Standard name
Human Ortholog
Description Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0.06 0.07 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.08 0.05 0.07 0 0 0 – 0.05 0 0.12 0.14 0.16 0.07 0.06 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.05 0 0 0 0.06 0 0 0 0 – 0 0 0 0.05 0 0.07 0.11 0.11 0.09 0 0.09 0.14 0.18 0.2
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0.11 0.74 0.73 0.4 0.56 0.62 0.58 0.7 – 0.74 0.83 0.05 0.05 0.24 0.06 0 0.11 0 0 0 0 0 0
Nucleus 0.63 0.73 0.42 0.48 0.37 0.39 0.44 0.45 0.47 – 0.45 0.37 0.75 0.59 0.47 0.6 0.49 0.39 0.32 0.6 0.38 0.28 0.23 0.19
Nuclear Periphery 0 0.05 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0 0.06 0 0.06 0 0 0
Nucleolus 0.32 0.18 0.16 0.25 0.32 0.31 0.21 0.21 0.24 – 0.14 0.2 0.14 0.23 0.25 0.25 0.34 0.4 0.29 0.2 0.2 0.27 0.17 0.17
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.08 0 0 0 0.19 0.11 0.08 0.1 0.09 – 0.05 0 0 0 0 0 0.06 0.08 0.13 0.06 0.07 0.16 0.18 0.2
Vac/Vac Membrane 0 0.05 0 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0.06 0.07 0 0.06 0.11 0.07 0.13 0.13
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 2
Bud 0 0 0 2 2 1 0 4 5 – 2 3 0 0 1 0 0 3 3 2 0 2 6 3
Bud Neck 0 0 0 0 0 1 2 0 0 – 1 0 0 0 0 0 0 0 1 0 0 1 0 2
Bud Site 0 0 0 1 1 3 4 8 6 – 8 15 0 0 0 1 0 1 – – – – – –
Cell Periphery 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 4 0 6 7 11 7 12 8 – 6 9 32 53 78 15 9 18 0 0 0 2 2 2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 1 3 3 2 0 0 0 1 1 0
Endosome 12 3 0 0 9 2 4 0 0 – 0 1 2 20 13 16 18 22 22 9 5 33 59 89
Golgi 1 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 2 0 0 1 2 2
Mitochondria 15 24 14 52 62 83 136 173 148 – 98 182 13 17 115 12 6 22 3 2 2 2 4 13
Nucleus 145 159 8 34 57 57 97 133 100 – 60 82 207 222 221 128 79 79 83 145 24 69 77 83
Nuclear Periphery 7 10 0 2 2 1 3 6 5 – 1 7 6 9 7 9 10 6 14 2 3 2 2 7
Nucleolus 73 38 3 18 50 45 47 61 51 – 19 43 38 85 121 54 54 82 74 48 12 66 55 76
Peroxisomes 0 0 0 0 0 1 1 1 0 – 0 0 0 1 0 0 1 1 1 0 0 0 0 2
SpindlePole 19 3 0 0 30 16 17 29 19 – 7 8 0 7 14 6 10 16 34 13 4 39 58 88
Vac/Vac Membrane 6 11 0 0 0 2 5 2 0 – 2 5 4 9 13 17 9 14 9 14 7 16 43 58
Unique Cell Count 229 217 19 71 155 147 219 297 211 132 220 277 376 475 214 161 204 259 243 64 248 328 450
Labelled Cell Count 280 253 25 115 220 223 323 429 342 204 355 302 423 584 261 199 266 259 243 64 248 328 450


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 5.2 3.7 4.0 4.2 3.8 3.6 3.7 3.2 – 3.3 2.8 5.6 5.7 4.8 8.1 9.0 9.4 5.7 5.1 5.9
Std Deviation (1e-4) 0.9 0.8 0.3 1.2 1.4 1.3 1.1 1.2 1.2 – 1.2 0.7 1.3 1.4 1.3 2.3 2.4 2.9 1.3 1.3 1.3
Intensity Change (Log2) – – – 0.09 0.15 0.01 -0.07 -0.02 -0.23 – -0.18 -0.4 0.59 0.62 0.36 1.11 1.27 1.33 0.6 0.45 0.66

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0.4 -0.5 -0.3 0.2 0.2 0.4 – 0.3 -0.4 3.1 1.5 0.4 1.5 0.6 -0.3
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 1.6 2.1
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.019 1.6757 1.8376 1.6545 1.5313 1.4015 3.2021 2.5995 2.6106 2.1116 2.0271 2.3309 0.7623 1.0011 0.8362 0.655 0.474 0.7083
Actin 0.0464 0.0005 0.0119 0.0021 0.0465 0.0005 0.0403 0.0002 0.0227 0.0026 0.0007 0.0046 0.0222 0.0004 0.0063 0.0008 0.0004 0.0003
Bud 0.0008 0.0003 0.0003 0.0003 0.0003 0.0001 0.001 0.0001 0.001 0.0001 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001
Bud Neck 0.0037 0.0026 0.0054 0.0132 0.0604 0.0052 0.0031 0.0014 0.0027 0.0014 0.0068 0.0035 0.0014 0.0008 0.007 0.0019 0.047 0.0047
Bud Periphery 0.0019 0.0011 0.0011 0.0012 0.0007 0.0003 0.0027 0.0003 0.0014 0.0002 0.0004 0.0005 0.0004 0.0003 0.0003 0.0006 0.0005 0.0002
Bud Site 0.0157 0.0055 0.0115 0.0019 0.0011 0.0004 0.0046 0.002 0.0048 0.0006 0.0005 0.0005 0.0011 0.0009 0.0022 0.0004 0.0015 0.0004
Cell Periphery 0.0007 0.0007 0.002 0.0007 0.0002 0.0001 0.0005 0.0001 0.0002 0.0001 0.0001 0.0001 0.0004 0.0003 0.0003 0.0001 0.0002 0.0001
Cytoplasm 0.0023 0.0101 0.0029 0.0002 0.0004 0.0011 0.0086 0.0046 0.002 0.001 0.0002 0.0009 0.0044 0.0048 0.0016 0.0005 0.0003 0.0011
Cytoplasmic Foci 0.0109 0.0026 0.0062 0.0028 0.0104 0.0003 0.0119 0.0017 0.0088 0.0042 0.0033 0.002 0.0021 0.0006 0.0028 0.0012 0.0071 0.0006
Eisosomes 0.0015 0.0001 0.0002 0.0002 0.0002 0 0.0006 0 0.0002 0.0001 0.0001 0 0.0004 0 0.0001 0.0001 0.0001 0
Endoplasmic Reticulum 0.0039 0.0017 0.0014 0.0005 0.0011 0.0008 0.005 0.0004 0.0018 0.0014 0.0001 0.0004 0.0078 0.0023 0.0005 0.0002 0.0001 0.0003
Endosome 0.0189 0.0054 0.007 0.0054 0.0059 0.0009 0.0355 0.0018 0.0149 0.0099 0.0072 0.0046 0.0101 0.0029 0.0017 0.0007 0.0016 0.0007
Golgi 0.008 0.0007 0.0035 0.0025 0.0066 0.0002 0.0123 0.0003 0.0043 0.0064 0.0066 0.0025 0.002 0.0003 0.0008 0.0003 0.0013 0.0002
Lipid Particles 0.0267 0.0054 0.0213 0.0169 0.021 0.0011 0.0247 0.0018 0.0189 0.0139 0.0148 0.0021 0.006 0.0033 0.0042 0.0036 0.0196 0.0018
Mitochondria 0.0055 0.0021 0.0021 0.0031 0.0013 0.0011 0.0398 0.0005 0.0053 0.0127 0.0249 0.0022 0.0024 0.0009 0.0006 0.0005 0.0006 0.0005
None 0.0056 0.0128 0.0018 0.0004 0.0006 0.0003 0.0099 0.0006 0.0006 0.0015 0.0004 0.0007 0.0192 0.0639 0.0026 0.0006 0.0004 0.0009
Nuclear Periphery 0.047 0.06 0.0514 0.0049 0.0057 0.045 0.067 0.0301 0.0548 0.0115 0.0115 0.0151 0.0171 0.0883 0.0678 0.0631 0.0031 0.0337
Nucleolus 0.1337 0.1843 0.3322 0.4826 0.2818 0.2096 0.1185 0.2074 0.2963 0.3929 0.2904 0.223 0.1727 0.1033 0.3512 0.4835 0.3705 0.1769
Nucleus 0.6159 0.5831 0.3799 0.1714 0.161 0.6124 0.4972 0.6671 0.4377 0.285 0.2239 0.6136 0.5917 0.5369 0.4023 0.2703 0.1464 0.6144
Peroxisomes 0.0069 0.0006 0.0029 0.002 0.0265 0.0001 0.0085 0.0006 0.004 0.0054 0.0015 0.0011 0.0033 0.0002 0.0058 0.0006 0.0038 0.0002
Punctate Nuclear 0.0353 0.1063 0.1447 0.2836 0.3674 0.1187 0.0965 0.0765 0.1145 0.2473 0.4051 0.1213 0.1302 0.1844 0.139 0.1699 0.3943 0.1617
Vacuole 0.0057 0.0112 0.0068 0.0031 0.0006 0.0009 0.0065 0.0017 0.0015 0.0009 0.0005 0.0007 0.0039 0.0027 0.0022 0.0003 0.0008 0.0007
Vacuole Periphery 0.003 0.003 0.0035 0.0008 0.0003 0.0009 0.0052 0.0007 0.0015 0.0009 0.0008 0.0004 0.001 0.0026 0.0007 0.0007 0.0001 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.9936 17.1378 8.478 11.0199 14.7296 19.8702 24.9491 17.1097 13.2836 17.4591
Translational Efficiency 0.5842 0.8344 0.692 0.5137 0.551 0.4106 0.4853 0.3937 0.5015 0.4689

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
338 738 1028 419 1564 1640 951 615 1902 2378 1979 1034

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 662.41 780.14 1014.22 941.02 676.36 757.73 929.48 981.60 673.88 764.68 973.50 965.16
Standard Deviation 75.07 126.41 128.55 137.25 93.73 102.51 118.44 136.18 90.85 110.97 130.83 138.06
Intensity Change Log 2 — 0.236009 0.614574 0.506501 — 0.163893 0.458632 0.537344 — 0.200025 0.537897 0.522166

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001045 0.000893 0.001236 0.001087 0.000411 0.000597 0.001311 0.001537 0.000524 0.000689 0.001272 0.001355
Bud Neck 0.002958 0.004553 0.024333 0.024417 0.006685 0.007498 0.011031 0.018999 0.006023 0.006584 0.017940 0.021195
Bud Site 0.000928 0.001408 0.003656 0.011801 0.001142 0.001558 0.002619 0.005646 0.001104 0.001511 0.003158 0.008140
Cell Periphery 0.000084 0.000120 0.000065 0.000191 0.000112 0.000108 0.000076 0.000097 0.000107 0.000112 0.000071 0.000135
Cytoplasm 0.023920 0.020836 0.002445 0.024456 0.023857 0.011908 0.002978 0.003238 0.023868 0.014679 0.002701 0.011836
Cytoplasmic Foci 0.011809 0.007223 0.000138 0.005430 0.004877 0.006879 0.001229 0.001722 0.006109 0.006986 0.000663 0.003225
Eisosomes 0.000067 0.000066 0.000038 0.000051 0.000050 0.000057 0.000053 0.000047 0.000053 0.000060 0.000045 0.000048
Endoplasmic Reticulum 0.001890 0.005102 0.005954 0.004399 0.002299 0.004501 0.004552 0.007592 0.002226 0.004688 0.005280 0.006298
Endosome 0.001588 0.002378 0.000642 0.020182 0.001941 0.002860 0.001063 0.005351 0.001878 0.002710 0.000845 0.011361
Golgi 0.001332 0.001512 0.000370 0.004685 0.001200 0.002822 0.000771 0.002809 0.001224 0.002415 0.000563 0.003569
Lipid Particles 0.007845 0.004503 0.000341 0.001733 0.002339 0.006971 0.000758 0.000924 0.003318 0.006205 0.000541 0.001252
Mitochondria 0.007013 0.005672 0.002012 0.022641 0.003876 0.011935 0.001598 0.009427 0.004433 0.009991 0.001813 0.014781
Mitotic Spindle 0.023539 0.045869 0.049960 0.396583 0.020981 0.041581 0.057595 0.272474 0.021435 0.042912 0.053629 0.322766
None 0.015530 0.020911 0.002719 0.009944 0.018552 0.006342 0.004008 0.003016 0.018015 0.010864 0.003338 0.005824
Nuclear Periphery 0.002859 0.003004 0.001973 0.006810 0.003205 0.009409 0.001274 0.006874 0.003144 0.007422 0.001637 0.006848
Nuclear Periphery Foci 0.024472 0.043034 0.009729 0.015810 0.034064 0.029022 0.010870 0.030142 0.032359 0.033370 0.010277 0.024335
Nucleolus 0.359499 0.261886 0.154739 0.141957 0.363327 0.279280 0.352813 0.248058 0.362647 0.273882 0.249922 0.205063
Nucleus 0.506876 0.564089 0.734890 0.273543 0.507677 0.568521 0.541790 0.365292 0.507534 0.567145 0.642097 0.328113
Peroxisomes 0.005490 0.004744 0.001212 0.004251 0.002203 0.004387 0.001943 0.001563 0.002787 0.004498 0.001563 0.002652
Vacuole 0.000889 0.001642 0.003245 0.022417 0.000840 0.002801 0.001342 0.010666 0.000849 0.002442 0.002330 0.015428
Vacuole Periphery 0.000368 0.000554 0.000303 0.007613 0.000363 0.000962 0.000327 0.004525 0.000364 0.000835 0.000315 0.005776

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.19 -1.37 -1.76 -5.95 -1.61 -3.22 -6.95 -12.91 -11.15 -3.35 -2.05 -7.95 -10.76 -12.83 -3.77
Bud Neck -3.48 -16.78 -10.36 -9.71 -0.43 -1.44 -6.99 -12.66 -12.26 -9.07 -1.58 -16.16 -15.81 -15.46 -5.38
Bud Site -2.25 -5.06 -8.30 -6.98 -4.78 -1.33 -3.42 -8.70 -8.15 -4.66 -2.23 -5.84 -11.88 -10.83 -6.57
Cell Periphery -2.76 -0.34 -4.29 -1.64 -4.86 0.16 2.13 -0.13 -0.28 -3.10 -0.45 2.08 -1.99 -1.17 -5.74
Cytoplasm 0.43 4.00 0.53 0.14 -6.27 4.28 9.09 7.50 4.48 -2.96 3.53 10.13 5.03 2.04 -6.92
Cytoplasmic Foci 1.16 4.44 3.57 4.02 -3.67 -1.63 5.70 4.18 5.14 -0.59 -0.99 8.04 5.61 6.54 -2.27
Eisosomes -0.32 4.65 -0.15 0.12 -4.43 -2.56 -2.15 -2.10 0.06 -0.32 -3.09 1.73 -2.60 -0.19 -4.00
Endoplasmic Reticulum -6.48 -10.58 -9.81 -5.56 -3.92 -7.66 -9.83 -10.56 -7.25 -6.42 -10.04 -15.15 -14.34 -9.27 -7.17
Endosome -1.11 2.90 -3.63 -3.07 -4.13 -1.13 2.83 -1.74 -0.61 -4.08 -1.34 3.84 -3.81 -3.00 -5.39
Golgi -0.24 2.72 -0.15 0.02 -2.20 -2.04 2.63 0.34 2.01 -1.21 -2.07 4.31 0.01 1.78 -2.52
Lipid Particles 1.50 3.84 3.26 4.01 -5.19 -4.60 4.88 5.66 6.42 -0.81 -3.60 6.83 5.55 7.30 -3.52
Mitochondria 0.22 1.32 -0.71 -1.10 -2.17 -6.56 5.09 -1.17 3.53 -2.80 -5.27 3.58 -1.70 1.69 -3.30
Mitotic Spindle -3.07 -4.26 -14.17 -12.71 -12.32 -4.09 -7.20 -15.13 -13.47 -10.75 -5.22 -8.50 -20.86 -18.59 -16.35
None -1.38 4.76 2.52 4.14 -4.02 8.74 10.31 10.91 4.75 -0.42 4.95 12.18 9.71 4.99 -3.71
Nuclear Periphery -0.38 0.23 -5.01 -5.40 -5.97 -7.41 4.80 -5.73 1.64 -8.40 -7.02 3.27 -7.59 -0.65 -10.00
Nuclear Periphery Foci -2.90 4.17 2.74 6.58 -2.50 2.24 7.68 4.40 2.51 -2.22 0.44 9.90 6.04 5.96 -3.46
Nucleolus 5.92 10.42 13.00 10.29 4.95 8.73 1.31 12.82 5.91 10.70 10.75 11.23 19.57 11.05 9.64
Nucleus -3.09 -9.64 2.73 6.51 13.62 -6.11 -1.94 3.93 8.50 5.18 -6.74 -10.59 5.18 10.85 13.94
Peroxisomes -0.05 2.70 2.18 3.19 -1.27 -2.83 1.01 2.82 4.71 3.04 -2.77 3.15 2.99 5.46 0.24
Vacuole -1.25 -5.28 -7.21 -7.09 -6.34 -4.51 -4.18 -6.95 -5.82 -6.10 -4.81 -7.24 -9.72 -8.95 -8.36
Vacuole Periphery -1.33 -0.87 -2.14 -1.94 -2.09 -3.35 -0.59 -2.13 -1.22 -2.09 -3.59 -1.14 -3.00 -2.20 -2.94
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin
Localization
Cell Percentages nucleus (51%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Ycg1

Ycg1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ycg1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available