Standard name
Human Ortholog
Description Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.1 0.1 0 0 0 0 0 0 0 0 0
Cytoplasm 0.78 0.92 0.79 0.91 0.93 0.91 0.88 0.9 0.87 0.86 0.88 0.88 0.84 0.88 0.87 0.34 0.32 0.36 0.13 0.25 0.11 0.16 0.09 0.07
Endoplasmic Reticulum 0.05 0 0 0 0 0 0 0 0 0 0 0 0.18 0.08 0.14 0 0 0 0.17 0.08 0.12 0.24 0.13 0.15
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.07 0.07 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.29 0.28 0.26 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.22 0.08 0.24 0.15 0.08 0.06 0.09 0.08 0.11 0.15 0.12 0.14 0 0 0 0.58 0.59 0.56 0.64 0.59 0.7 0.52 0.67 0.67
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 2 5 2 3 8 5 1 1 2 2 1 0 0 2 3 1 1 0 2
Bud 2 1 1 3 3 18 25 21 12 15 16 13 1 3 0 2 1 0 3 3 4 1 3 6
Bud Neck 0 0 0 0 0 0 0 0 0 1 0 0 0 2 0 0 1 0 4 7 1 1 2 1
Bud Site 0 0 0 0 0 0 0 2 1 2 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 0 0 0 11 7 1 12 6 11 10 23 50 62 0 0 0 0 0 0 0 0 0
Cytoplasm 371 436 294 274 286 395 549 591 399 480 305 377 310 437 531 153 109 100 67 127 43 52 26 27
Endoplasmic Reticulum 26 8 7 3 3 10 4 5 2 3 0 4 66 41 85 9 10 11 87 39 47 79 38 62
Endosome 4 2 12 5 2 4 3 6 3 7 0 2 1 1 1 14 7 3 11 11 12 5 8 16
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 1 1 0 0 0 2
Mitochondria 1 5 1 1 3 10 18 23 32 39 21 28 0 0 0 13 1 5 2 8 5 9 6 11
Nucleus 10 1 1 0 3 5 14 13 8 8 2 8 3 2 4 129 94 72 0 0 0 0 1 1
Nuclear Periphery 0 0 0 0 1 0 6 0 0 2 0 0 0 1 0 0 0 0 3 0 1 0 1 1
Nucleolus 0 0 0 1 0 2 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 0 0 0 0 2 0 1 0 0 0 0 0 0 0 0 2 4 0 0 2 0
Vac/Vac Membrane 103 36 89 45 26 27 56 52 53 86 43 58 1 7 5 258 202 154 338 304 288 175 197 277
Unique Cell Count 474 475 373 301 306 433 623 659 461 559 347 428 371 495 611 446 340 276 531 519 411 334 294 416
Labelled Cell Count 519 490 406 332 327 484 689 720 525 659 403 501 406 547 690 580 425 345 531 519 411 334 294 416


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.4 5.4 5.2 5.9 5.9 6.0 5.2 5.5 5.3 5.2 5.3 5.5 7.5 7.3 7.3 7.6 7.6 7.6 8.2 8.4 8.4
Std Deviation (1e-4) 1.1 0.9 1.1 1.8 1.4 1.5 1.3 1.3 1.3 1.3 1.2 1.5 1.2 1.1 1.2 1.5 1.8 1.8 1.5 1.5 1.9
Intensity Change (Log2) – – – 0.18 0.17 0.2 -0.0 0.07 0.01 -0.02 0.02 0.08 0.52 0.48 0.48 0.53 0.54 0.54 0.65 0.68 0.68


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 3.6 3.6 3.1 2.7 2.8 3.8 3.0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 3.1 0 0 3.1 0 3.5 0 4.9 6.3 6.4 0 0 0
Cytoplasm 4.3 5.4 5.0 3.9 4.8 3.0 2.8 3.3 3.5 1.7 3.8 3.3 -12.7 -12.6 -11.0
Endoplasmic Reticulum 0 0 0.4 0 0 0 0 0 -1.1 7.3 4.1 6.3 0.1 0.9 1.6
Endosome -1.3 -2.3 -2.3 -3.4 -2.7 -2.8 -2.1 -3.4 -3.0 -3.1 -3.6 0 -0.1 -1.0 -1.8
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 2.5 2.9 3.3 4.9 5.0 4.5 4.7 0 0 0 2.9 0 0
Nucleus 0 0 0 2.5 2.3 0 0 0 0 0 0 0 11.2 10.7 10.3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.9 -5.3 -7.1 -6.4 -7.2 -4.7 -3.2 -4.0 -3.8 -9.9 -10.4 -11.9 9.8 9.6 8.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.2498 3.7813 3.9753 3.6078 3.2966 3.8586 6.4365 7.709 7.2339 6.7556 6.5723 7.3573 5.5123 6.0852 5.6866 4.764 5.2203 5.2878
Actin 0.0001 0.0002 0.0003 0.0001 0 0.0001 0.0011 0.0002 0.0002 0.0001 0.0001 0.0001 0.0041 0.0002 0.0237 0.0106 0.1586 0.0028
Bud 0.0016 0.0022 0.0009 0.0009 0.001 0.0014 0.0002 0.002 0.0005 0.0003 0.0008 0.0004 0.0008 0.0002 0.001 0.0003 0.0028 0.0003
Bud Neck 0.0013 0.0042 0.0045 0.0018 0.0031 0.0039 0.0004 0.0019 0.0015 0.0017 0.0019 0.0037 0.0017 0.0015 0.0041 0.001 0.0022 0.006
Bud Periphery 0.0024 0.0019 0.0018 0.0011 0.0026 0.0035 0.0007 0.0017 0.0014 0.0006 0.0014 0.0014 0.0014 0.0006 0.0016 0.0005 0.0034 0.0009
Bud Site 0.01 0.0103 0.0043 0.0025 0.0023 0.0015 0.0006 0.0057 0.0018 0.0013 0.0033 0.001 0.002 0.0026 0.0085 0.001 0.0028 0.0008
Cell Periphery 0.0034 0.0034 0.0034 0.0013 0.0026 0.0043 0.0063 0.0072 0.0061 0.0068 0.0048 0.0052 0.0055 0.0095 0.0073 0.0044 0.0013 0.0036
Cytoplasm 0.1909 0.1995 0.2179 0.1743 0.1289 0.1947 0.2207 0.2382 0.2215 0.1737 0.1816 0.2563 0.2045 0.2629 0.1891 0.1252 0.1093 0.1623
Cytoplasmic Foci 0.0241 0.0182 0.0233 0.024 0.0139 0.0212 0.0118 0.0167 0.0157 0.0065 0.0136 0.0078 0.021 0.0126 0.0277 0.0164 0.022 0.0153
Eisosomes 0 0 0 0 0 0 0 0 0 0 0 0 0.0001 0 0.0001 0 0.0004 0
Endoplasmic Reticulum 0.1372 0.073 0.1388 0.0566 0.0623 0.1206 0.3785 0.2727 0.2733 0.4155 0.2584 0.2997 0.1889 0.2339 0.2609 0.214 0.06 0.2728
Endosome 0.1765 0.1413 0.1839 0.2254 0.1671 0.1444 0.0912 0.079 0.1193 0.0713 0.1277 0.0533 0.1074 0.0579 0.0883 0.1615 0.1288 0.0822
Golgi 0.0024 0.0023 0.0039 0.0027 0.0021 0.0023 0.0022 0.0021 0.0038 0.001 0.0026 0.0013 0.0106 0.0012 0.008 0.0039 0.016 0.007
Lipid Particles 0.0088 0.0041 0.0051 0.0016 0.0027 0.0053 0.0157 0.0147 0.0214 0.0111 0.0057 0.0054 0.0197 0.0127 0.0282 0.0152 0.0108 0.0111
Mitochondria 0.0029 0.0018 0.0061 0.001 0.001 0.0032 0.0007 0.0005 0.0012 0.0002 0.0008 0.0008 0.0036 0.0003 0.0057 0.0011 0.0071 0.0021
None 0.0217 0.0259 0.0193 0.0016 0.0025 0.0218 0.0183 0.0081 0.0045 0.0009 0.016 0.0103 0.0298 0.0105 0.0178 0.0083 0.0026 0.0036
Nuclear Periphery 0.019 0.0157 0.0189 0.011 0.0136 0.013 0.0136 0.0118 0.0113 0.0103 0.0192 0.0133 0.0373 0.017 0.0154 0.0286 0.0343 0.0242
Nucleolus 0.0026 0.003 0.0026 0.0007 0.0014 0.0022 0.0003 0.0023 0.0009 0.0003 0.0007 0.0007 0.0012 0.0008 0.0015 0.0007 0.001 0.0005
Nucleus 0.0141 0.0194 0.0128 0.0063 0.0093 0.0194 0.0034 0.0092 0.004 0.0036 0.0084 0.0067 0.052 0.0056 0.0065 0.0078 0.0209 0.0109
Peroxisomes 0.0003 0.0002 0.0004 0.0003 0.0002 0.0005 0.0001 0.0001 0.0001 0 0.0002 0.0001 0.0012 0.0001 0.0048 0.001 0.0459 0.0054
Punctate Nuclear 0.0012 0.0013 0.0016 0.0003 0.0005 0.0015 0.0004 0.0017 0.0003 0.0003 0.0007 0.0005 0.0045 0.0005 0.002 0.0079 0.0065 0.001
Vacuole 0.3587 0.4547 0.3292 0.4558 0.5562 0.4145 0.2261 0.3177 0.2993 0.2882 0.3414 0.3223 0.2876 0.361 0.2852 0.3756 0.3389 0.3738
Vacuole Periphery 0.0208 0.0173 0.0211 0.0307 0.0267 0.0206 0.0077 0.0064 0.012 0.0064 0.0107 0.0095 0.0149 0.0084 0.0127 0.0151 0.0247 0.0134

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 94.6548 60.4397 77.1401 81.1515 87.6601 97.3053 91.6658 80.8412 94.7312 91.8758
Translational Efficiency 1.661 2.1227 1.578 1.7857 1.5763 1.5471 1.3445 1.5398 1.4631 1.3318

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
669 1987 1365 169 1607 1869 324 1385 2276 3856 1689 1554

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 748.56 847.03 1025.32 967.34 775.33 822.99 1086.40 1068.04 767.46 835.38 1037.04 1057.09
Standard Deviation 88.92 130.24 153.06 119.43 111.81 117.96 127.98 185.77 106.30 125.02 150.51 182.46
Intensity Change Log 2 — 0.178295 0.453884 0.369905 — 0.086064 0.486673 0.462083 — 0.132107 0.470660 0.417539

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000070 0.000423 0.001996 0.000585 0.000098 0.000231 0.001279 0.005771 0.000090 0.000330 0.001858 0.005207
Bud Neck 0.008565 0.013622 0.006214 0.004246 0.010217 0.013994 0.003786 0.016180 0.009731 0.013802 0.005748 0.014883
Bud Site 0.002736 0.012198 0.017894 0.006308 0.006193 0.022095 0.010646 0.049804 0.005177 0.016995 0.016503 0.045074
Cell Periphery 0.000347 0.000769 0.002480 0.001012 0.000320 0.000942 0.002527 0.011297 0.000328 0.000853 0.002489 0.010179
Cytoplasm 0.550495* 0.322678* 0.238806* 0.181118* 0.292490* 0.229713* 0.160606* 0.335854* 0.368327* 0.277618* 0.223805* 0.319026*
Cytoplasmic Foci 0.198920* 0.094804 0.020988 0.081330 0.106804 0.073489 0.017991 0.042866 0.133880 0.084473 0.020413 0.047049
Eisosomes 0.000258 0.000250 0.000372 0.000341 0.000130 0.000331 0.000308 0.001298 0.000168 0.000289 0.000359 0.001194
Endoplasmic Reticulum 0.007641 0.069087 0.539648* 0.069690 0.042640 0.122468* 0.629295* 0.258232* 0.032353 0.094961 0.556845* 0.237727*
Endosome 0.014079 0.031558 0.007834 0.023549 0.046603 0.046659 0.006954 0.013498 0.037043 0.038877 0.007665 0.014591
Golgi 0.000952 0.003651 0.001448 0.000347 0.001705 0.004591 0.000980 0.004801 0.001484 0.004107 0.001358 0.004316
Lipid Particles 0.015693 0.014691 0.013010 0.021031 0.011798 0.017555 0.010736 0.039367 0.012943 0.016079 0.012574 0.037373
Mitochondria 0.000299 0.002319 0.000415 0.000178 0.001094 0.003627 0.000253 0.001894 0.000860 0.002953 0.000384 0.001707
Mitotic Spindle 0.000030 0.001363 0.000594 0.002355 0.000095 0.004509 0.000098 0.002122 0.000076 0.002887 0.000499 0.002147
None 0.003097 0.001819 0.000839 0.000163 0.002075 0.001784 0.000366 0.000989 0.002375 0.001802 0.000749 0.000899
Nuclear Periphery 0.000720 0.000655 0.003724 0.005855 0.000949 0.001653 0.002758 0.000371 0.000881 0.001139 0.003539 0.000967
Nuclear Periphery Foci 0.003413 0.001962 0.027591 0.040023 0.002042 0.001712 0.026673 0.009818 0.002445 0.001841 0.027415 0.013103
Nucleolus 0.000591 0.000791 0.000104 0.000519 0.000914 0.000902 0.000077 0.000248 0.000819 0.000845 0.000098 0.000278
Nucleus 0.098480 0.037664 0.045581 0.087867 0.027264 0.023670 0.033806 0.028115 0.048197 0.030881 0.043322 0.034613
Peroxisomes 0.001028 0.001688 0.000479 0.001474 0.001372 0.001666 0.000362 0.002451 0.001270 0.001677 0.000457 0.002344
Vacuole 0.092177 0.384412* 0.069572 0.471712* 0.442317* 0.417157* 0.090284 0.173789 0.339398* 0.400284* 0.073545 0.206188*
Vacuole Periphery 0.000408 0.003595 0.000412 0.000299 0.002881 0.011252 0.000215 0.001235 0.002154 0.007306 0.000374 0.001133

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.92 -4.80 -3.94 -0.90 3.38 -5.34 -2.77 -9.68 -9.45 -6.00 -3.77 -5.29 -9.77 -9.23 -5.18
Bud Neck -2.61 1.06 2.15 6.68 1.65 -3.05 5.23 -4.18 -1.19 -7.89 -4.14 3.66 -3.88 -0.64 -6.75
Bud Site -9.25 -7.61 -2.01 2.90 4.48 -8.00 -1.44 -13.41 -7.44 -8.52 -10.48 -6.55 -13.71 -9.16 -8.32
Cell Periphery -6.55 -8.78 -6.73 -1.81 5.88 -8.75 -3.15 -11.77 -11.01 -7.19 -10.59 -9.09 -11.79 -11.09 -8.59
Cytoplasm 22.67 28.36 24.12 10.30 4.20 7.80 9.82 -4.69 -11.88 -12.59 13.44 17.39 5.62 -5.44 -10.38
Cytoplasmic Foci 16.48 30.27 14.66 2.39 -9.66 8.53 23.31 16.82 9.05 -8.15 14.47 36.19 24.46 13.30 -11.20
Eisosomes 0.45 -2.12 -2.46 -2.47 0.65 -4.27 -1.96 -10.87 -8.07 -6.77 -4.57 -4.23 -10.66 -9.00 -7.67
Endoplasmic Reticulum -15.18 -49.63* -4.82 0.49 30.33* -12.94 -26.99 -20.71 -11.28 16.54 -15.54 -53.11 -22.12 -14.32 26.26
Endosome -11.42 5.10 -4.96 4.69 -9.59 -0.09 24.00 19.27 19.59 -6.46 -1.22 22.89 16.55 20.86 -7.48
Golgi -9.00 -2.80 5.77 11.68 7.67 -6.57 2.96 -5.24 0.25 -7.00 -9.29 0.76 -5.53 0.20 -6.00
Lipid Particles 0.54 1.06 -1.54 -2.75 -3.05 -5.48 0.69 -10.55 -8.03 -10.28 -3.44 0.07 -10.16 -9.00 -9.78
Mitochondria -7.62 -2.76 0.92 7.40 1.95 -5.35 3.31 -1.14 2.72 -2.76 -7.06 2.64 -1.43 2.47 -2.47
Mitotic Spindle -2.11 -3.45 -1.06 -0.37 -0.68 -3.75 -0.18 -3.21 1.56 -3.20 -4.28 -3.24 -3.40 0.57 -2.48
None 1.54 2.95 3.90 5.18 4.24 0.32 2.50 1.67 1.32 -2.01 0.91 3.07 2.81 2.50 -0.43
Nuclear Periphery 0.61 -7.85 -4.34 -4.41 -1.44 -3.75 -3.49 5.62 7.78 4.62 -2.32 -8.18 -0.29 1.44 7.69
Nuclear Periphery Foci 3.74 -15.63 -9.17 -9.60 -2.40 1.52 -9.27 -11.91 -12.33 6.15 3.27 -18.80 -13.99 -14.91 9.70
Nucleolus -3.61 12.56 1.00 3.24 -4.94 0.09 5.64 4.51 3.67 -6.87 -0.17 6.83 5.13 6.30 -8.20
Nucleus 15.80 11.85 1.18 -5.75 -4.47 2.30 -1.96 -1.41 -3.52 1.42 9.84 0.88 5.38 -2.79 3.65
Peroxisomes -5.01 4.84 -0.72 0.53 -1.71 -1.94 8.07 -4.47 -3.10 -9.90 -3.72 7.98 -4.99 -2.91 -9.39
Vacuole -38.29* 2.93 -20.54 -5.20 -21.73 2.47 30.81* 27.30 23.91 -8.89 -8.01 37.89 13.20 22.65 -20.96
Vacuole Periphery -14.39 -0.03 2.81 14.97 1.50 -10.24 15.51 7.82 12.41 -6.88 -12.06 12.96 6.21 14.57 -5.14
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2
Localization
Cell Percentages vacuole (39%), cytoplasm (13%), mixed (26%)
Cell Cycle Regulation Yes
vacuole - S/G2 (9.1e-06)
Subcompartmental Group N/A

Fpr2

Fpr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Fpr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available