Standard name
Human Ortholog
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.09 0 0.19 0.37 0.31 0.3 0.39 – 0.45 0.34 0.52 0.47 0.39 0.55 0.68 0.23 0.17 0.18 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Endosome 0.05 0 0 0 0 0 0 – 0 0 0 0 0.12 0.07 0.06 0 0 0 0.05 0 0.05 0.1 0.06 0.1
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0.32 0 0 0 0.14 0 – 0.09 0.1 0.08 0.09 0 0 0 0.05 0 0.05 0 0 0 0 0 0
Nucleus 0.17 0.18 0.43 0.34 0.21 0.24 0.24 – 0.24 0.22 0.14 0.14 0 0.05 0 0.4 0.31 0.39 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.74 0.76 0.53 0.52 0.71 0.58 0.57 – 0.51 0.56 0.52 0.53 0.61 0.53 0.39 0.47 0.58 0.53 0.82 0.86 0.78 0.8 0.82 0.74
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 1 – 0 1 1 0 1 0 0 0 0 0 1 0 0 0 0 0
Bud 0 0 0 0 1 2 2 – 1 1 3 2 1 1 0 0 0 0 0 0 0 2 3 2
Bud Neck 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 1 – 0 0 0 1 0 0 0 0 2 0 0 0 0 0 0 0
Cytoplasm 14 1 9 60 86 78 185 – 128 121 148 196 73 156 254 31 20 18 2 1 4 1 7 4
Endoplasmic Reticulum 1 0 0 0 3 3 0 – 3 3 1 1 4 4 1 3 9 4 1 1 0 1 3 2
Endosome 8 0 0 1 8 0 3 – 1 1 0 1 22 20 21 5 5 4 8 2 4 17 21 22
Golgi 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 1 0 0 3 0 1 0 0 2
Mitochondria 11 12 1 6 2 37 9 – 27 34 24 36 2 2 0 6 2 5 2 0 1 1 5 4
Nucleus 25 7 20 54 58 62 116 – 69 79 41 58 8 14 10 53 38 38 4 2 4 3 3 5
Nuclear Periphery 1 0 0 1 0 0 1 – 1 2 0 4 0 1 0 0 0 1 1 0 0 2 9 7
Nucleolus 3 1 0 1 0 0 0 – 0 0 0 0 2 1 1 1 1 2 1 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 0 0 0 1 – 0 2 0 1 1 3 1 1 2 2 2 0 1 0 5 1
Vac/Vac Membrane 109 29 25 83 195 150 273 – 146 198 146 222 115 152 146 63 70 52 141 61 75 139 288 158
Unique Cell Count 148 38 47 161 275 257 476 285 354 283 418 187 286 371 133 121 98 173 71 96 174 353 216
Labelled Cell Count 172 50 57 206 354 332 594 376 443 364 522 229 354 434 164 149 126 173 71 96 174 353 216


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.2 6.1 5.7 6.1 7.9 5.8 7.7 – 6.3 6.5 6.2 6.3 6.5 6.0 5.7 10.5 12.3 10.8 7.5 7.2 7.9
Std Deviation (1e-4) 2.6 1.5 1.5 1.6 2.1 2.1 2.6 – 2.4 2.4 2.2 2.3 1.8 1.4 1.2 3.6 3.9 3.8 2.1 2.6 2.6
Intensity Change (Log2) – – – 0.09 0.48 0.03 0.44 – 0.14 0.18 0.12 0.14 0.2 0.07 0.01 0.88 1.11 0.93 0.41 0.35 0.48

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.3 1.7 1.6 2.7 – 3.3 2.1 4.2 3.6 2.6 4.5 6.6 0.6 -0.4 -0.1
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 2.3 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus -1.1 -3.2 -2.6 -2.7 – -2.6 -3.0 -4.6 -5.0 -7.2 0 0 -0.3 -1.4 -0.4
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole -0.2 2.4 0.7 0.5 – -0.2 0.4 -0.2 0 1.0 0 -1.8 -0.7 0.5 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.2925 2.1796 1.2261 0.5716 1.6322 1.8034 1.5603 3.3511 2.7443 1.7353 2.3349 3.4534 3.7107 6.1248 4.8524 4.405 4.994 5.368
Actin 0.0006 0 0 0 0 0 0.02 0 0.0073 0 0 0 0.0092 0 0.0004 0.0394 0.0019 0.0004
Bud 0.0003 0.0004 0.0002 0.0003 0.0001 0.0003 0.0014 0.0009 0.0006 0.0002 0.0003 0.0003 0.0004 0.0002 0.0003 0.002 0.0011 0.0003
Bud Neck 0.0006 0.0008 0.0005 0.0008 0.0006 0.001 0.0015 0.0014 0.0022 0.0008 0.0013 0.0018 0.0009 0.0016 0.001 0.0015 0.0018 0.0017
Bud Periphery 0.0008 0.001 0.0007 0.0007 0.0004 0.0011 0.0024 0.002 0.0012 0.0005 0.0009 0.0011 0.001 0.0007 0.0008 0.0085 0.0027 0.0013
Bud Site 0.0009 0.0011 0.0006 0.0007 0.0003 0.0005 0.0076 0.0025 0.0018 0.0006 0.001 0.0007 0.0013 0.0007 0.0012 0.0031 0.0076 0.0008
Cell Periphery 0.0032 0.0055 0.0031 0.0029 0.0025 0.0045 0.0024 0.0035 0.003 0.0016 0.0017 0.0051 0.0019 0.0035 0.0028 0.0034 0.0035 0.0046
Cytoplasm 0.0054 0.0063 0.0035 0.0011 0.0011 0.0013 0.009 0.0169 0.0072 0.0098 0.0023 0.0067 0.0081 0.0109 0.0026 0.0376 0.0091 0.0015
Cytoplasmic Foci 0.0117 0.0039 0.0081 0.0035 0.0039 0.0023 0.0259 0.0137 0.0195 0.0073 0.0121 0.0076 0.0188 0.0073 0.0059 0.0088 0.0228 0.0059
Eisosomes 0.0001 0 0.0001 0 0 0 0.0001 0 0.0001 0 0 0 0.0001 0 0 0.0003 0.0001 0
Endoplasmic Reticulum 0.0016 0.0038 0.0012 0.001 0.0009 0.0013 0.0028 0.0042 0.0056 0.0031 0.0012 0.0018 0.0057 0.0025 0.0024 0.0031 0.0036 0.0016
Endosome 0.1781 0.1021 0.1738 0.2027 0.172 0.0932 0.2752 0.176 0.2117 0.2001 0.2858 0.1448 0.2249 0.1086 0.1689 0.1549 0.1579 0.0876
Golgi 0.0082 0.0031 0.0068 0.0068 0.0029 0.0041 0.0146 0.0048 0.0149 0.004 0.0085 0.0037 0.0144 0.0024 0.0062 0.0111 0.0263 0.0033
Lipid Particles 0.0368 0.0076 0.0328 0.0081 0.008 0.0208 0.0325 0.0195 0.0257 0.0207 0.0069 0.02 0.0424 0.008 0.0132 0.0067 0.0535 0.011
Mitochondria 0.0288 0.0187 0.0556 0.0118 0.005 0.0234 0.0216 0.0143 0.0434 0.0057 0.0043 0.0019 0.0214 0.001 0.0238 0.076 0.0317 0.0025
None 0.0052 0.004 0.0033 0.0002 0.0002 0.0001 0.0265 0.0172 0.0099 0.0333 0.0005 0.0206 0.0057 0.0014 0.0004 0.0026 0.0021 0.0002
Nuclear Periphery 0.0031 0.0152 0.0027 0.002 0.0016 0.0052 0.0149 0.0097 0.0116 0.0065 0.0021 0.0029 0.0141 0.0056 0.0073 0.0016 0.0031 0.0034
Nucleolus 0.0064 0.0045 0.0031 0.0034 0.0026 0.0029 0.0142 0.0046 0.0043 0.0031 0.0159 0.0055 0.0044 0.0016 0.0093 0.0029 0.0026 0.0044
Nucleus 0.005 0.007 0.0022 0.0019 0.0016 0.0029 0.0143 0.0085 0.0029 0.0034 0.0308 0.0044 0.0135 0.0034 0.0044 0.0028 0.0031 0.0088
Peroxisomes 0.0032 0.0005 0.0026 0.0007 0.0006 0.0008 0.0061 0.0011 0.0035 0.001 0.0011 0.0007 0.0067 0.0002 0.001 0.0033 0.0103 0.0021
Punctate Nuclear 0.0021 0.0003 0.0002 0.0001 0.0001 0.0001 0.0047 0.0002 0.0004 0.0004 0.0001 0.0002 0.0022 0.0002 0.0006 0.0003 0.0007 0.0009
Vacuole 0.4879 0.6046 0.4827 0.5075 0.6081 0.6157 0.3874 0.561 0.4536 0.5702 0.4648 0.5994 0.4411 0.6702 0.5534 0.5511 0.5499 0.6779
Vacuole Periphery 0.2101 0.2094 0.2163 0.244 0.1874 0.2185 0.1147 0.1379 0.1697 0.1275 0.1583 0.1709 0.1618 0.1698 0.1943 0.079 0.1046 0.1796

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 162.744 145.4832 127.3867 151.0361 167.7488 138.2558 157.027 170.7636 157.2857 156.2602
Translational Efficiency 1.7002 1.5853 1.7484 1.5488 1.5294 1.8929 1.4547 1.5916 1.7228 1.6874

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1872 1133 1363 1553 1489 1984 144 1493 3361 3117 1507 3046

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 675.99 854.58 968.67 903.05 725.76 850.99 957.87 900.62 698.04 852.29 967.64 901.86
Standard Deviation 122.78 143.02 144.70 166.71 92.29 126.46 126.47 163.50 113.05 132.73 143.10 165.15
Intensity Change Log 2 — 0.338214 0.519003 0.417804 — 0.229650 0.400337 0.311426 — 0.283025 0.458783 0.363706

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000089 0.000107 0.000219 0.001745 0.000026 0.000038 0.000295 0.000557 0.000061 0.000063 0.000227 0.001163
Bud Neck 0.031318 0.016996 0.028687 0.033327 0.023633 0.013031 0.025823 0.040279 0.027913 0.014472 0.028414 0.036734
Bud Site 0.019301 0.023755 0.014979 0.058229 0.007219 0.007156 0.026667 0.070913 0.013948 0.013189 0.016095 0.064446
Cell Periphery 0.001065 0.001201 0.000272 0.000530 0.000423 0.002544 0.000150 0.000423 0.000781 0.002056 0.000260 0.000477
Cytoplasm 0.101289 0.052748 0.048100 0.197921 0.104052 0.011091 0.104905 0.249691 0.102513 0.026233 0.053528 0.223296
Cytoplasmic Foci 0.047516 0.030274 0.013207 0.033177 0.043266 0.003874 0.032728 0.035366 0.045633 0.013470 0.015072 0.034250
Eisosomes 0.000078 0.000032 0.000036 0.000031 0.000054 0.000032 0.000056 0.000033 0.000067 0.000032 0.000038 0.000032
Endoplasmic Reticulum 0.002026 0.004016 0.005038 0.001697 0.002241 0.006045 0.004246 0.003009 0.002121 0.005308 0.004963 0.002341
Endosome 0.081963 0.058747 0.103164 0.074180 0.060243 0.033251 0.104599 0.063129 0.072341 0.042519 0.103301 0.068764
Golgi 0.002506 0.002469 0.001039 0.003603 0.000897 0.001657 0.000858 0.004137 0.001793 0.001952 0.001022 0.003865
Lipid Particles 0.004529 0.001497 0.002174 0.001867 0.003106 0.001021 0.004386 0.002013 0.003898 0.001194 0.002385 0.001938
Mitochondria 0.004438 0.003651 0.000605 0.002099 0.001091 0.004809 0.000172 0.001258 0.002955 0.004388 0.000564 0.001687
Mitotic Spindle 0.001256 0.000267 0.001653 0.014186 0.000519 0.000489 0.000679 0.017318 0.000929 0.000408 0.001560 0.015721
None 0.002763 0.000389 0.001223 0.001540 0.000574 0.000762 0.000548 0.001257 0.001793 0.000627 0.001159 0.001402
Nuclear Periphery 0.000354 0.000414 0.001915 0.000849 0.000320 0.000806 0.001463 0.000788 0.000339 0.000664 0.001872 0.000819
Nuclear Periphery Foci 0.000328 0.000281 0.002623 0.001868 0.000228 0.000317 0.017366 0.001441 0.000284 0.000304 0.004031 0.001659
Nucleolus 0.001558 0.001072 0.010456 0.001167 0.000900 0.002711 0.006208 0.001714 0.001266 0.002115 0.010051 0.001435
Nucleus 0.017585 0.008332 0.079174 0.037848 0.025304 0.016089 0.060578 0.050222 0.021005 0.013269 0.077397 0.043913
Peroxisomes 0.002473 0.002459 0.002874 0.006496 0.001906 0.000590 0.004240 0.005294 0.002222 0.001269 0.003005 0.005907
Vacuole 0.658448 0.752797 0.664574 0.518995 0.714071 0.864873 0.596763 0.440543 0.683090 0.824135 0.658095 0.480542
Vacuole Periphery 0.019118 0.038498 0.017987 0.008644 0.009926 0.028813 0.007270 0.010615 0.015046 0.032333 0.016963 0.009610

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.58 -1.63 -1.81 -1.77 -1.53 -1.34 -4.78 -4.90 -4.74 -0.39 -0.15 -2.37 -2.50 -2.49 -1.77
Bud Neck 6.03 0.47 1.50 -4.46 0.92 5.62 0.58 -4.45 -9.62 -2.99 9.02 -0.58 -1.88 -10.46 -0.92
Bud Site -1.81 2.15 -7.40 -5.14 -8.75 0.04 -2.56 -13.33 -13.14 -4.11 0.58 -1.54 -14.41 -14.29 -12.32
Cell Periphery -0.70 7.59 6.16 4.79 -1.68 -9.56 6.38 2.80 10.12 -3.17 -7.83 8.03 6.82 11.06 -1.84
Cytoplasm 8.15 8.12 -17.39 -23.82 -24.23 18.71 -2.33 -20.72 -36.96 -8.12 20.89 7.93 -26.98 -44.73 -32.27
Cytoplasmic Foci 4.72 12.90 5.89 0.20 -8.25 15.20 2.07 3.85 -14.32 -0.18 15.68 14.85 6.96 -10.44 -9.36
Eisosomes 5.05 4.68 4.84 -1.05 0.51 4.83 -1.93 4.21 -1.25 4.89 6.58 5.02 6.09 -1.72 2.26
Endoplasmic Reticulum -4.05 -6.83 1.75 4.91 7.87 -11.26 -4.32 -0.52 6.25 3.18 -11.35 -7.42 0.11 9.13 6.64
Endosome 5.14 -3.09 7.86 2.53 9.80 8.05 -1.56 4.40 -2.95 3.05 10.94 -5.31 9.05 -1.13 11.46
Golgi 0.07 5.23 0.63 0.41 -2.14 -1.35 0.83 -2.62 -1.16 -3.12 -0.34 4.02 -1.23 -0.70 -3.42
Lipid Particles 5.59 3.90 4.74 -2.17 1.01 5.07 -1.77 2.40 -5.19 3.33 7.75 3.33 5.28 -5.64 1.82
Mitochondria 0.68 6.40 3.87 1.93 -1.59 -3.92 5.27 -0.31 3.89 -8.22 -1.86 6.85 3.87 4.12 -2.59
Mitotic Spindle 2.03 -1.84 -6.49 -7.23 -5.42 0.09 -0.68 -7.56 -7.62 -7.46 1.57 -2.38 -9.92 -10.46 -8.04
None 3.56 1.86 1.88 -4.82 -0.47 -0.66 -1.41 -5.02 -2.65 -2.42 2.84 1.03 0.73 -4.16 -0.68
Nuclear Periphery -0.42 -8.17 -5.95 -5.06 3.34 -2.04 -3.54 -11.74 -2.52 0.66 -2.00 -9.01 -10.70 -4.12 3.61
Nuclear Periphery Foci 0.47 -4.51 -4.85 -5.02 1.41 -1.12 -3.47 -4.51 -4.18 3.22 -0.32 -5.64 -6.58 -6.50 3.48
Nucleolus 1.64 -8.13 0.94 -0.99 8.58 -3.78 -1.51 -4.13 1.71 1.18 -2.38 -8.62 -1.28 1.67 8.41
Nucleus 5.64 -13.38 -14.19 -17.81 3.56 3.99 -5.25 -14.97 -17.15 0.18 5.10 -13.84 -20.73 -23.42 2.14
Peroxisomes 0.10 -0.56 -2.88 -2.62 -2.25 2.93 -1.51 -2.61 -5.39 -0.30 3.15 -1.34 -3.84 -6.35 -2.26
Vacuole -8.20 0.64 13.61 21.07 12.98 -16.43 5.68 25.51 47.09 5.56 -19.90 4.27 27.01 49.40 18.84
Vacuole Periphery -8.04 1.52 12.09 14.89 10.38 -11.54 3.09 3.21 13.45 -1.04 -12.37 -0.66 11.55 20.16 9.59
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication
Localization
Cell Percentages vacuole (75%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Cpr5

Cpr5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cpr5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available