Standard name
Human Ortholog
Description NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 0.99 0.99 1.0 0.98 0.96 0.89 0.83 0.72 0.73 0.69 0.72 0.66 1.0 0.98 0.99 0.98 0.97 0.98 0.98 0.97 0.96 0.98 0.97 0.95
Endoplasmic Reticulum 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.06 0.07 0.12 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.08 0.13 0.19 0.17 0.2 0.14 0.25 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 4 2 1 0 8 0 0 0 0 0 0 0 0 0 0 0 1
Bud 2 0 1 0 0 0 1 1 3 3 6 11 0 0 0 1 0 0 0 2 0 0 2 5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 3 0 6 8 11 15 14 9 15 14 5 4 9 6 14 19 0 0 0 0 0 0
Cytoplasm 259 182 138 306 450 346 472 418 309 307 253 341 448 589 693 368 390 354 247 177 145 431 585 627
Endoplasmic Reticulum 1 0 0 1 6 8 12 28 13 13 4 12 0 2 3 7 8 11 1 0 0 1 2 2
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 0 0 0 0 1 2 3
Golgi 1 0 0 0 0 2 0 4 0 0 0 1 0 4 0 0 2 1 1 0 0 0 2 3
Mitochondria 2 1 0 1 1 7 18 18 27 29 43 24 0 0 0 1 1 0 0 0 0 0 0 2
Nucleus 0 1 2 2 3 3 10 14 8 19 7 13 1 3 3 0 1 1 0 1 2 2 3 2
Nuclear Periphery 0 0 0 0 0 0 0 2 1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 0 11 21 31 72 113 73 87 51 129 2 6 2 7 7 4 0 0 1 1 2 3
Unique Cell Count 261 183 138 313 470 388 570 583 424 442 352 515 450 600 698 375 401 361 253 183 151 442 607 658
Labelled Cell Count 266 185 144 321 487 405 596 617 450 471 379 554 456 609 710 391 424 390 253 183 151 442 607 658


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.0 13.3 13.1 11.9 11.9 10.8 10.5 10.8 9.9 9.8 9.7 10.5 16.7 18.0 19.4 32.1 35.4 35.0 13.6 14.6 15.3
Std Deviation (1e-4) 1.8 2.3 1.9 2.1 2.0 1.8 1.9 2.2 2.1 2.2 2.4 2.6 3.1 3.7 3.9 8.8 10.9 10.7 2.1 2.6 2.7
Intensity Change (Log2) – – – -0.14 -0.13 -0.28 -0.32 -0.28 -0.4 -0.42 -0.42 -0.32 0.36 0.46 0.57 1.3 1.44 1.42 0.06 0.16 0.23

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700010203040WT3HU80HU120HU160010203040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3010203040WT1AF100AF140AF180010203040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 1.1 0 0 0 0 0 0 1.5
Cytoplasm -1.8 -2.5 -4.0 -5.2 -7.1 -6.9 -7.4 -7.0 -8.0 -0.8 -1.6 -1.0 -1.6 -2.0 -1.6
Endoplasmic Reticulum 0 0 0 0 2.6 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 3.0 3.1 4.3 2.6 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 3.4 4.4 5.6 5.2 5.7 4.7 6.6 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.7616 11.4986 11.057 8.879 9.5717 10.1821 8.9188 11.5424 10.6318 9.8568 7.9218 10.5161 10.5971 10.7436 11.7391 10.623 10.285 12.33
Actin 0.0002 0.0004 0.0017 0.0005 0.0006 0.0003 0.0126 0.0018 0.0076 0.0192 0.0009 0.0007 0.0103 0.0009 0.0014 0.0029 0.0585 0.0004
Bud 0.0001 0.0002 0.0038 0.0075 0.0002 0.0008 0.0012 0.0003 0.0019 0.0003 0.0002 0.0002 0.0008 0.0086 0.0018 0.0002 0.0001 0.0001
Bud Neck 0.0002 0.0002 0.0003 0.0014 0.001 0.0021 0.0025 0.0002 0.001 0.0009 0.0006 0.0013 0.001 0.0002 0.0004 0.0005 0.0005 0.0006
Bud Periphery 0 0 0.0006 0.003 0.0001 0.0002 0.0007 0.0001 0.0009 0.0004 0.0001 0.0001 0.0005 0.0012 0.0004 0.0001 0.0001 0.0001
Bud Site 0.0001 0.0006 0.0009 0.0007 0.0002 0.0003 0.0024 0.0011 0.0027 0.0003 0.0005 0.0001 0.001 0.0021 0.0022 0.0002 0.0002 0
Cell Periphery 0 0 0.0001 0.0001 0 0 0.0001 0 0.0001 0.0001 0.0001 0 0.0003 0.0002 0.0001 0.0001 0 0
Cytoplasm 0.9326 0.9698 0.948 0.8931 0.9184 0.9202 0.8122 0.9755 0.9245 0.8752 0.7045 0.948 0.8982 0.9554 0.9605 0.9064 0.8944 0.9593
Cytoplasmic Foci 0.0037 0.002 0.0022 0.0078 0.0023 0.0077 0.0419 0.0033 0.0111 0.0144 0.0381 0.0052 0.0079 0.0028 0.0033 0.0044 0.0014 0.0014
Eisosomes 0 0 0 0 0 0 0.0001 0 0 0.0004 0 0 0.0001 0 0 0.0001 0.0002 0
Endoplasmic Reticulum 0.0054 0.0018 0.001 0.004 0.0024 0.0022 0.0049 0.0007 0.0025 0.004 0.0063 0.0013 0.0033 0.0011 0.0009 0.0035 0.0011 0.0015
Endosome 0.0052 0.0009 0.0011 0.0179 0.0012 0.003 0.0366 0.0006 0.0106 0.0232 0.169 0.004 0.0089 0.0009 0.0051 0.0123 0.0009 0.0041
Golgi 0.0001 0.0001 0.0005 0.0008 0 0.0002 0.0076 0.0003 0.0023 0.004 0.0134 0.0019 0.0015 0.0001 0.001 0.0019 0.0018 0.0003
Lipid Particles 0.0002 0 0.0011 0.0001 0 0.0004 0.0134 0.0001 0.0029 0.0034 0.0211 0.0009 0.0015 0 0.0005 0.0022 0.0012 0.0001
Mitochondria 0.0002 0.0001 0.0053 0.0005 0.0004 0.0002 0.0034 0.0069 0.0015 0.0066 0.0046 0.0005 0.0055 0.0003 0.0004 0.0028 0.0006 0.0004
None 0.0058 0.0014 0.0016 0.0034 0.0032 0.0017 0.0102 0.0012 0.0039 0.0021 0.0025 0.0015 0.0031 0.0017 0.0012 0.0021 0.0006 0.0007
Nuclear Periphery 0.0057 0.0027 0.0025 0.0062 0.006 0.005 0.006 0.0008 0.0029 0.0041 0.0068 0.0032 0.0077 0.0037 0.0024 0.0231 0.0042 0.008
Nucleolus 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0006 0 0.0002 0.0001 0.0005 0.0002 0.0048 0.0001 0.0001 0.0002 0 0.0001
Nucleus 0.0373 0.0181 0.0259 0.0452 0.0615 0.0511 0.0155 0.0055 0.0151 0.0212 0.0155 0.0262 0.0331 0.018 0.0161 0.027 0.0281 0.0205
Peroxisomes 0.0001 0.0001 0.0019 0.0002 0 0.0002 0.0147 0.0007 0.0037 0.011 0.0016 0.0002 0.001 0.0002 0.0006 0.0002 0.0028 0
Punctate Nuclear 0.001 0.0006 0.0006 0.002 0.0014 0.003 0.0091 0.0005 0.002 0.0013 0.0026 0.0038 0.006 0.0011 0.0009 0.0022 0.0028 0.0006
Vacuole 0.0018 0.0008 0.0007 0.0047 0.0007 0.001 0.0033 0.0002 0.0016 0.006 0.0081 0.0006 0.0027 0.0011 0.0006 0.0057 0.0003 0.0011
Vacuole Periphery 0.0003 0.0001 0.0002 0.0008 0.0002 0.0002 0.0011 0.0001 0.0006 0.0019 0.0029 0.0002 0.0006 0.0002 0.0001 0.0021 0.0001 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 61.1044 35.7154 60.0201 65.2429 51.8007 76.3382 57.6196 61.2911 78.2062 67.4088
Translational Efficiency 2.0185 3.1839 1.7344 2.063 2.554 1.9952 2.2724 2.1042 1.876 1.9059

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1432 1074 2161 100 1589 2088 413 1149 3021 3162 2574 1249

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1116.03 1292.62 1332.04 1995.19 1073.00 1230.57 1643.61 1349.05 1093.40 1251.65 1382.03 1400.78
Standard Deviation 201.55 227.48 214.14 329.72 168.56 200.15 316.47 394.90 186.18 211.88 260.09 427.69
Intensity Change Log 2 — 0.211922 0.255262 0.838150 — 0.197677 0.615218 0.330294 — 0.204957 0.442913 0.611387

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000255 0.000260 0.000153 0.000835 0.000090 0.000206 0.000426 0.000166 0.000168 0.000224 0.000197 0.000220
Bud Neck 0.000451 0.000492 0.000993 0.003625 0.000612 0.000713 0.001933 0.000993 0.000536 0.000638 0.001144 0.001204
Bud Site 0.002920 0.004230 0.002780 0.004842 0.002716 0.004374 0.004254 0.003585 0.002813 0.004325 0.003016 0.003686
Cell Periphery 0.000061 0.000061 0.000049 0.000726 0.000037 0.000036 0.000288 0.000125 0.000049 0.000045 0.000087 0.000173
Cytoplasm 0.864538 0.857585 0.778517 0.418387 0.858117 0.872376 0.525793 0.810504 0.861160 0.867352 0.737967 0.779110
Cytoplasmic Foci 0.025110 0.024642 0.006299 0.018023 0.030780 0.023887 0.022466 0.013029 0.028092 0.024143 0.008893 0.013429
Eisosomes 0.000005 0.000008 0.000005 0.000010 0.000004 0.000004 0.000067 0.000005 0.000005 0.000005 0.000015 0.000006
Endoplasmic Reticulum 0.000812 0.000745 0.000257 0.000454 0.000470 0.000172 0.006290 0.000389 0.000632 0.000367 0.001225 0.000394
Endosome 0.000994 0.001867 0.000688 0.001629 0.000669 0.000956 0.002798 0.001902 0.000823 0.001265 0.001026 0.001880
Golgi 0.000486 0.001436 0.000868 0.000668 0.001108 0.001152 0.000353 0.000525 0.000813 0.001248 0.000785 0.000537
Lipid Particles 0.000258 0.000691 0.000792 0.002655 0.000249 0.000218 0.005764 0.000374 0.000253 0.000378 0.001589 0.000556
Mitochondria 0.000406 0.000739 0.000300 0.000125 0.000249 0.000474 0.000216 0.000565 0.000323 0.000564 0.000286 0.000529
Mitotic Spindle 0.001681 0.006806 0.005957 0.000761 0.001710 0.006863 0.005104 0.007884 0.001696 0.006844 0.005820 0.007313
None 0.005553 0.007656 0.005883 0.003063 0.006154 0.007385 0.012420 0.006106 0.005869 0.007477 0.006932 0.005862
Nuclear Periphery 0.000078 0.000107 0.000255 0.000434 0.000072 0.000066 0.000853 0.000195 0.000075 0.000080 0.000351 0.000214
Nuclear Periphery Foci 0.003759 0.004755 0.001019 0.008793 0.001442 0.001515 0.006546 0.002616 0.002540 0.002615 0.001906 0.003110
Nucleolus 0.000137 0.000694 0.000114 0.000129 0.000099 0.000114 0.000387 0.000135 0.000117 0.000311 0.000158 0.000135
Nucleus 0.071669 0.066012 0.156253 0.345464 0.077260 0.063535 0.243077 0.103834 0.074610 0.064376 0.170184 0.123180
Peroxisomes 0.000142 0.001141 0.000419 0.000074 0.000140 0.000300 0.001507 0.000074 0.000141 0.000586 0.000593 0.000074
Vacuole 0.019802 0.019266 0.038200 0.188908 0.017777 0.015345 0.159193 0.046012 0.018737 0.016676 0.057613 0.057452
Vacuole Periphery 0.000884 0.000807 0.000199 0.000396 0.000244 0.000310 0.000264 0.000981 0.000547 0.000479 0.000210 0.000935

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.14 0.13 -5.71 -5.87 -5.89 -2.03 -10.19 -7.06 -0.64 7.41 -1.05 -2.22 -3.66 -2.09 -0.12
Bud Neck -0.33 -5.91 -6.04 -6.04 -5.17 -0.66 -11.12 -5.97 -4.51 7.88 -0.89 -11.16 -8.23 -7.48 -0.48
Bud Site -1.51 -0.34 -6.01 -4.11 -5.93 -1.95 -6.92 -4.18 -0.88 4.13 -2.44 -2.56 -5.98 -1.71 -3.51
Cell Periphery -0.28 0.11 -7.38 -7.36 -7.38 -0.37 -13.04 -10.11 -9.97 6.65 0.60 -10.14 -10.84 -10.98 -7.23
Cytoplasm 2.04 23.82 19.90 19.16 13.85 -1.99 28.10 15.15 16.88 -18.63 -0.22 33.10 19.78 19.79 -4.35
Cytoplasmic Foci -0.62 10.99 -0.52 -0.09 -6.46 3.33 5.67 8.41 6.03 1.72 2.09 15.57 8.36 6.71 -7.31
Eisosomes -1.95 -1.04 -6.88 -4.95 -6.68 -0.04 -8.57 -3.94 -3.80 7.92 -1.39 -7.92 -5.46 -3.16 3.47
Endoplasmic Reticulum 0.40 4.83 2.49 0.78 -2.98 3.46 -2.51 1.30 -4.33 2.64 2.57 -0.49 3.75 0.00 2.29
Endosome -2.12 2.89 -1.43 0.97 -3.03 -1.14 -8.74 -1.55 -0.98 2.49 -2.09 -0.45 -1.30 -0.26 -1.17
Golgi -1.81 0.07 -1.80 1.28 -0.97 0.08 1.49 1.50 2.03 0.18 -0.95 1.04 1.48 2.68 0.16
Lipid Particles -2.86 -2.30 -7.08 -6.37 -6.15 0.45 -3.32 -6.63 -6.88 2.70 -2.32 -3.93 -9.14 -7.19 -0.12
Mitochondria -0.63 0.69 1.51 1.46 2.08 -0.99 0.18 -0.41 0.36 -0.52 -0.99 0.53 -0.02 0.74 -0.32
Mitotic Spindle -2.19 -4.09 -0.64 1.93 3.81 -3.03 -2.37 -4.86 -1.52 -1.60 -3.78 -4.72 -5.08 -1.52 -1.35
None -1.77 0.32 5.71 5.66 8.74 -1.24 -0.18 1.00 3.06 0.49 -2.26 0.50 1.34 3.88 0.78
Nuclear Periphery -1.95 -21.81 -8.03 -7.45 -3.77 -0.72 -12.95 -12.52 -12.09 9.63 -1.94 -24.68 -14.40 -12.85 7.59
Nuclear Periphery Foci -1.58 8.48 -4.56 -2.97 -7.05 -1.18 -8.61 -5.39 -4.44 6.40 -0.84 1.61 -2.79 -1.42 -4.19
Nucleolus -1.28 -0.04 0.27 1.32 1.21 -0.71 -7.40 -1.99 -0.87 4.80 -1.28 -1.96 -0.42 1.20 2.13
Nucleus 1.09 -25.62 -7.19 -7.36 -2.19 3.84 -15.34 -9.41 -12.66 10.67 3.53 -30.62 -12.32 -14.44 11.44
Peroxisomes -1.86 -1.15 0.31 1.91 1.33 -1.75 -1.08 1.94 2.86 1.26 -2.30 -1.55 1.99 2.71 2.03
Vacuole -1.11 -15.98 -10.64 -10.54 -8.62 0.15 -17.05 -14.12 -14.32 10.58 -0.38 -22.53 -16.51 -16.44 -1.33
Vacuole Periphery 0.23 1.75 1.64 1.12 -0.82 -0.42 0.45 -0.95 -0.79 -1.11 0.38 1.92 0.06 -0.24 -1.30
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ypr1

Ypr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ypr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available