.168247 0.154957 0.140676 0.180052*
Eisosomes 0.000925 0.000524 0.000258 0.000236 0.000450 0.000166 0.000720 0.000204 0.000585 0.000479 0.000535 0.000220
Endoplasmic Reticulum 0.000909 0.000395 0.000598 0.000649 0.000723 0.000336 0.000514 0.000443 0.000776 0.000388 0.000548 0.000546
Endosome 0.048267 0.054783 0.065219 0.121897 0.071126 0.127727 0.040022 0.153231 0.064628 0.063870 0.050124 0.137597
Golgi 0.436312* 0.541302* 0.514149* 0.499094* 0.524621* 0.469870* 0.578276* 0.498881* 0.499516* 0.532403* 0.552566* 0.498988*
Lipid Particles 0.105564* 0.058820 0.128840* 0.053382 0.058122 0.066517 0.125653* 0.029931 0.071609 0.059779 0.126931* 0.041632
Mitochondria 0.141743* 0.133070* 0.032061 0.057474 0.117179* 0.056365 0.044074 0.046700 0.124162* 0.123515* 0.039258 0.052076
Mitotic Spindle 0.001094 0.000569 0.003850 0.010652 0.001847 0.001441 0.001760 0.006783 0.001633 0.000677 0.002598 0.008714
None 0.000436 0.000207 0.000116 0.000134 0.000258 0.000087 0.000201 0.000083 0.000309 0.000192 0.000167 0.000109
Nuclear Periphery 0.000711 0.000135 0.000744 0.000783 0.000209 0.000182 0.000750 0.000348 0.000352 0.000141 0.000748 0.000565
Nuclear Periphery Foci 0.000489 0.000131 0.000712 0.001009 0.000334 0.000279 0.000656 0.000846 0.000378 0.000150 0.000678 0.000928
Nucleolus 0.000095 0.000066 0.000038 0.000192 0.000094 0.000050 0.000040 0.000061 0.000095 0.000064 0.000039 0.000127
Nucleus 0.000045 0.000034 0.000026 0.000060 0.000066 0.000041 0.000025 0.000029 0.000060 0.000035 0.000026 0.000044
Peroxisomes 0.016295 0.016526 0.008681 0.015478 0.020188 0.024403 0.007465 0.017616 0.019081 0.017507 0.007953 0.016549
Vacuole 0.003349 0.001640 0.006343 0.019089 0.003026 0.002678 0.004402 0.010879 0.003118 0.001770 0.005180 0.014975
Vacuole Periphery 0.002901 0.002453 0.005630 0.011993 0.003482 0.002975 0.004853 0.006429 0.003317 0.002518 0.005164 0.009205

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.75 2.08 2.36 2.71 1.28 1.66 -8.79 -1.67 -4.08 8.61 -0.06 -3.26 0.94 1.96 8.33
Bud Neck 3.01 1.28 0.11 -6.57 -2.26 0.97 0.24 0.60 -0.64 0.63 3.83 0.88 -0.29 -7.00 -1.87
Bud Site 0.55 -2.05 -7.48 -8.15 -6.10 -0.79 -0.38 -4.57 -2.02 -5.10 0.20 -1.45 -8.23 -8.74 -8.26
Cell Periphery 2.80 2.96 -0.17 -3.88 -4.11 1.99 2.81 1.22 -1.59 -4.88 3.09 3.63 0.54 -4.50 -5.82
Cytoplasm -0.68 1.15 -3.99 -4.41 -5.72 -0.27 0.09 -4.28 -2.01 -5.29 -1.61 0.66 -5.99 -5.45 -7.83
Cytoplasmic Foci 0.94 -2.46 -0.91 -4.73 3.55 -4.16 7.06 -1.64 3.49 -14.91 1.60 3.45 -1.43 -5.33 -9.45
Eisosomes 1.95 3.26 3.36 8.66 0.91 4.43 -3.64 3.92 -1.74 11.99 1.38 0.64 4.89 10.17 11.08
Endoplasmic Reticulum 3.21 1.92 1.56 -3.79 -0.73 2.80 1.63 2.15 -1.63 1.72 3.67 2.22 2.17 -3.43 0.04
Endosome -0.73 -1.88 -7.69 -14.04 -11.03 -4.57 4.61 -10.01 -2.19 -21.27* 0.13 2.63 -11.72 -18.13 -23.82
Golgi -3.42 -2.51 -1.99 3.83 1.31 2.18 -2.80 1.30 -1.47 7.29 -1.96 -3.23 0.06 3.80 6.70
Lipid Particles 2.53 -1.21 2.79 1.03 10.52 -0.64 -7.37 3.39 3.44 17.94 1.42 -6.46 3.69 4.57 19.38
Mitochondria 0.34 4.43 3.38 9.82 -4.52 3.42 4.78 4.53 0.92 -0.52 0.05 6.54 5.48 11.21 -3.38
Mitotic Spindle 1.52 -2.68 -5.00 -5.33 -3.23 0.35 0.08 -2.71 -3.16 -3.02 1.40 -1.17 -5.09 -6.50 -4.63
None 3.61 5.06 4.77 6.21 -1.80 5.88 2.09 6.68 0.26 11.33 4.29 5.31 7.57 9.04 7.67
Nuclear Periphery 2.37 -0.14 -0.28 -5.26 -0.24 0.55 -4.10 -1.64 -1.84 2.64 2.88 -3.48 -2.08 -5.73 1.59
Nuclear Periphery Foci 2.88 -1.19 -2.91 -6.55 -1.54 0.45 -1.47 -1.50 -1.60 -0.47 4.01 -2.02 -2.93 -4.28 -1.09
Nucleolus 0.62 1.99 -1.16 -1.39 -1.78 0.74 1.14 0.65 -0.26 -1.10 0.62 1.58 -0.70 -1.20 -1.96
Nucleus 0.73 3.19 -1.11 -1.40 -2.36 0.86 2.02 1.75 0.55 -0.64 1.33 2.36 0.85 -0.75 -2.43
Peroxisomes -0.05 1.82 0.16 0.42 -3.28 -0.58 3.12 0.58 1.08 -5.26 0.46 3.53 0.74 0.47 -6.15
Vacuole 1.91 -2.84 -8.43 -10.49 -7.23 0.39 -1.68 -6.04 -7.00 -5.69 2.23 -3.11 -10.34 -13.16 -9.38
Vacuole Periphery 1.15 -4.78 -8.39 -9.25 -5.72 0.41 -1.28 -2.40 -3.63 -2.17 1.05 -2.35 -6.11 -10.63 -6.11
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
Localization
Cell Percentages mitochondrion (10%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sec7

Sec7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sec7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available