Standard name
Human Ortholog
Description bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm – 0 0.07 0.13 0.11 0.15 0.2 0.25 0.24 0.27 0.29 0.31 – 0.08 0.11 0.1 0.1 0.15 0.06 0 0 0.05 0 0
Endoplasmic Reticulum – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0.05 0 0.05 0 0 0 0 0 0
Endosome – 0 0 0 0 0.05 0.05 0 0 0 0 0 – 0 0.06 0 0 0 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria – 0.31 0 0.07 0 0.17 0.2 0.25 0.67 0.53 0.63 0.58 – 0 0 0.1 0 0 0 0 0 0.07 0.14 0.12
Nucleus – 0.88 0.91 0.8 0.79 0.61 0.57 0.43 0.29 0.31 0.23 0.21 – 0.88 0.72 0.79 0.82 0.78 0.69 0.87 0.82 0.58 0.43 0.29
Nuclear Periphery – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.08 0.1
Peroxisomes – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0.05 0.06 0 0.06 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0.05
Vac/Vac Membrane – 0 0 0 0 0.11 0.05 0.11 0 0.05 0 0.05 – 0.05 0.07 0.08 0.06 0.08 0.1 0.05 0.06 0.12 0.17 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 2 0 1
Bud – 0 0 0 1 2 4 4 12 2 12 17 – 0 0 0 0 0 0 0 2 1 1 4
Bud Neck – 0 0 0 1 1 3 6 3 5 5 7 – 0 0 0 0 0 0 0 0 0 0 2
Bud Site – 1 0 1 1 1 2 2 8 2 3 3 – 0 0 0 0 0 – – – – – –
Cell Periphery – 0 1 0 0 0 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0
Cytoplasm – 5 26 31 32 48 69 108 86 106 107 119 – 5 13 15 13 19 2 2 5 3 1 3
Endoplasmic Reticulum – 0 1 0 0 0 0 0 0 0 0 0 – 0 0 7 3 6 1 0 1 0 1 1
Endosome – 0 2 4 7 16 16 13 3 7 4 3 – 0 7 4 4 1 0 3 1 0 3 3
Golgi – 0 0 1 0 0 0 2 0 0 0 0 – 0 0 1 0 0 0 0 1 0 2 4
Mitochondria – 50 3 17 8 55 69 109 237 207 234 225 – 0 4 15 4 2 1 0 8 4 19 15
Nucleus – 143 326 193 235 193 192 186 105 120 85 82 – 56 83 120 103 99 24 145 303 36 62 35
Nuclear Periphery – 2 2 0 1 0 0 0 1 2 0 1 – 0 1 6 1 0 0 1 0 1 3 1
Nucleolus – 0 0 8 8 10 4 2 1 2 4 6 – 0 3 2 3 1 1 1 10 2 12 11
Peroxisomes – 0 0 0 0 2 0 0 0 0 0 0 – 0 1 0 0 0 0 0 1 0 3 0
SpindlePole – 0 1 4 8 10 17 26 11 22 19 9 – 1 2 0 1 1 0 0 5 0 3 5
Vac/Vac Membrane – 5 4 8 13 36 17 48 13 19 15 21 – 3 8 12 7 10 3 8 20 7 25 21
Unique Cell Count 163 359 241 296 319 337 431 356 392 371 390 64 116 152 126 127 35 167 371 62 146 123
Labelled Cell Count 206 366 267 315 374 393 506 480 494 488 493 65 122 182 139 140 35 167 371 62 146 123


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 4.4 6.8 6.4 6.4 5.1 4.7 4.9 3.6 4.0 3.7 3.7 – 6.4 6.6 5.5 7.3 8.1 5.4 7.0 6.8
Std Deviation (1e-4) – 0.7 1.6 1.9 2.0 1.8 1.5 1.5 1.3 1.4 1.2 0.8 – 0.9 6.6 1.2 1.5 1.8 0.5 1.9 2.3
Intensity Change (Log2) – – – -0.09 -0.08 -0.42 -0.52 -0.46 -0.89 -0.74 -0.86 -0.87 – -0.08 -0.04 -0.31 0.11 0.25 -0.32 0.05 0.01


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.2705 7.373 7.4796 7.0507 7.6303 7.6193 8.164 10.1881 9.3733 7.2805 8.6779 8.796 5.2558 6.9195 6.3027 6.1836 6.1556 5.6639
Actin 0.0136 0 0.0044 0 0 0.0167 0.085 0.0909 0.0023 0.0571 0.0007 0.0006 0.008 0 0.0145 0 0 0.0125
Bud 0.0004 0.0007 0.0012 0.0001 0 0.0003 0.0013 0.0008 0.0001 0.0011 0.0001 0.0003 0.0005 0.0001 0.0002 0.0001 0.0001 0.0002
Bud Neck 0.0009 0.0002 0.0006 0.0005 0.0005 0.0049 0.0027 0.0003 0.002 0.0003 0.0005 0.0012 0.0005 0.0003 0.0014 0.0004 0.0005 0.0014
Bud Periphery 0.0008 0.0006 0.0031 0.0001 0.0001 0.0006 0.0025 0.0007 0.0001 0.0008 0.0001 0.0008 0.0008 0.0001 0.0002 0.0002 0.0002 0.0006
Bud Site 0.0024 0.0014 0.0027 0.0001 0.0001 0.0014 0.0066 0.0043 0.0003 0.0025 0.0002 0.0005 0.0012 0.0005 0.0048 0.0002 0.0002 0.0008
Cell Periphery 0.0005 0.0002 0.0004 0 0 0.0004 0.0006 0.0002 0.0001 0.0001 0.0001 0.0003 0.0004 0.0001 0.0003 0.0001 0.0001 0.0004
Cytoplasm 0.0019 0.0002 0.0005 0.0478 0.0001 0.002 0.0218 0.0026 0.004 0.005 0.041 0.0003 0.0112 0.0001 0.0211 0.0001 0 0.0023
Cytoplasmic Foci 0.0128 0 0.0047 0.0002 0 0.0032 0.0075 0.0079 0.0104 0.0348 0.0033 0.0003 0.0078 0 0.017 0 0 0.0069
Eisosomes 0.0002 0 0.0001 0 0 0.0001 0.0006 0.0003 0 0.0001 0 0 0.0002 0 0.0001 0 0 0.0004
Endoplasmic Reticulum 0.0016 0 0.0002 0.0003 0 0.0022 0.0039 0.0066 0.0018 0.0016 0.0052 0.0006 0.0037 0 0.0046 0 0 0.0011
Endosome 0.012 0 0.0107 0.0008 0 0.0057 0.0131 0.0166 0.0201 0.0346 0.0391 0.0032 0.0166 0 0.0046 0.0001 0 0.0093
Golgi 0.0043 0 0.0012 0 0 0.0012 0.0066 0.0194 0.0087 0.0366 0.0006 0.0005 0.0035 0 0.002 0 0 0.0088
Lipid Particles 0.0118 0 0.0029 0 0 0.0027 0.003 0.0043 0.001 0.0035 0.0003 0.0004 0.0125 0 0.0043 0.0001 0 0.003
Mitochondria 0.0048 0.0003 0.0021 0.0001 0.0002 0.0088 0.005 0.0051 0.0008 0.006 0.0018 0.007 0.0084 0.0003 0.0011 0.0006 0.0005 0.0043
None 0.0038 0 0.0011 0.0003 0 0.0008 0.0049 0.0007 0.0001 0.0011 0.0039 0.0001 0.0106 0 0.0131 0 0 0.008
Nuclear Periphery 0.0055 0.0024 0.0005 0.0005 0.0019 0.0025 0.0192 0.0033 0.0013 0.0344 0.0297 0.002 0.0169 0.0006 0.0099 0.0042 0.0005 0.0026
Nucleolus 0.2299 0.1418 0.3088 0.3082 0.195 0.2256 0.0928 0.0101 0.3012 0.0116 0.1135 0.2421 0.1917 0.2173 0.2521 0.1578 0.2127 0.2418
Nucleus 0.6672 0.8498 0.6482 0.6375 0.8013 0.7106 0.6755 0.8222 0.6437 0.7497 0.7488 0.7164 0.6748 0.7794 0.6335 0.8348 0.7846 0.6784
Peroxisomes 0.0049 0 0.0029 0 0 0.0045 0.0029 0.0021 0.0005 0.0147 0.0002 0.0001 0.0014 0 0.0088 0 0 0.002
Punctate Nuclear 0.0102 0.0006 0.0011 0.0025 0.0006 0.004 0.0353 0.0008 0.0006 0.0019 0.0067 0.0191 0.021 0.0004 0.0036 0.0003 0.0002 0.0017
Vacuole 0.0085 0.0011 0.0023 0.0007 0.0001 0.0014 0.0061 0.0004 0.0005 0.0012 0.0028 0.0029 0.0053 0.0004 0.0014 0.0006 0.0003 0.009
Vacuole Periphery 0.002 0.0004 0.0005 0.0001 0.0001 0.0005 0.0031 0.0004 0.0003 0.0013 0.0016 0.0014 0.0028 0.0002 0.0014 0.0005 0.0001 0.0045

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 599.9599 664.5797 650.6077 569.8869 519.992 684.3577 719.9948 594.3563 621.1213 591.2013
Translational Efficiency 0.2173 0.2367 0.1869 0.2134 0.2198 0.3864 0.2566 0.3193 0.2594 0.2068

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
156 672 1332 188 1421 2138 2305 863 1577 2810 3637 1051

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 696.91 711.41 1052.69 950.83 700.76 860.03 992.47 955.22 700.38 824.49 1014.52 954.43
Standard Deviation 123.61 152.97 159.94 143.45 98.49 123.79 143.73 151.16 101.26 145.86 152.65 149.82
Intensity Change Log 2 — 0.029709 0.595036 0.448215 — 0.295467 0.502103 0.446913 — 0.169063 0.549190 0.447562

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000590 0.000524 0.000964 0.011403 0.000119 0.000206 0.000676 0.001183 0.000166 0.000282 0.000781 0.003011
Bud Neck 0.001420 0.004521 0.024492 0.019057 0.002420 0.005311 0.048936 0.037045 0.002321 0.005122 0.039984 0.033828
Bud Site 0.000728 0.001974 0.002333 0.021958 0.000192 0.000798 0.004565 0.016846 0.000245 0.001079 0.003748 0.017760
Cell Periphery 0.000214 0.000285 0.000115 0.000366 0.000079 0.000162 0.000121 0.000191 0.000092 0.000192 0.000119 0.000222
Cytoplasm 0.015037 0.020157 0.002600 0.081833 0.005833 0.003437 0.008313 0.070483 0.006743 0.007436 0.006221 0.072513
Cytoplasmic Foci 0.002763 0.001228 0.000090 0.017919 0.001208 0.001786 0.000695 0.002048 0.001362 0.001652 0.000473 0.004887
Eisosomes 0.000030 0.000022 0.000042 0.000083 0.000015 0.000016 0.000031 0.000040 0.000016 0.000018 0.000035 0.000047
Endoplasmic Reticulum 0.002480 0.005704 0.004481 0.006854 0.003070 0.003788 0.005697 0.008102 0.003011 0.004246 0.005251 0.007879
Endosome 0.000487 0.000606 0.000439 0.017700 0.000325 0.001227 0.001883 0.002757 0.000341 0.001079 0.001354 0.005430
Golgi 0.000211 0.000146 0.000166 0.001275 0.000446 0.000719 0.000703 0.001597 0.000423 0.000582 0.000506 0.001540
Lipid Particles 0.002337 0.000333 0.000169 0.004525 0.000597 0.001114 0.000212 0.000684 0.000769 0.000928 0.000196 0.001371
Mitochondria 0.000723 0.000852 0.001582 0.031108 0.000941 0.003535 0.002508 0.002451 0.000919 0.002893 0.002169 0.007577
Mitotic Spindle 0.001906 0.002940 0.004221 0.045754 0.001831 0.003868 0.009198 0.019753 0.001838 0.003646 0.007375 0.024404
None 0.015104 0.020375 0.003827 0.034452 0.005333 0.006137 0.003334 0.010106 0.006299 0.009542 0.003514 0.014461
Nuclear Periphery 0.000388 0.000508 0.001278 0.005676 0.000755 0.001288 0.002694 0.003899 0.000719 0.001101 0.002175 0.004217
Nuclear Periphery Foci 0.000511 0.000578 0.000680 0.007601 0.000344 0.001008 0.000792 0.001724 0.000361 0.000905 0.000751 0.002775
Nucleolus 0.032647 0.026588 0.104140 0.030849 0.024527 0.017842 0.038769 0.036009 0.025331 0.019933 0.062710 0.035086
Nucleus 0.920199* 0.910228* 0.845579* 0.568981* 0.951029* 0.944803* 0.864328* 0.759207* 0.947979* 0.936535* 0.857462* 0.725180*
Peroxisomes 0.001449 0.000436 0.000664 0.006264 0.000326 0.000936 0.000219 0.000576 0.000437 0.000816 0.000382 0.001593
Vacuole 0.000659 0.001757 0.001775 0.081258 0.000446 0.001410 0.005305 0.024174 0.000467 0.001493 0.004012 0.034385
Vacuole Periphery 0.000116 0.000238 0.000363 0.005083 0.000164 0.000609 0.001023 0.001124 0.000159 0.000520 0.000781 0.001832

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.27 -1.04 -1.63 -1.74 -1.43 -2.80 -16.86 -14.37 -13.16 -7.73 -2.11 -13.99 -5.37 -5.09 -3.31
Bud Neck -4.28 -22.52 -9.20 -8.23 -1.05 -5.06 -30.96 -17.08 -15.73 3.57 -5.98 -36.49 -18.95 -17.45 1.35
Bud Site -1.64 -3.12 -3.69 -3.37 -3.21 -3.95 -7.86 -7.71 -7.38 -5.33 -4.39 -9.48 -8.58 -8.07 -6.40
Cell Periphery -0.64 1.18 0.22 1.36 -2.41 -2.56 -2.43 -7.26 -0.60 -5.38 -3.29 -1.08 -5.41 0.31 -6.02
Cytoplasm -0.35 2.66 -3.56 -3.77 -6.38 1.98 -3.69 -11.82 -12.68 -10.72 -0.38 -0.61 -12.66 -12.69 -12.87
Cytoplasmic Foci 1.63 2.46 -0.54 -2.18 -2.94 -1.25 1.62 -1.21 0.19 -3.22 -0.66 2.78 -1.69 -1.09 -4.57
Eisosomes 1.50 -1.67 -6.96 -9.38 -7.18 -1.23 -11.59 -13.59 -13.40 -9.19 -1.00 -13.41 -15.83 -16.00 -10.79
Endoplasmic Reticulum -4.32 -4.06 -7.61 -5.51 -6.48 -2.40 -11.26 -14.63 -13.51 -9.18 -4.38 -11.48 -16.43 -14.28 -11.79
Endosome -0.23 0.42 -4.25 -4.25 -4.36 -3.76 -4.28 -8.17 -4.49 -3.56 -3.96 -4.42 -8.89 -6.29 -6.19
Golgi 0.66 0.33 -2.29 -4.03 -3.91 -0.80 -0.11 -0.67 -0.16 -0.64 -0.54 0.15 -0.78 -0.46 -0.99
Lipid Particles 1.28 1.34 0.42 -3.61 -3.88 -1.57 1.68 -3.28 -0.44 -9.88 -0.18 2.14 -1.85 -2.07 -9.42
Mitochondria -0.38 -4.63 -1.36 -1.35 -1.16 -2.98 -5.68 -5.45 0.93 0.52 -2.90 -5.37 -2.79 -0.71 -1.25
Mitotic Spindle -0.32 -0.95 -4.16 -4.09 -3.99 -1.56 -5.70 -7.36 -6.86 -4.85 -1.55 -5.52 -8.43 -7.94 -6.46
None -0.93 2.56 -0.24 0.65 -2.84 -0.65 2.47 -2.20 -1.28 -5.82 -2.39 3.44 -2.23 0.22 -5.69
Nuclear Periphery -0.89 -2.42 -5.46 -5.26 -4.22 -2.48 -7.87 -8.02 -6.78 -2.99 -2.31 -7.61 -9.25 -8.16 -4.94
Nuclear Periphery Foci -0.18 -0.78 -2.99 -2.98 -2.84 -2.03 -2.91 -6.09 -4.37 -4.92 -2.14 -3.07 -6.71 -5.38 -5.68
Nucleolus 0.66 -9.93 -0.66 -1.49 8.91 3.01 -5.75 -2.23 -4.45 2.37 2.42 -14.62 -2.50 -4.44 9.74
Nucleus 0.38 6.01 11.15 12.20 8.82 1.51 21.26 25.18 24.26 13.43 2.75 24.58 27.97 26.72 15.66
Peroxisomes 1.27 1.00 0.01 -1.83 -1.43 -2.62 0.78 -2.79 1.04 -4.26 -1.68 0.26 -2.08 -0.26 -2.90
Vacuole -2.27 -5.00 -8.46 -8.36 -8.33 -2.94 -10.03 -13.22 -12.98 -11.22 -3.74 -10.98 -15.56 -15.30 -14.13
Vacuole Periphery -2.89 -4.61 -2.53 -2.32 -2.10 -4.58 -4.70 -5.15 -0.99 0.10 -4.84 -5.51 -5.32 -2.42 -1.70
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Gcn4

Gcn4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gcn4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available