Standard name
Human Ortholog
Description Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0.12 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.99 1.0 0.99 0.98 – 0.81 0.83 0.71 0.72 0.64 0.99 0.99 0.98 0.98 0.97 0.94 0.95 0.92 0.89 0.89 0.89 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 – 0.11 0.09 0.18 0.09 0.15 0 0 0 0.05 0.06 0.05 0 0 0.05 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0.05 0 0 0 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0.06 0.05 0.14 0.17 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 2 3 2 4 2 0 0 1 0 0 0 0 0 0 0 0 0
Bud 0 0 1 0 0 0 – 0 0 0 1 0 0 0 0 0 0 1 1 0 0 0 0 3
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 1 0 – 1 3 10 6 1 1 0 3 4 2 9 0 0 1 0 0 0
Cytoplasm 198 292 121 58 92 65 – 85 73 60 50 30 231 226 254 337 334 399 180 278 117 181 280 299
Endoplasmic Reticulum 0 3 0 0 1 0 – 12 8 15 6 7 5 2 5 18 22 23 0 5 6 5 13 9
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 5 2 2 3 5 0 0 1 0 1 3 0 0 0 0 1 1
Mitochondria 0 0 0 0 0 0 – 2 5 4 10 8 0 0 0 0 5 12 0 0 0 1 1 0
Nucleus 0 0 0 0 0 0 – 2 0 0 0 0 0 0 0 0 1 0 0 2 0 1 0 1
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 1 – 0 0 0 0 0 0 1 0 1 3 9 1 5 0 5 5 5
Unique Cell Count 198 296 122 58 93 66 105 88 85 69 47 233 229 260 344 346 425 191 301 132 203 317 331
Labelled Cell Count 198 296 122 58 94 66 109 94 93 80 53 237 229 264 360 368 457 191 301 132 203 317 331


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 221.9 253.4 118.6 134.0 114.5 103.4 – 83.8 71.4 72.6 68.6 62.9 191.3 180.5 170.8 228.5 219.3 216.0 190.5 195.6 204.6
Std Deviation (1e-4) 52.3 64.5 39.3 38.0 38.6 37.9 – 27.7 22.7 22.2 23.8 20.3 54.9 62.3 54.2 77.4 71.5 76.9 67.5 70.6 73.4
Intensity Change (Log2) – – – 0.18 -0.05 -0.2 – -0.5 -0.73 -0.71 -0.79 -0.92 0.69 0.61 0.53 0.95 0.89 0.86 0.68 0.72 0.79

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000100200300WT3HU80HU120HU1600100200300WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30100200300WT1AF100AF140AF1800100200300
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.7 -0.2 -0.4 – -4.7 -4.4 -6.1 -5.8 -6.7 0 -0.4 -1.0 -0.9 -1.5 -2.4
Endoplasmic Reticulum 0 0 0 – 3.8 0 4.8 0 0 0 0 0 0 2.9 2.6
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 227.9761 294.6392 259.552 290.7605 240.0931 263.6969 200.4166 270.073 231.7443 262.815 226.7108 216.0426 171.8682 315.3212 269.5141 225.5476 153.1848 244.6882
Actin 0.0127 0.0012 0.0119 0.0008 0.0006 0.0343 0.0135 0.0008 0.0107 0.0008 0.0017 0.0054 0.0171 0.0012 0.0055 0.0013 0.0111 0.0065
Bud 0.007 0.0039 0.0079 0.0027 0.0033 0.0086 0.0055 0.0037 0.0051 0.0034 0.0064 0.0163 0.0056 0.0032 0.0084 0.0035 0.0115 0.0191
Bud Neck 0.0013 0.0017 0.0018 0.0013 0.0022 0.006 0.0015 0.0009 0.0018 0.001 0.0012 0.0026 0.0011 0.0007 0.0018 0.0015 0.0026 0.0031
Bud Periphery 0.0081 0.0024 0.0068 0.002 0.0015 0.0075 0.0078 0.0026 0.0045 0.0018 0.0057 0.0347 0.0071 0.0019 0.008 0.0028 0.0278 0.0185
Bud Site 0.0036 0.003 0.0048 0.0008 0.0004 0.0019 0.0031 0.002 0.0026 0.0005 0.0007 0.0015 0.0035 0.0031 0.0035 0.0021 0.0014 0.0038
Cell Periphery 0.0774 0.0617 0.0535 0.1009 0.0339 0.035 0.0865 0.0505 0.0465 0.0641 0.0169 0.0163 0.0663 0.0271 0.0537 0.0506 0.0155 0.0552
Cytoplasm 0.3839 0.6335 0.5427 0.2026 0.5403 0.5366 0.398 0.7288 0.5023 0.3425 0.5455 0.3589 0.3655 0.7797 0.6353 0.3267 0.4126 0.5896
Cytoplasmic Foci 0.0068 0.0013 0.0109 0.001 0.0039 0.0106 0.0084 0.0013 0.0062 0.0015 0.0022 0.0072 0.0115 0.0019 0.0046 0.0135 0.02 0.0023
Eisosomes 0.0023 0.0005 0.0008 0.0001 0.0015 0.002 0.0019 0 0.0006 0 0.0001 0.0001 0.0036 0.0004 0.0006 0.0011 0.0007 0.0004
Endoplasmic Reticulum 0.0394 0.0136 0.0245 0.0014 0.018 0.0241 0.0364 0.0066 0.0101 0.0017 0.002 0.0149 0.0355 0.0068 0.0055 0.0103 0.0044 0.0053
Endosome 0.0086 0.0035 0.0077 0.0036 0.0133 0.0273 0.008 0.0022 0.0154 0.0062 0.0099 0.0375 0.0243 0.0031 0.0074 0.0175 0.0131 0.0065
Golgi 0.0025 0.0005 0.004 0.0003 0.0009 0.024 0.0068 0.0004 0.0097 0.0008 0.0005 0.0067 0.0043 0.0005 0.0022 0.0022 0.0047 0.0022
Lipid Particles 0.0034 0.0012 0.0025 0.0035 0.0107 0.0065 0.0035 0.0013 0.0093 0.0015 0.0012 0.0025 0.0091 0.0014 0.0034 0.0193 0.0037 0.0066
Mitochondria 0.0606 0.0113 0.0213 0.0028 0.0039 0.0459 0.0366 0.0034 0.0132 0.0029 0.0162 0.0477 0.0588 0.0124 0.0144 0.0144 0.0804 0.0833
None 0.0106 0.0009 0.0071 0.0007 0.0094 0.0056 0.0055 0.0007 0.0029 0.0009 0.0008 0.0022 0.0181 0.002 0.0043 0.023 0.0423 0.0028
Nuclear Periphery 0.0573 0.0148 0.014 0.0279 0.0145 0.0301 0.0651 0.0052 0.0125 0.0082 0.0223 0.0246 0.1048 0.01 0.0156 0.0301 0.0261 0.0357
Nucleolus 0.0087 0.0029 0.0072 0.015 0.0031 0.0073 0.0087 0.0015 0.0122 0.0053 0.0026 0.0066 0.021 0.0071 0.008 0.0363 0.0089 0.004
Nucleus 0.0324 0.0178 0.0169 0.0269 0.0146 0.0146 0.0348 0.006 0.0122 0.0166 0.0144 0.0586 0.0343 0.0117 0.0183 0.0385 0.0379 0.0311
Peroxisomes 0.0006 0.0003 0.0008 0.0003 0.0003 0.0021 0.0006 0.0002 0.0009 0.0002 0.0002 0.0013 0.0012 0.0003 0.0006 0.001 0.0016 0.0006
Punctate Nuclear 0.0004 0.0001 0.0009 0.0001 0.0002 0.0004 0.0006 0 0.0004 0.0001 0.0001 0.0006 0.0028 0.0001 0.0003 0.0021 0.0006 0.0003
Vacuole 0.1924 0.1854 0.1862 0.3624 0.2231 0.0972 0.207 0.16 0.2573 0.4147 0.2255 0.2125 0.1383 0.104 0.1588 0.2844 0.1924 0.0827
Vacuole Periphery 0.08 0.0386 0.0657 0.2429 0.1003 0.0724 0.0602 0.0219 0.0637 0.1253 0.1238 0.1414 0.0662 0.0215 0.0397 0.1177 0.0807 0.0406

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2512.5716 2606.5684 3105.574 2528.541 2723.3339 2347.3117 2363.6377 2146.4353 2333.624 2204.555
Translational Efficiency 1.4016 1.3947 1.2056 1.4002 1.5806 1.5314 1.3839 1.4737 1.4159 1.481

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1907 2034 495 184 2339 164 2305 1388 4246 2198 2800 1572

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 7476.17 9864.26 16305.94 11849.29 8919.16 14003.15 13318.40 10046.52 8271.07 10173.08 13846.55 10257.53
Standard Deviation 1942.42 3256.80 3724.08 6024.90 2595.43 2898.78 2950.86 3418.89 2433.22 3409.56 3304.38 3860.74
Intensity Change Log 2 — 0.399911 1.125026 0.664429 — 0.650772 0.578441 0.171716 — 0.541757 0.853498 0.417370

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000056 0.000111 0.000144 0.000448 0.000036 0.000051 0.000084 0.000440 0.000045 0.000107 0.000095 0.000441
Bud Neck 0.000219 0.000406 0.002591 0.002265 0.000153 0.000607 0.000469 0.001914 0.000182 0.000421 0.000844 0.001955
Bud Site 0.002932 0.005098 0.003317 0.013667 0.001446 0.001350 0.002859 0.015470 0.002113 0.004818 0.002940 0.015259
Cell Periphery 0.027013 0.021842 0.084533 0.071185 0.032891 0.081790 0.036954 0.058713 0.030251 0.026315 0.045365 0.060173
Cytoplasm 0.481577 0.522421 0.066400 0.272355 0.530348 0.108720 0.405827 0.491887 0.508444 0.491553 0.345821 0.466191
Cytoplasmic Foci 0.012972 0.014924 0.008270 0.011299 0.010454 0.010520 0.008237 0.005776 0.011585 0.014596 0.008243 0.006423
Eisosomes 0.000002 0.000003 0.000016 0.000010 0.000002 0.000007 0.000003 0.000008 0.000002 0.000004 0.000005 0.000008
Endoplasmic Reticulum 0.005551 0.004063 0.001128 0.000599 0.005491 0.000556 0.004696 0.001222 0.005518 0.003801 0.004065 0.001149
Endosome 0.001120 0.001565 0.000813 0.001590 0.000958 0.000732 0.001335 0.001294 0.001031 0.001502 0.001243 0.001329
Golgi 0.099192 0.072459 0.086210 0.029568 0.058183 0.162805 0.051954 0.019380 0.076601 0.079200 0.058010 0.020573
Lipid Particles 0.021886 0.021624 0.034126 0.030545 0.023884 0.044507 0.027651 0.028127 0.022986 0.023331 0.028795 0.028410
Mitochondria 0.000472 0.000662 0.000173 0.000687 0.000337 0.000073 0.000419 0.000553 0.000398 0.000618 0.000376 0.000569
Mitotic Spindle 0.000708 0.000934 0.001286 0.003650 0.000577 0.000979 0.000699 0.000737 0.000636 0.000937 0.000803 0.001078
None 0.001857 0.003081 0.000677 0.001445 0.001663 0.000970 0.001308 0.002950 0.001750 0.002924 0.001196 0.002774
Nuclear Periphery 0.000930 0.000795 0.004003 0.000762 0.001240 0.002186 0.001227 0.000592 0.001101 0.000899 0.001718 0.000612
Nuclear Periphery Foci 0.013340 0.013453 0.012148 0.005730 0.012694 0.015805 0.014700 0.007374 0.012984 0.013628 0.014248 0.007181
Nucleolus 0.000113 0.000112 0.000132 0.000244 0.000084 0.000089 0.000114 0.000278 0.000097 0.000110 0.000117 0.000274
Nucleus 0.002683 0.004214 0.003672 0.011839 0.002630 0.002009 0.003918 0.010008 0.002654 0.004049 0.003874 0.010222
Peroxisomes 0.000045 0.000076 0.000019 0.000135 0.000079 0.000011 0.000104 0.000211 0.000064 0.000071 0.000089 0.000202
Vacuole 0.136476 0.145802 0.443476 0.454814 0.144135 0.299825 0.285543 0.304386 0.140695 0.157294 0.313463 0.321994
Vacuole Periphery 0.190857 0.166357 0.246867 0.087162 0.172715 0.266407 0.151899 0.048679 0.180863 0.173822 0.168688 0.053183

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.14 -3.41 -1.86 -1.63 -1.40 -1.69 -3.31 -4.19 -4.03 -3.59 -2.51 -4.13 -4.52 -3.63 -3.79
Bud Neck -4.13 -7.21 -5.59 -5.14 0.92 -4.46 -6.71 -10.21 -7.35 -7.86 -6.08 -9.35 -11.23 -9.79 -6.03
Bud Site -2.84 -0.92 -3.67 -3.02 -3.39 0.44 -5.50 -11.53 -11.51 -10.19 -5.39 -2.60 -11.41 -8.83 -10.69
Cell Periphery 3.26 -13.80 -5.62 -6.46 2.67 -6.37 -1.72 -7.95 3.27 -6.55 2.71 -8.44 -10.34 -11.43 -4.33
Cytoplasm -3.43 38.72 7.68 9.26 -8.28 24.14 12.27 3.20 -20.66 -7.35 1.82 19.10 3.91 2.03 -10.95
Cytoplasmic Foci -1.59 2.13 -0.19 0.29 -1.02 -0.20 2.79 4.14 2.28 2.08 -3.06 4.57 4.56 6.29 1.25
Eisosomes -1.19 -7.45 -3.73 -3.17 0.38 -3.44 -4.76 -7.80 -0.95 -6.17 -1.75 -8.26 -8.40 -3.75 -3.87
Endoplasmic Reticulum 2.28 7.86 8.38 8.12 1.57 9.09 1.48 7.99 -4.49 10.67 3.37 3.38 11.23 7.63 10.61
Endosome -4.32 3.10 -0.73 0.01 -1.21 1.87 -4.26 -1.53 -2.34 0.22 -5.36 -2.90 -1.43 0.93 -0.36
Golgi 7.36 3.14 15.76 10.87 10.36 -9.16 3.05 19.55 12.76 17.52 -0.82 8.96 29.35 23.65 20.76
Lipid Particles 0.12 -5.76 -1.75 -1.78 1.71 -3.63 -2.15 -1.86 2.91 -0.14 -0.28 -4.44 -2.75 -2.20 0.53
Mitochondria -1.48 2.65 -0.88 -0.58 -1.26 7.32 -1.36 -2.51 -5.13 -0.87 -2.20 -0.38 -2.05 -0.19 -1.56
Mitotic Spindle -2.99 -3.74 -1.14 -1.04 -0.80 -3.23 -3.43 -1.43 0.61 -0.73 -4.41 -4.39 -1.59 -0.60 -0.92
None -2.44 9.66 0.14 1.62 -1.62 4.00 1.27 -1.80 -2.75 -2.18 -2.54 2.50 -1.68 0.14 -2.42
Nuclear Periphery 2.25 -11.30 0.31 -0.76 10.79 -4.13 -0.13 3.95 8.53 7.82 2.12 -6.16 4.58 3.96 12.53
Nuclear Periphery Foci -0.19 0.84 10.32 10.42 7.67 -1.74 -2.75 5.71 4.55 7.79 -0.98 -2.36 7.44 7.43 8.66
Nucleolus -0.05 -0.95 -3.14 -3.89 -3.14 -0.38 -3.26 -6.35 -5.66 -4.90 -0.97 -1.69 -5.91 -5.96 -5.34
Nucleus -2.99 -3.07 -3.59 -3.25 -3.18 1.15 -3.36 -9.83 -10.08 -7.45 -3.02 -4.21 -10.16 -7.88 -7.97
Peroxisomes -2.87 4.38 -1.94 -1.20 -2.56 6.12 -1.21 -3.66 -6.16 -2.93 -0.63 -1.74 -4.49 -4.16 -3.52
Vacuole -1.77 -27.24 -13.64 -13.19 -0.22 -8.15 -22.87 -19.40 -0.28 -1.61 -3.46 -32.03 -23.68 -19.84 -0.48
Vacuole Periphery 4.10 -5.09 11.32 9.09 13.36 -5.74 4.64 28.98 13.90 27.54 1.58 3.65 36.08 27.76 31.33
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Rpl12b

Rpl12b


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rpl12b-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available