Standard name
Human Ortholog
Description Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.1 0.11 0.16 0.12 0.14 0.07 0.09 0.07 0 0 0 0.08 0 0 0.05 0.24 0.31 0.24 0 0.06 0.05 0.05 0.13 0.09
Bud 0 0 0 0 0 0.05 0 0 0.06 0.07 0.08 0.06 0 0 0 0 0.08 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.06 0.05 0 0 0 0 0 0 0 0 0 0.08 0.1 0.33 0.29 0.24 0 0 0 0 0.08 0.08
Cytoplasm 0.2 0.33 0.43 0.51 0.49 0.49 0.43 0.48 0.5 0.46 0.41 0.46 0.15 0.26 0.29 0.34 0.25 0.39 0 0.06 0.05 0 0 0
Endoplasmic Reticulum 0.74 0.46 0.34 0.24 0.25 0.21 0.29 0.14 0.08 0.08 0 0.16 0.81 0.53 0.59 0.07 0.12 0.05 0.84 0.59 0.64 0.71 0.67 0.67
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Mitochondria 0.08 0.16 0 0.09 0.06 0.19 0.23 0.21 0.39 0.45 0.52 0.27 0.08 0 0 0 0.1 0.05 0 0.15 0.15 0.1 0.07 0.08
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.05 0.05 0.05 0.08 0.06 0.05 0.12 0 0.06 0.1 0.05 0 0 0 0.09 0 0.05 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 26 32 62 41 60 34 60 39 9 14 14 38 10 12 13 16 16 9 9 22 28 9 44 25
Bud 2 10 9 9 11 23 31 23 35 34 39 29 1 3 2 0 4 0 0 1 2 1 1 1
Bud Neck 0 0 4 0 3 2 1 1 0 2 1 1 0 0 0 0 0 0 0 6 9 2 3 2
Bud Site 1 0 0 0 0 0 1 0 2 1 3 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 1 24 18 11 16 16 18 13 13 10 14 8 22 28 22 15 9 0 2 12 7 28 23
Cytoplasm 55 93 161 178 216 248 302 267 272 227 188 219 37 71 81 23 13 15 9 21 27 6 3 3
Endoplasmic Reticulum 200 129 129 82 110 107 199 76 46 41 10 78 204 144 163 5 6 2 262 207 379 128 227 190
Endosome 0 10 1 11 9 12 4 1 16 6 3 4 5 18 11 2 1 2 0 6 3 0 0 2
Golgi 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 3 3 2 2 1 0 1
Mitochondria 21 45 1 31 28 98 160 117 213 222 239 128 21 11 9 3 5 2 11 53 90 19 22 21
Nucleus 1 0 1 0 2 0 2 9 3 7 9 4 1 1 0 1 1 1 0 0 0 0 0 1
Nuclear Periphery 3 1 0 0 1 0 2 4 0 6 4 0 9 0 3 0 0 0 2 2 4 0 0 0
Nucleolus 0 0 1 0 0 0 0 2 1 3 3 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 1 0 1 1 3 0 0 0 6 1 1 0 0 0 1 1 0 0 0
SpindlePole 2 0 4 3 7 5 9 8 5 10 1 13 0 4 0 3 4 0 0 1 2 0 0 0
Vac/Vac Membrane 1 14 18 17 34 32 38 64 23 29 44 24 4 10 7 6 2 2 7 16 23 2 3 5
Unique Cell Count 269 280 376 346 438 507 697 552 545 495 463 475 251 270 275 67 52 38 311 350 596 182 340 283
Labelled Cell Count 315 336 415 390 492 578 825 630 639 618 568 553 300 303 318 83 68 45 311 350 596 182 340 283


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 5.4 6.2 5.9 6.3 5.1 5.5 5.7 4.8 4.7 4.4 5.3 6.2 6.6 6.5 9.4 8.7 9.6 5.7 5.8 6.4
Std Deviation (1e-4) 0.7 0.8 0.7 0.7 1.0 0.7 0.9 1.0 0.8 1.0 0.7 0.9 0.8 1.2 1.0 1.5 1.6 2.3 1.0 1.0 1.3
Intensity Change (Log2) – – – -0.08 0.02 -0.28 -0.19 -0.13 -0.38 -0.4 -0.51 -0.24 -0.01 0.07 0.06 0.6 0.48 0.62 -0.14 -0.1 0.03


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.8 -1.1 -4.6 -3.9 -4.5 0 0 0 -3.8 -4.8 -4.7 -4.6 1.5 2.5 1.1
Bud 0.2 0.1 1.7 1.7 1.5 0 0 0 2.6 0 -1.2 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.7 -2.7 -2.3 -3.4 -2.2 0 0 0 -2.4 -1.8 0.9 1.8 6.5 0 0
Cytoplasm 2.3 1.9 1.8 0.2 1.7 2.1 0.9 -0.6 1.0 -7.4 -4.3 -3.5 -1.3 -2.5 -0.4
Endoplasmic Reticulum -3.1 -2.9 -4.4 -2.0 -7.4 0 0 0 -6.0 11.5 4.8 6.3 -4.4 -3.3 -3.7
Endosome 3.1 0 2.6 0 0 0 0 0 0 0 4.7 3.5 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 5.7 4.7 8.9 9.9 9.4 0 0 0 10.8 5.4 3.5 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0.7 0 0 0 0 0 0 1.7 0 0 0 0 0 0
Vacuole 0.1 1.7 1.0 0.5 3.6 -0.4 0.7 2.6 0.2 -2.1 -0.7 -1.5 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.9295 1.1115 1.0706 1.2395 0.6343 1.0444 1.6739 1.9906 1.8361 1.8883 1.8875 1.771 1.8219 2.1146 1.8536 1.7866 1.6364 1.7392
Actin 0.0115 0.0091 0.0119 0.0315 0.0072 0.0088 0.0368 0.0141 0.0381 0.0287 0.0063 0.0168 0.0436 0.005 0.0029 0.0436 0.0066 0.0148
Bud 0.0011 0.001 0.0005 0.0004 0.0005 0.0003 0.0005 0.0005 0.0012 0.0008 0.0015 0.0004 0.0007 0.0001 0.0001 0.0003 0.0001 0.0001
Bud Neck 0.0024 0.0026 0.0097 0.0023 0.0019 0.007 0.0011 0.0015 0.0052 0.007 0.0021 0.0092 0.0019 0.0009 0.004 0.0148 0.0028 0.0059
Bud Periphery 0.0026 0.0029 0.0014 0.0007 0.0013 0.0009 0.0011 0.0012 0.0039 0.0016 0.0085 0.0011 0.0017 0.0003 0.0003 0.001 0.0002 0.0002
Bud Site 0.0052 0.0252 0.0183 0.0009 0.0014 0.0006 0.0033 0.0273 0.0094 0.0021 0.0014 0.0008 0.0038 0.0061 0.01 0.0023 0.0004 0.0003
Cell Periphery 0.0077 0.0082 0.0083 0.0011 0.002 0.0038 0.0064 0.0149 0.0145 0.0052 0.0046 0.0046 0.0112 0.0102 0.0058 0.0121 0.0016 0.0018
Cytoplasm 0.1859 0.2947 0.2514 0.3202 0.2855 0.3151 0.1499 0.2087 0.1948 0.2111 0.1367 0.2441 0.1495 0.2532 0.2066 0.1766 0.1678 0.2222
Cytoplasmic Foci 0.0216 0.0246 0.0275 0.0269 0.0202 0.037 0.0405 0.0245 0.0269 0.0395 0.0442 0.026 0.0201 0.018 0.0288 0.0166 0.0183 0.0179
Eisosomes 0.0006 0.0006 0.0006 0.0004 0.001 0.0006 0.0007 0.0012 0.0012 0.0007 0.0002 0.0003 0.0013 0.0004 0.0003 0.0007 0.0001 0.0002
Endoplasmic Reticulum 0.5717 0.4114 0.4768 0.3467 0.385 0.4194 0.5167 0.5036 0.5032 0.4013 0.4361 0.54 0.5793 0.5441 0.5956 0.6034 0.6786 0.6163
Endosome 0.0498 0.0595 0.0529 0.0408 0.0736 0.0431 0.0485 0.0474 0.0575 0.0474 0.1581 0.046 0.0331 0.0445 0.0376 0.0262 0.0126 0.0192
Golgi 0.0175 0.01 0.0101 0.0071 0.0084 0.0087 0.0204 0.0243 0.0244 0.0408 0.0353 0.0127 0.011 0.0067 0.007 0.0128 0.0039 0.009
Lipid Particles 0.0368 0.0354 0.034 0.0167 0.0206 0.0287 0.0671 0.0594 0.0458 0.0868 0.0606 0.0263 0.0563 0.043 0.0452 0.0114 0.0215 0.0212
Mitochondria 0.0057 0.0044 0.0048 0.0091 0.0139 0.0141 0.0057 0.0069 0.0262 0.0156 0.0662 0.0063 0.0023 0.0009 0.0013 0.002 0.0037 0.0019
None 0.0462 0.0687 0.0583 0.1222 0.1404 0.0847 0.0462 0.0382 0.0249 0.0735 0.0041 0.0412 0.0477 0.0454 0.0347 0.0477 0.0047 0.055
Nuclear Periphery 0.0146 0.0209 0.0126 0.0382 0.0171 0.0098 0.0308 0.0117 0.0089 0.0068 0.0083 0.0118 0.0151 0.0087 0.0083 0.0106 0.0068 0.0056
Nucleolus 0.0006 0.0005 0.0005 0.0007 0.0006 0.0003 0.0004 0.0003 0.0002 0.0006 0.0003 0.0002 0.0007 0.0001 0.0002 0.0001 0.0207 0.0001
Nucleus 0.0022 0.0036 0.0039 0.015 0.0046 0.0048 0.003 0.0017 0.0014 0.0016 0.0018 0.0017 0.0042 0.0014 0.0013 0.0015 0.0114 0.0011
Peroxisomes 0.0045 0.0007 0.0025 0.0026 0.0009 0.002 0.008 0.0008 0.0014 0.0164 0.0031 0.0008 0.0027 0.0003 0.0008 0.0007 0.0267 0.0015
Punctate Nuclear 0.0013 0.0019 0.0024 0.0076 0.0022 0.0023 0.0022 0.0013 0.0012 0.002 0.0023 0.0011 0.0054 0.0009 0.0013 0.0006 0.0065 0.0007
Vacuole 0.0088 0.0122 0.01 0.0075 0.0094 0.0067 0.0085 0.0094 0.0085 0.0091 0.0144 0.007 0.0067 0.0092 0.0071 0.0131 0.004 0.0044
Vacuole Periphery 0.0016 0.0018 0.0015 0.0015 0.0023 0.0013 0.0024 0.0012 0.0014 0.0015 0.0037 0.0016 0.0015 0.0007 0.0007 0.0018 0.0011 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.0036 20.111 18.7408 16.8039 13.5667 12.5496 26.0089 21.0651 19.7425 23.8099
Translational Efficiency 0.7214 0.8282 0.7008 0.7956 0.7837 1.0743 0.6892 0.698 0.7202 0.6252

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
940 1018 1351 1094 2118 1251 208 154 3058 2269 1559 1248

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 725.98 866.82 1123.37 919.77 843.25 810.17 1059.73 981.66 807.20 835.59 1114.88 927.41
Standard Deviation 367.24 119.00 158.38 114.08 103.86 114.27 102.14 131.32 227.72 119.78 153.61 118.12
Intensity Change Log 2 — 0.255803 0.629831 0.341343 — -0.057736 0.329664 0.219263 — 0.095817 0.476321 0.277028

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000728 0.001800 0.000939 0.003279 0.001297 0.000718 0.000860 0.005783 0.001122 0.001204 0.000928 0.003588
Bud Neck 0.005021 0.001487 0.002194 0.007850 0.002212 0.003528 0.001910 0.005078 0.003075 0.002613 0.002156 0.007508
Bud Site 0.002905 0.005013 0.005138 0.018301 0.002816 0.006150 0.002390 0.006818 0.002843 0.005640 0.004771 0.016884
Cell Periphery 0.001538 0.002750 0.000303 0.000752 0.002417 0.001472 0.000628 0.000520 0.002147 0.002045 0.000346 0.000724
Cytoplasm 0.244029* 0.134059* 0.091798 0.207446* 0.206260* 0.137311* 0.092070 0.196895* 0.217870* 0.135852* 0.091834 0.206144*
Cytoplasmic Foci 0.087863 0.032766 0.007615 0.051192 0.027284 0.053691 0.031081 0.068971 0.045905 0.044303 0.010746 0.053386
Eisosomes 0.001550 0.001577 0.000029 0.000437 0.002593 0.000886 0.000232 0.000488 0.002272 0.001196 0.000056 0.000443
Endoplasmic Reticulum 0.352929* 0.670818* 0.527693* 0.308360* 0.611017* 0.569220* 0.393370* 0.129041* 0.531683* 0.614803* 0.509772* 0.286232*
Endosome 0.011893 0.008544 0.012261 0.019268 0.005077 0.017257 0.019429 0.024400 0.007172 0.013348 0.013218 0.019902
Golgi 0.029360 0.039363 0.000831 0.003452 0.035850 0.033885 0.001248 0.011853 0.033855 0.036343 0.000887 0.004489
Lipid Particles 0.174460* 0.062737 0.008705 0.046070 0.052947 0.091216 0.045902 0.039176 0.090299 0.078439 0.013668 0.045220
Mitochondria 0.012098 0.007172 0.000568 0.001870 0.005656 0.013613 0.000276 0.004709 0.007636 0.010723 0.000529 0.002220
Mitotic Spindle 0.000330 0.000163 0.003108 0.016232 0.000621 0.000668 0.000946 0.021120 0.000531 0.000441 0.002820 0.016836
None 0.002728 0.002689 0.000397 0.001186 0.010475 0.002350 0.000300 0.000692 0.008094 0.002502 0.000384 0.001126
Nuclear Periphery 0.007557 0.001100 0.123958* 0.022573 0.001099 0.008780 0.064559 0.031198 0.003084 0.005334 0.116033* 0.023637
Nuclear Periphery Foci 0.006683 0.005999 0.166966 0.086117 0.003818 0.008967 0.182159 0.098081 0.004699 0.007635 0.168993 0.087593
Nucleolus 0.000434 0.000105 0.000082 0.000458 0.000141 0.000786 0.000442 0.000388 0.000231 0.000480 0.000130 0.000449
Nucleus 0.027769 0.005583 0.022638 0.064375 0.012725 0.012356 0.044362 0.072774 0.017349 0.009317 0.025536 0.065412
Peroxisomes 0.010280 0.007157 0.000227 0.002010 0.007473 0.007307 0.002206 0.004529 0.008336 0.007240 0.000491 0.002321
Vacuole 0.017006 0.007444 0.023956 0.136228 0.007340 0.025092 0.115263 0.274810* 0.010311 0.017174 0.036138 0.153329
Vacuole Periphery 0.002841 0.001676 0.000594 0.002541 0.000883 0.004745 0.000369 0.002676 0.001485 0.003368 0.000564 0.002558

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.74 -0.88 -3.44 -1.90 -3.01 2.46 1.34 -1.04 -1.24 -1.17 -0.35 0.45 -3.11 -3.01 -3.22
Bud Neck 4.24 2.94 -3.20 -7.87 -6.64 -2.00 0.25 -3.90 -2.37 -3.84 0.99 1.50 -6.38 -6.79 -7.18
Bud Site -1.41 -2.01 -6.54 -5.25 -5.25 -2.25 0.10 -3.31 -1.38 -3.26 -2.68 -2.33 -7.15 -5.35 -5.60
Cell Periphery -2.18 5.43 3.54 3.93 -6.18 3.37 7.88 9.19 4.37 0.91 0.35 11.60 9.16 5.14 -5.58
Cytoplasm 12.08 17.37 2.97 -8.82 -14.01 10.15 8.91 0.50 -3.16 -4.69 15.39 21.70 0.83 -9.84 -14.78
Cytoplasmic Foci 11.26 18.48 7.21 -5.48 -16.17 -7.98 -1.50 -4.95 -1.17 -3.57 0.59 17.29 -2.63 -2.96 -16.11
Eisosomes -0.09 6.27 4.58 5.89 -8.24 6.34 9.24 7.97 3.35 -1.07 5.01 11.66 9.54 7.11 -8.04
Endoplasmic Reticulum -21.07* -12.28 5.76 28.45* 19.92 3.37 9.92 36.88* 29.81* 10.77 -8.43 2.95 26.28 31.91 21.63
Endosome 3.44 -0.70 -5.41 -8.31 -5.21 -9.64 -8.15 -5.76 -1.04 -0.17 -7.69 -10.04 -11.67 -4.57 -4.86
Golgi -3.29 15.51 13.73 14.66 -3.67 0.78 22.79 5.19 4.66 -1.12 -1.25 27.98 21.20 18.38 -3.14
Lipid Particles 15.16 25.03 18.91 4.74 -15.02 -8.49 1.28 5.05 10.82 2.13 3.13 26.71 14.56 10.84 -12.72
Mitochondria 2.21 6.03 5.33 4.57 -3.26 -5.09 12.68 1.02 3.63 -1.14 -2.64 10.77 7.26 8.25 -3.14
Mitotic Spindle 1.03 -3.89 -6.11 -6.18 -4.85 -0.10 -0.60 -2.50 -2.50 -2.44 0.25 -3.44 -6.46 -6.51 -5.43
None 0.04 4.06 2.20 1.89 -1.91 5.57 7.34 6.44 1.83 -2.11 5.31 7.92 6.66 2.45 -2.20
Nuclear Periphery 6.00 -22.27 -6.30 -10.84 18.96 -6.02 -8.25 -4.92 -2.95 4.71 -2.85 -24.57 -10.44 -8.60 19.42
Nuclear Periphery Foci 0.80 -30.97* -19.12 -19.24 13.25 -5.40 -12.41 -7.20 -6.66 5.87 -4.60 -33.83 -21.02 -20.01 14.48
Nucleolus 4.39 4.74 -1.28 -4.11 -4.29 -2.40 -2.02 -3.57 1.21 0.20 -1.70 2.50 -3.31 -0.52 -4.09
Nucleus 12.90 1.39 -11.56 -19.93 -12.32 0.11 -4.99 -6.25 -6.24 -2.20 8.30 -5.26 -16.89 -19.57 -11.96
Peroxisomes 2.65 10.06 8.08 7.23 -8.00 0.18 2.67 2.28 2.17 -0.15 1.71 15.02 11.23 9.41 -4.27
Vacuole 6.88 -4.83 -23.10 -24.67 -21.23 -8.39 -9.41 -14.82 -14.02 -8.20 -5.26 -12.01 -27.37 -26.03 -21.40
Vacuole Periphery 2.06 4.22 0.81 -0.82 -2.60 -6.41 5.05 -0.59 2.06 -0.97 -4.89 4.73 -1.13 1.90 -2.77
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
Localization
Cell Percentages ER (98%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Gtb1

Gtb1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gtb1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available