Standard name
Human Ortholog
Description Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.1 0.16 0.15 0.18 0.2 0.22 0.22 0.26 0.21 0 0 0 0.09 0.09 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0.05 0.05 0.1 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06
Golgi 0 0 0 0.1 0.09 0.06 0.05 0 0 0 0 0 0 0 0 0.06 0.08 0 0 0 0 0 0 0
Mitochondria 0.13 0 0 0 0.05 0.12 0.17 0.08 0.25 0.15 0.22 0.17 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.07 0.12 0 0 0.07 0.07 0 0.05 0 0 0 0 0.07 0 0 0 0 0.06 0 0.06 0 0.07 0.06 0
Nuclear Periphery 0.19 0.09 0.08 0.2 0.07 0.12 0.13 0.13 0.1 0.07 0.08 0.05 0.07 0.15 0.14 0.11 0.2 0.14 0.08 0 0.05 0 0 0
Nucleolus 0.13 0 0.06 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.73 0.83 0.85 0.78 0.72 0.61 0.58 0.54 0.57 0.54 0.52 0.61 0.87 0.86 0.88 0.85 0.82 0.82 0.81 0.8 0.84 0.82 0.81 0.79
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 4 2 2 3 3 0 0 1 0 0 1 0 2 0 0 0 0
Bud 0 0 0 0 0 0 0 0 2 2 0 0 0 0 0 0 0 0 1 0 2 0 6 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 1 6 2 5 6 13 14 6 0 0 1 3 0 2 0 0 0 0 0 0
Cytoplasm 3 2 9 19 39 36 59 53 55 67 66 56 12 18 16 22 21 17 0 0 1 0 0 1
Endoplasmic Reticulum 0 2 2 2 4 11 18 26 9 16 7 4 1 2 7 8 6 7 0 0 0 0 0 0
Endosome 2 1 6 2 1 1 2 1 1 1 1 1 13 19 12 3 8 2 6 3 5 6 24 25
Golgi 0 3 4 18 23 15 15 5 1 8 4 3 6 7 13 15 19 6 0 0 0 0 1 1
Mitochondria 18 1 4 8 11 29 55 20 62 44 55 45 4 3 1 4 4 7 1 2 3 3 3 6
Nucleus 10 17 8 6 16 16 13 12 6 13 9 10 23 15 13 9 10 11 5 9 4 20 22 17
Nuclear Periphery 26 12 15 37 18 29 43 33 24 21 21 13 23 62 55 28 44 29 12 5 10 5 7 16
Nucleolus 18 5 11 7 4 1 3 3 4 1 2 0 17 24 14 5 5 5 2 2 2 8 6 8
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 1 0 0 0 0 1 2 0 0 0 0 1 1 0 0 5
Vac/Vac Membrane 99 115 168 142 176 148 194 140 143 165 132 160 304 365 349 209 185 164 120 131 177 232 311 342
Unique Cell Count 135 138 197 181 244 244 332 260 251 303 254 264 350 426 396 245 225 200 149 164 212 282 386 433
Labelled Cell Count 176 158 228 241 293 293 404 303 316 353 314 301 403 516 484 306 302 251 149 164 212 282 386 433


Vacuole Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.9 15.8 12.7 12.5 13.2 11.3 10.4 9.9 9.0 9.3 9.3 9.1 14.4 13.4 13.7 16.8 16.4 15.2 13.8 13.4 14.7
Std Deviation (1e-4) 2.6 4.2 3.4 2.8 3.6 3.5 3.0 2.8 2.6 2.7 2.3 2.5 4.9 3.9 3.9 6.5 7.7 5.9 3.7 4.4 4.4
Intensity Change (Log2) – – – -0.03 0.05 -0.17 -0.3 -0.36 -0.5 -0.45 -0.46 -0.48 0.18 0.08 0.11 0.4 0.37 0.25 0.12 0.08 0.21

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 2.5 2.9 0 0 0 0 0 0 0
Cytoplasm 2.2 3.8 3.5 4.4 4.9 5.2 5.3 6.1 5.1 -0.7 -0.2 -0.3 1.8 1.9 1.6
Endoplasmic Reticulum 0 0 2.2 2.6 4.0 0 2.5 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0.4 0.8 0 0 0.3 0
Golgi 3.3 3.2 2.1 1.5 0 0 0 0 0 0 0 0.9 2.1 2.9 0
Mitochondria 1.3 1.4 3.9 5.1 2.7 6.7 4.6 6.1 5.2 0 0 0 0 0 0.9
Nucleus -0.4 1.1 1.1 -0.1 0.3 -1.0 0.1 -0.3 -0.1 1.2 -0.3 -0.5 -0.2 0.2 0.7
Nuclear Periphery 3.6 -0.1 1.5 1.9 1.8 0.7 -0.3 0.3 -1.2 -0.5 2.4 2.2 1.3 3.5 2.2
Nucleolus -0.8 -2.3 -3.3 -3.2 -2.7 -2.3 0 -3.0 0 -0.4 0 -1.2 -2.0 -1.8 -1.6
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.7 -3.3 -5.7 -6.4 -7.1 -6.5 -7.1 -7.4 -5.8 0.5 0.1 1.0 0 -0.8 -0.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.3393 7.9763 7.05 6.1956 5.9298 6.6255 5.8297 8.2174 7.9231 6.5621 6.5677 7.5653 6.2979 10.1098 7.9176 7.0919 7.5706 7.9151
Actin 0.0119 0.0001 0.006 0 0.0002 0.0023 0.0381 0.0078 0.0046 0.0001 0.0056 0.0002 0 0 0 0 0 0
Bud 0.0002 0.0002 0.0003 0.0017 0.0003 0.0001 0.0002 0.0002 0.0004 0.0001 0.0002 0.0001 0.0001 0.0001 0.0003 0 0.0002 0.0001
Bud Neck 0.0006 0.0001 0.0003 0.0002 0.0006 0.0001 0.0007 0.0003 0.0007 0.0001 0.0001 0.0001 0.0001 0.0001 0 0 0.0001 0
Bud Periphery 0.0004 0.0005 0.0006 0.0016 0.0008 0.0003 0.0005 0.0003 0.0013 0.0002 0.0003 0.0004 0.0004 0.0002 0.001 0.0001 0.0008 0.001
Bud Site 0.0008 0.0004 0.0006 0.0007 0.0005 0.0001 0.0009 0.0018 0.0009 0.0002 0.0003 0.0002 0.0002 0.0001 0 0 0.0001 0
Cell Periphery 0.0013 0.0011 0.0011 0.0007 0.0004 0.0007 0.0012 0.001 0.0011 0.0003 0.0003 0.0003 0.0012 0.0011 0.0007 0.0001 0.0005 0.0011
Cytoplasm 0.0016 0.0022 0.0059 0.0011 0.0006 0.0002 0.0012 0.0024 0.0029 0.0003 0.0004 0.0002 0.0003 0.0001 0.0003 0 0.0001 0.0001
Cytoplasmic Foci 0.0082 0.0003 0.0032 0.0002 0.001 0.0013 0.0056 0.0049 0.0077 0.0051 0.03 0.0005 0.0007 0.0001 0.0006 0 0 0.0001
Eisosomes 0.0001 0 0.0001 0 0 0 0.0005 0.0001 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0025 0.0003 0.0008 0.0002 0.0006 0.0004 0.0018 0.0007 0.0011 0.0009 0.0006 0.0005 0.0003 0.0002 0.0003 0.0001 0.0003 0.0003
Endosome 0.0267 0.0062 0.0201 0.015 0.0141 0.0109 0.0381 0.0095 0.026 0.0386 0.0256 0.0096 0.0148 0.0043 0.0127 0.0024 0.0037 0.005
Golgi 0.0056 0.0002 0.0016 0.0001 0.0004 0.0011 0.0061 0.0006 0.0026 0.005 0.0126 0.0009 0.0009 0.0001 0.0006 0 0 0.0001
Lipid Particles 0.012 0.0011 0.0043 0.0001 0.0009 0.0051 0.0166 0.0011 0.0057 0.0247 0.0536 0.0072 0.002 0.0006 0.0054 0.0002 0.0002 0.0014
Mitochondria 0.0125 0.0103 0.0234 0.0003 0.0014 0.0038 0.0479 0.0088 0.0136 0.0062 0.0035 0.0202 0.0116 0.0011 0.0067 0.0002 0.0004 0.0015
None 0.001 0 0.0017 0 0.0002 0.0001 0.0013 0.0004 0.0014 0.0002 0.0003 0.0002 0.0001 0 0 0 0 0
Nuclear Periphery 0.0139 0.0161 0.01 0.0024 0.0206 0.0318 0.0105 0.0113 0.0065 0.0087 0.0037 0.028 0.0041 0.0198 0.006 0.0066 0.0068 0.0181
Nucleolus 0.0058 0.0013 0.0074 0.0007 0.007 0.001 0.0029 0.0014 0.0029 0.0009 0.0004 0.0042 0.004 0.0012 0.0024 0 0.0002 0.0014
Nucleus 0.0056 0.0022 0.0132 0.0015 0.0394 0.0016 0.0026 0.0016 0.0024 0.0011 0.0007 0.0039 0.0034 0.0011 0.0011 0.0002 0.0007 0.0013
Peroxisomes 0.0051 0.0007 0.001 0 0.0001 0.0093 0.0146 0.003 0.0099 0.0013 0.0433 0.0005 0.0003 0 0.0001 0 0 0
Punctate Nuclear 0.001 0 0.0043 0 0.0006 0.0024 0.005 0.0002 0.0046 0.0006 0.0104 0.0017 0.0001 0 0 0 0 0
Vacuole 0.3469 0.3384 0.3152 0.3056 0.2631 0.2119 0.2882 0.3049 0.2826 0.2348 0.2863 0.1527 0.2927 0.2552 0.2643 0.1645 0.2604 0.1981
Vacuole Periphery 0.5364 0.6182 0.579 0.668 0.6472 0.7156 0.5154 0.6378 0.6211 0.6707 0.5217 0.7685 0.6627 0.7145 0.6975 0.8253 0.7256 0.7702

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.4935 23.7806 16.1117 22.5487 25.4931 33.5231 23.2604 19.7563 23.9401 31.3604
Translational Efficiency 1.3769 1.278 1.378 1.0729 1.2478 0.832 1.2236 1.1359 0.8881 0.9887

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
608 1156 2925 922 2549 1477 271 1127 3157 2633 3196 2049

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1279.35 1251.64 1363.21 1319.51 1298.91 1257.31 1450.52 1383.01 1295.14 1254.82 1370.61 1354.44
Standard Deviation 277.26 323.81 270.74 239.49 252.87 229.17 196.80 249.34 257.86 274.78 266.38 246.99
Intensity Change Log 2 — -0.031591 0.091597 0.044591 — -0.046961 0.159269 0.090510 — -0.039314 0.126086 0.067908

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000022 0.000074 0.000016 0.000083 0.000005 0.000054 0.000093 0.000147 0.000008 0.000063 0.000022 0.000118
Bud Neck 0.000170 0.000743 0.000464 0.000776 0.000047 0.000928 0.007225 0.000754 0.000071 0.000846 0.001038 0.000764
Bud Site 0.001317 0.003536 0.001869 0.003275 0.000335 0.001676 0.004426 0.002851 0.000524 0.002493 0.002086 0.003042
Cell Periphery 0.000703 0.001253 0.000568 0.000598 0.000729 0.000346 0.000310 0.000401 0.000724 0.000744 0.000546 0.000489
Cytoplasm 0.001911 0.004548 0.000518 0.000429 0.000374 0.001480 0.000916 0.001913 0.000670 0.002827 0.000552 0.001245
Cytoplasmic Foci 0.000977 0.005993 0.000264 0.001516 0.000158 0.004731 0.001957 0.001464 0.000315 0.005285 0.000408 0.001487
Eisosomes 0.000005 0.000014 0.000019 0.000013 0.000003 0.000011 0.000056 0.000008 0.000003 0.000012 0.000022 0.000010
Endoplasmic Reticulum 0.000382 0.000733 0.000250 0.000399 0.000271 0.000326 0.000936 0.000383 0.000292 0.000505 0.000308 0.000390
Endosome 0.003069 0.008672 0.001104 0.006889 0.000719 0.007566 0.010420 0.004172 0.001172 0.008051 0.001894 0.005394
Golgi 0.001488 0.006395 0.001288 0.020223 0.000723 0.005354 0.002681 0.007823 0.000870 0.005811 0.001406 0.013403
Lipid Particles 0.000152 0.000805 0.000578 0.000664 0.000251 0.000714 0.000357 0.000380 0.000232 0.000754 0.000559 0.000508
Mitochondria 0.005300 0.006574 0.002574 0.011050 0.001555 0.008031 0.007105 0.003687 0.002277 0.007392 0.002958 0.007000
Mitotic Spindle 0.000045 0.000347 0.000107 0.000552 0.000014 0.001032 0.000915 0.000402 0.000020 0.000731 0.000176 0.000469
None 0.000140 0.001150 0.000304 0.000332 0.000136 0.000381 0.000278 0.000170 0.000137 0.000719 0.000302 0.000243
Nuclear Periphery 0.000243 0.000655 0.000812 0.002082 0.000294 0.001676 0.003372 0.001075 0.000284 0.001228 0.001029 0.001528
Nuclear Periphery Foci 0.000118 0.001208 0.000379 0.001415 0.000095 0.002524 0.001849 0.000585 0.000100 0.001946 0.000504 0.000959
Nucleolus 0.000374 0.002764 0.002176 0.001388 0.000364 0.003466 0.030831 0.001682 0.000366 0.003158 0.004605 0.001550
Nucleus 0.000334 0.003079 0.001545 0.000622 0.000219 0.001415 0.015457 0.000927 0.000241 0.002146 0.002724 0.000790
Peroxisomes 0.000190 0.000667 0.000058 0.000176 0.000015 0.000414 0.002378 0.000293 0.000049 0.000525 0.000254 0.000241
Vacuole 0.183585 0.223415 0.237665 0.360615 0.156726 0.194079 0.436836 0.361573 0.161899 0.206959 0.254553 0.361142
Vacuole Periphery 0.799475 0.727374 0.747441 0.586903 0.836966 0.763796 0.471604 0.609309 0.829746 0.747805 0.724052 0.599227

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.97 0.85 -3.35 -0.14 -3.91 -4.72 -6.46 -1.64 -1.06 -0.62 -5.71 -3.99 -2.27 -1.08 -1.98
Bud Neck -4.16 -3.84 -5.75 -0.18 -2.58 -5.85 -6.17 -7.37 0.95 5.55 -7.53 -7.93 -9.96 0.67 2.01
Bud Site -3.04 -0.97 -2.27 0.21 -1.76 -4.36 -3.96 -2.98 -1.45 1.30 -6.09 -4.59 -4.29 -1.03 -1.53
Cell Periphery -1.73 0.64 0.45 2.49 -0.27 4.57 3.25 2.64 -0.50 -0.62 -0.16 2.16 2.30 1.95 0.69
Cytoplasm -1.46 1.18 1.25 3.35 0.55 -2.29 -0.97 -2.02 -0.99 -1.31 -3.29 0.41 -1.47 1.26 -1.75
Cytoplasmic Foci -4.16 2.05 -1.12 3.76 -3.95 -5.61 -3.19 -2.88 3.52 0.77 -7.23 -1.03 -3.95 5.15 -3.67
Eisosomes -3.93 -7.94 -3.93 0.30 2.87 -4.01 -6.53 -5.28 1.29 5.86 -6.27 -13.84 -7.27 1.11 7.38
Endoplasmic Reticulum -2.40 1.45 -0.17 2.63 -2.90 -1.49 -1.81 -1.32 -0.62 1.48 -3.61 -0.48 -1.78 1.54 -1.28
Endosome -4.27 2.59 -3.24 1.28 -6.24 -7.48 -4.39 -5.69 3.16 2.83 -9.56 -2.57 -7.60 3.08 -5.97
Golgi -5.44 0.45 -6.82 -4.86 -6.95 -7.37 -2.95 -6.05 -1.87 -3.86 -9.52 -2.28 -8.98 -5.14 -8.60
Lipid Particles -5.85 -12.29 -4.72 1.13 -0.80 -5.09 -2.51 -1.20 2.38 -0.20 -7.44 -13.41 -3.59 2.52 0.63
Mitochondria -0.48 1.21 -2.02 -1.95 -4.56 -5.50 -3.47 -2.72 3.35 2.02 -4.96 -1.01 -4.53 0.31 -4.08
Mitotic Spindle -2.47 -1.98 -2.20 -0.66 -1.91 -2.79 -2.18 -3.60 1.50 1.03 -3.39 -3.50 -3.88 1.00 -2.48
None -3.02 -4.82 -3.77 2.44 -0.62 -5.43 -3.87 -1.08 5.10 3.37 -3.90 -6.19 -3.46 3.18 2.28
Nuclear Periphery -2.72 -8.28 -3.56 -2.66 -2.45 -3.69 -4.06 -3.93 1.39 2.91 -4.28 -8.51 -4.84 -0.92 -1.88
Nuclear Periphery Foci -3.48 -3.41 -4.00 -0.26 -3.12 -3.98 -5.99 -6.04 3.14 4.12 -5.05 -5.49 -5.64 2.54 -2.72
Nucleolus -4.47 -7.49 -3.25 2.30 2.14 -4.07 -5.54 -3.25 2.02 5.28 -5.74 -8.05 -4.53 2.89 5.14
Nucleus -3.28 -6.38 -1.86 2.94 4.69 -3.69 -4.54 -4.17 1.14 4.30 -4.65 -7.54 -4.91 3.13 5.48
Peroxisomes -2.01 1.31 0.12 2.16 -2.21 -4.21 -2.75 -1.42 0.57 2.37 -4.00 -2.69 -1.71 1.94 0.12
Vacuole -4.10 -6.31 -16.46 -14.49 -14.85 -6.50 -20.20 -27.32 -20.19 4.98 -9.41 -19.53 -34.09 -24.70 -17.22
Vacuole Periphery 6.37 5.51 17.90 12.60 17.69 10.47 22.64 28.34 16.22 -7.90 14.30 20.40 36.45 20.48 18.42
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
Localization
Cell Percentages vacuolar membrane (96%)
Cell Cycle Regulation No
Subcompartmental Group vac memb-2

Ypq2

Ypq2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ypq2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available