Standard name
Human Ortholog
Description Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.08 0.14 0.16 0.11 0.12 0.1 0.07 0.07 0.06 0.05 0.12 0.24 0.27 0.22 0.27 0.23 0 0 0 0.05 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.38 0.29 0.21 0.28 0.4 0.72 0.69 0.59 0.62 0.75 0.72 0.77 0 0 0 0 0.06 0 0 0 0 0 0 0
Nucleus 0.81 0.82 0.79 0.68 0.59 0.61 0.55 0.66 0.67 0.61 0.66 0.63 0.84 0.71 0.66 0.67 0.58 0.52 0.8 0.8 0.72 0.71 0.61 0.52
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.06 0.05 0 0.09 0.05 0 0 0 0 0 0 0 0.08 0.06 0.16 0.21 0.25 0.13 0.11 0.15 0.15 0.22 0.23
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1
Bud 1 0 0 0 4 3 4 4 3 5 4 3 0 0 0 0 0 1 2 4 3 3 3 3
Bud Neck 1 0 0 0 0 0 0 0 1 0 0 0 1 1 0 0 0 0 1 1 0 0 0 1
Bud Site 0 0 0 1 2 8 3 10 9 17 19 10 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 17 12 25 21 33 27 30 38 32 34 24 22 38 85 103 19 26 26 6 9 8 18 9 12
Endoplasmic Reticulum 1 1 0 0 0 0 0 0 0 0 0 0 1 2 1 5 3 6 0 0 1 0 0 1
Endosome 0 0 1 2 6 0 0 0 3 1 0 0 5 3 6 1 0 3 6 2 7 2 3 4
Golgi 0 0 2 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 2 0 5 0 0 3
Mitochondria 177 95 68 42 84 181 174 231 278 347 272 325 0 4 8 2 6 5 3 4 4 11 7 11
Nucleus 383 274 253 101 124 153 140 257 302 282 249 266 273 257 252 58 56 59 401 281 266 276 159 151
Nuclear Periphery 1 0 0 1 1 1 0 1 4 1 3 5 0 1 2 0 0 1 1 0 1 0 1 3
Nucleolus 0 0 0 0 3 1 0 3 3 5 5 8 0 0 0 0 0 0 1 0 0 3 5 10
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0
SpindlePole 0 1 0 3 2 0 0 2 1 1 4 0 1 0 3 0 1 0 3 5 7 8 6 9
Vac/Vac Membrane 16 20 16 5 19 12 9 12 18 17 9 16 12 29 23 14 20 29 67 37 56 58 56 67
Unique Cell Count 471 333 321 148 210 251 253 391 449 464 380 424 324 361 380 87 97 114 504 353 369 388 260 290
Labelled Cell Count 597 403 365 176 278 386 360 558 654 710 589 655 331 383 399 99 112 131 504 353 369 388 260 290


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 4.5 4.6 4.5 4.5 3.8 3.9 3.9 3.8 3.5 3.3 3.4 6.2 6.1 5.6 7.0 6.7 6.8 6.3 6.5 6.7
Std Deviation (1e-4) 0.5 0.7 1.2 1.9 1.8 1.7 2.0 1.9 1.4 1.1 1.3 1.3 1.2 1.5 1.2 1.4 1.5 1.5 1.6 1.8 1.7
Intensity Change (Log2) – – – -0.03 -0.04 -0.27 -0.24 -0.22 -0.27 -0.39 -0.49 -0.45 0.45 0.42 0.29 0.61 0.55 0.56 0.47 0.51 0.55

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 3.5 4.8 6.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.6139 4.6274 4.6879 4.3121 4.1365 4.3461 2.4773 2.4851 2.5202 1.9407 1.905 2.3295 1.9644 2.1149 1.7613 1.8221 1.5441 2.1173
Actin 0.005 0.0002 0.0071 0.0011 0.001 0.006 0.0033 0 0.004 0.0045 0 0 0.0018 0 0 0 0 0
Bud 0.0006 0.0002 0.0002 0.0004 0.0023 0.0003 0.0001 0 0.0001 0.0001 0 0 0.0009 0 0 0 0 0
Bud Neck 0.0033 0.0004 0.0008 0.0011 0.0004 0.0041 0.0018 0.0002 0.0006 0.0008 0.0018 0.0008 0.004 0.0001 0.0001 0 0.0003 0.0004
Bud Periphery 0.0016 0.0001 0.0006 0.0026 0.0009 0.0011 0.0002 0.0001 0.0001 0.0002 0 0 0.0002 0 0 0 0 0
Bud Site 0.0074 0.0011 0.0009 0.0009 0.0004 0.0004 0.0002 0.0003 0.0003 0.0019 0.0001 0 0.0003 0.0001 0 0 0 0
Cell Periphery 0.002 0 0.0006 0.0003 0.0003 0.0002 0.0001 0 0 0 0 0 0.0001 0 0 0 0 0
Cytoplasm 0.0069 0.0102 0.013 0.007 0.033 0.0035 0.0015 0.0049 0.0003 0.0002 0.0026 0.0002 0.0029 0.0041 0.0033 0.0001 0.0003 0.0045
Cytoplasmic Foci 0.0147 0.0004 0.0014 0.0003 0.0072 0.0011 0.0019 0.0001 0.0002 0.0043 0.0001 0 0.0015 0 0.0001 0 0 0.0032
Eisosomes 0.0002 0 0.0001 0.0001 0.0001 0 0.0001 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0045 0.0005 0.0045 0.0005 0.002 0.0013 0.0016 0.0001 0.0002 0 0.0001 0 0.0003 0.0004 0.0004 0 0 0
Endosome 0.0145 0.0005 0.0025 0.0046 0.007 0.0027 0.0075 0.0002 0.0009 0.0011 0.0004 0 0.0025 0.0002 0.0003 0 0 0
Golgi 0.0035 0 0.0023 0.0002 0.0006 0.0012 0.0014 0 0.0003 0.0014 0 0 0.0004 0 0 0 0 0
Lipid Particles 0.0097 0.0001 0.0005 0.0002 0.0062 0.0014 0.0079 0 0.0002 0.0027 0 0 0.0011 0 0.0001 0 0 0
Mitochondria 0.0159 0.0003 0.0019 0.018 0.0028 0.001 0.0022 0.0001 0.0002 0.0005 0.0001 0.0001 0.0004 0.0001 0.0001 0.0001 0 0
None 0.0067 0.0116 0.0219 0.0124 0.0358 0.0006 0.0016 0.0027 0.0002 0.0002 0.0002 0 0.0029 0.0029 0.0026 0 0.0001 0.0009
Nuclear Periphery 0.0344 0.0058 0.0089 0.0076 0.0083 0.0055 0.009 0.0036 0.0039 0.001 0.0021 0.0011 0.0047 0.0068 0.0031 0.0003 0.0014 0.0013
Nucleolus 0.0079 0.0068 0.006 0.0161 0.0109 0.0132 0.0058 0.0055 0.0042 0.0032 0.0081 0.0085 0.0031 0.0029 0.0021 0.0032 0.008 0.0057
Nucleus 0.8035 0.9367 0.8742 0.8989 0.8515 0.9395 0.9407 0.9775 0.9793 0.9687 0.9798 0.9828 0.9555 0.9783 0.9861 0.9961 0.9849 0.9747
Peroxisomes 0.0077 0 0.0002 0.0001 0.0009 0.0002 0.0009 0 0.0001 0.007 0 0 0.0004 0 0 0 0 0
Punctate Nuclear 0.0414 0.0234 0.0509 0.004 0.0061 0.0151 0.0098 0.004 0.0047 0.0018 0.0042 0.0063 0.0157 0.0035 0.0015 0.0002 0.0048 0.0091
Vacuole 0.0055 0.0013 0.0013 0.0207 0.0175 0.0012 0.0013 0.0005 0.0001 0.0001 0.0004 0.0001 0.0009 0.0004 0.0002 0 0.0001 0.0001
Vacuole Periphery 0.0032 0.0002 0.0003 0.0029 0.0049 0.0003 0.0011 0.0001 0.0001 0 0 0 0.0002 0.0001 0 0 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 4.8289 7.914 9.0758 7.7367 8.3478 4.8262 8.5475 5.1552 8.7137 7.4451
Translational Efficiency 1.2664 0.8441 0.7122 0.7905 0.5579 1.1917 0.7604 1.2113 0.77 0.7952

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1681 821 2859 1461 1474 1405 212 320 3155 2226 3071 1781

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 611.02 755.57 814.11 861.64 671.96 760.60 933.24 830.20 639.49 758.74 822.33 855.99
Standard Deviation 84.15 104.82 106.95 126.12 85.11 99.47 111.96 161.62 89.90 101.50 111.47 133.75
Intensity Change Log 2 — 0.306346 0.414004 0.495866 — 0.178763 0.473873 0.305084 — 0.240933 0.445670 0.399094

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000060 0.000359 0.000283 0.001210 0.000125 0.001033 0.000449 0.000633 0.000090 0.000784 0.000295 0.001106
Bud Neck 0.002917 0.004767 0.014847 0.020765 0.001594 0.008312 0.001988 0.014334 0.002299 0.007005 0.013959 0.019610
Bud Site 0.002342 0.002688 0.004686 0.015571 0.000519 0.004840 0.000392 0.024330 0.001490 0.004046 0.004390 0.017145
Cell Periphery 0.000402 0.000146 0.000197 0.000220 0.000122 0.000170 0.000041 0.000913 0.000272 0.000161 0.000186 0.000345
Cytoplasm 0.142408 0.064261 0.025662 0.028980 0.089127 0.056241 0.002952 0.152330 0.117515 0.059199 0.024095 0.051143
Cytoplasmic Foci 0.022677 0.010542 0.000460 0.005931 0.013137 0.010536 0.000101 0.034728 0.018220 0.010538 0.000435 0.011105
Eisosomes 0.000039 0.000029 0.000018 0.000031 0.000026 0.000034 0.000028 0.000169 0.000033 0.000032 0.000019 0.000055
Endoplasmic Reticulum 0.002317 0.005148 0.003685 0.011552 0.001371 0.004218 0.006172 0.002474 0.001875 0.004561 0.003856 0.009921
Endosome 0.000958 0.000957 0.000715 0.007148 0.000820 0.002569 0.000177 0.013564 0.000894 0.001974 0.000678 0.008301
Golgi 0.000515 0.000710 0.000136 0.006216 0.000398 0.002643 0.000029 0.020338 0.000460 0.001930 0.000129 0.008754
Lipid Particles 0.004367 0.001815 0.000186 0.001100 0.002522 0.003859 0.000254 0.007277 0.003505 0.003105 0.000191 0.002210
Mitochondria 0.003084 0.002495 0.001652 0.009046 0.002709 0.006976 0.000408 0.010018 0.002909 0.005323 0.001566 0.009221
Mitotic Spindle 0.000739 0.007335 0.003395 0.037275 0.001295 0.009748 0.000026 0.009144 0.000998 0.008858 0.003162 0.032221
None 0.024365 0.007291 0.004796 0.004266 0.007789 0.003895 0.001631 0.040881 0.016621 0.005147 0.004577 0.010845
Nuclear Periphery 0.001810 0.001408 0.001075 0.003566 0.001161 0.002439 0.000507 0.000792 0.001507 0.002059 0.001036 0.003068
Nuclear Periphery Foci 0.000682 0.000840 0.000125 0.001781 0.000658 0.000995 0.000096 0.000434 0.000671 0.000938 0.000123 0.001539
Nucleolus 0.004276 0.005292 0.001071 0.001670 0.002442 0.004066 0.001446 0.003358 0.003419 0.004518 0.001097 0.001973
Nucleus 0.780602 0.876550 0.932268 0.811169 0.869742 0.865947 0.978986 0.629317 0.822248 0.869858 0.935493 0.778495
Peroxisomes 0.001459 0.002006 0.000153 0.000470 0.001716 0.002907 0.000098 0.007145 0.001579 0.002575 0.000150 0.001669
Vacuole 0.003333 0.005101 0.004223 0.023568 0.002489 0.007724 0.004167 0.024359 0.002938 0.006757 0.004219 0.023710
Vacuole Periphery 0.000650 0.000260 0.000368 0.008463 0.000239 0.000849 0.000050 0.003464 0.000458 0.000631 0.000346 0.007565

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.49 -8.38 -9.90 -6.64 -7.00 -1.60 -5.53 -7.63 -0.12 -2.04 -1.98 -6.64 -10.80 -1.03 -7.80
Bud Neck -2.98 -12.77 -13.40 -10.58 -2.31 -6.96 -3.43 -4.23 -1.60 -3.69 -7.24 -13.62 -14.34 -8.71 -2.32
Bud Site -0.50 -2.92 -6.21 -5.86 -4.48 -4.25 -1.41 -3.67 -2.46 -3.58 -3.43 -4.68 -7.92 -5.36 -5.27
Cell Periphery 4.88 4.15 4.34 -1.25 0.34 -1.45 5.12 -4.54 -3.83 -5.29 3.30 3.10 1.02 -2.65 -2.41
Cytoplasm 11.51 23.54 21.82 6.61 -2.31 6.21 19.05 -1.58 -4.67 -9.87 13.76 26.80 18.02 4.27 -7.18
Cytoplasmic Foci 4.89 12.55 10.64 3.82 -3.57 1.63 9.87 -0.93 -1.71 -4.68 5.29 15.73 9.29 3.89 -5.77
Eisosomes 3.04 8.76 0.00 -3.42 -10.97 -2.10 -2.72 -4.51 -4.11 -3.90 0.14 8.21 -4.76 -4.50 -8.02
Endoplasmic Reticulum -4.64 -3.41 -13.18 -10.10 -13.49 -9.96 -9.15 -8.73 -4.79 0.24 -8.08 -7.75 -17.29 -12.60 -13.57
Endosome -0.15 1.41 -5.02 -4.96 -5.53 -3.81 3.12 -3.43 -2.48 -3.72 -3.70 1.57 -6.14 -3.86 -6.54
Golgi -0.58 2.58 -2.82 -2.51 -3.37 -3.11 1.93 -2.34 -1.75 -2.43 -3.13 2.84 -3.67 -2.01 -4.06
Lipid Particles 4.35 7.87 6.19 3.09 -3.33 -1.39 6.03 -0.72 -0.07 -1.87 0.65 10.07 4.14 2.54 -3.16
Mitochondria 0.63 2.19 -2.80 -3.02 -4.87 -2.91 2.59 -1.39 0.67 -2.75 -2.54 2.33 -3.22 -0.46 -5.36
Mitotic Spindle -2.61 -3.97 -7.93 -4.45 -6.56 -4.47 1.06 -3.17 -1.09 -3.39 -5.29 -3.49 -8.42 -4.66 -7.05
None 6.53 8.74 8.87 2.31 0.62 4.23 7.47 -2.68 -3.38 -3.79 8.28 9.41 5.37 -1.86 -2.74
Nuclear Periphery 1.00 1.58 -4.61 -6.32 -6.95 -4.28 2.11 -5.24 0.65 -6.74 -2.37 1.33 -6.11 -4.42 -7.48
Nuclear Periphery Foci -0.49 2.91 -2.05 -1.00 -4.60 -0.95 1.61 -1.27 -0.49 -2.43 -1.11 3.56 -2.37 -1.07 -5.21
Nucleolus -0.92 5.83 4.72 3.15 -2.37 -2.50 3.27 0.00 1.49 -1.22 -1.69 7.24 4.47 4.56 -2.70
Nucleus -9.42 -20.55 -5.09 4.52 13.57 0.70 -12.95 9.61 9.17 14.83 -6.84 -21.09 2.27 7.72 18.01
Peroxisomes -0.96 5.35 4.62 3.59 -2.10 -1.57 3.31 -1.16 -0.26 -2.70 -2.10 5.39 2.23 4.06 -3.12
Vacuole -2.29 -2.65 -13.70 -12.23 -12.93 -6.60 -3.05 -8.31 -7.50 -7.08 -6.61 -4.27 -16.01 -13.76 -14.86
Vacuole Periphery 1.29 0.98 -3.36 -3.95 -3.84 -3.15 3.37 -2.19 -1.27 -2.46 -0.84 0.74 -3.90 -3.73 -4.13
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member
Localization
Cell Percentages nucleus (75%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Esc2

Esc2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Esc2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available