Standard name
Human Ortholog
Description Inner plaque spindle pole body (SPB) component; ortholog of human kendrin; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.05 0 0 0 0 0 0 0 0 0 0 0 0.1 0.1 0.08 0.07 0.07 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.1 0.27 0.32 0.18 0.4 0.33 0.32 0.49 0.43 0.48 0.49 0 0 0.09 0 0 0 0 0 0 0 0 0
Nucleus 0.84 0.93 0.92 0.94 0.93 0.87 0.89 0.85 0.83 0.81 0.81 0.79 0.88 0.88 0.86 0.88 0.87 0.87 0.85 0.92 0.91 0.85 0.78 0.59
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0.09 0 0 0 0.08 0.08 0.09 0.09 0.16 0.11 0.16 0 0 0.09 0 0 0 0 0 0 0 0 0.1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0.05 0.07 0.11 0.19
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 1 0 1 0 2 3 3 8 11 4 4 0 0 0 1 0 0 1 0 1 0 0 3
Bud Neck 0 0 0 0 0 0 1 0 1 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Bud Site 0 0 0 1 2 10 10 17 13 25 6 18 0 0 1 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 1 4 9 8 8 11 17 15 2 5 9 15 20 18 29 20 20 0 0 0 0 0 1
Endoplasmic Reticulum 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 9 1 4 0 0 2 0 0 3
Endosome 1 0 0 0 1 0 0 1 0 1 0 0 0 3 0 6 3 1 2 0 0 0 2 3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 4 2 0 0 0 2 1
Mitochondria 3 8 79 118 77 173 203 233 252 278 183 244 1 0 21 12 3 11 0 0 0 0 3 6
Nucleus 106 75 271 350 406 375 544 616 422 522 307 397 129 176 197 388 247 256 113 78 262 44 144 140
Nuclear Periphery 0 0 0 0 7 1 14 20 0 15 9 9 2 0 1 1 2 1 0 0 0 0 0 0
Nucleolus 5 7 3 11 12 33 47 68 46 101 43 82 4 4 21 4 4 4 0 1 0 0 7 22
Peroxisomes 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 9 1 2 0 0 3 1 3 3 9 0 4 2 1 3 1 2 1 9 2 3 0 3 3
Vac/Vac Membrane 3 0 0 3 2 3 5 1 0 1 1 1 0 2 5 15 14 18 0 2 13 3 19 44
Unique Cell Count 126 81 295 374 435 429 613 728 510 648 378 502 147 200 229 442 284 295 133 86 289 53 186 237
Labelled Cell Count 133 93 360 493 515 608 839 979 760 966 559 768 154 206 268 467 297 321 133 86 289 53 186 237


SpindlePole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.0 5.7 5.0 4.9 5.1 4.7 4.4 4.6 4.1 4.1 4.3 4.0 7.8 7.3 5.9 8.1 9.1 9.5 6.9 7.3 8.1
Std Deviation (1e-4) 2.2 1.1 1.0 0.9 1.0 1.2 0.9 1.1 1.2 0.8 1.1 1.0 2.1 1.7 1.4 1.8 1.9 2.1 1.3 1.5 2.4
Intensity Change (Log2) – – – -0.03 0.02 -0.09 -0.17 -0.12 -0.27 -0.27 -0.2 -0.3 0.64 0.56 0.26 0.71 0.87 0.93 0.48 0.56 0.7


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0 0 0 1.0 1.4 0 0 0 4.3 4.4 3.7 3.3 3.4 3.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.3 -2.9 0 0 0 0 0 0 0 -6.7 -8.0 -5.1 -9.7 -8.9 -7.8
Nucleus 0.9 0.8 -1.9 -1.5 -3.1 -3.6 -4.4 -3.9 -4.7 -1.4 -1.4 -2.1 -1.8 -1.9 -2.0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.7 1.6 0 0 0 0 0 0 0 0 0 4.4 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 3.2 3.9 4.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.3608 3.2645 3.0256 2.8511 2.2207 3.332 3.4606 3.1746 3.2921 3.053 3.1104 2.7618 3.4714 3.0755 3.2717 3.4224 2.9548 3.0066
Actin 0.0498 0.004 0.0076 0.0001 0.0004 0.0167 0.0028 0.0002 0.0172 0.0007 0.0625 0.0025 0.0002 0 0 0.0001 0.0029 0
Bud 0.0002 0.0001 0.0002 0 0.0001 0.0001 0.0002 0.0001 0.0002 0 0.0005 0 0 0 0 0 0.0002 0
Bud Neck 0.0038 0.0006 0.0006 0.0002 0.0004 0.0006 0.0003 0.0003 0.0009 0.0002 0.0016 0.0001 0.0007 0 0.0001 0.0036 0.0006 0.0006
Bud Periphery 0.0004 0.0001 0.0005 0.0001 0.0002 0.0001 0.0003 0.0001 0.0002 0 0.001 0.0001 0.0001 0 0 0 0.0004 0
Bud Site 0.0014 0.0004 0.0008 0.0001 0.0007 0 0.0027 0.0116 0.0011 0.0002 0.0013 0 0.0005 0 0.0001 0.0001 0.0007 0
Cell Periphery 0.0002 0 0.0001 0.0001 0.0001 0 0.0001 0.0001 0 0 0.0002 0 0 0 0 0 0.0001 0
Cytoplasm 0.0018 0 0.0137 0.0027 0.0001 0.0001 0.0059 0.0001 0.0012 0.0002 0.0004 0.0001 0.0007 0 0.0001 0 0.0004 0
Cytoplasmic Foci 0.0311 0.0076 0.0246 0.0356 0.0497 0.0017 0.0365 0.0068 0.0384 0.0634 0.0744 0.0019 0.0145 0.0043 0.0077 0.0314 0.0344 0.0096
Eisosomes 0.0007 0.0003 0.0004 0 0.0001 0.0002 0.0001 0 0.0001 0 0.0005 0 0 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0005 0 0.0008 0.0018 0.0002 0.0003 0.0031 0 0.0005 0.0001 0.0014 0.0002 0.0003 0 0.0001 0 0.0002 0
Endosome 0.0033 0.0001 0.0039 0.003 0.0031 0.0018 0.0273 0.0007 0.0055 0.0063 0.0115 0.0032 0.0017 0 0.0002 0.0005 0.005 0.0002
Golgi 0.0045 0.0003 0.0023 0.0003 0.0028 0.0018 0.0037 0.0011 0.003 0.0059 0.0162 0.0021 0.0004 0 0.0003 0.0013 0.0045 0.0002
Lipid Particles 0.0264 0.0015 0.0149 0.0138 0.0869 0.0016 0.0332 0.0073 0.0191 0.0186 0.0976 0.0037 0.0057 0.0005 0.0064 0.0363 0.0302 0.0029
Mitochondria 0.0029 0.0075 0.0105 0.0004 0.0079 0.0004 0.004 0.0001 0.0013 0.0094 0.043 0.0019 0.0002 0 0.0001 0.0011 0.0266 0
None 0.0034 0 0.0005 0.0022 0.0004 0.0006 0.0027 0 0.0004 0.0001 0.0005 0.0001 0.0005 0 0 0 0.0012 0
Nuclear Periphery 0.0015 0.0006 0.0048 0.0199 0.001 0.003 0.0227 0.0003 0.0028 0.0003 0.0013 0.0029 0.0032 0.0001 0.0019 0.0003 0.002 0.0006
Nucleolus 0.0129 0.055 0.0349 0.0272 0.0107 0.0155 0.0224 0.0375 0.0061 0.0031 0.0497 0.0051 0.0391 0.0041 0.0119 0.006 0.0623 0.0279
Nucleus 0.1335 0.1337 0.1835 0.1227 0.0013 0.2326 0.0631 0.0643 0.0313 0.0011 0.0019 0.0179 0.3478 0.3784 0.2857 0.2879 0.2053 0.2623
Peroxisomes 0.0221 0.0013 0.0023 0.0003 0.0073 0.0006 0.0084 0.0022 0.0088 0.0102 0.0084 0.0005 0.0005 0 0.0003 0.0084 0.0161 0.0002
Punctate Nuclear 0.6992 0.7867 0.6927 0.7632 0.8247 0.7218 0.7555 0.8672 0.8614 0.8796 0.6247 0.9568 0.5833 0.6125 0.6848 0.623 0.6059 0.6953
Vacuole 0.0002 0.0001 0.0002 0.0036 0.0013 0.0001 0.003 0.0001 0.0004 0.0003 0.0006 0.0003 0.0004 0 0.0001 0 0.0005 0
Vacuole Periphery 0.0002 0.0001 0.0002 0.0028 0.0008 0.0002 0.0021 0 0.0002 0.0002 0.0007 0.0005 0.0001 0 0.0001 0 0.0003 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.5471 11.1337 4.9054 7.3605 27.2498 14.7817 15.3029 13.7712 9.3574 21.2923
Translational Efficiency 2.1312 3.2657 1.5382 1.4943 1.3242 2.6563 1.5299 1.1217 1.3361 1.4776

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
24 948 521 350 1685 1843 1017 156 1709 2791 1538 506

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 709.81 790.21 1005.49 866.26 671.66 763.83 946.14 938.33 672.20 772.79 966.24 888.48
Standard Deviation 94.83 104.59 124.88 121.96 101.94 99.32 118.94 142.40 101.94 101.91 124.20 132.85
Intensity Change Log 2 — 0.154803 0.502394 0.287367 — 0.185520 0.494323 0.482364 — 0.169819 0.498475 0.385467

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000405 0.000562 0.000561 0.000422 0.000264 0.000468 0.000154 0.000202 0.000266 0.000500 0.000292 0.000354
Bud Neck 0.003520 0.004178 0.002378 0.010595 0.004357 0.010194 0.001421 0.001022 0.004345 0.008151 0.001745 0.007643
Bud Site 0.008813 0.005474 0.007794 0.014220 0.006108 0.010321 0.002406 0.004651 0.006146 0.008675 0.004231 0.011270
Cell Periphery 0.000394 0.000151 0.000064 0.000155 0.000276 0.000244 0.000039 0.000027 0.000278 0.000212 0.000047 0.000116
Cytoplasm 0.197228* 0.007516 0.023501 0.055850 0.024689 0.023019 0.004991 0.001006 0.027112 0.017753 0.011261 0.038941
Cytoplasmic Foci 0.452159* 0.075424 0.029807 0.041546 0.178983 0.120171 0.004537 0.030025 0.182819* 0.104972 0.013097 0.037994
Eisosomes 0.000093 0.000130 0.000022 0.000091 0.000207 0.000135 0.000021 0.000021 0.000205 0.000133 0.000021 0.000069
Endoplasmic Reticulum 0.000348 0.001417 0.000780 0.001375 0.001284 0.001673 0.000531 0.000234 0.001271 0.001586 0.000615 0.001023
Endosome 0.008312 0.011846 0.004409 0.015893 0.016915 0.022544 0.001284 0.003808 0.016794 0.018910 0.002342 0.012167
Golgi 0.007273 0.011281 0.001429 0.006159 0.019155 0.014192 0.000648 0.001006 0.018988 0.013204 0.000912 0.004570
Lipid Particles 0.003434 0.030380 0.009836 0.006306 0.047666 0.029380 0.002102 0.006545 0.047045 0.029719 0.004722 0.006380
Mitochondria 0.000517 0.004171 0.000079 0.007732 0.004174 0.006643 0.000290 0.000070 0.004123 0.005804 0.000219 0.005370
Mitotic Spindle 0.101810* 0.654664* 0.847694* 0.646201* 0.381931* 0.471321* 0.922354* 0.922217* 0.377997* 0.533596* 0.897063* 0.731297*
None 0.013015 0.004353 0.000497 0.013189 0.018231 0.008007 0.001077 0.000067 0.018158 0.006766 0.000881 0.009143
Nuclear Periphery 0.000293 0.000450 0.000398 0.000825 0.000535 0.001184 0.000321 0.000248 0.000531 0.000935 0.000347 0.000647
Nuclear Periphery Foci 0.009157 0.079425 0.039700 0.008304 0.136476 0.091177 0.023199 0.013396 0.134688 0.087185 0.028788 0.009874
Nucleolus 0.017229 0.035456 0.003574 0.030124 0.047880 0.075224 0.009871 0.000766 0.047450 0.061717 0.007738 0.021073
Nucleus 0.020778 0.019361 0.010545 0.113769 0.023573 0.050568 0.018542 0.001385 0.023534 0.039968 0.015833 0.079121
Peroxisomes 0.152192* 0.051914 0.010715 0.014771 0.085297 0.057647 0.003784 0.006845 0.086236 0.055700 0.006132 0.012327
Vacuole 0.002921 0.001545 0.006121 0.010277 0.001768 0.004784 0.002374 0.003869 0.001784 0.003684 0.003643 0.008301
Vacuole Periphery 0.000109 0.000302 0.000095 0.002197 0.000231 0.001103 0.000055 0.002588 0.000229 0.000831 0.000069 0.002317

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.71 -1.27 -1.08 -2.37 0.10 -3.88 -4.07 -2.06 -1.23 -0.34 -5.00 -6.14 -4.13 -2.97 -1.07
Bud Neck -0.16 -2.08 -3.96 -4.33 -2.88 -4.98 -4.04 -1.43 2.64 1.23 -5.11 -5.59 -4.98 -2.94 -3.08
Bud Site 1.83 0.14 -0.13 -4.64 -0.57 -4.55 -2.79 -1.91 -1.28 -1.32 -4.27 -6.04 -5.10 -4.13 -2.59
Cell Periphery 1.54 1.94 1.42 -0.48 -2.37 1.77 10.70 10.56 9.79 0.32 2.93 10.26 5.11 3.21 -3.58
Cytoplasm 2.45 2.12 1.54 -5.49 -3.09 -1.05 3.49 6.39 7.89 2.05 1.22 1.21 -3.70 -4.20 -4.16
Cytoplasmic Foci 5.63 6.26 6.37 6.14 1.07 5.72 26.82 11.03 7.80 -2.55 8.51 24.18 17.20 11.94 -3.30
Eisosomes -3.98 1.80 -0.44 6.79 -5.50 6.04 21.61 20.69 18.38 1.93 6.44 22.27 16.12 13.48 -4.53
Endoplasmic Reticulum -4.49 -3.05 -3.64 -1.56 -1.59 -1.18 -0.27 5.97 6.48 4.13 -2.56 -0.92 -1.66 -1.04 -1.18
Endosome 0.35 0.90 -0.10 -0.50 -1.08 -2.38 11.37 5.39 6.67 -0.39 -0.78 9.86 1.90 2.28 -2.02
Golgi -2.53 2.14 1.36 6.25 -1.03 5.01 19.35 18.88 17.66 0.40 5.47 18.99 13.09 10.63 -1.52
Lipid Particles -6.07 -0.73 0.63 7.07 1.58 7.11 16.87 10.40 5.73 -1.56 6.93 15.80 14.14 10.80 -1.22
Mitochondria -0.99 1.34 -2.01 -1.30 -2.32 -1.79 1.98 2.47 5.41 2.04 -1.34 2.17 -1.21 -0.54 -2.18
Mitotic Spindle -7.54 -10.31 -7.79 -1.49 4.40 -6.10 -34.22* -22.88 -19.21 -1.44 -10.28 -34.13 -15.84 -10.08 5.59
None 1.45 1.79 0.66 -1.86 -2.73 4.25 7.41 8.76 9.33 1.84 5.02 8.00 1.73 -0.86 -2.48
Nuclear Periphery -1.56 -3.32 -4.69 -4.39 -3.03 -4.84 -2.14 -1.18 1.02 -0.44 -4.29 -3.13 -4.24 -2.47 -3.15
Nuclear Periphery Foci -5.98 -2.31 1.29 13.79 6.43 5.06 18.87 17.43 13.77 2.48 6.17 18.16 23.34 21.80 6.47
Nucleolus -3.51 0.89 -2.83 0.15 -5.18 -5.90 3.88 14.19 17.56 7.91 -4.90 6.60 2.06 5.38 -1.98
Nucleus -0.40 -1.42 -6.77 -7.13 -6.28 -5.80 -5.10 1.29 5.60 5.34 -5.26 -5.45 -7.07 -5.75 -4.75
Peroxisomes 2.00 3.24 3.30 9.65 0.54 5.17 21.49 16.23 12.69 -1.42 5.85 20.68 18.22 16.15 -1.72
Vacuole 0.95 -4.83 -4.09 -4.37 -1.82 -3.06 -3.62 -1.62 -1.30 -0.90 -3.16 -6.87 -4.72 -4.43 -2.95
Vacuole Periphery -1.30 -2.27 -1.66 -1.56 -1.52 -4.04 -1.11 -0.98 -0.75 -0.97 -4.21 -2.25 -1.84 -1.45 -1.78
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Inner plaque spindle pole body (SPB) component; ortholog of human kendrin; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
Localization
Cell Percentages spindle pole (94%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Spc110

Spc110


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Spc110-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available