Standard name
Human Ortholog
Description NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.06 0 0.06 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.69 0.67 0.9 0.92 0.97 0.83 0.83 0.77 0.62 0.66 0.58 0.62 0.9 0.89 0.93 0.92 0.87 0.84 0.45 0.51 0.55 0.52 0.56 0.69
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.25 0.06 0 0.06 0 0.22 0.26 0.24 0.47 0.38 0.55 0.45 0 0 0 0 0 0 0.07 0.05 0.14 0.05 0.08 0.05
Nucleus 0.14 0.22 0 0 0 0 0 0.06 0.1 0.09 0.05 0.11 0.09 0.07 0.05 0 0 0.06 0.18 0.19 0.05 0.1 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.05
Vac/Vac Membrane 0.07 0.11 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.09 0.13 0.15 0.09 0.19 0.14 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 7 0 2 2 6 3
Bud 0 0 1 1 0 1 5 5 11 8 4 11 0 0 0 0 0 0 8 4 1 1 6 7
Bud Neck 1 0 11 1 19 9 1 15 3 15 5 13 1 0 0 5 3 0 4 0 1 1 2 5
Bud Site 0 0 0 0 0 0 0 3 8 3 1 5 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 2 1 0 0 1 3 0 1 0 0 4 1 3 3 10 7 1 0 1 0 1 0
Cytoplasm 275 133 175 184 294 263 343 270 222 213 148 199 141 191 226 270 335 290 175 110 112 98 143 212
Endoplasmic Reticulum 1 2 3 0 1 0 0 0 0 0 0 0 1 0 0 13 31 28 1 1 1 0 5 2
Endosome 0 1 0 0 0 0 1 0 0 0 0 0 0 2 3 1 4 6 9 3 1 1 1 2
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 2 2 1 0 3 0 0
Mitochondria 101 11 6 11 7 69 106 83 169 122 142 144 2 5 0 3 6 15 26 11 28 9 20 16
Nucleus 55 43 8 8 3 3 15 21 36 28 13 34 14 15 12 13 12 19 70 41 10 18 8 3
Nuclear Periphery 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 1 1 0 0 0 1 1
Peroxisomes 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
SpindlePole 0 0 2 1 1 1 5 8 7 5 4 10 0 0 0 0 3 1 18 6 8 8 9 15
Vac/Vac Membrane 26 21 3 3 1 6 4 7 5 8 4 4 2 3 8 14 27 30 49 31 19 35 36 28
Unique Cell Count 399 198 195 199 303 318 412 351 358 324 257 320 157 215 244 295 384 345 392 218 203 190 255 309
Labelled Cell Count 461 212 212 210 326 352 481 415 463 405 321 420 165 218 253 325 435 400 392 218 203 190 255 309


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.2 4.2 4.2 4.1 4.4 3.4 3.2 3.8 3.1 3.2 2.9 3.3 4.6 4.9 4.9 5.7 5.4 5.2 4.7 5.2 5.2
Std Deviation (1e-4) 0.8 1.0 0.9 1.2 1.9 1.2 1.3 1.6 1.2 0.9 1.3 1.2 1.5 1.7 2.1 1.7 1.8 1.9 2.5 3.0 2.0
Intensity Change (Log2) – – – -0.03 0.08 -0.29 -0.37 -0.15 -0.45 -0.4 -0.5 -0.35 0.16 0.25 0.24 0.45 0.36 0.33 0.17 0.33 0.32


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 1.9 2.8 3.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.1711 -0.208 -0.3577 -0.2803 -0.4882 -0.0433 -0.4676 -1.2423 -1.3195 -1.1833 -1.19 -0.9309 -1.3932 -1.7724 -2.0924 -1.5183 -1.7844 -1.5205
Actin 0.0334 0.0006 0.0063 0.0286 0.0069 0.0051 0.0197 0.0002 0.0032 0.0009 0.004 0.0014 0.0224 0.0007 0.002 0.0269 0.0196 0.0047
Bud 0.0007 0.002 0.0028 0.0026 0.0013 0.0023 0.0032 0.0014 0.0019 0.0009 0.0059 0.0009 0.0006 0.0028 0.0029 0.0017 0.0033 0.0012
Bud Neck 0.0031 0.0005 0.0029 0.0009 0.0012 0.0033 0.0056 0.0007 0.0008 0.0006 0.0015 0.006 0.0108 0.0008 0.0009 0.0046 0.0011 0.0044
Bud Periphery 0.002 0.0019 0.0045 0.0084 0.0014 0.0023 0.0039 0.0015 0.0019 0.002 0.0059 0.0011 0.0008 0.0026 0.0052 0.0025 0.0045 0.0016
Bud Site 0.0015 0.0029 0.0038 0.0018 0.0014 0.0003 0.002 0.0033 0.004 0.0002 0.0018 0.0004 0.0057 0.0073 0.0036 0.002 0.0005 0.0005
Cell Periphery 0.0006 0.0002 0.0004 0.0002 0.0001 0.0001 0.0002 0.0002 0.0002 0 0.0002 0.0001 0.0003 0.0004 0.0002 0.0002 0.0002 0.0001
Cytoplasm 0.0577 0.1291 0.0654 0.0687 0.0631 0.0975 0.0443 0.0461 0.0441 0.026 0.0567 0.0571 0.0941 0.1249 0.0948 0.0446 0.0795 0.1582
Cytoplasmic Foci 0.0191 0.0034 0.0132 0.0067 0.0055 0.0036 0.0108 0.0035 0.0112 0.0055 0.0057 0.0045 0.0185 0.0072 0.0084 0.0049 0.0245 0.0056
Eisosomes 0.0018 0.0004 0.0008 0.0004 0.0002 0.0001 0.0004 0.0001 0.0003 0.0001 0.0001 0.0001 0.0003 0.0002 0.0002 0.0004 0.0003 0.0001
Endoplasmic Reticulum 0.0033 0.0013 0.0032 0.001 0.0033 0.0012 0.002 0.0007 0.0015 0.0003 0.0013 0.0007 0.0059 0.0038 0.0023 0.0021 0.0018 0.0018
Endosome 0.0097 0.0011 0.0108 0.0017 0.0197 0.0031 0.0167 0.0007 0.0034 0.0046 0.0042 0.0016 0.009 0.0051 0.0041 0.0081 0.0092 0.0033
Golgi 0.0038 0.0002 0.0045 0.0004 0.0043 0.0015 0.0027 0.0001 0.0012 0.0075 0.0017 0.0005 0.0032 0.0001 0.0005 0.0034 0.0025 0.0008
Lipid Particles 0.0099 0.0002 0.0113 0.0004 0.008 0.0008 0.0093 0.0003 0.0047 0.0023 0.0108 0.0033 0.0037 0.0006 0.0023 0.0039 0.0115 0.0004
Mitochondria 0.0052 0.0011 0.006 0.0022 0.0045 0.0015 0.0063 0.0008 0.0026 0.0178 0.0024 0.0025 0.0021 0.0012 0.0025 0.0031 0.0012 0.0011
None 0.421 0.7199 0.7507 0.7637 0.7499 0.4684 0.4023 0.6925 0.7898 0.7983 0.6827 0.4447 0.4165 0.6431 0.7398 0.7255 0.728 0.4583
Nuclear Periphery 0.0109 0.0021 0.0072 0.0026 0.0112 0.0077 0.0157 0.003 0.0055 0.0009 0.0091 0.0068 0.0177 0.007 0.0052 0.0117 0.0018 0.011
Nucleolus 0.0052 0.0026 0.0057 0.0037 0.0028 0.0057 0.0077 0.009 0.0069 0.0039 0.0076 0.0109 0.0047 0.0045 0.0046 0.0051 0.0031 0.0061
Nucleus 0.3792 0.1209 0.0797 0.0928 0.1027 0.3545 0.4015 0.2036 0.0849 0.1211 0.1694 0.4132 0.3516 0.1688 0.1075 0.1318 0.0805 0.3025
Peroxisomes 0.0109 0.0003 0.0055 0.0007 0.0015 0.0006 0.0124 0.0002 0.0083 0.0034 0.004 0.0025 0.0053 0.0002 0.0022 0.0019 0.0203 0.0003
Punctate Nuclear 0.0182 0.0077 0.0106 0.01 0.0084 0.0391 0.0293 0.0299 0.0217 0.0025 0.0227 0.0406 0.0227 0.012 0.0061 0.0131 0.0039 0.0338
Vacuole 0.0019 0.0016 0.0034 0.0021 0.0015 0.0009 0.0025 0.0019 0.0015 0.0006 0.0016 0.0009 0.0033 0.0059 0.0039 0.0017 0.0024 0.0036
Vacuole Periphery 0.0008 0.0002 0.0012 0.0004 0.0011 0.0004 0.0016 0.0002 0.0005 0.0004 0.0007 0.0003 0.0008 0.0008 0.0009 0.0007 0.0005 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.4526 4.4312 10.522 14.8741 2.5707 1.9817 2.6882 4.5359 14.364 9.1182
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
47 606 900 1682 1684 1166 189 1515 1731 1772 1089 3197

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 886.61 711.06 742.51 739.65 652.55 702.24 888.16 855.38 658.91 705.26 767.79 794.49
Standard Deviation 345.30 105.47 119.57 138.37 76.20 94.94 96.85 121.66 101.65 98.75 128.40 142.92
Intensity Change Log 2 — -0.318328 -0.255889 -0.261457 — 0.105876 0.444731 0.390477 — -0.123075 0.083322 0.051440

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001083 0.001995 0.000166 0.000507 0.000067 0.000432 0.000241 0.000456 0.000095 0.000966 0.000179 0.000483
Bud Neck 0.014222 0.030051 0.003181 0.012432 0.007782 0.030154 0.001671 0.019520 0.007956 0.030119 0.002919 0.015791
Bud Site 0.051664 0.008718 0.002347 0.018788 0.001553 0.011270 0.000659 0.023693 0.002914 0.010397 0.002054 0.021112
Cell Periphery 0.000441 0.000155 0.000111 0.000320 0.000196 0.000205 0.000104 0.000181 0.000202 0.000188 0.000110 0.000254
Cytoplasm 0.340276* 0.278010* 0.097487 0.266533* 0.337193* 0.315845* 0.042726 0.239349* 0.337276* 0.302906* 0.087983 0.253651*
Cytoplasmic Foci 0.085270 0.169382 0.004120 0.007223 0.104616 0.195922* 0.009965 0.008009 0.104090 0.186846* 0.005134 0.007596
Eisosomes 0.000142 0.000121 0.000024 0.000033 0.000086 0.000143 0.000059 0.000032 0.000088 0.000135 0.000030 0.000032
Endoplasmic Reticulum 0.011035 0.001893 0.002935 0.005511 0.000806 0.001702 0.003553 0.003828 0.001084 0.001768 0.003042 0.004713
Endosome 0.020779 0.016691 0.000726 0.001839 0.003727 0.022139 0.000828 0.005539 0.004190 0.020275 0.000744 0.003593
Golgi 0.002637 0.002671 0.000035 0.000665 0.000466 0.005208 0.000036 0.004426 0.000525 0.004340 0.000035 0.002447
Lipid Particles 0.010252 0.007204 0.000713 0.000846 0.006668 0.011439 0.001419 0.000855 0.006765 0.009991 0.000836 0.000850
Mitochondria 0.003135 0.015432 0.000489 0.002708 0.003500 0.016512 0.000317 0.003120 0.003490 0.016143 0.000459 0.002903
Mitotic Spindle 0.013711 0.005765 0.001440 0.006824 0.001805 0.009104 0.000149 0.060942 0.002128 0.007962 0.001216 0.032470
None 0.015934 0.008476 0.007340 0.012168 0.006014 0.007262 0.005421 0.006473 0.006284 0.007677 0.007007 0.009469
Nuclear Periphery 0.001926 0.001537 0.001040 0.001971 0.000921 0.001189 0.000930 0.003032 0.000948 0.001308 0.001021 0.002473
Nuclear Periphery Foci 0.014597 0.000728 0.000224 0.001060 0.000348 0.000644 0.000338 0.001026 0.000735 0.000673 0.000244 0.001044
Nucleolus 0.008598 0.004215 0.001271 0.001034 0.002002 0.004211 0.001159 0.001041 0.002181 0.004212 0.001252 0.001037
Nucleus 0.279758* 0.372356* 0.865306* 0.619292* 0.501488* 0.288192* 0.912947* 0.565772* 0.495468* 0.316975* 0.873574* 0.593930*
Peroxisomes 0.008270 0.021206 0.000121 0.000360 0.004083 0.018897 0.000220 0.000723 0.004197 0.019687 0.000139 0.000532
Vacuole 0.107935 0.051474 0.010801 0.039192 0.016102 0.056758 0.017168 0.049214 0.018595 0.054950 0.011906 0.043941
Vacuole Periphery 0.008335 0.001920 0.000121 0.000693 0.000579 0.002773 0.000089 0.002771 0.000790 0.002481 0.000116 0.001678

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.49 2.71 1.80 1.06 -7.20 -4.84 -5.86 -12.58 -1.60 -2.25 -1.94 -5.13 -15.36 0.85 -8.27
Bud Neck -2.35 2.07 0.21 4.27 -7.51 -8.39 4.96 -6.05 4.51 -10.31 -9.85 4.72 -5.89 6.53 -12.05
Bud Site 1.83 2.12 1.56 -2.61 -6.15 -6.24 -0.14 -8.32 -2.41 -7.97 -5.75 0.53 -8.84 -3.21 -9.15
Cell Periphery 4.45 5.07 2.68 -2.91 -4.08 -0.35 2.73 3.44 2.91 -0.44 0.81 5.11 0.23 -0.48 -4.08
Cytoplasm 1.08 5.36 2.14 3.59 -15.96 2.30 28.72 15.37 11.37 -15.27 4.01 30.64 15.49 10.90 -19.34
Cytoplasmic Foci -5.01 5.27 5.10 19.41 -2.44 -12.53 20.76 24.92 31.43 1.72 -13.16 25.07 25.18 36.72 -1.05
Eisosomes 0.78 4.06 3.65 9.23 -4.06 -6.34 0.87 8.01 11.54 3.01 -6.63 10.03 9.60 14.81 -2.57
Endoplasmic Reticulum 1.98 1.58 0.80 -12.12 -8.33 -2.21 -6.96 -17.82 -9.02 -0.22 -2.14 -9.54 -20.33 -13.91 -7.69
Endosome 1.13 3.66 3.53 6.80 -3.04 -10.07 3.81 0.97 10.64 -3.19 -10.77 5.33 2.96 12.89 -4.68
Golgi 0.44 3.37 2.84 3.64 -1.48 -6.28 5.25 -1.96 3.85 -2.74 -7.07 6.13 -1.38 5.51 -3.13
Lipid Particles 1.09 3.45 3.42 8.42 -0.78 -3.97 6.92 9.56 10.22 2.73 -3.41 9.60 9.92 12.51 0.53
Mitochondria -3.93 2.39 0.69 4.40 -3.61 -6.20 4.52 1.76 7.18 -7.86 -7.08 4.48 1.77 8.34 -6.39
Mitotic Spindle 0.78 1.21 0.33 -1.68 -5.11 -3.69 1.23 -9.79 -7.23 -10.18 -3.58 0.58 -10.43 -6.64 -10.82
None 0.70 0.90 0.64 -0.37 -1.95 -0.77 0.75 -0.54 0.48 -1.02 -1.09 -0.00 -1.69 -0.20 -1.71
Nuclear Periphery 0.38 0.67 -1.49 -4.31 -12.49 -1.07 -3.34 -13.45 -9.45 -11.16 -1.73 -4.79 -18.63 -10.27 -16.20
Nuclear Periphery Foci 3.02 3.08 2.77 -3.13 -4.48 -1.79 -1.69 -5.24 -3.63 -2.79 0.59 1.43 -3.40 -4.66 -5.63
Nucleolus 1.41 2.15 2.09 5.44 -1.13 -4.06 4.25 0.50 4.12 -2.69 -4.57 3.98 2.01 6.42 -2.28
Nucleus -2.35 -14.87 -8.76 -15.87 22.48 18.55 -22.62 -7.70 -25.11 16.86 16.82 -36.53 -11.62 -31.07 29.47
Peroxisomes -1.88 1.92 1.89 7.30 -2.37 -8.47 7.55 7.31 11.08 -1.35 -9.89 7.94 7.62 13.14 -3.04
Vacuole 2.59 3.98 1.88 -3.52 -13.64 -13.53 -3.24 -18.18 -7.85 -5.81 -13.95 -1.25 -21.62 -7.92 -17.53
Vacuole Periphery 1.84 2.35 2.25 5.13 -2.22 -6.28 3.24 -1.19 3.29 -2.44 -5.95 3.91 0.13 5.63 -3.10
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3
Localization
Cell Percentages nucleus (37%), cytoplasm (6%), mixed (46%)
Cell Cycle Regulation Yes
nucleus - T/G1 (0.00043)
Subcompartmental Group N/A

Hst4

Hst4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hst4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available