Standard name | |
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Human Ortholog | |
Description | Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping; binds URS1 upstream regulatory sequence, represses transcription by recruiting conserved histone deacetylase Rpd3p (through co-repressor Sin3p) and chromatin-remodeling factor Isw2p; couples metabolic responses to nutritional cues with initiation and progression of meiosis |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 2 | – | 3 | 10 | 4 | 4 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 2 | 1 | 4 | 4 | 10 |
Bud Neck | 0 | 0 | 1 | 0 | 0 | 0 | 2 | – | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 |
Bud Site | 0 | 1 | 1 | 1 | 6 | 7 | 18 | – | 12 | 17 | 10 | 11 | 2 | 0 | 0 | 0 | 0 | 2 | – | – | – | – | – | – |
Cell Periphery | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 6 | 7 | 10 | 12 | 16 | 18 | 25 | – | 10 | 12 | 9 | 9 | 29 | 40 | 82 | 33 | 29 | 26 | 0 | 0 | 0 | 1 | 0 | 1 |
Endoplasmic Reticulum | 1 | 2 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 7 | 11 | 0 | 0 | 0 | 0 | 2 | 3 |
Endosome | 0 | 3 | 1 | 1 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 5 | 2 | 3 | 4 | 4 | 0 | 2 | 4 | 5 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5 | 0 | 0 | 2 | 1 |
Mitochondria | 19 | 22 | 15 | 15 | 10 | 71 | 94 | – | 91 | 122 | 107 | 68 | 29 | 12 | 12 | 25 | 18 | 30 | 2 | 1 | 2 | 2 | 2 | 5 |
Nucleus | 348 | 343 | 308 | 249 | 244 | 327 | 302 | – | 153 | 174 | 138 | 124 | 402 | 409 | 448 | 320 | 322 | 242 | 338 | 340 | 284 | 274 | 314 | 287 |
Nuclear Periphery | 0 | 0 | 2 | 0 | 2 | 2 | 1 | – | 2 | 1 | 2 | 0 | 3 | 5 | 4 | 1 | 4 | 5 | 1 | 0 | 0 | 0 | 1 | 1 |
Nucleolus | 29 | 15 | 5 | 6 | 3 | 11 | 16 | – | 15 | 25 | 30 | 21 | 10 | 16 | 19 | 6 | 10 | 8 | 20 | 10 | 12 | 26 | 38 | 48 |
Peroxisomes | 1 | 1 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
SpindlePole | 1 | 1 | 7 | 4 | 4 | 4 | 13 | – | 0 | 1 | 4 | 2 | 1 | 6 | 4 | 0 | 2 | 4 | 0 | 3 | 4 | 0 | 6 | 5 |
Vac/Vac Membrane | 4 | 6 | 4 | 2 | 3 | 2 | 2 | – | 1 | 4 | 2 | 0 | 1 | 3 | 8 | 6 | 13 | 11 | 12 | 24 | 29 | 46 | 46 | 56 |
Unique Cell Count | 377 | 372 | 330 | 268 | 268 | 386 | 367 | 195 | 213 | 194 | 160 | 437 | 459 | 547 | 377 | 379 | 288 | 387 | 396 | 344 | 370 | 433 | 438 | |
Labelled Cell Count | 410 | 401 | 354 | 290 | 288 | 443 | 476 | 288 | 368 | 308 | 239 | 480 | 493 | 579 | 403 | 408 | 344 | 387 | 396 | 344 | 370 | 433 | 438 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.9 | 6.4 | 6.1 | 5.7 | 6.1 | 4.9 | 5.0 | – | 4.8 | 4.3 | 4.3 | 4.7 | 5.7 | 5.7 | 5.5 | 8.4 | 8.9 | 7.9 | 5.4 | 5.4 | 5.6 |
Std Deviation (1e-4) | 0.8 | 1.2 | 1.2 | 1.4 | 1.4 | 1.3 | 1.3 | – | 1.6 | 1.4 | 1.4 | 1.7 | 1.2 | 1.2 | 1.4 | 2.2 | 2.8 | 2.2 | 1.2 | 1.3 | 1.4 |
Intensity Change (Log2) | – | – | – | -0.09 | 0.01 | -0.3 | -0.28 | – | -0.34 | -0.49 | -0.5 | -0.38 | -0.1 | -0.1 | -0.13 | 0.46 | 0.56 | 0.37 | -0.16 | -0.16 | -0.12 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 3.7 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.9 | 1.8 | 1.1 | 2.3 | – | 1.2 | 1.5 | 1.0 | 1.4 | 2.3 | 3.2 | 5.6 | 3.2 | 2.7 | 3.2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.6 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.6 | -0.5 | 5.7 | 7.6 | – | 0 | 0 | 0 | 0 | 1.2 | -1.5 | -2.0 | 1.2 | 0.1 | 2.8 |
Nucleus | -0.2 | -1.0 | -3.6 | -4.4 | – | -5.0 | -4.2 | -6.9 | -5.1 | -0.7 | -2.0 | -4.8 | -3.6 | -3.5 | -3.7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 1.2 | 2.2 | – | 0 | 0 | 0 | 0 | 0.8 | 1.7 | 1.7 | 0.1 | 1.0 | 1.1 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | -1.2 | 1.1 | – | 0 | 0 | 0 | 0 | 0 | -0.9 | 0 | 0 | 0 | -0.7 |
Vacuole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.9 | 2.1 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.3594 | 3.8119 | 4.0624 | 3.4688 | 3.5932 | 4.0291 | 2.6987 | 2.2871 | 1.7404 | 2.4529 | 2.2925 | 1.8319 | 2.2259 | 2.2733 | 1.8083 | 1.8756 | 1.6658 | 1.7902 |
Actin | 0.0136 | 0.0002 | 0.0141 | 0.0424 | 0.0147 | 0.0051 | 0.0214 | 0.006 | 0.0019 | 0.0286 | 0.0022 | 0.0022 | 0.0003 | 0 | 0 | 0 | 0 | 0.0001 |
Bud | 0.0005 | 0.0001 | 0.0008 | 0.0008 | 0.0002 | 0.0002 | 0.0015 | 0.0001 | 0.0002 | 0.0007 | 0.0012 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0.0124 | 0.0003 | 0.0025 | 0.0295 | 0.0033 | 0.0025 | 0.0113 | 0.0002 | 0.0001 | 0.0012 | 0.0014 | 0.0014 | 0.0002 | 0.0001 | 0 | 0 | 0.0003 | 0.0005 |
Bud Periphery | 0.0014 | 0.0001 | 0.0014 | 0.001 | 0.0003 | 0.0007 | 0.0031 | 0.0001 | 0.0004 | 0.0015 | 0.0036 | 0.0002 | 0 | 0 | 0 | 0 | 0.0001 | 0 |
Bud Site | 0.0116 | 0.001 | 0.0098 | 0.0136 | 0.0003 | 0.0003 | 0.0066 | 0.0004 | 0.0008 | 0.0041 | 0.0018 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0001 |
Cell Periphery | 0.0009 | 0.0001 | 0.0005 | 0.0005 | 0.0001 | 0.0002 | 0.0005 | 0 | 0.0001 | 0.0005 | 0.0004 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.0189 | 0.003 | 0.002 | 0.0027 | 0.001 | 0.0036 | 0.007 | 0.0019 | 0.0003 | 0.0089 | 0.0013 | 0.0002 | 0.0013 | 0.0002 | 0.0001 | 0.0001 | 0.0007 | 0.0002 |
Cytoplasmic Foci | 0.0362 | 0.0002 | 0.0027 | 0.0342 | 0.0013 | 0.0005 | 0.0058 | 0.003 | 0.0012 | 0.0054 | 0.0012 | 0.0011 | 0.0003 | 0 | 0 | 0 | 0 | 0.0005 |
Eisosomes | 0.0003 | 0 | 0.0002 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0005 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0103 | 0.0006 | 0.0028 | 0.0021 | 0.0038 | 0.0041 | 0.0087 | 0.0001 | 0.0003 | 0.0081 | 0.0036 | 0.0004 | 0.0005 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0.025 | 0.0013 | 0.0094 | 0.021 | 0.0167 | 0.0039 | 0.032 | 0.0022 | 0.0048 | 0.0348 | 0.0209 | 0.0018 | 0.0009 | 0 | 0 | 0 | 0 | 0.0003 |
Golgi | 0.0064 | 0.0002 | 0.0027 | 0.0073 | 0.0035 | 0.0023 | 0.0056 | 0.0023 | 0.0012 | 0.0248 | 0.0034 | 0.003 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Lipid Particles | 0.0218 | 0 | 0.0028 | 0.0252 | 0.0027 | 0.0008 | 0.0047 | 0.0006 | 0.0009 | 0.0122 | 0.0041 | 0.0003 | 0.0007 | 0 | 0 | 0 | 0 | 0.0001 |
Mitochondria | 0.0026 | 0.0004 | 0.0095 | 0.0076 | 0.0021 | 0.0162 | 0.0103 | 0.0003 | 0.0072 | 0.0214 | 0.0504 | 0.001 | 0.0005 | 0 | 0 | 0 | 0.0001 | 0.0001 |
None | 0.0278 | 0.0001 | 0.0011 | 0.0052 | 0.0021 | 0.0004 | 0.0041 | 0.0007 | 0.0002 | 0.0047 | 0.0008 | 0.0002 | 0.0058 | 0 | 0.0003 | 0 | 0.0181 | 0.0003 |
Nuclear Periphery | 0.0114 | 0.0016 | 0.0038 | 0.0029 | 0.0367 | 0.0043 | 0.0246 | 0.0013 | 0.0014 | 0.0093 | 0.0271 | 0.0026 | 0.0061 | 0.0016 | 0.0014 | 0.0005 | 0.0007 | 0.0013 |
Nucleolus | 0.0287 | 0.0155 | 0.0165 | 0.0126 | 0.0502 | 0.0408 | 0.0204 | 0.0139 | 0.0113 | 0.0086 | 0.0546 | 0.0298 | 0.0095 | 0.0138 | 0.0084 | 0.0069 | 0.0237 | 0.0297 |
Nucleus | 0.7033 | 0.9712 | 0.9015 | 0.7592 | 0.8468 | 0.9035 | 0.807 | 0.9621 | 0.9656 | 0.8134 | 0.7735 | 0.9532 | 0.9694 | 0.9832 | 0.9815 | 0.9921 | 0.9542 | 0.962 |
Peroxisomes | 0.0224 | 0 | 0.0018 | 0.0103 | 0.0004 | 0.0004 | 0.0016 | 0.0007 | 0.0003 | 0.001 | 0.0005 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Punctate Nuclear | 0.0385 | 0.0033 | 0.0073 | 0.0154 | 0.0112 | 0.0041 | 0.0138 | 0.0038 | 0.0007 | 0.0034 | 0.0341 | 0.0012 | 0.0037 | 0.0008 | 0.0079 | 0.0003 | 0.0016 | 0.0048 |
Vacuole | 0.0049 | 0.0009 | 0.0055 | 0.005 | 0.0006 | 0.0034 | 0.0066 | 0.0001 | 0.0005 | 0.0045 | 0.008 | 0.0003 | 0.0003 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 |
Vacuole Periphery | 0.001 | 0.0002 | 0.0012 | 0.0011 | 0.0018 | 0.0026 | 0.0032 | 0.0001 | 0.0004 | 0.0024 | 0.0061 | 0.0004 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 13.4026 | 12.5703 | 7.5788 | 11.7647 | 8.2612 | 13.1756 | 14.4971 | 13.2695 | 13.7132 | 14.2743 |
Translational Efficiency | 1.0609 | 1.5136 | 1.6942 | 0.9566 | 1.7358 | 0.9725 | 0.961 | 1.1385 | 0.9678 | 0.9941 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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