Standard name
Human Ortholog
Description Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, removing ethanolamine phosphate from the first mannose of GPI anchors; mutants display elevated Ca2+-dependent signaling resulting in secondary actin polarization and Golgi inheritance defects; enzyme is Mn2+-dependent; mutants have cell division cycle defect and fragile cell walls
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.89 0.98 0.99 0.95 0.93 0.9 0.86 0.88 0.81 0.8 0.69 0.76 1.0 1.0 0.99 0.87 0.91 0.9 0.68 0.78 0.67 0.88 0.81 0.75
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.09 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.26 0 0 0.08 0.07 0.26 0.3 0.18 0.32 0.37 0.53 0.47 0 0 0 0.05 0 0 0.14 0.07 0.16 0.05 0.06 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.14 0.11 0.1 0.07 0.05 0.05 0 0 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 3 1 1 0 2 8
Bud 0 0 1 2 4 3 0 8 6 6 9 3 1 2 0 0 0 0 1 0 1 2 8 15
Bud Neck 0 0 0 0 0 0 0 2 3 3 1 3 0 0 0 0 0 0 2 0 0 1 3 4
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 0 1 1 0 0 1 2 0 0 2 3 0 0 2 3 0 0 2 0 0 1 2
Cytoplasm 162 112 161 118 162 223 209 316 173 209 129 178 290 473 503 203 179 126 136 105 107 225 301 328
Endoplasmic Reticulum 0 0 0 1 0 0 1 1 1 0 1 0 0 0 2 13 18 3 1 0 3 0 1 3
Endosome 0 0 0 0 4 0 0 0 0 0 0 0 0 1 0 7 3 4 4 1 5 3 3 5
Golgi 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 1 0 0 1 1
Mitochondria 47 5 2 10 12 65 72 64 69 97 100 111 0 0 0 12 1 3 28 9 25 12 20 18
Nucleus 0 0 0 0 2 0 0 3 1 2 0 1 1 0 1 3 0 1 0 1 0 0 0 1
Nuclear Periphery 0 1 0 0 0 0 0 1 0 0 0 1 0 0 1 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 0 2 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 1 0 0 0 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 0 0 1 2 4 1 9 3 0 0 0 0 0 0 0 0 1 2 1 6 3
Vac/Vac Membrane 0 0 1 1 2 4 2 3 4 2 0 2 0 2 0 32 22 14 14 7 7 6 11 36
Unique Cell Count 183 114 163 124 174 247 243 361 213 261 188 235 290 475 506 233 196 140 201 135 162 257 371 438
Labelled Cell Count 210 118 166 133 187 297 286 405 260 332 243 302 295 479 508 273 226 151 201 135 162 257 371 438


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.3 4.0 3.8 3.5 4.0 3.1 2.8 3.3 3.0 2.9 2.8 2.6 4.1 3.9 4.0 5.1 6.5 5.8 3.8 4.2 4.9
Std Deviation (1e-4) 0.8 1.0 1.6 1.6 1.9 1.2 0.9 1.3 1.7 1.7 1.0 1.0 1.0 1.0 1.1 2.0 3.4 1.8 0.9 1.5 1.3
Intensity Change (Log2) – – – -0.09 0.1 -0.26 -0.44 -0.2 -0.31 -0.39 -0.42 -0.54 0.13 0.06 0.11 0.45 0.8 0.62 0.02 0.16 0.37


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 4.6 4.1 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8933 0.3667 0.2023 0.6264 0.1981 0.5349 1.6718 1.4027 1.569 1.2434 1.2951 1.5461 2.1413 2.4126 2.4902 2.7481 2.0697 2.0894
Actin 0.064 0.0004 0.0058 0.0216 0.0089 0.0235 0.0568 0.0169 0.0078 0.0036 0.0113 0.0023 0.045 0.0033 0.0218 0.0003 0.0019 0.0043
Bud 0.0019 0.006 0.0004 0.0005 0.0011 0.0044 0.0015 0.006 0.0037 0.0004 0.001 0.0003 0.0008 0.0013 0.0017 0.0005 0.0001 0.0002
Bud Neck 0.0068 0.0002 0.0046 0.0058 0.0007 0.002 0.0035 0.0005 0.001 0.0002 0.0023 0.0008 0.0123 0.0018 0.0005 0.0001 0.0005 0.0003
Bud Periphery 0.0066 0.0012 0.0007 0.0012 0.0009 0.0087 0.0037 0.0111 0.0036 0.0011 0.0014 0.0015 0.0021 0.0029 0.0037 0.0015 0.0001 0.0004
Bud Site 0.0116 0.0036 0.0019 0.0042 0.0208 0.0013 0.013 0.0149 0.0123 0.0003 0.0056 0.0001 0.0065 0.0077 0.0049 0.0001 0.0002 0.0002
Cell Periphery 0.0013 0.0006 0.0003 0.0005 0.0002 0.0002 0.001 0.001 0.001 0.0001 0.0002 0.0001 0.0004 0.0011 0.0003 0.0002 0.0001 0.0001
Cytoplasm 0.1171 0.2832 0.2191 0.2912 0.182 0.2894 0.0632 0.1687 0.0668 0.0914 0.0613 0.113 0.1005 0.1506 0.1098 0.1137 0.1794 0.1934
Cytoplasmic Foci 0.0621 0.0476 0.0705 0.0307 0.096 0.0377 0.0406 0.016 0.0382 0.0634 0.0666 0.04 0.0381 0.0253 0.0294 0.0299 0.0576 0.0261
Eisosomes 0.0011 0.0001 0.0004 0.0004 0.0001 0.0002 0.0011 0.0006 0.0006 0.0001 0.0002 0.0002 0.0005 0.0003 0.0005 0.0003 0.0003 0.0001
Endoplasmic Reticulum 0.0143 0.0073 0.0046 0.008 0.005 0.0033 0.0045 0.0021 0.002 0.0025 0.0026 0.0008 0.0042 0.0051 0.0033 0.0048 0.0021 0.0031
Endosome 0.0346 0.0323 0.0419 0.0389 0.1158 0.0199 0.0328 0.0105 0.0344 0.0338 0.0332 0.0052 0.0336 0.0167 0.0214 0.0826 0.018 0.0078
Golgi 0.0123 0.0017 0.0065 0.0083 0.0121 0.0031 0.0084 0.0018 0.0116 0.0118 0.0097 0.001 0.0051 0.0016 0.0033 0.0043 0.002 0.0009
Lipid Particles 0.0286 0.0083 0.0155 0.03 0.0392 0.0055 0.0204 0.0075 0.0066 0.0099 0.0232 0.003 0.0165 0.0029 0.0065 0.0008 0.0011 0.0024
Mitochondria 0.0073 0.0013 0.0024 0.0015 0.003 0.0028 0.0078 0.0033 0.0135 0.0022 0.0402 0.0027 0.0057 0.0018 0.0039 0.0059 0.001 0.0011
None 0.5638 0.59 0.6016 0.5395 0.4877 0.5741 0.692 0.7213 0.7821 0.7728 0.696 0.8117 0.6658 0.7671 0.7687 0.7441 0.6959 0.7532
Nuclear Periphery 0.0168 0.003 0.0018 0.0042 0.0029 0.0022 0.0062 0.0006 0.0007 0.0011 0.0007 0.0046 0.0085 0.002 0.0035 0.0018 0.0037 0.0005
Nucleolus 0.0015 0.0004 0.001 0.0005 0.001 0.0005 0.0024 0.0004 0.0008 0.0003 0.0006 0.0002 0.001 0.0005 0.0004 0.0002 0.002 0.0006
Nucleus 0.0041 0.0011 0.0016 0.0014 0.001 0.0012 0.0061 0.0009 0.0009 0.0005 0.0004 0.0014 0.0112 0.0024 0.003 0.0007 0.0053 0.001
Peroxisomes 0.022 0.0014 0.0075 0.0037 0.009 0.0043 0.0231 0.0096 0.007 0.0011 0.0382 0.0084 0.0261 0.0007 0.0069 0.0007 0.0164 0.0021
Punctate Nuclear 0.0158 0.0027 0.0045 0.0042 0.0045 0.0138 0.0063 0.0006 0.002 0.0012 0.0031 0.0014 0.0094 0.0013 0.0038 0.0003 0.0099 0.001
Vacuole 0.0044 0.0067 0.0064 0.003 0.0069 0.0014 0.004 0.0048 0.0029 0.0016 0.0018 0.001 0.0056 0.0033 0.0023 0.0051 0.0018 0.0011
Vacuole Periphery 0.0021 0.0009 0.0012 0.0008 0.0013 0.0005 0.0016 0.0007 0.0006 0.0006 0.0006 0.0004 0.001 0.0005 0.0006 0.0023 0.0004 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.791 19.38 15.3726 31.4654 22.7774 26.1503 30.7441 31.9233 24.8766 37.7173
Translational Efficiency 1.6086 1.7274 1.9237 0.9368 1.3776 1.3854 1.217 0.8725 1.288 0.7869

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2420 132 2055 1451 1552 1151 278 188 3972 1283 2333 1639

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 648.40 648.87 808.92 816.34 649.81 664.44 831.72 716.60 648.95 662.84 811.64 804.90
Standard Deviation 252.39 91.45 83.62 101.13 75.66 94.75 89.02 75.43 202.60 94.54 84.61 103.53
Intensity Change Log 2 — 0.001045 0.319113 0.332286 — 0.032121 0.356080 0.141150 — 0.016684 0.337735 0.239777

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000143 0.002300 0.000136 0.000571 0.000241 0.000713 0.000131 0.000083 0.000181 0.000876 0.000136 0.000515
Bud Neck 0.027016 0.148166 0.005087 0.009462 0.045693 0.026166 0.001746 0.002399 0.034313 0.038718 0.004689 0.008652
Bud Site 0.006547 0.059377 0.010223 0.041504 0.007999 0.011391 0.007709 0.002832 0.007114 0.016328 0.009924 0.037068
Cell Periphery 0.000191 0.000850 0.000064 0.000107 0.000208 0.000204 0.000127 0.000291 0.000198 0.000270 0.000072 0.000128
Cytoplasm 0.473733* 0.243233* 0.542403* 0.523576* 0.336810* 0.409694* 0.515968* 0.505047* 0.420232* 0.392568* 0.539253* 0.521451*
Cytoplasmic Foci 0.208323* 0.209359* 0.010166 0.026602 0.319330* 0.217097* 0.064613 0.150258 0.251697* 0.216301* 0.016654 0.040786
Eisosomes 0.000270 0.001008 0.000014 0.000041 0.000374 0.000248 0.000068 0.000099 0.000311 0.000326 0.000021 0.000048
Endoplasmic Reticulum 0.001464 0.000539 0.000572 0.001684 0.000888 0.000714 0.001312 0.000727 0.001239 0.000696 0.000660 0.001574
Endosome 0.018210 0.054551 0.001062 0.002882 0.017611 0.017362 0.003727 0.007670 0.017976 0.021188 0.001380 0.003431
Golgi 0.003189 0.007930 0.000071 0.001152 0.006431 0.006046 0.000064 0.000642 0.004455 0.006240 0.000070 0.001094
Lipid Particles 0.012331 0.008587 0.000457 0.001054 0.007781 0.010884 0.001136 0.004212 0.010553 0.010648 0.000538 0.001416
Mitochondria 0.006550 0.014459 0.001336 0.001640 0.013517 0.009183 0.000143 0.001791 0.009272 0.009726 0.001194 0.001657
Mitotic Spindle 0.000705 0.000819 0.003871 0.033532 0.000253 0.003615 0.001029 0.000852 0.000528 0.003327 0.003532 0.029783
None 0.004549 0.001274 0.004188 0.002859 0.002413 0.004687 0.002456 0.003083 0.003715 0.004336 0.003982 0.002884
Nuclear Periphery 0.000401 0.000241 0.001044 0.001274 0.000287 0.000513 0.000749 0.000844 0.000356 0.000485 0.001008 0.001225
Nuclear Periphery Foci 0.000255 0.000251 0.000183 0.000950 0.000154 0.000372 0.001368 0.000764 0.000215 0.000360 0.000324 0.000929
Nucleolus 0.001343 0.000663 0.000372 0.000278 0.000814 0.001281 0.000236 0.001142 0.001136 0.001218 0.000356 0.000377
Nucleus 0.144665* 0.074291 0.391380* 0.202325* 0.136122* 0.192712* 0.230006* 0.265972* 0.141327* 0.180528* 0.372150* 0.209625*
Peroxisomes 0.005137 0.040186 0.000497 0.002185 0.011447 0.018021 0.000226 0.000853 0.007603 0.020301 0.000464 0.002032
Vacuole 0.083343 0.128607 0.026649 0.144233 0.089841 0.067418 0.167068 0.049145 0.085882 0.073713 0.043381 0.133326
Vacuole Periphery 0.001636 0.003310 0.000224 0.002090 0.001787 0.001680 0.000116 0.001294 0.001695 0.001848 0.000211 0.001999

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.25 0.12 -4.40 1.96 -3.95 -1.34 1.74 2.68 1.75 1.30 -2.12 0.98 -3.57 1.47 -3.87
Bud Neck -6.15 13.44 11.45 7.18 -2.41 6.21 18.95 18.49 10.52 -1.41 -1.19 20.99 18.53 10.26 -2.50
Bud Site -5.20 -1.87 -5.83 3.70 -4.21 -1.87 0.71 4.09 4.31 1.28 -4.81 -1.41 -5.41 -0.92 -4.03
Cell Periphery -2.87 14.03 11.42 3.31 -4.58 0.20 5.58 -1.93 -2.01 -3.61 -2.69 15.28 7.80 5.66 -5.58
Cytoplasm 10.74 -5.62 7.11 -7.53 11.28 -6.87 -4.36 -7.77 -3.99 -3.07 3.45 -12.21 0.08 -2.85 9.62
Cytoplasmic Foci -0.08 50.93 47.13 10.61 -7.55 12.08 37.69 14.12 5.58 -8.47 5.23 68.32 56.38 29.95 -9.57
Eisosomes -2.12 19.86 16.93 2.76 -19.83 4.73 18.13 15.45 5.96 -2.53 -0.30 28.88 25.16 6.49 -17.02
Endoplasmic Reticulum 4.02 3.79 -4.52 -12.13 -14.39 1.22 -4.82 0.36 -0.81 5.12 3.59 3.16 -6.45 -12.44 -13.12
Endosome -4.89 19.24 17.76 7.14 -6.68 0.22 13.15 5.81 5.04 -2.46 -1.94 24.70 21.69 12.71 -6.22
Golgi -2.41 13.94 8.04 3.85 -1.38 0.24 10.77 8.23 4.68 -1.39 -1.74 16.32 11.19 5.60 -1.62
Lipid Particles 1.92 17.17 15.85 4.23 -14.66 -2.80 14.18 5.17 5.68 -6.40 -0.13 21.85 19.14 9.41 -14.08
Mitochondria -1.57 6.43 7.54 2.72 0.62 2.01 8.38 5.72 3.72 -1.17 -0.21 9.69 10.39 5.91 0.12
Mitotic Spindle -0.25 -3.99 -6.66 -6.60 -5.03 -3.49 -1.31 -1.59 2.21 -0.50 -3.24 -4.28 -6.76 -5.00 -5.05
None 3.41 0.70 2.15 -2.67 3.50 -2.00 0.61 -0.79 1.45 -1.67 -0.69 -0.08 1.46 1.61 2.92
Nuclear Periphery 2.32 -15.92 -18.58 -18.39 -11.06 -4.72 -9.52 -7.42 -4.45 0.23 -3.10 -19.77 -19.77 -17.58 -10.89
Nuclear Periphery Foci -0.20 1.07 -13.59 -8.96 -13.89 -2.56 -11.54 -6.24 -3.00 5.89 -1.93 -6.44 -15.06 -8.26 -11.38
Nucleolus 3.27 5.45 5.66 2.84 0.67 -3.12 7.88 -2.26 0.92 -6.91 -0.75 6.80 6.10 5.83 -1.79
Nucleus 5.24 -39.56 -13.75 -11.23 21.12 -7.20 -6.88 -7.82 -4.30 -1.91 -5.83 -40.35 -16.27 -6.67 19.09
Peroxisomes -4.04 10.26 8.11 4.54 -1.50 -2.86 14.02 12.99 8.02 -5.60 -5.86 16.39 13.67 9.07 -1.76
Vacuole -2.91 15.69 -24.65 -8.50 -31.52 4.37 -11.40 3.69 1.10 12.25 2.54 5.99 -23.16 -22.70 -24.94
Vacuole Periphery -1.61 7.18 1.52 2.22 -1.01 0.32 9.89 0.64 0.48 -1.23 -0.37 10.73 1.73 1.72 -1.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, removing ethanolamine phosphate from the first mannose of GPI anchors; mutants display elevated Ca2+-dependent signaling resulting in secondary actin polarization and Golgi inheritance defects; enzyme is Mn2+-dependent; mutants have cell division cycle defect and fragile cell walls
Localization
Cell Percentages cytoplasm (33%), vacuole (3%), mixed (42%)
Cell Cycle Regulation Yes
vacuole - MA (0.00025)
Subcompartmental Group N/A

Cdc1

Cdc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cdc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available