Standard name
Human Ortholog
Description Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.1 0.06 0.05 0.05 0 0 – 0 0 0 0 0 0 0 0 0.05 0.06 0.05 0.06 0 0.07 0.05 0.08 0
Bud 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0.1 0.08 0.05 – 0.05 0 0 0 0 0.06 0.06 0.06 0.07 0.07 0.11 0 0 0 0 0 0
Cytoplasm 0.3 0.44 0.3 0.3 0.48 0.36 – 0.27 0.23 0.21 0.19 0.17 0.44 0.66 0.66 0.81 0.8 0.62 0.05 0.16 0 0.1 0.08 0.09
Endoplasmic Reticulum 0.62 0.51 0.54 0.39 0.06 0.15 – 0.1 0.08 0.11 0.11 0.13 0.54 0.34 0.31 0 0.07 0 0.7 0.57 0.7 0.56 0.63 0.68
Endosome 0 0 0.06 0.07 0.17 0.07 – 0.12 0.06 0.05 0 0 0 0 0 0 0 0.05 0 0 0 0.05 0 0
Golgi 0 0 0.05 0.05 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.07 0.05 0 0
Mitochondria 0 0.06 0.09 0.26 0.16 0.46 – 0.53 0.67 0.69 0.77 0.77 0 0 0 0.11 0.06 0.09 0 0.06 0.05 0.14 0.08 0.05
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0 0 0 0.16 0.06 – 0.05 0.08 0.06 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 23 19 13 9 2 5 – 10 8 8 3 9 4 1 5 11 7 7 17 15 21 7 26 15
Bud 1 3 3 4 6 5 – 14 18 18 19 16 1 0 0 1 2 0 1 3 0 1 3 2
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 4 0 2 7 0 0 4 3
Bud Site 0 2 0 0 0 0 – 2 2 3 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 9 11 18 22 16 – 22 16 14 10 15 6 8 11 17 9 15 1 6 3 1 8 8
Cytoplasm 71 139 71 55 134 122 – 116 99 104 78 73 41 85 122 183 102 83 13 61 7 14 27 32
Endoplasmic Reticulum 145 161 130 71 18 49 – 44 35 55 45 54 51 43 57 9 9 6 193 216 214 81 219 240
Endosome 5 2 14 12 48 25 – 50 26 22 12 10 1 0 1 6 3 7 9 13 10 6 8 4
Golgi 7 5 11 9 1 1 – 0 2 0 1 2 0 0 1 0 0 2 18 16 21 7 9 8
Mitochondria 4 20 21 48 45 154 – 226 292 336 310 329 1 0 0 25 7 12 11 21 16 19 28 18
Nucleus 0 0 1 1 1 1 – 2 0 1 1 0 0 1 1 2 4 1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 3 1 0 – 4 2 1 2 4 0 0 0 0 1 0 0 1 1 0 0 0
Nucleolus 0 0 1 0 0 0 – 1 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 1 3 6 2 – 3 2 4 3 5 0 0 0 0 0 0 1 0 2 0 0 1
SpindlePole 1 0 1 1 2 2 – 7 6 11 3 2 0 0 0 5 1 4 0 1 0 0 0 0
Vac/Vac Membrane 13 4 9 5 45 21 – 22 36 29 16 13 1 2 1 2 3 9 2 11 2 3 7 12
Unique Cell Count 233 317 240 182 281 336 424 438 488 402 428 94 128 184 227 127 134 275 381 306 146 351 352
Labelled Cell Count 271 364 287 239 331 403 523 546 606 505 534 106 140 199 261 152 146 275 381 306 146 351 352


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.8 7.0 7.2 6.9 6.9 5.6 – 5.6 5.1 5.0 4.9 4.8 7.3 7.5 7.6 5.6 6.4 8.0 8.2 8.3 8.7
Std Deviation (1e-4) 0.8 1.0 1.7 1.5 1.8 1.1 – 1.0 1.1 1.1 1.0 1.0 1.0 0.9 1.0 0.8 1.2 1.3 1.4 1.4 1.8
Intensity Change (Log2) – – – -0.05 -0.06 -0.37 – -0.37 -0.5 -0.53 -0.54 -0.58 0.02 0.07 0.09 -0.35 -0.17 0.15 0.19 0.21 0.28


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.2 -3.2 -2.7 – -2.1 -2.6 -2.9 -3.7 0 0 0 -1.4 -0.3 0 -0.1
Bud 0 0 0 – 1.6 2.1 1.8 2.3 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 2.1 1.5 0.1 – 0.3 -0.6 -1.2 -1.4 0 0 0.7 0.6 1.3 1.0 2.4
Cytoplasm 0.1 4.2 1.7 – -0.6 -2.0 -2.5 -3.0 -3.8 2.4 6.8 7.5 11.1 9.3 6.1
Endoplasmic Reticulum -3.1 -12.0 -10.1 – -12.3 -13.4 -12.5 -11.8 0 0 -3.8 -4.8 -11.9 -8.8 -9.6
Endosome 0.3 4.0 0.8 – 2.5 0.1 -0.8 -1.8 0 0 0 -2.9 -1.7 -1.5 -0.2
Golgi 0.2 -3.2 -3.6 – 0 0 0 0 0 0 0 -2.5 -3.3 0 0
Mitochondria 4.8 2.5 9.5 – 11.4 14.5 15.2 16.8 0 -2.5 -3.4 -4.1 0.8 -1.1 0.1
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.6 4.6 1.3 – 0.8 2.2 1.3 0.1 -0.5 0 0 0 -2.0 0 1.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.7526 4.8294 4.1124 3.8599 3.7407 4.3328 4.4575 5.7703 5.3874 5.1803 5.3028 5.3909 6.0231 7.5479 6.8879 6.5556 6.6073 6.8747
Actin 0.0752 0.0088 0.0605 0.0142 0.0038 0.0056 0.0329 0.009 0.0155 0.02 0.0269 0.0201 0.0464 0.0181 0.0061 0.0064 0.0061 0.006
Bud 0.0008 0.0013 0.0009 0.0001 0.0001 0.0001 0.0003 0.0003 0.0001 0.0003 0.0002 0.0003 0.0004 0.0002 0.0001 0.0002 0.0036 0.0001
Bud Neck 0.0063 0.0008 0.0012 0.0012 0.0004 0.002 0.0027 0.0008 0.0005 0.0011 0.0009 0.0091 0.0022 0.0009 0.0019 0.0009 0.0013 0.0028
Bud Periphery 0.0012 0.0009 0.0014 0.0001 0.0001 0.0001 0.0005 0.0002 0.0002 0.0004 0.0003 0.0005 0.0005 0.0002 0.0002 0.0003 0.0027 0.0001
Bud Site 0.0069 0.0147 0.0124 0.0004 0.0001 0.0001 0.0039 0.0088 0.0015 0.0031 0.0006 0.0005 0.0063 0.0051 0.005 0.0006 0.0006 0.0002
Cell Periphery 0.0013 0.0031 0.0018 0.0004 0.0003 0.0006 0.0024 0.0041 0.003 0.002 0.0019 0.0023 0.0027 0.0042 0.0022 0.003 0.0009 0.0007
Cytoplasm 0.2585 0.2653 0.2409 0.3191 0.2454 0.229 0.1907 0.3564 0.2875 0.2639 0.4362 0.2414 0.1992 0.2194 0.2335 0.1687 0.1756 0.1446
Cytoplasmic Foci 0.0307 0.0294 0.0318 0.0432 0.0202 0.0398 0.0555 0.0586 0.0271 0.0467 0.0756 0.0862 0.054 0.0652 0.0373 0.0269 0.0918 0.0727
Eisosomes 0.0008 0.0001 0.0007 0 0 0 0.0005 0.0002 0.0001 0.0003 0.0002 0.0002 0.0008 0.0001 0.0001 0.0002 0.0001 0
Endoplasmic Reticulum 0.3922 0.5366 0.4909 0.5236 0.5883 0.4978 0.4286 0.3325 0.5071 0.4801 0.2225 0.3609 0.4367 0.4673 0.5751 0.5833 0.3972 0.4252
Endosome 0.0654 0.0658 0.0533 0.0319 0.0936 0.1222 0.0932 0.1018 0.0624 0.0822 0.0581 0.1357 0.1077 0.0917 0.054 0.0687 0.1685 0.163
Golgi 0.0271 0.0305 0.0402 0.0131 0.0169 0.0578 0.0428 0.0452 0.0255 0.0388 0.0268 0.0733 0.0529 0.079 0.0377 0.0385 0.075 0.1257
Lipid Particles 0.0356 0.0137 0.0156 0.01 0.0118 0.0194 0.0513 0.009 0.0129 0.0174 0.0343 0.0164 0.0474 0.0258 0.0155 0.0633 0.0372 0.0294
Mitochondria 0.0135 0.0023 0.0177 0.0005 0.0015 0.0089 0.0218 0.0009 0.0016 0.0028 0.0022 0.0081 0.004 0.0029 0.0036 0.0022 0.0042 0.008
None 0.0153 0.0087 0.0061 0.0053 0.0013 0.004 0.0221 0.062 0.0431 0.0199 0.0644 0.0201 0.0082 0.0025 0.0128 0.0124 0.0164 0.0053
Nuclear Periphery 0.0207 0.0069 0.0085 0.0296 0.0095 0.0057 0.0107 0.0033 0.0052 0.0076 0.0279 0.0034 0.0127 0.0053 0.0074 0.0057 0.0046 0.0029
Nucleolus 0.0005 0.0001 0.0002 0 0 0 0.0004 0.0001 0.0001 0.0002 0.0003 0.0001 0.0003 0.0001 0 0.0001 0.0003 0.0001
Nucleus 0.0064 0.0012 0.0011 0.0026 0.0022 0.001 0.0027 0.0008 0.001 0.0014 0.0031 0.0008 0.002 0.0008 0.0009 0.0007 0.0016 0.0005
Peroxisomes 0.0275 0.005 0.0082 0.0013 0.0003 0.0008 0.0171 0.0006 0.001 0.0014 0.0059 0.0161 0.0071 0.0062 0.0025 0.0124 0.0026 0.0027
Punctate Nuclear 0.0047 0.001 0.0027 0.001 0.0004 0.0005 0.0136 0.0007 0.0007 0.0051 0.009 0.0007 0.0039 0.001 0.0005 0.0006 0.0019 0.0006
Vacuole 0.0069 0.0032 0.0029 0.0017 0.0028 0.0031 0.0045 0.004 0.0034 0.0045 0.0016 0.0029 0.0035 0.0033 0.003 0.0042 0.0064 0.0058
Vacuole Periphery 0.0025 0.0006 0.001 0.0006 0.0009 0.0015 0.0019 0.0005 0.0005 0.0008 0.001 0.0009 0.0011 0.0007 0.0005 0.0008 0.0014 0.0035

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.6828 9.0701 11.7782 16.5902 11.5107 13.6899 16.966 16.7121 15.1047 17.5853
Translational Efficiency 0.7268 0.9076 0.7262 0.4024 0.4786 0.7207 0.5616 0.5043 0.578 0.5338

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
196 1370 1763 1291 1745 2123 1257 1634 1941 3493 3020 2925

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1015.42 936.19 1001.52 1041.12 822.16 936.64 996.87 1032.08 841.68 936.46 999.58 1036.07
Standard Deviation 143.94 139.04 124.46 149.08 101.86 122.53 123.87 132.67 121.70 129.26 124.24 140.22
Intensity Change Log 2 — -0.117203 -0.019885 0.036060 — 0.188075 0.277986 0.328064 — 0.027413 0.121031 0.174052

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003679 0.003300 0.001888 0.037051 0.001699 0.003873 0.007207 0.016178 0.001899 0.003648 0.004102 0.025391
Bud Neck 0.012607 0.004006 0.004340 0.014076 0.003666 0.004303 0.005546 0.016671 0.004568 0.004187 0.004842 0.015526
Bud Site 0.048330 0.010773 0.014773 0.069817 0.004132 0.007984 0.015933 0.052403 0.008595 0.009078 0.015256 0.060089
Cell Periphery 0.000700 0.000714 0.000608 0.007762 0.000719 0.001034 0.001736 0.003562 0.000717 0.000909 0.001078 0.005416
Cytoplasm 0.156314* 0.183675* 0.344846* 0.193561* 0.216880* 0.211048* 0.192721* 0.198528* 0.210764* 0.200312* 0.281528* 0.196336*
Cytoplasmic Foci 0.147424 0.200307* 0.075319 0.127608 0.149898 0.139044 0.069058 0.132847 0.149648 0.163072 0.072713 0.130535
Eisosomes 0.000451 0.000603 0.000118 0.003103 0.001661 0.001564 0.000839 0.002323 0.001539 0.001187 0.000418 0.002667
Endoplasmic Reticulum 0.074838 0.267015* 0.262326* 0.224443* 0.271472* 0.308055* 0.457649* 0.177441* 0.251616* 0.291959* 0.343625* 0.198186*
Endosome 0.060600 0.045860 0.017213 0.040628 0.021801 0.029370 0.023327 0.056068 0.025719 0.035838 0.019758 0.049253
Golgi 0.019535 0.071359 0.006523 0.046314 0.123615* 0.113711* 0.017823 0.033871 0.113105* 0.097100 0.011226 0.039363
Lipid Particles 0.024602 0.083092 0.027320 0.099928 0.122305* 0.106343* 0.063578 0.101654* 0.112439* 0.097224 0.042411 0.100892*
Mitochondria 0.007557 0.012636 0.000991 0.002215 0.021668 0.016941 0.000965 0.003988 0.020243 0.015252 0.000980 0.003205
Mitotic Spindle 0.019039 0.007937 0.015268 0.007368 0.000515 0.002643 0.003868 0.016856 0.002385 0.004720 0.010523 0.012668
None 0.000117 0.002834 0.000856 0.000392 0.002643 0.001965 0.000570 0.001386 0.002388 0.002306 0.000737 0.000947
Nuclear Periphery 0.003315 0.004573 0.011527 0.000334 0.001142 0.000779 0.001816 0.001326 0.001361 0.002267 0.007485 0.000888
Nuclear Periphery Foci 0.020066 0.010666 0.064052 0.013393 0.002590 0.002778 0.036356 0.018026 0.004355 0.005872 0.052525 0.015981
Nucleolus 0.000363 0.000661 0.000252 0.000192 0.000317 0.000395 0.000164 0.000421 0.000322 0.000499 0.000215 0.000320
Nucleus 0.024338 0.018066 0.076075 0.018661 0.024408 0.015866 0.035715 0.024053 0.024401 0.016729 0.059276 0.021673
Peroxisomes 0.009823 0.005313 0.001062 0.009423 0.010115 0.009850 0.002440 0.008001 0.010085 0.008071 0.001636 0.008628
Vacuole 0.353090* 0.058421 0.073871 0.082417 0.014932 0.018831 0.062092 0.131543 0.049079 0.034359 0.068968 0.109861
Vacuole Periphery 0.013215 0.008186 0.000774 0.001313 0.003824 0.003621 0.000596 0.002854 0.004772 0.005411 0.000700 0.002174

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.06 1.38 -12.41 -12.76 -13.55 -3.70 -4.73 -10.69 -8.38 -4.74 -3.89 -4.21 -16.88 -15.09 -14.38
Bud Neck 2.05 1.89 -0.82 -10.69 -10.19 -1.18 -2.76 -12.24 -11.45 -9.25 0.42 -1.08 -13.40 -15.43 -13.89
Bud Site 3.73 3.21 -2.82 -15.06 -13.33 -4.22 -7.48 -15.19 -13.65 -10.03 -0.82 -4.99 -19.72 -20.32 -16.47
Cell Periphery -0.72 -0.04 -9.15 -9.04 -9.22 -3.00 -5.25 -7.27 -6.27 -4.06 -2.43 -3.86 -11.48 -10.89 -10.39
Cytoplasm -1.76 -11.47 -2.46 -1.38 16.32 0.85 2.84 2.35 1.63 -0.61 1.72 -10.48 2.07 0.49 13.35
Cytoplasmic Foci -5.16 4.40 0.35 10.49 -9.21 2.17 15.60 3.53 1.61 -11.56 -3.25 17.66 4.06 8.12 -14.79
Eisosomes -1.71 2.93 -9.48 -8.75 -11.02 0.66 4.98 -1.88 -2.26 -4.68 2.88 9.92 -4.88 -6.93 -11.04
Endoplasmic Reticulum -13.43 -13.44 -10.47 3.89 3.17 -3.56 -14.24 10.57 14.43 23.45 -4.66 -9.17 6.99 13.30 18.03
Endosome 0.95 5.50 1.85 1.96 -10.07 -4.99 -0.80 -13.30 -9.76 -11.42 -7.05 3.92 -12.18 -6.31 -16.05
Golgi -9.50 1.96 -5.33 5.67 -12.46 1.80 23.53 19.76 19.70 -5.17 3.37 25.83 17.87 18.85 -13.39
Lipid Particles -13.42 -1.79 -14.93 -3.03 -16.11 3.39 11.45 4.20 1.25 -6.86 3.68 18.60 2.75 -0.76 -17.13
Mitochondria -2.09 1.68 1.28 8.60 -4.06 2.53 14.25 11.53 10.10 -5.07 3.04 14.24 12.32 13.27 -6.23
Mitotic Spindle 1.40 0.41 1.49 0.34 3.34 -3.34 -4.02 -8.13 -6.85 -6.09 -2.43 -5.68 -7.23 -5.75 -1.44
None -3.65 -6.24 -3.18 3.32 3.87 1.22 4.78 1.88 0.97 -1.38 0.16 4.31 3.01 2.94 -0.61
Nuclear Periphery -1.16 -5.63 2.07 6.92 13.01 2.03 -3.37 -1.23 -3.05 1.46 -3.01 -11.30 1.59 4.74 12.42
Nuclear Periphery Foci 2.61 -10.15 1.72 -2.60 19.47 -0.47 -16.64 -11.59 -11.42 7.13 -2.52 -28.05 -12.65 -11.39 19.10
Nucleolus -0.42 1.12 1.38 3.11 2.43 -0.58 3.94 -2.67 -0.27 -6.10 -1.47 3.00 0.12 1.57 -4.08
Nucleus 1.13 -9.21 0.87 -0.80 20.26 6.12 -5.36 -0.27 -5.84 4.95 5.70 -17.05 1.23 -5.10 19.10
Peroxisomes 1.52 3.54 -0.33 -4.89 -10.95 0.31 12.70 3.32 2.55 -9.54 2.78 15.36 2.24 -0.61 -15.29
Vacuole 15.48 14.42 14.16 -6.14 -0.99 -3.20 -15.56 -26.91 -26.03 -13.80 5.30 -5.08 -13.75 -25.01 -11.56
Vacuole Periphery 0.59 2.56 2.42 8.13 -2.14 0.49 9.55 1.72 1.51 -3.62 -1.51 7.77 4.11 6.84 -4.03
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
Localization
Cell Percentages ER (77%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Msc2

Msc2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Msc2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available