Standard name
Human Ortholog
Description Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.05 0 0.05 0.12 0.11 0.12 0.08 0.08 0.12 – 0.08 0.07 0.13 0.23 0.32 0.21 0.23 0.29 0 0 0 0.08 0.09 0.07
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.14 0 0.17 0.25 0.26 0.48 – 0.46 0.54 0 0 0 0 0.05 0 0 0 0 0 0 0
Nucleus 0.56 0.6 0.64 0.54 0.32 0.42 0.47 0.49 0.43 – 0.45 0.42 0.35 0.17 0.09 0.35 0.31 0.27 0.57 0.77 0.63 0.58 0.48 0.36
Nuclear Periphery 0.05 0 0 0 0 0 0.06 0 0.05 – 0 0 0 0 0 0 0 0 0.2 0 0.09 0 0 0.05
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.47 0.58 0.35 0.32 0.59 0.39 0.31 0.29 0.2 – 0.23 0.23 0.67 0.7 0.64 0.47 0.42 0.5 0.09 0.11 0.17 0.16 0.26 0.33
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 1 0 2 1 0 0 1 0 0 1 0 0
Bud 0 0 0 0 0 2 2 4 5 – 7 5 1 0 2 2 0 1 5 6 3 14 31 26
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 2
Bud Site 0 0 0 0 0 1 4 3 0 – 3 7 0 0 0 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 1 2 1 1 0 0 0 0 0 0 0
Cytoplasm 14 12 10 23 27 34 31 39 29 – 23 28 47 106 148 51 25 47 2 2 3 21 39 34
Endoplasmic Reticulum 2 0 0 0 1 2 0 1 0 – 0 1 1 4 0 7 5 8 2 0 1 0 4 6
Endosome 1 0 0 0 4 4 3 4 1 – 0 0 1 2 3 5 3 2 4 1 2 6 10 26
Golgi 1 0 0 0 0 0 0 0 0 – 0 0 0 0 1 3 2 1 5 2 1 1 0 1
Mitochondria 2 4 8 26 10 49 95 132 117 – 136 220 0 1 13 10 5 3 0 2 2 1 3 5
Nucleus 170 188 123 102 79 118 181 251 104 – 131 171 129 78 39 85 33 44 191 259 141 157 210 179
Nuclear Periphery 16 1 3 2 9 7 23 19 11 – 12 11 2 1 1 2 0 3 66 10 21 7 8 23
Nucleolus 0 0 0 0 2 1 3 4 3 – 4 8 0 0 1 3 3 5 21 11 5 7 6 9
Peroxisomes 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 2 1 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 0 1 0 0 2 – 1 0 0 1 0 1 1 0 4 0 2 3 8 11
Vac/Vac Membrane 143 184 68 60 147 110 121 148 48 – 67 94 249 318 295 115 45 80 30 36 37 42 114 163
Unique Cell Count 304 315 192 189 248 281 386 517 244 293 408 370 457 458 245 107 161 339 336 226 272 441 500
Labelled Cell Count 349 389 212 213 279 329 463 606 320 384 545 431 512 507 288 124 195 339 336 226 272 441 500


Cytoplasm, Nuclear Periphery, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.0 8.4 6.1 6.0 6.5 6.0 5.8 5.8 5.3 – 5.1 4.9 9.0 8.9 7.7 10.7 12.2 11.7 8.3 7.7 8.8
Std Deviation (1e-4) 1.4 1.9 1.0 1.1 1.0 1.3 1.1 1.1 1.7 – 1.4 1.1 1.7 1.7 1.5 3.1 4.1 3.9 3.1 1.6 1.8
Intensity Change (Log2) – – – -0.04 0.1 -0.02 -0.09 -0.09 -0.2 – -0.27 -0.32 0.56 0.54 0.33 0.81 1.0 0.94 0.44 0.34 0.52

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 2.4 2.1 2.5 1.2 1.1 2.4 – 1.1 0.8 2.8 5.5 7.4 4.7 4.7 6.1
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 3.3 -0.1 4.4 6.0 6.4 10.0 – 10.0 11.7 0 0 -0.9 0 0 -1.2
Nucleus -2.0 -6.7 -4.7 -3.9 -3.7 -4.4 – -4.2 -5.1 -6.6 -11.8 -14.9 -6.1 -5.5 -6.9
Nuclear Periphery 0 1.3 0 2.4 1.4 1.7 – 1.6 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole -0.8 5.0 0.8 -1.0 -1.7 -3.7 – -3.0 -3.2 7.2 8.1 6.8 2.4 1.1 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.423 11.1566 10.193 9.7747 9.1383 10.4142 5.7968 8.6457 7.6627 6.7733 6.4869 7.5835 6.4067 7.0735 6.5341 6.3826 6.1193 6.5533
Actin 0.0003 0.0002 0.0007 0.0002 0.0012 0.0005 0.0761 0.0002 0.0081 0.0424 0.0144 0.0045 0.0042 0.0002 0.0033 0.0004 0.0005 0.0003
Bud 0 0 0.0001 0 0 0.0001 0.0008 0 0.0002 0.0004 0.0006 0.0001 0 0 0.0001 0 0 0
Bud Neck 0.0002 0.0004 0.0004 0.001 0.0018 0.0035 0.0121 0.0001 0.0006 0.0118 0.0014 0.0013 0.0002 0.0002 0.0002 0.0002 0.0005 0.0019
Bud Periphery 0 0 0.0001 0 0.0001 0.0002 0.0011 0 0.0002 0.0006 0.0008 0.0003 0 0 0 0 0 0
Bud Site 0.0001 0.0002 0.0038 0 0.0001 0.0001 0.0055 0.0001 0.0054 0.0034 0.0052 0.0001 0.0001 0.0001 0.0007 0 0 0
Cell Periphery 0 0.0001 0.0001 0 0 0.0001 0.0004 0 0.0002 0.0004 0.0002 0 0 0 0 0 0 0
Cytoplasm 0.007 0.045 0.0131 0.0289 0.0032 0.0033 0.0158 0.005 0.0055 0.0215 0.0066 0.002 0.0042 0.0091 0.0042 0.0038 0.0016 0.0025
Cytoplasmic Foci 0 0.0002 0.0001 0.0001 0.0001 0 0.0259 0 0.005 0.0023 0.0346 0.0009 0.0043 0 0.0002 0 0 0
Eisosomes 0 0 0.0001 0 0 0 0.0005 0 0.0001 0.0005 0.0002 0.0001 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0042 0.0066 0.0012 0.002 0.0029 0.0039 0.0062 0.0013 0.003 0.0108 0.0028 0.003 0.0024 0.0016 0.0014 0.0033 0.0015 0.0015
Endosome 0.0008 0.0011 0.0003 0.0005 0.0019 0.0006 0.0305 0.0009 0.0045 0.0095 0.0259 0.0061 0.005 0.0003 0.0006 0.0005 0.0005 0.0003
Golgi 0 0 0.0001 0 0.0001 0 0.0145 0 0.0056 0.0038 0.0188 0.0054 0.0009 0 0.0002 0 0 0
Lipid Particles 0 0 0.0001 0 0.0001 0 0.0182 0 0.005 0.0027 0.0308 0.0044 0.0024 0 0.0003 0 0 0
Mitochondria 0.0004 0.0004 0.0019 0.0003 0.0012 0.0006 0.0119 0.0005 0.0045 0.0041 0.0168 0.0099 0.0005 0.0002 0.0004 0.0004 0.0008 0.0003
None 0.0002 0.0002 0.0001 0.0001 0.0002 0.0001 0.0267 0.0001 0.0087 0.0042 0.0066 0.0002 0.0017 0.0001 0.0006 0.0002 0.0001 0.0001
Nuclear Periphery 0.2292 0.1545 0.1715 0.159 0.1523 0.1389 0.2247 0.1975 0.2077 0.1879 0.2559 0.1654 0.2637 0.2268 0.2137 0.2947 0.2728 0.1656
Nucleolus 0.001 0.0012 0.0009 0.0011 0.0035 0.005 0.0023 0.0012 0.0007 0.0011 0.0028 0.0019 0.0009 0.0011 0.0007 0.0005 0.0033 0.0019
Nucleus 0.7524 0.7849 0.8028 0.8028 0.8262 0.8383 0.4873 0.7887 0.7284 0.6852 0.5425 0.7886 0.7028 0.7569 0.7675 0.6631 0.7117 0.8224
Peroxisomes 0 0 0.0001 0 0 0 0.0106 0 0.0022 0.0012 0.0223 0.0007 0.0014 0 0.0002 0 0 0
Punctate Nuclear 0.001 0.0012 0.0004 0.0023 0.0026 0.0017 0.0216 0.0006 0.0011 0.0024 0.0041 0.0009 0.0027 0.0016 0.0042 0.0311 0.0039 0.0014
Vacuole 0.0014 0.0026 0.001 0.0008 0.0011 0.0018 0.0032 0.0013 0.0011 0.0021 0.0025 0.0012 0.001 0.0009 0.0005 0.0004 0.0006 0.0008
Vacuole Periphery 0.0016 0.0011 0.0011 0.0007 0.0013 0.0013 0.0041 0.0023 0.0022 0.002 0.0042 0.003 0.0013 0.0009 0.0008 0.0015 0.0018 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 37.2305 33.0134 39.634 45.5329 29.7801 39.9106 39.7573 41.0287 45.0323 42.3328
Translational Efficiency 0.8717 0.6929 0.6 0.6376 0.6781 0.7558 0.6264 0.5724 0.5541 0.4854

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1468 321 162 1327 1957 1947 214 1165 3425 2268 376 2492

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 719.52 931.76 1406.24 1207.54 790.37 951.15 1281.99 1207.56 760.00 948.41 1335.52 1207.55
Standard Deviation 96.83 162.14 159.62 182.91 126.84 131.25 173.71 183.36 120.17 136.22 178.71 183.12
Intensity Change Log 2 — 0.372924 0.966736 0.746964 — 0.267145 0.697785 0.611495 — 0.318521 0.832213 0.677639

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000144 0.000929 0.002201 0.001110 0.000325 0.000231 0.001558 0.001200 0.000247 0.000330 0.001835 0.001152
Bud Neck 0.001843 0.003124 0.008868 0.026249 0.002406 0.002682 0.011830 0.021454 0.002165 0.002744 0.010554 0.024008
Bud Site 0.000714 0.001227 0.001457 0.019910 0.000517 0.000862 0.001467 0.006569 0.000602 0.000914 0.001463 0.013673
Cell Periphery 0.000122 0.000119 0.000126 0.000216 0.000117 0.000045 0.000134 0.000187 0.000119 0.000055 0.000131 0.000203
Cytoplasm 0.127241 0.066061 0.004495 0.071014 0.069285 0.026298 0.013349 0.046228 0.094126 0.031926 0.009534 0.059427
Cytoplasmic Foci 0.006906 0.007630 0.000238 0.005629 0.001749 0.002419 0.000244 0.005320 0.003959 0.003156 0.000241 0.005485
Eisosomes 0.000019 0.000025 0.000063 0.000026 0.000012 0.000011 0.000044 0.000022 0.000015 0.000013 0.000052 0.000024
Endoplasmic Reticulum 0.010286 0.036000 0.026522 0.007958 0.016509 0.020807 0.031488 0.012705 0.013842 0.022957 0.029349 0.010177
Endosome 0.001730 0.003062 0.000983 0.014333 0.001102 0.001923 0.001347 0.008269 0.001371 0.002084 0.001190 0.011498
Golgi 0.000442 0.000890 0.000131 0.005175 0.000119 0.000369 0.000110 0.006971 0.000257 0.000443 0.000119 0.006015
Lipid Particles 0.003122 0.003618 0.000957 0.003286 0.000795 0.001724 0.000683 0.001131 0.001792 0.001993 0.000801 0.002279
Mitochondria 0.004235 0.005629 0.001981 0.005529 0.002001 0.005320 0.002478 0.007858 0.002958 0.005364 0.002264 0.006618
Mitotic Spindle 0.001072 0.002329 0.000462 0.127324 0.003003 0.004718 0.002733 0.073303 0.002175 0.004380 0.001755 0.102069
None 0.020471 0.007243 0.000565 0.017306 0.016694 0.001994 0.003459 0.005635 0.018313 0.002737 0.002212 0.011850
Nuclear Periphery 0.047316 0.082564 0.004486 0.010366 0.074894 0.166536 0.018673 0.012897 0.063074 0.154651 0.012561 0.011549
Nuclear Periphery Foci 0.019439 0.051491 0.001432 0.007291 0.023508 0.017278 0.004103 0.007459 0.021764 0.022120 0.002952 0.007370
Nucleolus 0.012730 0.026299 0.011996 0.007575 0.021540 0.014358 0.009471 0.005062 0.017763 0.016048 0.010559 0.006400
Nucleus 0.738475 0.683778 0.909363 0.631913 0.762581 0.723511 0.880734 0.750555 0.752249 0.717888 0.893069 0.687377
Peroxisomes 0.000497 0.000959 0.000611 0.001135 0.000232 0.000466 0.000468 0.000313 0.000346 0.000536 0.000529 0.000751
Vacuole 0.002834 0.012787 0.022737 0.031696 0.002228 0.007505 0.015270 0.022676 0.002488 0.008252 0.018487 0.027479
Vacuole Periphery 0.000362 0.004234 0.000327 0.004958 0.000384 0.000942 0.000356 0.004187 0.000375 0.001408 0.000343 0.004598

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.15 -13.29 -16.76 -1.11 7.06 2.41 -11.54 -15.54 -16.87 3.82 -2.99 -17.36 -22.20 -17.10 7.70
Bud Neck -2.72 -7.66 -17.29 -15.65 -9.67 -1.40 -7.00 -14.82 -14.57 -3.88 -2.90 -9.46 -22.75 -22.06 -8.48
Bud Site -1.49 -5.47 -8.35 -6.35 -6.75 -1.85 -4.12 -10.99 -9.20 -3.95 -1.98 -5.69 -12.18 -10.72 -7.39
Cell Periphery -0.28 -2.38 -4.74 -2.76 -1.03 8.56 -2.92 -6.36 -15.32 -1.37 9.04 -3.77 -7.93 -18.35 -1.63
Cytoplasm 6.49 24.32 13.44 1.78 -16.49 12.46 15.43 7.43 -4.77 -9.08 18.93 27.68 14.29 -5.64 -16.93
Cytoplasmic Foci 0.03 8.89 7.06 2.16 -4.09 -1.27 4.79 0.62 1.70 -2.97 1.53 10.03 5.95 3.06 -4.78
Eisosomes -2.24 -8.97 -8.74 -2.40 6.29 0.06 -8.01 -14.38 -12.88 4.11 0.94 -11.78 -16.97 -15.15 7.01
Endoplasmic Reticulum -8.72 -8.17 1.92 9.26 8.94 -4.43 -5.82 5.93 9.64 7.92 -10.17 -9.33 6.71 14.88 11.70
Endosome -2.05 0.79 -3.04 -0.79 -3.70 -3.76 -3.59 -4.82 -2.65 -3.18 -2.99 -1.31 -5.37 -3.31 -4.78
Golgi -0.97 1.20 -1.23 -0.34 -1.94 -1.29 -2.20 -3.01 -2.47 -2.92 -0.90 0.87 -3.15 -2.51 -3.48
Lipid Particles -0.20 3.18 2.65 1.59 -0.18 -3.66 -1.07 -1.99 2.55 -0.44 -0.51 2.51 1.79 2.22 -0.45
Mitochondria -0.75 1.73 -0.23 0.76 -8.54 -4.86 -3.76 -5.04 0.26 -3.58 -3.16 0.70 -3.26 0.91 -6.50
Mitotic Spindle -1.11 -0.63 -13.93 -13.52 -13.67 -1.31 -0.74 -10.31 -9.93 -7.95 -2.16 -0.83 -17.15 -16.26 -14.50
None 6.33 11.11 4.51 -2.97 -11.59 10.62 9.13 6.63 -9.16 -5.01 13.96 14.17 7.33 -11.18 -11.13
Nuclear Periphery -3.62 11.88 10.11 7.87 -4.90 -13.34 11.75 15.74 26.18 0.61 -15.93 15.86 18.74 27.40 -0.74
Nuclear Periphery Foci -4.14 7.25 7.49 6.42 -1.07 2.62 8.28 9.00 7.06 -0.53 0.05 10.98 11.82 9.82 -0.96
Nucleolus -3.97 1.73 -0.02 3.79 -1.64 4.52 7.42 6.47 2.45 -1.27 1.51 6.35 5.05 3.10 -2.23
Nucleus 3.02 -13.41 3.29 -0.96 15.50 4.14 -7.88 0.81 -2.75 7.76 4.21 -14.09 3.45 -0.81 15.68
Peroxisomes -1.36 -0.14 1.10 1.78 1.51 -2.96 -3.10 -1.36 2.31 2.59 -2.00 -2.43 0.37 2.23 2.69
Vacuole -4.66 -7.45 -15.00 -9.50 -4.58 -5.42 -6.47 -13.59 -11.17 -2.50 -6.60 -9.54 -20.18 -16.28 -5.02
Vacuole Periphery -2.33 -0.07 -2.30 1.86 -2.36 -3.31 0.18 -1.85 -0.57 -1.87 -3.77 0.06 -2.87 0.65 -2.91
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog
Localization
Cell Percentages nucleus (46%), nuclear periphery (11%), mixed (36%)
Cell Cycle Regulation Yes
nucleus - MA (0.00067)
Subcompartmental Group N/A

Msn5

Msn5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Msn5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available