Standard name
Human Ortholog
Description Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 – – 0 0 0 0 0 0
Bud 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0.11 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 – – 0 0 0 0 0 0
Cytoplasm 0.08 0 0 0.06 0 0 0 0 0 0 0 0 0.09 0.08 0.05 0.05 – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.05 – – 0 0 0 0 0 0
Endosome 0.08 0.13 0 0 0 0 0 0 0 0 0 0 0.1 0.16 0.16 0 – – 0.11 0.09 0.05 0.1 0.09 0.08
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0.14 0.53 – – 0 0.05 0 0.07 0.1 0.09
Mitochondria 0.79 0.85 0.96 0.92 0.92 0.93 0.94 0.88 0.93 0.94 0.94 0.95 0.6 0.56 0.49 0 – – 0.73 0.72 0.79 0.6 0.59 0.57
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.06 0.12 0.08 0.11 0.13 0.07 0.08 0 0 0 0 – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.07 0.09 0.14 0.06 0.09 0.07 0.08 0 0 0 0.11 – – 0 0 0 0 0 0
Peroxisomes 0.06 0.12 0 0.06 0 0 0 0 0 0 0 0 0.07 0.11 0.06 0 – – 0 0 0.09 0.07 0.06 0.08
SpindlePole 0 0 0 0.06 0 0 0 0 0 0 0 0 0.08 0.07 0.06 0 – – 0 0 0 0 0 0
Vac/Vac Membrane 0.17 0.15 0 0 0.05 0 0 0.05 0 0 0 0 0.12 0.21 0.19 0.21 – – 0 0 0 0.05 0.06 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 3 0 0 0 0 0 1 0 0 0 9 1 5 1 – – 5 4 1 7 6 9
Bud 5 3 5 21 13 16 22 21 17 23 14 15 8 8 3 2 – – 0 1 0 0 2 4
Bud Neck 1 0 0 0 0 1 0 2 0 0 0 0 2 0 1 0 – – 1 1 0 3 1 4
Bud Site 1 0 1 1 0 12 5 5 7 6 7 1 0 0 0 0 – – – – – – – –
Cell Periphery 4 8 2 7 9 1 1 1 3 6 3 3 5 5 5 2 – – 0 0 0 0 0 1
Cytoplasm 22 6 5 15 14 19 8 20 12 10 10 6 18 25 14 1 – – 1 1 0 1 2 1
Endoplasmic Reticulum 6 0 6 1 0 2 3 1 1 4 1 3 9 4 23 1 – – 2 2 0 1 1 2
Endosome 22 31 0 0 11 1 1 2 0 2 0 1 21 48 47 0 – – 34 24 6 16 22 24
Golgi 2 1 0 0 0 0 0 1 1 0 0 1 15 16 41 10 – – 10 13 1 11 26 26
Mitochondria 217 199 141 248 432 454 478 610 393 504 326 488 122 164 147 0 – – 237 188 121 106 154 176
Nucleus 1 1 0 2 4 5 3 6 6 3 2 2 2 2 3 0 – – 0 0 0 0 0 1
Nuclear Periphery 3 1 5 2 15 31 63 58 47 71 23 40 0 1 2 0 – – 5 3 0 0 2 2
Nucleolus 0 2 1 3 19 34 48 96 26 51 25 41 0 1 0 2 – – 0 1 0 0 1 0
Peroxisomes 17 27 1 15 12 4 2 6 4 6 1 4 14 31 19 0 – – 12 9 14 11 16 23
SpindlePole 9 3 1 15 8 5 4 19 5 9 4 3 16 20 18 0 – – 5 1 1 0 2 1
Vac/Vac Membrane 46 36 3 5 23 21 22 34 17 16 9 16 25 63 57 4 – – 6 7 1 9 16 20
Unique Cell Count 275 234 147 270 469 490 506 693 422 539 345 513 203 295 301 19 326 263 153 176 260 307
Labelled Cell Count 357 318 174 335 560 606 660 882 540 711 425 624 266 389 385 23 326 263 153 176 260 307


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.7 5.8 4.1 3.9 4.9 4.9 4.9 5.3 5.5 5.6 5.7 6.3 6.2 6.2 6.4 10.8 – – 6.7 7.1 7.0
Std Deviation (1e-4) 0.8 1.8 0.6 1.2 1.2 1.2 1.5 1.6 1.7 1.8 2.0 2.2 2.7 1.6 1.2 2.6 – – 2.7 4.1 2.4
Intensity Change (Log2) – – – -0.07 0.26 0.28 0.28 0.37 0.43 0.45 0.49 0.62 0.61 0.6 0.66 1.41 – – 0.72 0.81 0.78

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_10510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 1.2 0 0 0 – –
Bud 0 0 0 0.5 0 0.3 0.5 0.3 0 0.3 0 0 0 – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Cytoplasm 1.0 0 0.3 0 0 0 0 0 0 2.0 2.0 0.6 0 – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0.2 0 1.4 0 – –
Endosome 0 0 0 0 0 0 0 0 0 4.0 5.2 5.1 0 – –
Golgi 0 0 0 0 0 0 0 0 0 3.4 2.9 4.7 0 – –
Mitochondria 0 0 -1.4 -0.7 -2.8 -1.2 -1.1 -0.7 -0.4 -7.7 -8.6 -9.8 -11.0 – –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Nuclear Periphery 0 0 1.3 3.2 2.1 2.8 3.3 1.4 1.9 0 0 0 0 – –
Nucleolus 0 0 2.9 3.6 4.5 2.7 3.6 3.0 3.2 0 0 0 0 – –
Peroxisomes 0 0 0 0 0 0 0 0 0 2.8 3.8 2.7 0 – –
SpindlePole 0 0 0 0 0 0 0 0 0 3.1 2.8 2.6 0 – –
Vacuole 0 1.5 1.3 1.3 1.5 1.1 0 0 0 3.5 5.4 4.9 0 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.7843 5.87 5.6472 5.7359 5.1801 5.4611 4.3722 5.3029 4.7242 4.7513 3.7643 4.6415 1.4373 2.2664 2.2987 1.7858 1.1283 2.0552
Actin 0.0294 0.0193 0.0103 0.0093 0.0127 0.0077 0.0318 0.0154 0.0122 0.0045 0.0314 0.0049 0.021 0.0206 0.0187 0.0019 0.0191 0.0146
Bud 0.0005 0.0011 0.0003 0.0059 0.0002 0.0001 0.0003 0.003 0.0003 0.0001 0.0003 0.0001 0.0005 0.0006 0.0006 0.0001 0.0005 0.0002
Bud Neck 0.0014 0.0002 0.0008 0.0002 0.0001 0.0001 0.0034 0.0001 0.004 0 0.0001 0.0001 0.0004 0.0003 0.0003 0.0001 0.0003 0.0002
Bud Periphery 0.0008 0.0013 0.0015 0.0186 0.0004 0.0001 0.0006 0.0045 0.0005 0.0002 0.0004 0.0001 0.0011 0.0011 0.0013 0.0001 0.001 0.0004
Bud Site 0.0021 0.0081 0.0014 0.0014 0.0002 0.0001 0.0017 0.0031 0.0016 0.0001 0.0005 0.0002 0.0012 0.0016 0.0013 0.0001 0.0006 0.0003
Cell Periphery 0.0002 0.0003 0.0003 0.0002 0.0001 0.0001 0.0003 0.0001 0.0002 0.0002 0.0001 0.0001 0.0002 0.0005 0.0003 0.0001 0.0002 0.0001
Cytoplasm 0.0016 0.0008 0.0009 0.0005 0.0001 0.0001 0.0006 0.0002 0.0009 0.0001 0.0003 0.0001 0.0005 0.0003 0.0011 0.0001 0.0001 0.0003
Cytoplasmic Foci 0.0156 0.0092 0.0135 0.0032 0.0039 0.003 0.0167 0.0112 0.0098 0.0008 0.0171 0.0039 0.024 0.0139 0.0091 0.0402 0.008 0.0052
Eisosomes 0.0005 0.0006 0.0003 0.0003 0.0001 0.0001 0.0009 0.0002 0.0007 0.0001 0.0004 0.0002 0.0005 0.0003 0.0004 0.0002 0.0004 0.0003
Endoplasmic Reticulum 0.0009 0.0002 0.0003 0.0011 0.0001 0.0002 0.0004 0.0001 0.0003 0.0001 0.0001 0.0001 0.0014 0.0017 0.0004 0.0001 0.0001 0.0003
Endosome 0.0364 0.0172 0.027 0.0149 0.0141 0.007 0.0119 0.0261 0.018 0.0113 0.0091 0.004 0.0351 0.0345 0.0333 0.0239 0.0118 0.0199
Golgi 0.0476 0.0593 0.0402 0.0106 0.021 0.0287 0.0327 0.0372 0.0217 0.0037 0.0303 0.0216 0.0595 0.0649 0.0284 0.0488 0.0364 0.0442
Lipid Particles 0.0133 0.0202 0.0095 0.0022 0.0161 0.0143 0.034 0.0066 0.0137 0.0015 0.0352 0.0066 0.0381 0.0317 0.0179 0.0258 0.1136 0.026
Mitochondria 0.7947 0.8199 0.8724 0.9181 0.9178 0.9261 0.7758 0.8412 0.8558 0.8983 0.8448 0.9206 0.7224 0.7672 0.8395 0.7584 0.7593 0.8468
None 0.0036 0.0003 0.0002 0.0008 0.0001 0.0001 0.0033 0.0001 0.0005 0 0.0004 0.0001 0.0015 0.0002 0.0003 0.0001 0.0001 0.0001
Nuclear Periphery 0.0085 0.0001 0.0003 0.0006 0.0001 0.0006 0.0007 0 0.0003 0.0001 0.0001 0.0001 0.0055 0.0051 0.0002 0 0.0001 0.0003
Nucleolus 0.0029 0.0031 0.0002 0.0002 0.0001 0 0.0005 0.0001 0.0002 0.0004 0.0001 0 0.0004 0.0003 0.0002 0 0.0001 0.0012
Nucleus 0.002 0.0004 0.0002 0.0004 0.0001 0.0001 0.0005 0 0.0001 0.0003 0 0 0.001 0.0007 0.0002 0 0.0001 0.0002
Peroxisomes 0.025 0.0343 0.0111 0.007 0.0106 0.0095 0.0809 0.0497 0.0547 0.0418 0.0269 0.0347 0.0778 0.0363 0.0334 0.0979 0.0449 0.0357
Punctate Nuclear 0.0075 0.0001 0.0001 0.0001 0.0001 0.0003 0.0012 0.0001 0.0002 0 0.0019 0.0001 0.0013 0.0001 0.0001 0.0009 0.0001 0.0001
Vacuole 0.0024 0.0017 0.0031 0.002 0.0008 0.0004 0.0008 0.0004 0.0018 0.0263 0.0002 0.0004 0.0031 0.0103 0.0069 0.0003 0.0008 0.0011
Vacuole Periphery 0.0031 0.0025 0.0063 0.0024 0.0011 0.0014 0.0012 0.0005 0.0024 0.0101 0.0005 0.0021 0.0036 0.0079 0.0061 0.0008 0.0024 0.0026

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.1775 18.0655 21.4486 31.5005 13.1008 16.1581 23.2892 24.6566 28.9588 26.2155
Translational Efficiency 5.1078 2.615 2.6107 3.1008 5.2446 7.5017 3.1263 3.5624 3.4774 2.3901

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1339 1304 3037 762 2285 1602 1727 1580 3624 2906 4764 2342

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 630.33 718.63 943.15 1050.95 728.96 732.35 1006.66 1028.48 692.52 726.19 966.17 1035.79
Standard Deviation 93.77 100.87 152.36 178.93 87.31 125.81 137.29 173.07 101.59 115.49 150.22 175.31
Intensity Change Log 2 — 0.189142 0.581380 0.737515 — 0.006694 0.465665 0.496602 — 0.094174 0.520480 0.613335

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000906 0.003775 0.005099 0.021747 0.000800 0.004055 0.006764 0.012030 0.000839 0.003929 0.005703 0.015192
Bud Neck 0.005313 0.008138 0.001386 0.003194 0.007599 0.005781 0.002809 0.001939 0.006755 0.006839 0.001901 0.002347
Bud Site 0.008153 0.024432 0.013772 0.045553 0.010635 0.014053 0.020977 0.029915 0.009718 0.018710 0.016384 0.035003
Cell Periphery 0.001121 0.000484 0.000310 0.001495 0.000333 0.000627 0.000329 0.001879 0.000624 0.000563 0.000317 0.001754
Cytoplasm 0.003966 0.007319 0.002857 0.005049 0.015005 0.006364 0.004015 0.004670 0.010926 0.006792 0.003277 0.004793
Cytoplasmic Foci 0.024399 0.069835 0.025010 0.038526 0.102640 0.044022 0.040762 0.018463 0.073731 0.055605 0.030720 0.024991
Eisosomes 0.000090 0.000133 0.000069 0.000170 0.000151 0.000151 0.000084 0.000141 0.000129 0.000143 0.000075 0.000150
Endoplasmic Reticulum 0.000417 0.000288 0.000513 0.001663 0.000797 0.000384 0.000585 0.000537 0.000656 0.000341 0.000539 0.000903
Endosome 0.031253 0.101758 0.049436 0.051552 0.076105 0.083075 0.063737 0.038010 0.059533 0.091459 0.054621 0.042416
Golgi 0.068941 0.141904 0.074791 0.105712 0.173330 0.130543 0.077887 0.073329 0.134760 0.135641 0.075914 0.083865
Lipid Particles 0.004748 0.004434 0.000731 0.000726 0.006188 0.003261 0.001292 0.000213 0.005656 0.003787 0.000935 0.000380
Mitochondria 0.809851 0.536478 0.738037 0.606121 0.540755 0.632259 0.676427 0.767300 0.640181 0.589279 0.715703 0.714859
Mitotic Spindle 0.003030 0.016782 0.030048 0.041720 0.007811 0.007237 0.042606 0.011099 0.006044 0.011520 0.034600 0.021062
None 0.000477 0.000435 0.000266 0.000398 0.000572 0.000630 0.000214 0.000304 0.000537 0.000543 0.000247 0.000335
Nuclear Periphery 0.000048 0.000066 0.000360 0.000680 0.000134 0.000117 0.000331 0.000045 0.000102 0.000094 0.000349 0.000252
Nuclear Periphery Foci 0.000122 0.000165 0.000369 0.000517 0.000358 0.000226 0.000569 0.000095 0.000271 0.000199 0.000441 0.000232
Nucleolus 0.000327 0.000981 0.000068 0.000060 0.000379 0.000412 0.000149 0.000201 0.000360 0.000667 0.000097 0.000155
Nucleus 0.000892 0.000741 0.000148 0.000120 0.000877 0.001751 0.000334 0.000134 0.000883 0.001298 0.000215 0.000129
Peroxisomes 0.025032 0.064002 0.013634 0.040001 0.030775 0.051396 0.029254 0.017996 0.028653 0.057053 0.019297 0.025155
Vacuole 0.002972 0.009307 0.022211 0.016773 0.011537 0.007080 0.017337 0.010264 0.008372 0.008079 0.020444 0.012382
Vacuole Periphery 0.007943 0.008544 0.020884 0.018225 0.013221 0.006576 0.013540 0.011435 0.011271 0.007459 0.018222 0.013645

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.15 -6.13 -6.83 -5.66 -5.34 -5.37 -6.44 -7.12 -4.73 -2.88 -5.87 -8.92 -9.84 -7.29 -6.11
Bud Neck -2.00 4.19 2.05 4.20 -3.69 1.67 5.41 6.86 4.82 1.85 -0.10 7.73 6.86 6.61 -1.49
Bud Site -6.12 -3.40 -8.19 -4.34 -7.13 -2.05 -5.55 -7.46 -5.65 -2.99 -6.02 -5.94 -11.00 -6.50 -7.95
Cell Periphery 2.81 3.55 -0.82 -2.57 -3.00 -3.46 0.08 -3.62 -2.87 -3.64 0.58 3.35 -3.47 -3.74 -4.56
Cytoplasm -2.48 1.04 -0.88 2.35 -3.77 5.21 8.76 8.08 1.44 -1.00 3.64 8.66 6.68 2.54 -3.62
Cytoplasmic Foci -14.13 -0.22 -4.49 8.36 -4.80 17.86 18.56 28.60 11.50 9.62 7.25 19.99 21.71 15.31 3.70
Eisosomes -4.10 2.98 -4.40 -1.93 -5.87 0.03 6.88 0.86 0.77 -5.50 -1.62 8.42 -2.11 -0.67 -8.75
Endoplasmic Reticulum 1.54 -1.04 -4.06 -4.63 -3.81 1.87 0.88 1.33 -1.21 0.70 2.28 0.80 -1.56 -4.63 -3.12
Endosome -15.38 -6.99 -5.60 9.80 -0.61 -1.66 3.39 11.40 11.61 7.91 -10.01 2.09 6.78 15.78 5.52
Golgi -11.52 -1.25 -5.04 4.56 -4.65 6.99 18.01 17.78 9.95 0.92 -0.18 15.83 11.30 11.24 -2.12
Lipid Particles 0.24 3.97 4.00 4.17 0.05 3.37 7.16 9.58 4.71 3.93 2.56 8.48 9.79 6.38 3.67
Mitochondria 21.91 7.57 13.12 -4.18 8.97 -8.23 -12.31 -21.57 -11.66 -8.03 5.87 -10.12 -8.27 -13.10 0.04
Mitotic Spindle -7.75 -15.26 -9.91 -5.87 -2.72 0.48 -12.36 -2.44 -2.93 10.97 -5.17 -18.16 -9.51 -5.52 6.55
None 0.16 2.21 0.90 0.48 -3.60 -0.33 2.56 1.92 1.63 -6.12 -0.17 3.08 2.17 1.74 -5.51
Nuclear Periphery -0.88 -3.38 -1.72 -1.66 -0.84 0.21 -1.72 1.83 1.27 2.72 0.15 -3.25 -1.21 -1.26 0.71
Nuclear Periphery Foci -1.34 -3.30 -2.31 -1.96 -0.80 0.52 -0.76 1.16 1.53 2.55 0.42 -1.06 0.26 -0.31 2.15
Nucleolus -1.55 3.30 3.41 2.02 0.60 -0.10 2.14 0.96 0.90 -0.27 -1.46 3.67 1.57 2.10 -0.47
Nucleus 0.31 2.13 2.25 2.87 0.81 -1.34 2.98 5.03 2.48 1.57 -1.08 4.12 4.69 3.17 1.34
Peroxisomes -8.68 4.55 -2.96 4.04 -5.64 -5.63 0.52 5.16 9.04 3.98 -9.98 5.36 1.51 10.14 -2.62
Vacuole -7.63 -16.70 -7.41 -3.74 2.58 4.20 -4.30 0.99 -2.68 4.73 0.37 -12.73 -4.07 -4.20 6.76
Vacuole Periphery -0.59 -10.15 -5.37 -5.11 1.30 7.88 -0.29 1.56 -4.91 1.64 5.78 -7.63 -2.43 -6.74 4.11
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Sdh4

Sdh4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sdh4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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