Standard name
Human Ortholog
Description Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.97 0.94 0.91 0.91 0.81 – 0.64 0.62 0.57 0.62 0.58 0.98 0.99 0.99 0.77 0.73 0.8 0.95 0.94 0.85 0.91 0.9 0.88
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.1 0.35 0.12 0.38 – 0.54 0.57 0.63 0.63 0.62 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0.05 0.05 0 0 0 0 0 0 0.36 0.36 0.31 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 2
Bud 1 0 5 0 0 1 – 5 6 3 7 11 1 1 0 1 1 0 1 0 0 2 1 1
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 – 1 0 3 0 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 1 1 2 – 1 2 2 3 1 0 0 2 5 2 3 0 0 1 0 1 0
Cytoplasm 179 308 212 154 157 180 – 225 175 186 234 252 352 425 390 288 211 235 170 300 195 238 255 250
Endoplasmic Reticulum 0 0 1 1 0 0 – 0 0 0 2 2 3 2 0 14 5 6 0 0 1 0 1 1
Endosome 0 0 0 0 1 0 – 0 0 0 0 1 0 2 4 21 11 9 1 0 3 4 2 6
Golgi 0 1 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 3 0 1 1 1 1 1
Mitochondria 4 8 23 60 21 85 – 190 160 204 239 272 0 1 1 4 10 2 1 4 7 3 4 2
Nucleus 0 1 2 0 2 4 – 12 5 4 11 12 0 1 3 2 8 4 0 3 0 1 1 4
Nuclear Periphery 0 0 0 0 0 1 – 1 6 3 2 7 0 2 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1 0 0 0 – 0 0 1 1 0 0 0 0 2 0 1 0 0 1 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 1 1 0 0 1 0 1 0 0 4 0 1 1
Vac/Vac Membrane 3 7 1 4 2 6 – 17 15 11 12 18 2 0 8 134 105 90 2 5 2 5 4 6
Unique Cell Count 183 317 225 170 172 223 353 280 326 380 437 358 430 395 375 288 294 179 319 229 261 283 284
Labelled Cell Count 187 326 245 220 184 279 452 369 417 511 581 359 434 408 473 353 354 179 319 229 261 283 284


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.6 5.4 3.7 3.7 4.6 3.8 – 3.8 3.7 3.9 3.7 3.6 5.1 5.1 5.5 8.6 8.6 8.3 5.1 5.2 5.4
Std Deviation (1e-4) 1.3 0.8 0.9 1.2 1.2 0.8 – 1.2 1.5 1.0 1.1 0.8 0.8 0.8 5.4 1.9 2.4 2.2 1.2 1.1 1.6
Intensity Change (Log2) – – – 0.01 0.3 0.04 – 0.04 0.0 0.06 0.01 -0.02 0.48 0.48 0.59 1.23 1.22 1.18 0.47 0.51 0.56

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.4 -1.1 -4.3 – -8.3 -8.4 -9.6 -8.8 -9.7 2.7 3.4 3.2 -5.5 -6.2 -4.7
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 2.5 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 3.6 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0 0 0 0 0 -6.2 -6.5 -6.2 -5.2 -3.1 -5.0
Nucleus 0 0 0 – 1.9 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 3.0 3.1 0 0 2.7 0 0 0 10.0 10.0 9.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.5661 1.1976 0.4207 0.4768 -0.4488 0.2381 0.3845 -0.0777 0.1612 -0.5505 0.2396 -0.0588 1.8523 1.3511 1.461 2.1013 1.0109 1.5233
Actin 0.0028 0.0003 0.002 0.0022 0.0272 0.0034 0.059 0.0037 0.0213 0.0345 0.0297 0.0068 0.0523 0.001 0.0031 0.0625 0.0009 0.0007
Bud 0.0003 0.0002 0.0009 0.0005 0.0007 0.0012 0.0017 0.0108 0.0015 0.0173 0.0008 0.0006 0.0033 0.0066 0.0052 0.0022 0.0001 0.0013
Bud Neck 0.0007 0.0027 0.0001 0.0001 0.0009 0.0027 0.0042 0.0002 0.0006 0.0004 0.0005 0.0006 0.004 0.0001 0.0002 0.0009 0.0002 0.0009
Bud Periphery 0.0013 0.0001 0.0013 0.0013 0.0013 0.0008 0.0031 0.0046 0.002 0.0079 0.0013 0.0005 0.0087 0.0022 0.001 0.0088 0.0001 0.0021
Bud Site 0.0004 0.0052 0.0016 0.0001 0.001 0.0011 0.0041 0.0076 0.0036 0.0068 0.0041 0.0001 0.0052 0.0058 0.004 0.0016 0 0.0001
Cell Periphery 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0005 0.0002 0.0001 0.0003 0.0011 0.0001 0.0006 0.0001 0.0001 0.0002 0 0.0001
Cytoplasm 0.2753 0.4428 0.3618 0.3548 0.4718 0.4492 0.1547 0.3191 0.2375 0.289 0.257 0.4248 0.2678 0.3411 0.3364 0.3263 0.416 0.373
Cytoplasmic Foci 0.012 0.0075 0.0145 0.0082 0.0129 0.0113 0.0177 0.0101 0.0233 0.0145 0.0414 0.0137 0.0143 0.0075 0.0122 0.0135 0.0085 0.0066
Eisosomes 0.0001 0 0.0002 0.0001 0.0001 0.0001 0.0008 0.0001 0.0001 0.0001 0.0004 0.0001 0.0005 0.0001 0.0001 0.0003 0 0
Endoplasmic Reticulum 0.0022 0.0028 0.0023 0.0015 0.0042 0.0015 0.0092 0.0017 0.0023 0.0016 0.0033 0.0033 0.0037 0.0014 0.0018 0.0031 0.0014 0.0011
Endosome 0.0028 0.0033 0.0048 0.0037 0.0111 0.0042 0.0394 0.0034 0.022 0.0016 0.0407 0.0053 0.0164 0.0013 0.0044 0.01 0.0106 0.0016
Golgi 0.0004 0.0002 0.0008 0.0031 0.0023 0.0014 0.0152 0.0006 0.0123 0.0008 0.0162 0.0006 0.0064 0.0003 0.0011 0.0066 0.0003 0.0001
Lipid Particles 0.001 0.0002 0.0004 0.0095 0.0004 0.0004 0.0205 0.0004 0.0022 0.0003 0.0148 0.0005 0.0096 0.0002 0.0024 0.003 0.0003 0.0001
Mitochondria 0.0002 0.0003 0.0026 0.0097 0.0028 0.0006 0.0131 0.0054 0.0039 0.0014 0.0075 0.0005 0.0045 0.0006 0.0069 0.0057 0.0017 0.0004
None 0.6867 0.5247 0.5933 0.5926 0.4493 0.5071 0.5842 0.6238 0.6502 0.5911 0.5477 0.5347 0.5672 0.6229 0.5864 0.5363 0.5141 0.5964
Nuclear Periphery 0.0014 0.0022 0.0015 0.0011 0.0052 0.0015 0.0315 0.0006 0.004 0.0019 0.0011 0.0012 0.0078 0.0007 0.0036 0.0024 0.0252 0.001
Nucleolus 0.0002 0.0002 0.0003 0.0001 0.0002 0.0017 0.0013 0.0003 0.0003 0.0021 0.0015 0.0001 0.0011 0.0003 0.0011 0.0002 0.0005 0.0003
Nucleus 0.0051 0.0035 0.0045 0.0027 0.0032 0.006 0.0106 0.0029 0.0015 0.008 0.002 0.0037 0.0043 0.0021 0.013 0.0027 0.0123 0.0062
Peroxisomes 0.0005 0.0002 0.001 0.0049 0.0013 0.0003 0.0151 0.0004 0.0039 0.0027 0.0026 0.0008 0.0082 0.0007 0.0022 0.0086 0.0003 0.0004
Punctate Nuclear 0.0054 0.0019 0.0051 0.0022 0.0023 0.0046 0.0039 0.0032 0.0063 0.0164 0.0122 0.0017 0.0115 0.0045 0.0138 0.0026 0.0048 0.0069
Vacuole 0.0008 0.0015 0.0008 0.001 0.0009 0.0006 0.0065 0.0009 0.0008 0.001 0.0111 0.0005 0.0017 0.0005 0.0007 0.002 0.0013 0.0005
Vacuole Periphery 0.0001 0.0003 0.0002 0.0003 0.0009 0.0001 0.0035 0.0002 0.0005 0.0003 0.0028 0.0001 0.0008 0.0001 0.0004 0.0005 0.0013 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.6411 10.0856 1.4968 4.3585 7.314 11.276 9.6877 9.6358 7.904 14.7556
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2529 1574 294 1626 1643 1724 2264 111 4172 3298 2558 1737

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 688.04 768.17 932.83 870.88 704.35 757.99 889.26 945.81 694.46 762.85 894.27 875.67
Standard Deviation 78.58 270.39 95.21 115.88 90.52 96.48 105.14 132.01 83.87 199.46 104.97 118.41
Intensity Change Log 2 — 0.158933 0.439122 0.339982 — 0.105886 0.336313 0.425258 — 0.132343 0.388031 0.383749

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000128 0.000693 0.000377 0.003975 0.000092 0.000582 0.000180 0.000371 0.000114 0.000635 0.000203 0.003745
Bud Neck 0.014271 0.037195 0.001950 0.012548 0.009693 0.039551 0.011906 0.001416 0.012468 0.038427 0.010762 0.011836
Bud Site 0.003467 0.018435 0.001691 0.050598 0.002252 0.020215 0.011680 0.003531 0.002988 0.019365 0.010532 0.047590
Cell Periphery 0.000092 0.000214 0.000162 0.000180 0.000081 0.000155 0.000092 0.000141 0.000088 0.000183 0.000100 0.000178
Cytoplasm 0.547868 0.436530 0.202079 0.467785 0.547062 0.430258 0.392688 0.381153 0.547551 0.433252 0.370781 0.462249
Cytoplasmic Foci 0.144468 0.198677 0.010057 0.017094 0.159166 0.219637 0.005093 0.020908 0.150257 0.209634 0.005663 0.017338
Eisosomes 0.000105 0.000086 0.000070 0.000043 0.000095 0.000128 0.000021 0.000065 0.000101 0.000108 0.000027 0.000045
Endoplasmic Reticulum 0.000878 0.003654 0.005797 0.002419 0.000521 0.000682 0.001796 0.006490 0.000738 0.002100 0.002256 0.002679
Endosome 0.006181 0.023611 0.003992 0.011725 0.004029 0.022804 0.001122 0.003227 0.005334 0.023189 0.001451 0.011181
Golgi 0.001456 0.005254 0.000089 0.005657 0.000907 0.006571 0.000063 0.000081 0.001240 0.005942 0.000066 0.005301
Lipid Particles 0.005501 0.004889 0.002700 0.002330 0.006121 0.005529 0.000597 0.001814 0.005745 0.005224 0.000839 0.002297
Mitochondria 0.002257 0.012873 0.000415 0.005289 0.004065 0.014882 0.001765 0.000291 0.002969 0.013923 0.001610 0.004969
Mitotic Spindle 0.000667 0.013023 0.001406 0.065674 0.001402 0.013263 0.011741 0.002643 0.000956 0.013148 0.010553 0.061646
None 0.006185 0.004308 0.003408 0.004655 0.001901 0.003207 0.005477 0.002869 0.004498 0.003732 0.005239 0.004541
Nuclear Periphery 0.000319 0.000780 0.002162 0.001768 0.000485 0.000476 0.002055 0.001757 0.000384 0.000621 0.002067 0.001767
Nuclear Periphery Foci 0.000309 0.000483 0.002187 0.001117 0.000210 0.000265 0.000422 0.003766 0.000270 0.000369 0.000625 0.001286
Nucleolus 0.001091 0.002104 0.000680 0.000924 0.000749 0.002296 0.000342 0.000281 0.000956 0.002204 0.000381 0.000883
Nucleus 0.219095 0.123515 0.693170 0.215631 0.222093 0.118022 0.511395 0.387946 0.220275 0.120643 0.532287 0.226642
Peroxisomes 0.002392 0.015079 0.000289 0.003805 0.002500 0.016060 0.000313 0.000242 0.002434 0.015592 0.000310 0.003577
Vacuole 0.042714 0.095326 0.067121 0.120372 0.036177 0.082550 0.040973 0.180866 0.040140 0.088648 0.043979 0.124238
Vacuole Periphery 0.000557 0.003275 0.000199 0.006413 0.000400 0.002867 0.000278 0.000142 0.000495 0.003062 0.000269 0.006012

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.30 -5.49 -3.25 -2.07 -2.44 -3.32 -4.50 -5.51 -0.39 -4.18 -4.58 -4.24 -3.36 -2.23 -3.03
Bud Neck -9.97 13.37 3.83 11.86 -7.29 -13.09 0.35 8.39 16.79 6.34 -15.94 3.86 3.20 16.78 -0.60
Bud Site -10.33 1.80 -9.02 -2.34 -9.47 -11.49 -5.33 -2.77 7.43 1.40 -15.28 -4.73 -9.35 -1.65 -6.81
Cell Periphery -2.03 -5.94 -3.01 1.67 4.22 -4.62 -0.73 -5.13 -0.29 -4.99 -3.17 -2.16 -4.19 2.18 -2.61
Cytoplasm 13.17 31.17 20.40 5.47 -15.54 12.70 29.83 10.35 5.21 -0.10 18.53 41.47 23.02 7.02 -9.87
Cytoplasmic Foci -8.42 37.56 37.62 34.97 -2.30 -8.90 35.77 28.74 35.83 -4.62 -12.82 53.63 49.19 52.44 -8.49
Eisosomes 3.51 1.43 12.33 9.37 6.07 -3.96 9.90 -0.37 2.61 -7.08 -1.45 16.63 12.16 14.80 -6.43
Endoplasmic Reticulum -2.39 -11.35 -10.87 0.55 8.45 -1.16 -18.81 -7.08 -6.92 -4.58 -2.43 -19.15 -15.07 -2.28 3.40
Endosome -12.00 2.29 1.32 11.99 -0.48 -14.26 11.18 -0.81 12.29 -4.95 -18.12 13.26 0.32 15.94 -5.81
Golgi -6.19 9.13 -0.49 4.21 -3.00 -6.96 5.51 4.92 8.07 -3.80 -9.07 10.88 -0.76 5.86 -3.09
Lipid Particles 1.18 4.56 7.06 6.19 3.03 0.67 6.86 3.41 3.73 -6.24 1.11 11.55 7.92 7.88 -3.71
Mitochondria -7.14 7.53 -0.79 6.82 -6.42 -5.95 2.87 4.32 9.14 7.85 -9.49 3.92 1.11 10.13 -2.95
Mitotic Spindle -6.62 -0.97 -12.62 -8.80 -10.08 -5.88 -6.50 -1.64 0.04 -0.18 -8.89 -7.18 -12.64 -8.95 -9.52
None 1.96 4.92 2.05 -0.73 -4.96 -2.01 -14.28 -0.92 1.01 5.51 1.28 -1.52 -0.32 -1.68 1.57
Nuclear Periphery -4.77 -19.01 -19.89 -14.83 -4.89 0.08 -28.67 -3.96 -3.96 -0.64 -3.83 -35.40 -19.78 -17.31 -3.43
Nuclear Periphery Foci -2.86 -7.69 -10.50 -8.10 3.81 -1.28 -7.22 -2.97 -2.96 -2.89 -2.76 -9.95 -6.01 -5.70 -4.27
Nucleolus -4.28 3.51 -0.97 2.95 -2.97 -3.53 4.31 0.70 3.57 -1.04 -4.87 8.53 -1.58 3.31 -4.86
Nucleus 16.82 -28.64 -6.34 -18.38 24.53 17.54 -46.66 -4.38 -8.70 9.91 24.75 -58.28 -7.26 -22.09 38.64
Peroxisomes -11.04 9.70 1.59 10.98 -2.50 -10.97 11.45 10.23 12.91 -2.00 -15.51 14.26 2.04 14.81 -2.77
Vacuole -15.04 -7.03 -28.48 -17.42 -10.28 -13.84 -10.78 -10.53 -8.42 -8.96 -20.10 -12.21 -30.75 -21.23 -23.10
Vacuole Periphery -3.94 8.32 -2.32 1.17 -2.83 -6.75 4.89 7.39 7.46 1.18 -6.81 8.27 -2.38 1.48 -2.88
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
Localization
Cell Percentages cytoplasm (30%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Csn9

Csn9


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Csn9-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available