ORF
Human Ortholog
Description Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0.64 0.66 0.7 0.48 0.62 0.43 0.44 0.44 0.41 0.46 0.25 0.44 0.88 0.94 0.96 – 0.84 0.89 0.22 0.33 0.22 0.19 0.24 0.16
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.1 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0.05 0.06 0.06 0.05 0.06 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0.47 0.41 0.32 0.58 0.41 0.67 0.66 0.62 0.71 0.73 0.86 0.74 0.07 0.05 0 – 0.07 0 0.56 0.38 0.52 0.54 0.49 0.49
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0.05 0.06 0.05 0 0 0 0.05 0 0 0 – 0 0 0 0 0 0.06 0.06 0
Vac/Vac Membrane 0 0.07 0.07 0 0.05 0.06 0 0 0 0 0 0 0.09 0.05 0 – 0.09 0.06 0.05 0.12 0.05 0 0.05 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 6 2 4 4 8 25
Bud 0 0 7 7 4 8 8 16 10 21 19 23 0 2 0 – 1 3 1 2 0 1 3 8
Bud Neck 0 0 1 1 0 1 0 7 0 3 2 1 0 0 0 – 3 0 1 0 0 0 1 14
Bud Site 0 0 0 1 0 4 3 4 8 8 1 7 0 0 0 – 0 0 – – – – – –
Cell Periphery 1 0 0 2 1 1 2 1 2 0 1 2 0 0 0 – 2 4 1 0 2 0 3 4
Cytoplasm 195 50 125 78 152 119 224 241 191 238 111 268 177 434 427 – 218 154 80 36 47 25 75 63
Endoplasmic Reticulum 8 1 0 1 1 1 0 0 1 0 3 0 1 1 2 – 26 8 8 0 4 0 3 5
Endosome 0 1 3 1 8 1 0 2 0 0 0 0 3 4 2 – 7 2 17 6 11 6 18 26
Golgi 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 – 2 0 1 1 1 0 1 1
Mitochondria 145 31 58 94 100 186 337 346 331 376 379 457 14 25 18 – 17 7 208 42 110 71 153 192
Nucleus 0 0 1 0 1 3 4 8 2 3 2 7 0 0 1 – 2 1 0 0 0 0 0 0
Nuclear Periphery 1 0 0 1 0 1 1 0 2 1 1 0 0 0 1 – 0 0 0 1 1 0 0 2
Nucleolus 0 0 1 0 1 0 0 3 1 1 0 2 0 0 2 – 0 0 0 0 0 1 0 1
Peroxisomes 0 0 0 0 0 1 1 1 1 1 1 1 0 0 0 – 0 0 3 0 2 0 0 3
SpindlePole 2 0 1 5 7 14 31 26 17 23 10 28 1 0 1 – 5 4 8 2 8 7 17 13
Vac/Vac Membrane 9 5 12 6 13 17 11 8 6 10 7 7 19 21 5 – 24 10 19 13 10 5 14 23
Unique Cell Count 306 76 179 162 244 277 511 554 463 516 442 616 202 462 443 258 174 370 111 213 133 312 397
Labelled Cell Count 361 88 209 197 289 357 622 663 572 685 537 803 215 487 460 307 193 370 111 213 133 312 397


Mitochondria, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.3 3.7 3.7 3.6 3.7 4.0 2.6 3.0 2.9 2.6 2.6 2.6 4.5 4.2 4.1 4.4 5.0 5.3 4.2 4.3 4.8
Std Deviation (1e-4) 0.4 1.1 1.2 1.0 1.3 6.4 0.9 1.1 1.1 0.8 0.5 1.2 1.6 1.1 0.9 1.4 1.8 1.7 1.7 1.9 1.8
Intensity Change (Log2) – – – -0.06 -0.04 0.1 -0.52 -0.33 -0.39 -0.54 -0.51 -0.54 0.27 0.16 0.12 0.23 0.43 0.51 0.16 0.19 0.36

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – 0 0
Bud Neck – – – – – – – – – – – – – 0 0
Bud Site – – – – – – – – – – – – – 0 0
Cell Periphery – – – – – – – – – – – – – 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – 0 0
Endosome – – – – – – – – – – – – – 0 0
Golgi – – – – – – – – – – – – – 0 0
Mitochondria – – – – – – – – – – – – – 0 0
Nuclear Periphery – – – – – – – – – – – – – 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – 0 0
Peroxisomes – – – – – – – – – – – – – 0 0
SpindlePole – – – – – – – – – – – – – 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – 0 0
Cytoplasm – – – – – – – – – – – – – 0 0
Nucleus – – – – – – – – – – – – – 0 0
Vacuole – – – – – – – – – – – – – 1.0 -0.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.486 -0.2294 -0.2943 -0.6879 -0.2395 -0.3158 0.5555 0.7915 0.5953 0.7756 0.7432 0.8764 0.5333 1.501 0.6686 1.0638 0.9683 0.7284
Actin 0.0222 0.0174 0.0249 0.0148 0.0171 0.0138 0.0205 0.0148 0.0236 0.0439 0.0047 0.0062 0.0315 0.0113 0.0127 0.0222 0.0441 0.0081
Bud 0.0011 0.0046 0.002 0.003 0.0045 0.0017 0.001 0.0129 0.0012 0.0057 0.0005 0.0006 0.0037 0.0028 0.0013 0.0058 0.0027 0.0005
Bud Neck 0.0119 0.002 0.0018 0.0006 0.0009 0.017 0.0016 0.0003 0.0014 0.0023 0.0024 0.0105 0.0087 0.0009 0.0008 0.0033 0.003 0.0039
Bud Periphery 0.0023 0.0067 0.0038 0.0107 0.0119 0.006 0.0026 0.0026 0.0029 0.0263 0.0012 0.0011 0.0062 0.0033 0.0033 0.008 0.007 0.0009
Bud Site 0.0103 0.038 0.0119 0.006 0.0043 0.0023 0.0047 0.0068 0.0085 0.0022 0.0012 0.0017 0.0196 0.0307 0.0045 0.005 0.0021 0.001
Cell Periphery 0.0015 0.0052 0.0011 0.0085 0.0012 0.0007 0.001 0.0011 0.0013 0.0005 0.0009 0.0005 0.0026 0.002 0.0019 0.0013 0.0005 0.0009
Cytoplasm 0.1337 0.2561 0.1959 0.2448 0.2446 0.2009 0.1376 0.1335 0.214 0.1744 0.1555 0.2124 0.1471 0.1716 0.2233 0.2215 0.1328 0.2252
Cytoplasmic Foci 0.106 0.0994 0.1035 0.1066 0.0686 0.1738 0.107 0.0639 0.0764 0.0517 0.1761 0.1028 0.1676 0.0895 0.1307 0.1561 0.1468 0.1589
Eisosomes 0.0008 0.0011 0.001 0.001 0.0004 0.0003 0.0011 0.0014 0.0007 0.0005 0.0007 0.0002 0.0014 0.001 0.0009 0.0008 0.0007 0.0003
Endoplasmic Reticulum 0.0276 0.0194 0.0135 0.0146 0.0074 0.0108 0.013 0.0071 0.0181 0.0262 0.0106 0.0052 0.0078 0.005 0.0144 0.0105 0.0073 0.0154
Endosome 0.1052 0.0773 0.0733 0.0582 0.0777 0.0894 0.0505 0.0549 0.0387 0.0491 0.0452 0.0769 0.0717 0.0341 0.0858 0.0611 0.101 0.0988
Golgi 0.0315 0.0182 0.0154 0.0154 0.0288 0.0211 0.0174 0.0042 0.009 0.032 0.0095 0.0119 0.0206 0.0215 0.022 0.0156 0.0378 0.0201
Lipid Particles 0.0421 0.0127 0.0242 0.02 0.0239 0.0306 0.0391 0.0146 0.008 0.0064 0.0555 0.0237 0.0425 0.0213 0.015 0.0212 0.0124 0.0142
Mitochondria 0.0466 0.0664 0.0905 0.0799 0.1393 0.0779 0.0429 0.0136 0.0595 0.0965 0.0164 0.0456 0.08 0.076 0.1012 0.0997 0.1287 0.0897
None 0.3657 0.3272 0.3646 0.3143 0.3008 0.254 0.4901 0.6316 0.502 0.449 0.4322 0.4577 0.3054 0.5035 0.3335 0.32 0.28 0.3014
Nuclear Periphery 0.0153 0.0051 0.0076 0.0097 0.0113 0.0127 0.0048 0.0019 0.0044 0.0071 0.0017 0.0023 0.0032 0.0014 0.0067 0.0029 0.0069 0.0035
Nucleolus 0.0095 0.0014 0.002 0.0009 0.0009 0.0016 0.0016 0.0007 0.0011 0.0004 0.0013 0.0008 0.0018 0.0009 0.001 0.0008 0.0005 0.001
Nucleus 0.0124 0.0119 0.0142 0.0081 0.0363 0.0159 0.0132 0.0025 0.0042 0.0024 0.0013 0.0053 0.0055 0.0022 0.0059 0.0036 0.0024 0.0152
Peroxisomes 0.0257 0.0066 0.0274 0.0636 0.0054 0.0418 0.0317 0.0042 0.0154 0.0109 0.0675 0.0209 0.0517 0.0139 0.0212 0.0295 0.0724 0.0233
Punctate Nuclear 0.0106 0.0078 0.0113 0.0036 0.003 0.0109 0.0069 0.0012 0.0034 0.0012 0.0098 0.0024 0.0105 0.0021 0.0047 0.0028 0.0046 0.0088
Vacuole 0.0133 0.0128 0.0079 0.0111 0.0078 0.0133 0.0097 0.0239 0.0048 0.0072 0.005 0.0091 0.009 0.0041 0.0067 0.0061 0.0039 0.0067
Vacuole Periphery 0.0049 0.0026 0.0024 0.0045 0.0036 0.0035 0.0021 0.0022 0.0014 0.0041 0.0009 0.0023 0.0018 0.0012 0.0024 0.0023 0.0022 0.0024

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.499 10.1898 7.5613 9.9336 8.3748 4.557 11.6767 9.9671 10.4055 10.1811
Translational Efficiency 2.1541 1.7299 2.1229 1.3298 1.3831 3.4835 1.421 1.2473 1.1334 1.4623

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2234 1880 194 1430 484 2321 939 746 2718 4201 1133 2176

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 593.81 695.19 871.75 833.56 720.24 695.18 886.38 820.55 616.32 695.18 883.87 829.10
Standard Deviation 139.77 91.97 86.74 111.78 77.21 90.59 94.95 104.74 139.49 91.21 93.75 109.59
Intensity Change Log 2 — 0.227406 0.553913 0.489285 — -0.051091 0.299448 0.188114 — 0.081449 0.420022 0.332035

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000176 0.000963 0.000615 0.004882 0.000157 0.000825 0.000227 0.001097 0.000172 0.000887 0.000293 0.003584
Bud Neck 0.046896 0.065409 0.002468 0.035891 0.021618 0.065308 0.002868 0.018578 0.042395 0.065353 0.002799 0.029956
Bud Site 0.014139 0.026013 0.007309 0.048437 0.004710 0.021407 0.003625 0.022087 0.012460 0.023468 0.004255 0.039404
Cell Periphery 0.000694 0.000161 0.000156 0.000321 0.000148 0.000142 0.000144 0.000276 0.000597 0.000150 0.000146 0.000305
Cytoplasm 0.321691 0.126511 0.217871 0.234695 0.376042 0.140076 0.411445 0.226814 0.331370 0.134005 0.378300 0.231993
Cytoplasmic Foci 0.205134 0.261928 0.011521 0.037198 0.260184 0.285054 0.025382 0.062218 0.214937 0.274705 0.023009 0.045776
Eisosomes 0.000324 0.000174 0.000061 0.000116 0.000121 0.000176 0.000052 0.000121 0.000288 0.000176 0.000054 0.000118
Endoplasmic Reticulum 0.004717 0.001651 0.008692 0.012897 0.001005 0.001049 0.003285 0.005594 0.004056 0.001318 0.004211 0.010393
Endosome 0.012388 0.049131 0.002929 0.008286 0.015823 0.035864 0.004328 0.022022 0.013000 0.041801 0.004088 0.012995
Golgi 0.004876 0.031589 0.000105 0.003097 0.004229 0.030231 0.000125 0.005549 0.004761 0.030839 0.000122 0.003937
Lipid Particles 0.024863 0.013532 0.002485 0.004016 0.009126 0.014135 0.002424 0.008603 0.022061 0.013865 0.002435 0.005589
Mitochondria 0.031548 0.156179 0.000531 0.009970 0.011988 0.150007 0.000434 0.010063 0.028065 0.152769 0.000450 0.010002
Mitotic Spindle 0.000657 0.020673 0.001907 0.057894 0.001570 0.018714 0.001451 0.023840 0.000819 0.019591 0.001529 0.046219
None 0.019377 0.002113 0.003536 0.005203 0.005840 0.002254 0.004285 0.007217 0.016967 0.002191 0.004157 0.005893
Nuclear Periphery 0.000939 0.000873 0.001821 0.002907 0.000664 0.000601 0.001784 0.003536 0.000890 0.000723 0.001790 0.003123
Nuclear Periphery Foci 0.000382 0.000463 0.002355 0.002264 0.000540 0.000357 0.001988 0.004045 0.000411 0.000404 0.002051 0.002875
Nucleolus 0.003588 0.004804 0.000708 0.002868 0.004494 0.003448 0.000912 0.006985 0.003749 0.004055 0.000877 0.004279
Nucleus 0.253257 0.083100 0.675569 0.399637 0.235701 0.097407 0.463255 0.440067 0.250130 0.091005 0.499609 0.413498
Peroxisomes 0.008759 0.075636 0.000681 0.017161 0.011016 0.072261 0.000411 0.010090 0.009161 0.073771 0.000457 0.014736
Vacuole 0.042319 0.071528 0.058438 0.110264 0.032823 0.056363 0.071306 0.116802 0.040628 0.063150 0.069103 0.112505
Vacuole Periphery 0.003275 0.007571 0.000244 0.001997 0.002199 0.004320 0.000270 0.004397 0.003083 0.005775 0.000265 0.002820

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -10.70 -5.13 -9.10 -7.34 -7.62 -8.65 -2.64 -4.01 -0.85 -3.51 -13.02 -4.62 -9.71 -7.39 -9.12
Bud Neck -5.07 19.04 4.86 9.63 -15.66 -9.70 4.98 1.11 15.82 -8.62 -8.26 19.42 6.28 16.18 -17.41
Bud Site -6.26 1.53 -7.48 -3.59 -6.05 -12.97 1.20 -4.78 0.97 -5.08 -7.78 5.60 -7.77 -3.21 -11.54
Cell Periphery 8.89 8.40 7.03 -6.99 -4.40 0.66 0.48 -4.30 -5.07 -4.90 9.09 9.08 6.79 -9.38 -8.93
Cytoplasm 29.67 8.01 16.53 -9.54 -0.19 18.80 0.51 10.78 -8.16 12.04 36.30 -0.59 19.27 -12.27 14.11
Cytoplasmic Foci -8.71 42.33 37.98 43.69 -7.24 -2.13 23.31 19.20 39.17 -7.93 -11.58 46.40 40.98 61.92 -7.55
Eisosomes 9.68 15.16 12.84 6.03 -5.58 -5.42 6.94 -0.40 6.10 -9.82 8.89 18.01 12.76 8.38 -12.58
Endoplasmic Reticulum 5.47 -5.36 -11.96 -20.07 -3.51 -0.37 -11.09 -13.31 -13.52 -4.63 6.00 -2.37 -12.34 -23.21 -12.37
Endosome -17.56 11.10 7.60 20.93 -3.64 -8.37 6.30 -0.72 6.93 -6.49 -21.02 12.33 2.83 21.68 -6.85
Golgi -15.72 15.35 5.40 17.17 -2.90 -13.99 4.58 0.37 13.46 -3.26 -21.69 15.43 4.11 22.43 -4.36
Lipid Particles 7.78 18.64 18.02 9.87 -3.69 -4.33 7.66 0.67 4.25 -4.85 7.26 20.26 15.97 11.13 -6.69
Mitochondria -22.16 16.64 12.48 28.15 -7.43 -27.15 5.59 1.68 28.65 -3.86 -32.38 17.51 12.08 40.88 -7.89
Mitotic Spindle -11.79 -1.53 -10.89 -5.43 -9.96 -10.74 0.22 -5.31 -0.73 -5.35 -16.43 -1.63 -12.14 -5.42 -11.74
None 9.68 8.66 8.39 -3.39 -0.92 3.49 2.39 0.02 -3.52 -2.40 9.95 9.07 8.02 -4.66 -2.20
Nuclear Periphery 0.33 -7.23 -14.85 -13.83 -7.64 0.55 -13.68 -6.13 -6.24 -3.40 1.66 -12.57 -13.20 -14.01 -7.75
Nuclear Periphery Foci -1.77 -6.03 -13.33 -12.53 0.02 2.12 -6.56 -3.63 -3.81 -1.79 -0.23 -8.70 -8.14 -8.09 -2.19
Nucleolus -2.50 8.96 2.56 4.14 -7.12 0.85 4.78 -1.85 -2.86 -6.10 -1.69 9.10 -0.69 0.85 -8.01
Nucleus 26.58 -20.76 -17.11 -37.05 12.09 12.28 -16.41 -12.48 -26.65 2.19 29.91 -25.29 -21.24 -45.60 7.21
Peroxisomes -21.83 13.89 -2.75 18.65 -8.40 -21.12 7.43 1.21 21.58 -5.25 -32.31 16.72 -1.92 28.00 -10.06
Vacuole -9.34 -4.40 -22.61 -16.68 -7.98 -8.09 -13.62 -15.58 -12.68 -4.58 -10.47 -13.42 -26.93 -21.93 -9.08
Vacuole Periphery -7.91 14.97 6.70 11.56 -3.40 -6.11 7.08 -1.04 1.46 -3.55 -8.64 16.33 3.60 9.67 -4.82
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (11%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YDR514C

YDR514C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ydr514c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available