Standard name
Human Ortholog
Description Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 – 0.96 0.99 0.98 0.94 0.88 0.86 0.85 0.83 0.76 0.83 0.98 0.99 0.98 0.95 0.94 0.97 0.94 0.95 0.95 0.93 0.9 0.9
Endoplasmic Reticulum 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 – 0 0 0 0.09 0.15 0.19 0.26 0.25 0.36 0.25 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 – 0 0 0 0.05 0.07 0 0 0.05 0 0 0 0 0 0 0.11 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 1 1
Bud 1 – 0 0 1 1 3 10 4 9 4 9 0 1 0 0 0 1 0 0 0 0 6 3
Bud Neck 0 – 0 1 1 0 0 1 2 3 0 0 0 0 1 0 0 0 0 0 0 0 1 1
Bud Site 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0 2 4 1 0 5 3 2 1 0 0 1 1 5 6 7 0 0 0 0 0 0
Cytoplasm 230 – 23 336 535 439 574 560 331 461 274 328 125 393 406 180 203 207 229 33 66 87 305 312
Endoplasmic Reticulum 0 – 0 1 1 0 0 0 0 0 0 0 0 1 2 7 11 4 0 0 0 0 1 2
Endosome 1 – 0 0 0 0 2 1 0 0 2 0 0 1 2 0 1 0 2 0 0 0 4 6
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 0 0 0 0 0 0 2
Mitochondria 12 – 1 1 4 44 96 122 100 138 129 99 0 1 0 1 2 3 2 0 1 3 5 4
Nucleus 1 – 0 2 1 5 10 7 5 6 1 11 2 0 3 3 1 6 0 0 0 0 1 0
Nuclear Periphery 1 – 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 1 1 1 0 0 2 0 1 0 0 0 0 0 0 0 0 0 1
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 – 0 0 0 0 0 2 2 0 0 0 0 0 1 0 0 0 1 0 0 0 5 4
Vac/Vac Membrane 0 – 0 2 10 24 43 28 12 30 11 8 0 0 4 5 23 8 4 0 0 0 1 0
Unique Cell Count 236 24 338 545 466 653 654 391 556 362 395 127 396 415 190 217 214 244 35 70 94 338 348
Labelled Cell Count 246 24 345 557 514 729 737 460 650 423 458 127 400 422 203 248 236 244 35 70 94 338 348


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.1 – 4.7 5.4 5.9 5.1 4.6 4.7 4.4 4.3 4.0 4.2 5.5 6.4 6.0 8.5 9.0 8.8 5.0 5.9 6.0
Std Deviation (1e-4) 0.6 – 0.4 1.5 1.5 1.5 1.4 1.3 1.7 1.1 1.3 1.0 0.8 1.3 1.1 1.6 2.0 1.9 0.9 1.4 1.3
Intensity Change (Log2) – – – 0.21 0.34 0.13 -0.01 0.02 -0.07 -0.12 -0.21 -0.17 0.24 0.45 0.35 0.87 0.95 0.92 0.09 0.34 0.35

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.9 0.8 -0.3 -1.2 -1.4 -1.5 -1.7 -2.3 -1.7 0.8 1.7 0.6 -0.2 -0.4 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.4284 2.3319 1.9551 1.6901 1.0235 1.9133 1.0199 2.287 1.5382 2.2706 1.1585 1.9287 1.5031 2.1426 1.5249 1.2916 1.0995 1.3703
Actin 0.0106 0.0011 0.0079 0.001 0.0007 0.007 0.0461 0.0037 0.0113 0.0349 0.0344 0.0004 0.0515 0.0001 0.0175 0.0138 0.0438 0.0271
Bud 0.0016 0.0138 0.0054 0.0012 0.0117 0.0045 0.0029 0.0004 0.0001 0.0021 0.0009 0.0056 0.0004 0.0001 0.0001 0.0005 0.0003 0.0002
Bud Neck 0.0046 0.0008 0.0019 0.0004 0.0009 0.0048 0.0036 0.002 0.0003 0.0297 0.0066 0.0006 0.0078 0.0001 0.0002 0.0005 0.0019 0.0011
Bud Periphery 0.0009 0.0018 0.0014 0.0005 0.0032 0.002 0.0024 0.0003 0.0001 0.0033 0.0016 0.0021 0.0005 0 0.0001 0.0005 0.0003 0.0001
Bud Site 0.0049 0.0194 0.0049 0.0003 0.0008 0.0029 0.0051 0.0127 0.0004 0.0132 0.0089 0.0002 0.0019 0.0002 0.0002 0.0011 0.0066 0.0001
Cell Periphery 0.0002 0.0004 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0008 0.0003 0 0.0002 0 0.0001 0.0001 0.0001 0
Cytoplasm 0.6262 0.728 0.6944 0.7323 0.6452 0.7036 0.636 0.7991 0.7641 0.6251 0.646 0.838 0.7225 0.9022 0.8654 0.8421 0.8366 0.8548
Cytoplasmic Foci 0.023 0.0104 0.0137 0.0112 0.0231 0.0219 0.0353 0.003 0.0092 0.0133 0.0468 0.0057 0.0134 0.002 0.0041 0.0174 0.018 0.0129
Eisosomes 0.0001 0 0.0001 0 0 0 0.0002 0 0.0001 0.0006 0.0007 0 0.0003 0 0.0002 0.0001 0.0003 0.0001
Endoplasmic Reticulum 0.0032 0.0025 0.0029 0.0032 0.0013 0.002 0.0022 0.0011 0.0024 0.0018 0.0065 0.0014 0.0049 0.0011 0.0029 0.0026 0.0021 0.0016
Endosome 0.0084 0.0041 0.0044 0.0053 0.0034 0.0061 0.0111 0.0005 0.0051 0.0183 0.0255 0.002 0.0109 0.0005 0.0036 0.0088 0.0214 0.0035
Golgi 0.0014 0.0002 0.0004 0.0002 0.0002 0.001 0.0051 0.0002 0.0012 0.0096 0.0144 0.0001 0.0049 0 0.0016 0.0093 0.003 0.0052
Lipid Particles 0.0015 0.0001 0.0004 0.0001 0.0002 0.0008 0.0122 0.0001 0.0042 0.009 0.0247 0 0.0098 0 0.002 0.0112 0.0086 0.0012
Mitochondria 0.0019 0.0012 0.001 0.0006 0.0005 0.0013 0.0018 0.0001 0.0019 0.0207 0.023 0.0004 0.0028 0.0001 0.0005 0.0031 0.0005 0.0196
None 0.2846 0.1883 0.2107 0.2074 0.2802 0.2068 0.2123 0.174 0.1899 0.171 0.0735 0.1386 0.087 0.0907 0.0841 0.0737 0.0438 0.0633
Nuclear Periphery 0.0041 0.0028 0.0037 0.0055 0.0011 0.0024 0.0008 0.0003 0.0014 0.0017 0.0119 0.0005 0.0163 0.0004 0.002 0.0012 0.0011 0.0008
Nucleolus 0.0009 0.0009 0.0012 0.0003 0.0005 0.0005 0.0002 0.0001 0.0002 0.0006 0.0019 0 0.0018 0 0 0.0001 0.001 0
Nucleus 0.0073 0.0167 0.0258 0.0147 0.0064 0.0136 0.0023 0.0012 0.0021 0.0034 0.0035 0.0031 0.0299 0.0018 0.0034 0.0018 0.0016 0.0051
Peroxisomes 0.0056 0.0003 0.0009 0.0005 0.0009 0.0012 0.0147 0.0001 0.0037 0.0355 0.0346 0.0001 0.021 0 0.0103 0.0093 0.0024 0.0012
Punctate Nuclear 0.0074 0.0057 0.0171 0.013 0.0184 0.0158 0.0037 0.0004 0.0015 0.0024 0.0314 0.0006 0.0097 0.0002 0.0007 0.0022 0.0035 0.0013
Vacuole 0.0012 0.0015 0.0015 0.0018 0.0011 0.0012 0.0015 0.0003 0.0006 0.002 0.0016 0.0004 0.0018 0.0004 0.0007 0.0005 0.0027 0.0005
Vacuole Periphery 0.0004 0.0002 0.0003 0.0005 0.0002 0.0003 0.0002 0 0.0002 0.0011 0.0014 0.0001 0.0008 0 0.0002 0.0003 0.0004 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.7439 8.0685 12.7228 16.0151 14.6279 22.552 15.2964 19.2715 18.5024 15.7753
Translational Efficiency 1.2424 2.3761 1.3595 1.2036 1.1613 1.443 1.5338 1.3168 1.2003 1.2387

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1420 355 2742 352 1793 1706 947 963 3213 2061 3689 1315

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 691.50 844.36 835.00 865.38 715.94 780.37 875.04 914.49 705.14 791.39 845.28 901.34
Standard Deviation 101.41 91.80 99.91 120.12 84.78 91.98 107.86 124.01 93.29 95.07 103.50 124.89
Intensity Change Log 2 — 0.288129 0.272047 0.323605 — 0.124320 0.289510 0.353129 — 0.207127 0.280957 0.338698

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000098 0.000436 0.000127 0.000293 0.000167 0.000411 0.000332 0.000244 0.000137 0.000415 0.000179 0.000257
Bud Neck 0.008020 0.012290 0.005391 0.002306 0.009083 0.012743 0.003342 0.005786 0.008613 0.012665 0.004865 0.004854
Bud Site 0.005237 0.021517 0.011011 0.006341 0.004192 0.008208 0.007622 0.024274 0.004654 0.010500 0.010141 0.019474
Cell Periphery 0.000093 0.000166 0.000067 0.000123 0.000101 0.000085 0.000125 0.000133 0.000097 0.000099 0.000082 0.000130
Cytoplasm 0.617697 0.492308 0.566729 0.575089 0.594242 0.601134 0.530904 0.572856 0.604608 0.582389 0.557532 0.573454
Cytoplasmic Foci 0.170015 0.247952 0.005342 0.015110 0.177490 0.135856 0.014734 0.018682 0.174186 0.155165 0.007753 0.017726
Eisosomes 0.000068 0.000099 0.000013 0.000041 0.000081 0.000071 0.000039 0.000036 0.000076 0.000076 0.000020 0.000038
Endoplasmic Reticulum 0.000690 0.001019 0.001056 0.002367 0.001030 0.000542 0.002837 0.001967 0.000880 0.000624 0.001513 0.002074
Endosome 0.008482 0.029481 0.000839 0.002457 0.008755 0.007666 0.002656 0.005214 0.008634 0.011424 0.001305 0.004476
Golgi 0.001700 0.003174 0.000058 0.000095 0.001591 0.001573 0.000099 0.002636 0.001639 0.001849 0.000068 0.001956
Lipid Particles 0.003378 0.004250 0.000361 0.001123 0.004292 0.001958 0.001196 0.000831 0.003888 0.002353 0.000575 0.000909
Mitochondria 0.002075 0.003619 0.000642 0.000207 0.003792 0.001961 0.000923 0.001030 0.003033 0.002247 0.000714 0.000810
Mitotic Spindle 0.000420 0.006129 0.004998 0.024868 0.003572 0.007764 0.005319 0.026994 0.002179 0.007482 0.005081 0.026425
None 0.006528 0.001576 0.005313 0.010918 0.002434 0.002425 0.006430 0.006249 0.004244 0.002279 0.005600 0.007499
Nuclear Periphery 0.000263 0.000252 0.001178 0.000765 0.000418 0.000309 0.001134 0.000812 0.000350 0.000299 0.001167 0.000799
Nuclear Periphery Foci 0.000859 0.001375 0.000444 0.003411 0.000472 0.000458 0.002632 0.001899 0.000643 0.000616 0.001006 0.002304
Nucleolus 0.000987 0.001138 0.000222 0.000191 0.000605 0.000776 0.000301 0.000391 0.000774 0.000838 0.000242 0.000338
Nucleus 0.116217 0.073839 0.362130 0.171944 0.133229 0.143327 0.342440 0.160287 0.125710 0.131358 0.357075 0.163407
Peroxisomes 0.002160 0.009980 0.000161 0.000159 0.003129 0.005706 0.001104 0.000501 0.002700 0.006442 0.000403 0.000409
Vacuole 0.054113 0.087447 0.033743 0.182092 0.050595 0.066497 0.075627 0.168081 0.052150 0.070106 0.044495 0.171831
Vacuole Periphery 0.000901 0.001953 0.000176 0.000101 0.000729 0.000531 0.000202 0.001096 0.000805 0.000776 0.000183 0.000829

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.40 -1.59 -6.50 0.83 -4.74 -1.90 -4.51 -2.43 1.03 2.29 -2.65 -2.55 -5.11 1.06 -2.70
Bud Neck -2.56 2.37 6.09 7.04 4.96 -2.35 5.98 5.59 6.21 -0.79 -3.18 4.99 7.31 7.75 2.33
Bud Site -5.29 -2.43 -0.55 5.18 2.18 -4.49 -1.85 -3.56 -1.22 -2.02 -6.20 -3.48 -3.41 0.84 -0.74
Cell Periphery -5.12 4.76 -1.08 4.11 -4.05 1.42 -3.25 0.99 -0.58 3.47 -0.18 3.36 0.37 0.39 -1.87
Cytoplasm 7.79 14.05 12.86 4.02 5.80 -0.06 14.21 15.91 15.57 1.56 3.67 18.93 21.00 16.21 7.22
Cytoplasmic Foci -6.17 33.96 31.81 20.68 -6.75 7.13 36.78 37.48 29.62 0.45 3.91 51.28 49.20 35.07 -7.51
Eisosomes -4.00 15.22 3.58 6.13 -11.53 0.78 6.37 7.96 1.98 1.59 -0.01 17.03 9.16 2.65 -13.25
Endoplasmic Reticulum -1.95 -8.92 -8.22 -5.56 -4.73 3.08 -11.75 -5.15 -9.86 7.67 2.26 -11.50 -9.20 -11.90 -0.33
Endosome -5.11 10.12 8.60 6.87 -6.03 1.37 8.92 8.63 8.00 0.90 -2.68 14.61 11.50 10.33 -3.11
Golgi -2.20 5.46 5.28 5.19 -5.70 0.08 6.68 2.20 2.02 -1.18 -0.65 8.64 3.41 3.58 -1.30
Lipid Particles -0.94 11.36 7.28 3.09 -10.71 5.09 7.28 8.27 3.34 3.57 4.27 13.08 10.99 4.42 -9.37
Mitochondria -0.72 2.69 3.52 1.68 9.10 1.95 3.52 3.78 2.77 0.55 1.15 4.46 4.79 3.28 1.85
Mitotic Spindle -2.39 -6.73 -4.42 -2.90 -3.34 -2.37 -0.51 -4.77 -2.91 -4.34 -3.66 -3.56 -6.70 -3.87 -5.45
None 4.73 1.49 0.53 -3.66 -0.64 0.13 -6.17 -6.57 -6.17 -1.73 3.74 -1.91 -3.15 -6.94 -2.21
Nuclear Periphery 0.01 -26.92 -13.79 -13.75 1.02 1.15 -14.12 -12.55 -17.92 -0.53 0.69 -24.17 -18.12 -21.84 -0.09
Nuclear Periphery Foci -2.75 2.75 -7.87 -4.89 -9.58 -0.02 -12.22 -11.31 -10.93 4.34 0.08 -7.01 -12.68 -12.61 -7.84
Nucleolus -0.89 7.74 7.82 3.32 0.79 -1.17 5.89 4.39 2.97 -0.59 -0.69 9.97 8.08 4.13 -0.88
Nucleus 6.24 -46.80 -6.73 -9.85 19.67 -2.19 -27.77 -11.62 -9.62 15.03 -1.59 -55.10 -14.03 -11.91 27.04
Peroxisomes -4.30 7.94 8.01 5.52 0.01 -2.86 5.06 8.56 6.71 1.73 -4.74 10.21 11.31 8.38 1.24
Vacuole -5.62 -0.32 -17.75 -14.60 -17.73 -6.72 -12.65 -26.37 -23.54 -14.98 -8.15 -8.23 -31.62 -27.95 -28.17
Vacuole Periphery -1.20 5.04 5.46 2.20 2.61 2.49 8.11 3.43 1.88 -1.12 0.27 8.57 5.14 3.07 -1.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (64%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Apa2

Apa2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Apa2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available