Standard name
Human Ortholog
Description Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.07 0.12
Bud 0 0 0.07 0.07 0.16 0.16 0.1 0.12 0.15 0.1 0.1 0.1 0.07 0 0.09 0.06 0 0 0.26 0.25 0.27 0.13 0 0.07
Bud Neck 0.18 0.06 0.21 0.14 0.25 0.15 0.17 0.18 0.15 0.13 0.11 0.1 0.17 0.16 0.2 0.24 0.19 0.14 0.34 0.16 0.29 0.19 0.07 0.12
Bud Site 0.13 0.11 0.1 0.16 0.16 0.14 0.09 0.05 0.08 0.05 0 0.07 0.13 0.17 0.14 0.11 0 0.05 – – – – – –
Cell Periphery 0.09 0 0 0 0 0 0 0 0 0 0.05 0.07 0.08 0.05 0.11 0.14 0.08 0.09 0 0 0 0 0 0.05
Cytoplasm 0.49 0.61 0.52 0.47 0.35 0.39 0.52 0.48 0.53 0.55 0.6 0.57 0.47 0.41 0.41 0.39 0.65 0.53 0.27 0.44 0.26 0.55 0.72 0.51
Endoplasmic Reticulum 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0.08 0.13 0.05 0.11 0.1 0.15 0.24 0.27 0.27 0.33 0 0 0 0.1 0 0.06 0 0 0 0 0 0
Nucleus 0.06 0 0.06 0.09 0.06 0.1 0.06 0.07 0 0.05 0 0 0 0.06 0.08 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.13 0.06 0.12 0 0.09 0.11 0.08 0.13 0.1 0.11 0.06 0.07 0.11 0.11 0.09 0.18 0.14 0.15 0 0 0 0 0 0
Peroxisomes 0 0.06 0 0 0 0 0 0 0 0 0 0 0.11 0.07 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.11 0 0 0.1 0.15 0.17 0.15 0.12 0.11 0.08 0.06 0.08 0.12 0.13 0.1 0.07 0.08 0.05 0.06 0 0.06 0 0 0
Vac/Vac Membrane 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 0 2 4 3 5 2 5 0 2 3 1 4 3 4 2 0 0 2 0 0 0 12 23
Bud 13 0 7 11 48 40 42 66 40 36 24 31 5 5 12 5 0 0 100 13 30 9 6 13
Bud Neck 59 1 20 21 76 38 71 97 42 49 28 32 13 19 27 20 7 11 131 8 33 12 12 22
Bud Site 41 2 10 24 50 35 39 28 22 17 8 23 10 21 19 9 1 4 – – – – – –
Cell Periphery 28 0 0 6 6 9 7 6 12 11 12 22 6 6 14 12 3 7 1 0 0 0 2 9
Cytoplasm 158 11 50 71 107 96 217 254 145 207 149 180 35 49 54 32 24 43 102 23 29 38 124 98
Endoplasmic Reticulum 0 1 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 3 1 0 0 1 1 3
Endosome 6 0 2 1 6 4 5 5 0 0 0 0 2 6 2 1 1 3 3 0 0 0 1 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 1 0 0 0 0 0 1
Mitochondria 1 1 8 20 15 27 43 79 67 103 67 103 1 2 4 8 0 5 1 0 1 2 1 5
Nucleus 19 0 6 13 18 25 24 39 12 20 9 6 1 7 11 0 1 2 0 0 2 0 0 0
Nuclear Periphery 0 0 0 0 0 0 2 2 1 0 1 0 0 0 0 0 0 0 1 0 1 0 0 0
Nucleolus 42 1 12 5 27 26 33 70 28 40 16 21 8 13 12 15 5 12 3 0 3 0 0 0
Peroxisomes 3 1 2 3 13 7 4 4 4 6 2 2 8 8 5 2 0 2 1 0 1 0 0 0
SpindlePole 36 0 4 15 45 43 65 64 29 31 15 25 9 16 13 6 3 4 21 1 7 0 0 0
Vac/Vac Membrane 7 1 0 1 3 4 2 10 2 1 5 5 1 0 0 5 1 3 7 1 1 1 3 5
Unique Cell Count 322 18 96 150 309 246 421 534 275 375 250 316 75 120 132 83 37 81 383 54 115 69 172 192
Labelled Cell Count 418 19 123 195 417 359 556 730 404 523 339 451 104 155 177 119 46 100 383 54 115 69 172 192


Ambiguous, Bud, Bud Neck, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.4 6.1 5.2 5.1 5.5 5.0 4.7 4.7 4.2 4.1 4.0 3.7 8.0 8.1 7.2 12.1 11.4 14.6 6.8 7.2 6.6
Std Deviation (1e-4) 2.9 1.4 1.3 1.2 1.4 1.3 1.4 1.5 1.1 1.4 1.3 1.3 2.4 2.4 2.2 3.0 4.7 5.8 1.2 7.5 1.6
Intensity Change (Log2) – – – -0.01 0.08 -0.05 -0.15 -0.14 -0.3 -0.34 -0.37 -0.47 0.63 0.66 0.49 1.22 1.14 1.5 0.39 0.47 0.36


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 2.1 2.2 0 0 0 0 0 0 -0.2 -1.0 0.5 -0.3 0 0
Bud Neck -1.4 0.8 -1.2 0 0 0 0 0 0 -0.6 -0.9 -0.1 0.5 -0.2 -1.3
Bud Site 1.2 1.4 0.9 0 0 0 0 0 0 0.6 1.5 0.9 0.1 0 -1.3
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 3.3 3.9 0 0
Cytoplasm -0.7 -3.1 -2.2 -0.1 -0.8 0.1 0.5 1.3 0.8 -0.7 -1.6 -1.7 -1.8 1.3 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.2 -1.3 0.7 0 0 0 0 0 0 0 0 -1.8 0.3 0 -0.5
Nucleus 0.7 -0.2 1.1 -0.2 0.4 0 -0.4 0 0 0 -0.1 0.6 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -2.8 -1.1 -0.5 0 0 0 0 0 0 -0.4 -0.4 -0.8 1.0 0 0.4
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1.7 2.7 3.2 0 0 0 0 0 0 1.9 2.3 1.6 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.3191 5.053 5.2925 5.0205 4.2327 4.4829 4.5631 6.928 8.1346 6.9925 6.1684 6.6168 2.4267 4.7324 5.2301 5.104 4.9833 3.6826
Actin 0.0053 0.0008 0.001 0.0001 0.0002 0.0103 0.0731 0.0173 0.032 0.0529 0.0274 0.015 0.0102 0.0015 0.0067 0.0116 0.0002 0.0063
Bud 0.0289 0.0257 0.0083 0.0002 0.0019 0.0207 0.017 0.033 0.0092 0.0006 0.0021 0.0228 0.0238 0.0407 0.0075 0.0007 0.0012 0.0381
Bud Neck 0.0457 0.0409 0.6618 0.9053 0.9193 0.4683 0.0382 0.0244 0.5757 0.8695 0.4883 0.4191 0.0571 0.0287 0.6881 0.953 0.9163 0.4249
Bud Periphery 0.0182 0.0291 0.0087 0.0002 0.0023 0.0207 0.0119 0.0262 0.0052 0.0008 0.0038 0.033 0.0176 0.0184 0.0074 0.0008 0.0017 0.0411
Bud Site 0.4261 0.7021 0.2879 0.0048 0.0028 0.0433 0.2494 0.6486 0.2874 0.0025 0.018 0.0226 0.4617 0.6388 0.1984 0.0037 0.0255 0.0278
Cell Periphery 0.0087 0.0055 0.0033 0.0009 0.0014 0.0052 0.0068 0.0089 0.0042 0.001 0.0017 0.002 0.0067 0.0083 0.0031 0.0006 0.0014 0.0053
Cytoplasm 0.2281 0.0855 0.0003 0.0439 0.0004 0.3054 0.2412 0.1632 0.0098 0.0011 0.0197 0.3886 0.1697 0.073 0.0006 0.003 0.0001 0.3318
Cytoplasmic Foci 0.1161 0.027 0.0076 0.0035 0.0131 0.074 0.1224 0.0316 0.0406 0.0279 0.0651 0.0323 0.0892 0.0436 0.0239 0.0023 0.0246 0.0526
Eisosomes 0.0004 0 0 0 0 0.0001 0.0005 0.0001 0.0003 0.0003 0.0011 0.0001 0.0003 0.0004 0.0001 0.0001 0 0.0001
Endoplasmic Reticulum 0.0054 0.0003 0 0.0003 0 0.0012 0.0149 0.0008 0.0001 0.0012 0.0054 0.0013 0.0048 0.0006 0.0001 0.0004 0 0.0017
Endosome 0.0013 0.0008 0.0001 0.0012 0.0005 0.0015 0.0634 0.001 0.0025 0.008 0.1115 0.0038 0.0148 0.0011 0.0016 0.0013 0.0002 0.0043
Golgi 0.0009 0.0002 0.0002 0.0003 0.0006 0.0013 0.0319 0.0011 0.0039 0.015 0.0689 0.0033 0.0049 0.0003 0.0016 0.0006 0.0003 0.0015
Lipid Particles 0.0064 0.0005 0.0005 0.0003 0.0038 0.0028 0.0439 0.0009 0.0044 0.0032 0.0244 0.0068 0.0115 0.0007 0.0065 0.0002 0.0152 0.0042
Mitochondria 0.0016 0.0034 0.0002 0.0001 0.0006 0.0005 0.0073 0.0012 0.0042 0.0008 0.0513 0.0045 0.0127 0.0014 0.0066 0.0003 0.001 0.0049
None 0.071 0.0024 0.0001 0.0002 0 0.0088 0.0112 0.002 0.0003 0.0002 0.0087 0.0157 0.0369 0.0162 0.0004 0.0013 0.0001 0.0241
Nuclear Periphery 0.0005 0.0014 0 0 0 0.0003 0.0207 0.0011 0.0001 0.0002 0.0088 0.0003 0.0017 0.0007 0.0003 0.0005 0 0.0007
Nucleolus 0.013 0.0165 0.0122 0.034 0.0423 0.0065 0.0045 0.0109 0.0094 0.0037 0.0113 0.0214 0.0272 0.0307 0.0219 0.0144 0.007 0.0047
Nucleus 0.0026 0.0378 0.0033 0.0029 0.0042 0.0032 0.0041 0.0069 0.0022 0.0008 0.0065 0.0013 0.0044 0.037 0.0033 0.0025 0.0018 0.0048
Peroxisomes 0.0056 0.0007 0.0004 0.0001 0.0037 0.003 0.0141 0.0011 0.0049 0.0063 0.0111 0.0026 0.0181 0.0031 0.0139 0.0007 0.0017 0.0026
Punctate Nuclear 0.0088 0.0092 0.0024 0.0006 0.0011 0.0198 0.0112 0.0029 0.001 0.0033 0.0488 0.0015 0.0155 0.0092 0.0061 0.002 0.0009 0.0076
Vacuole 0.0052 0.0085 0.0016 0.0009 0.0015 0.003 0.0089 0.0159 0.0023 0.0005 0.0113 0.0018 0.0104 0.043 0.0018 0.0002 0.0006 0.0101
Vacuole Periphery 0.0003 0.0016 0.0001 0 0.0001 0.0002 0.0033 0.0008 0.0002 0.0001 0.0046 0.0004 0.001 0.0026 0.0002 0 0.0001 0.0011

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 78.5158 28.7657 19.6378 40.0398 71.5515 80.402 29.0123 21.986 32.3802 77.2415
Translational Efficiency 1.5588 1.5435 0.9404 1.0186 1.2272 1.569 1.1018 0.8093 0.8441 1.0614

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
789 1212 170 1151 741 1543 44 3089 1530 2755 214 4240

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 732.53 863.14 1285.60 1152.63 775.00 890.41 1206.91 1204.23 753.10 878.41 1269.42 1190.22
Standard Deviation 319.29 164.61 169.73 199.21 126.06 134.30 144.93 228.59 246.41 149.02 167.97 222.19
Intensity Change Log 2 — 0.236707 0.811482 0.653970 — 0.200273 0.639050 0.635843 — 0.218092 0.725413 0.644679

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000656 0.000832 0.001639 0.002163 0.000809 0.000730 0.000584 0.000624 0.000730 0.000775 0.001422 0.001042
Bud Neck 0.151015 0.157709 0.121681 0.147095 0.195990* 0.177526 0.102023 0.186798* 0.172797 0.168808 0.117639 0.176020
Bud Site 0.378841* 0.475782* 0.442893* 0.592914* 0.493805* 0.508370* 0.392949* 0.603022* 0.434519* 0.494034* 0.432624* 0.600278*
Cell Periphery 0.006458 0.004747 0.000897 0.002705 0.004644 0.005115 0.000466 0.005655 0.005579 0.004953 0.000808 0.004854
Cytoplasm 0.265338* 0.179613* 0.160169* 0.112254* 0.153083* 0.176484* 0.125578* 0.126064* 0.210971* 0.177861* 0.153057* 0.122315*
Cytoplasmic Foci 0.090590 0.088409 0.113032 0.052544 0.071877 0.070717 0.154295 0.031633 0.081527 0.078500 0.121516 0.037309
Eisosomes 0.001614 0.001485 0.001189 0.001263 0.000994 0.001466 0.001896 0.003497 0.001314 0.001474 0.001334 0.002890
Endoplasmic Reticulum 0.000742 0.001524 0.001828 0.000328 0.000676 0.000436 0.001050 0.000150 0.000710 0.000914 0.001668 0.000199
Endosome 0.008266 0.009803 0.004282 0.004612 0.009643 0.008479 0.008142 0.001091 0.008933 0.009061 0.005076 0.002047
Golgi 0.002573 0.003531 0.000515 0.003820 0.002505 0.004223 0.000925 0.000841 0.002540 0.003919 0.000599 0.001649
Lipid Particles 0.001190 0.001013 0.001846 0.000596 0.000747 0.001415 0.009345 0.000080 0.000976 0.001238 0.003388 0.000220
Mitochondria 0.002652 0.004217 0.000344 0.005670 0.003171 0.001177 0.000421 0.008181 0.002904 0.002514 0.000360 0.007499
Mitotic Spindle 0.001821 0.004983 0.005010 0.013022 0.002965 0.004681 0.013318 0.006044 0.002375 0.004814 0.006718 0.007938
None 0.017765 0.002888 0.000408 0.000401 0.003342 0.001029 0.000103 0.000790 0.010780 0.001847 0.000345 0.000684
Nuclear Periphery 0.000069 0.000067 0.000264 0.000100 0.000059 0.000038 0.000244 0.000044 0.000064 0.000051 0.000260 0.000059
Nuclear Periphery Foci 0.002318 0.001406 0.007323 0.000755 0.001242 0.001020 0.006416 0.000385 0.001797 0.001190 0.007137 0.000485
Nucleolus 0.004715 0.008106 0.009431 0.000926 0.005313 0.000859 0.001979 0.002126 0.005005 0.004047 0.007899 0.001800
Nucleus 0.023182 0.010387 0.022116 0.003495 0.007424 0.005565 0.010824 0.002898 0.015550 0.007686 0.019794 0.003060
Peroxisomes 0.012979 0.018316 0.015226 0.008821 0.017787 0.007438 0.029313 0.010550 0.015308 0.012223 0.018122 0.010080
Vacuole 0.026068 0.023262 0.089689 0.044188 0.021820 0.022199 0.139926 0.008809 0.024011 0.022667 0.100018 0.018413
Vacuole Periphery 0.001149 0.001919 0.000218 0.002330 0.002104 0.001034 0.000203 0.000720 0.001611 0.001423 0.000214 0.001157

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.21 -3.03 -3.60 -3.15 -0.51 0.28 0.12 0.21 -0.09 0.05 -0.32 -2.75 -2.25 -2.06 1.46
Bud Neck -0.68 4.77 2.36 3.77 -3.46 1.79 5.72 1.31 -0.92 -5.58 0.56 7.94 0.64 0.05 -8.64
Bud Site -6.41 1.67 -10.20 -4.42 -7.32 -0.95 2.84 -7.87 -9.16 -4.84 -5.62 4.09 -14.97 -11.21 -10.36
Cell Periphery 1.33 5.04 3.30 2.65 -3.28 -0.56 6.98 -1.42 -0.74 -15.32 0.80 7.39 1.13 0.31 -13.15
Cytoplasm 6.29 2.52 8.61 2.66 2.58 -2.09 -0.23 1.87 5.30 0.81 3.66 0.71 8.74 6.21 3.28
Cytoplasmic Foci 0.23 -1.30 5.25 5.64 4.16 0.09 -3.02 7.73 10.27 4.77 0.53 -3.00 10.71 12.65 7.16
Eisosomes 0.31 1.92 1.39 1.57 -1.11 -1.92 -1.36 -6.46 -4.85 -3.07 -0.67 1.13 -4.63 -4.46 -5.70
Endoplasmic Reticulum -1.02 -3.92 3.74 1.58 4.71 1.30 -1.48 3.43 2.77 3.34 -0.58 -4.11 5.68 2.12 5.35
Endosome -1.10 2.40 3.50 4.35 1.13 0.83 0.45 7.43 7.91 2.99 -0.06 2.64 9.36 9.85 5.04
Golgi -2.04 6.95 -0.66 0.19 -2.54 -2.61 3.60 7.00 5.44 -0.04 -3.25 9.24 2.96 4.97 -2.86
Lipid Particles 0.43 -3.79 1.96 0.69 4.71 -1.74 -1.13 5.30 3.56 1.23 -0.93 -2.18 6.28 3.55 2.69
Mitochondria -0.99 1.81 -1.51 -0.55 -4.53 3.06 4.52 -5.15 -9.00 -10.38 0.44 3.56 -4.75 -6.15 -11.28
Mitotic Spindle -2.56 -1.93 -5.66 -3.92 -0.63 -1.57 -0.94 -4.65 -1.78 0.53 -3.01 -2.07 -7.83 -3.93 0.58
None 5.41 6.53 6.54 3.40 -0.00 2.02 2.93 2.31 0.82 -11.61 5.86 7.02 6.81 3.22 -2.91
Nuclear Periphery -0.04 -5.81 -3.91 -3.55 4.84 1.64 -2.26 0.76 -1.73 2.36 1.13 -6.24 -1.32 -2.77 6.08
Nuclear Periphery Foci 2.11 -5.35 3.36 1.73 6.66 1.04 -3.54 5.62 4.52 4.02 2.49 -6.59 5.53 4.76 7.84
Nucleolus -1.74 -0.46 3.60 5.04 1.36 3.50 2.46 2.48 -4.47 -0.57 1.02 -0.22 3.87 3.41 1.14
Nucleus 4.09 -2.11 6.27 3.05 6.30 1.14 -1.37 3.60 2.45 2.56 4.45 -3.58 7.52 4.43 6.98
Peroxisomes -2.31 0.64 2.71 5.39 1.11 4.40 -0.79 3.18 -2.67 1.62 1.89 0.43 3.75 2.33 1.50
Vacuole 0.97 -7.97 -8.54 -9.35 5.09 -0.16 -4.50 5.51 6.64 4.83 0.70 -9.27 -1.80 -2.67 9.02
Vacuole Periphery -2.24 5.17 -1.37 -0.15 -2.74 0.97 1.86 1.32 0.69 -5.62 0.32 2.64 0.97 1.03 -4.29
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication
Localization
Cell Percentages bud neck (34%), cytoplasm (24%), mixed (17%)
Cell Cycle Regulation Yes
cytoplasm - T/G1 (5e-08)
bud neck - S/G2 (5.2e-06)
bud neck - MA (6.3e-05)
Subcompartmental Group N/A

Gin4

Gin4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gin4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available