Standard name
Human Ortholog
Description Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0 0.13 0.06 0.05 – 0 0.05 0 0 0 0.11 0.13 0.18 0.11 0.11 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.08 0 0 – 0 0.12 0.07 0.08 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.94 0.92 0.96 0.81 0.88 0.86 – 0.8 0.72 0.75 0.7 0.72 0.86 0.83 0.7 0.81 0.82 0.88 0.95 0.92 0.92 0.81 0.7 0.54
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0.09 0.08 0.2 – 0.32 0.36 0.39 0.44 0.45 0 0.07 0.12 0 0 0 0 0 0 0.05 0.05 0.09
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0.05 0 0 0 0.08 0.17 0.26
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1
Bud 0 0 0 0 0 1 – 1 0 2 1 0 0 0 0 0 0 0 1 1 0 0 2 1
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 3 – 3 5 3 9 5 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 22 12 3 7 7 10 – 5 11 9 6 8 23 23 33 39 38 12 1 2 0 2 3 2
Endoplasmic Reticulum 0 0 1 0 0 0 – 0 0 0 0 0 0 0 0 3 5 4 1 0 0 0 0 3
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 3 3 2 0 1 4 2 1 1 0 3
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0 3 2 0 0 0 0
Mitochondria 3 5 1 4 0 8 – 9 30 18 14 15 1 0 2 5 10 2 1 1 0 1 2 2
Nucleus 468 216 79 43 99 166 – 180 176 191 121 137 183 147 125 285 292 212 482 220 76 113 125 98
Nuclear Periphery 0 0 0 0 0 0 – 2 1 1 0 0 0 0 0 0 1 1 0 0 0 0 0 2
Nucleolus 6 4 1 5 9 39 – 72 88 100 76 85 7 13 22 12 5 8 0 0 0 6 8 15
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 4 4 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 1 1 6 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 4 3 0 0 2 4 – 1 2 0 2 1 1 2 1 19 16 13 8 4 1 11 31 47
Unique Cell Count 497 236 82 53 113 194 226 243 256 172 190 213 178 179 354 358 242 508 240 83 140 179 183
Labelled Cell Count 503 240 85 59 117 231 273 313 324 229 252 216 193 196 365 368 253 508 240 83 140 179 183


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.7 15.8 9.8 11.7 15.6 12.1 – 11.9 11.3 11.5 10.9 10.8 16.0 15.0 14.9 25.6 25.2 24.7 14.4 15.4 15.7
Std Deviation (1e-4) 4.6 4.7 3.7 3.1 3.5 4.2 – 4.9 5.9 5.0 6.1 4.6 7.8 5.9 7.9 10.7 11.6 8.7 5.9 4.4 4.9
Intensity Change (Log2) – – – 0.26 0.67 0.31 – 0.28 0.21 0.24 0.16 0.15 0.7 0.62 0.61 1.39 1.36 1.33 0.56 0.65 0.68

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 – 0 0 0 0 0 1.9 2.3 3.2 2.0 2.0 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0 3.0 0 0 0 0 0 0 0 0 0
Nucleus -2.9 -2.1 -2.6 – -3.5 -4.6 -4.3 -4.7 -4.5 -2.5 -3.1 -4.8 -3.5 -3.3 -2.3
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 4.1 – 5.6 6.1 6.5 7.0 7.1 0 0 2.9 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.5672 9.4892 8.6641 7.431 9.7653 9.0141 9.2694 9.3584 9.1066 7.877 8.1544 8.6442 10.607 11.1768 10.2893 9.5362 9.3488 9.8973
Actin 0.0083 0 0.0155 0.0019 0 0 0.0087 0 0 0.036 0.0003 0 0.0417 0 0.0048 0.0078 0.0216 0.0092
Bud 0.0002 0 0.0002 0.0001 0 0.0001 0.0006 0.0019 0.0002 0.0001 0.0001 0 0.0004 0 0.0002 0.0001 0.0003 0.0001
Bud Neck 0.0007 0.0001 0.0002 0.0001 0.0004 0.0005 0.0014 0.0001 0 0.0002 0.0007 0.0005 0.0004 0 0.0004 0.0271 0.0003 0.0007
Bud Periphery 0.0002 0 0.0002 0.0001 0.0001 0.0003 0.0012 0.0008 0.0002 0.0002 0.0005 0.0001 0.0007 0 0.0002 0.0004 0.0005 0.0004
Bud Site 0.0017 0 0.0008 0.0005 0 0.0001 0.0014 0.002 0.0002 0.0007 0.0001 0 0.0012 0 0.0025 0.0033 0.0005 0.0001
Cell Periphery 0.0001 0 0.0003 0.0001 0.0001 0.0001 0.0006 0.0003 0.0002 0 0.0005 0 0.0002 0 0 0.0006 0.0001 0.0002
Cytoplasm 0.0081 0.0001 0.0039 0.0041 0 0 0.0037 0.0025 0.0003 0.0033 0.0001 0.0001 0.0028 0.0153 0.0002 0.0002 0.0013 0.0003
Cytoplasmic Foci 0.019 0.0001 0.0063 0.0096 0 0 0.0106 0.0001 0.0017 0.0223 0.0005 0.002 0.0143 0 0.0033 0.0079 0.0393 0.0029
Eisosomes 0.0001 0 0 0 0 0 0.0001 0 0 0.0003 0 0 0.0001 0 0 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0021 0 0.0005 0.0028 0 0 0.002 0.0001 0.0001 0.0003 0.0001 0 0.0016 0 0.0003 0 0.0018 0.0002
Endosome 0.0238 0.0001 0.0042 0.0246 0 0 0.0123 0 0.0002 0.0041 0.004 0.0001 0.0152 0 0.0076 0.0009 0.0189 0.0012
Golgi 0.0049 0 0.0038 0.0058 0 0 0.0029 0 0 0.0065 0.0018 0.0001 0.0057 0 0.0032 0.0017 0.0196 0.0023
Lipid Particles 0.0151 0 0.0074 0.0364 0 0 0.0183 0 0.0006 0.0105 0.0004 0.0022 0.0083 0 0.0023 0.0023 0.0061 0.0098
Mitochondria 0.0025 0.0001 0.0106 0.0049 0.0007 0.0002 0.0123 0.0002 0.001 0.0028 0.0405 0.0002 0.0025 0.0001 0.005 0.0003 0.0078 0.0046
None 0.0031 0 0.0004 0.0042 0 0 0.0032 0.0003 0.0001 0.0188 0.0001 0 0.003 0.0001 0.0001 0.0001 0.003 0.0003
Nuclear Periphery 0.0062 0.0011 0.0032 0.0108 0.0005 0.0003 0.0132 0.002 0.0019 0.0009 0.0014 0.0003 0.0265 0.0006 0.0026 0.001 0.0027 0.0014
Nucleolus 0.0103 0.0228 0.0119 0.0104 0.1228 0.0562 0.0254 0.0127 0.0126 0.0044 0.0957 0.0594 0.0126 0.0073 0.0051 0.0231 0.1156 0.0675
Nucleus 0.8656 0.974 0.9253 0.8667 0.8747 0.9406 0.8518 0.9745 0.9774 0.8595 0.8469 0.9339 0.8367 0.9764 0.9599 0.9036 0.7156 0.8936
Peroxisomes 0.0058 0 0.0007 0.0015 0 0 0.0054 0 0 0.0162 0.0006 0.0001 0.0025 0 0.0017 0.0181 0.0293 0.0008
Punctate Nuclear 0.0184 0.0012 0.0028 0.0105 0.0001 0.0001 0.0143 0.0004 0.0006 0.0125 0.0003 0.0005 0.0196 0.0002 0.0004 0.0009 0.0141 0.0013
Vacuole 0.0025 0.0002 0.0009 0.0029 0.0002 0.0011 0.0066 0.0017 0.0012 0.0001 0.0018 0.0002 0.0018 0 0.0003 0.0005 0.0006 0.0014
Vacuole Periphery 0.0013 0.0001 0.0007 0.002 0.0003 0.0003 0.0039 0.0003 0.0013 0.0001 0.0039 0.0001 0.0024 0 0.0002 0.0001 0.001 0.0018

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.9898 61.9154 57.0338 66.8384 78.9624 47.74 64.7613 87.419 108.7563 68.5665
Translational Efficiency 4.8816 3.6874 3.4565 3.9311 2.7841 4.0589 2.7288 2.2455 1.855 2.385

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2275 1249 306 1526 1945 1816 2224 1609 4220 3065 2530 3135

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 961.33 1198.01 1743.38 1503.19 1138.51 1229.57 1584.54 1775.34 1042.99 1216.71 1603.75 1642.87
Standard Deviation 183.39 261.39 274.26 427.12 220.89 238.27 281.05 354.03 220.04 248.44 284.98 414.29
Intensity Change Log 2 — 0.317536 0.858783 0.644924 — 0.111007 0.476917 0.640948 — 0.209239 0.664341 0.642770

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000321 0.000434 0.000555 0.000704 0.000389 0.000434 0.000416 0.000724 0.000352 0.000434 0.000433 0.000714
Bud Neck 0.002544 0.003215 0.005148 0.012684 0.003372 0.004393 0.007038 0.012549 0.002925 0.003913 0.006809 0.012615
Bud Site 0.000539 0.000675 0.000449 0.002452 0.000697 0.001001 0.000734 0.001921 0.000612 0.000868 0.000700 0.002180
Cell Periphery 0.001310 0.000557 0.000027 0.000253 0.000435 0.001053 0.000253 0.000292 0.000907 0.000851 0.000226 0.000273
Cytoplasm 0.001681 0.001002 0.000018 0.002903 0.000337 0.000283 0.000070 0.000377 0.001061 0.000576 0.000064 0.001607
Cytoplasmic Foci 0.000038 0.000600 0.000036 0.001740 0.000259 0.000429 0.000061 0.001019 0.000140 0.000499 0.000058 0.001370
Eisosomes 0.000218 0.000139 0.000135 0.000048 0.000170 0.000343 0.000194 0.000069 0.000196 0.000260 0.000187 0.000059
Endoplasmic Reticulum 0.009352 0.002840 0.000671 0.001325 0.004040 0.004869 0.001545 0.001099 0.006904 0.004042 0.001440 0.001209
Endosome 0.000165 0.000570 0.000008 0.001702 0.000307 0.000628 0.000066 0.001273 0.000230 0.000605 0.000059 0.001482
Golgi 0.000039 0.000483 0.000020 0.000720 0.000059 0.000597 0.000009 0.001354 0.000048 0.000550 0.000011 0.001046
Lipid Particles 0.000010 0.000212 0.000009 0.001325 0.000133 0.000258 0.000029 0.000102 0.000067 0.000239 0.000027 0.000698
Mitochondria 0.000337 0.000699 0.001141 0.003583 0.001069 0.001072 0.000910 0.002224 0.000674 0.000920 0.000938 0.002885
Mitotic Spindle 0.000002 0.000146 0.000006 0.006898 0.001524 0.001616 0.000480 0.003003 0.000704 0.001017 0.000423 0.004899
None 0.004597 0.001439 0.000263 0.005967 0.001019 0.000884 0.000327 0.000732 0.002948 0.001110 0.000319 0.003280
Nuclear Periphery 0.000099 0.000084 0.000025 0.000858 0.000099 0.000676 0.000079 0.000485 0.000099 0.000435 0.000072 0.000667
Nuclear Periphery Foci 0.000058 0.000524 0.000001 0.000774 0.000126 0.000581 0.000025 0.000437 0.000089 0.000558 0.000022 0.000601
Nucleolus 0.003980 0.006665 0.007957 0.010358 0.005234 0.006537 0.002517 0.005752 0.004558 0.006589 0.003175 0.007994
Nucleus 0.970501 0.976795 0.981514 0.942259 0.978399 0.968728 0.984261 0.963053 0.974141 0.972015 0.983929 0.952931
Peroxisomes 0.000065 0.000445 0.001585 0.000660 0.000393 0.000362 0.000179 0.000278 0.000216 0.000396 0.000349 0.000464
Vacuole 0.003950 0.001940 0.000373 0.001517 0.001626 0.003970 0.000734 0.002079 0.002879 0.003143 0.000690 0.001805
Vacuole Periphery 0.000194 0.000535 0.000059 0.001269 0.000315 0.001285 0.000072 0.001179 0.000250 0.000980 0.000070 0.001223

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.93 -7.62 -11.67 -7.24 -4.04 -1.34 -0.87 -1.83 -1.61 -1.70 -3.73 -3.58 -3.73 -2.95 -2.95
Bud Neck -1.56 -6.17 -10.24 -8.35 -7.51 -1.58 -5.16 -8.28 -7.26 -5.16 -2.53 -7.41 -13.10 -10.93 -7.46
Bud Site -1.07 0.59 -4.00 -3.24 -4.14 -1.07 -0.14 -2.43 -1.73 -2.37 -1.63 -0.51 -4.52 -3.39 -3.99
Cell Periphery 2.51 7.70 5.90 1.27 -3.08 -2.02 1.78 1.06 2.47 -0.21 0.18 6.44 5.32 2.81 -0.48
Cytoplasm 0.96 3.86 -1.57 -2.30 -4.31 0.18 2.01 -0.55 -0.89 -3.79 1.43 4.13 -1.43 -2.68 -4.73
Cytoplasmic Foci -1.91 0.13 -3.21 -1.43 -3.22 -0.84 1.18 -1.83 -1.32 -2.56 -2.21 0.95 -3.69 -2.03 -4.05
Eisosomes 2.14 2.31 5.21 5.10 5.77 -2.14 -0.72 3.33 3.65 8.72 -1.27 0.38 6.10 4.45 10.31
Endoplasmic Reticulum 12.16 19.34 17.64 4.87 -6.84 -2.07 10.22 10.84 10.45 2.45 8.16 19.69 20.37 11.51 1.74
Endosome -1.92 3.88 -3.28 -1.91 -3.69 -1.74 2.11 -2.34 -1.38 -3.10 -2.78 2.74 -4.02 -2.35 -4.71
Golgi -1.51 0.90 -2.71 -0.31 -2.80 -1.74 2.00 -2.10 -0.94 -2.19 -2.30 2.38 -2.91 -0.94 -3.04
Lipid Particles -1.30 0.24 -1.99 -1.45 -1.99 -1.19 1.80 0.42 1.51 -2.12 -1.95 1.35 -1.95 -1.14 -2.10
Mitochondria -3.69 -8.85 -4.23 -3.71 -3.09 -0.05 0.40 -2.81 -3.39 -4.57 -1.22 -1.61 -5.26 -4.74 -4.87
Mitotic Spindle -2.13 -3.08 -5.07 -4.94 -5.06 -0.18 1.31 -1.36 -1.22 -2.56 -0.73 0.56 -4.83 -4.26 -5.14
None 4.06 5.91 -0.78 -3.93 -5.20 0.48 2.85 1.02 0.76 -3.05 4.26 6.33 -0.24 -3.83 -5.50
Nuclear Periphery 0.56 10.11 -2.47 -2.50 -2.70 -1.60 0.64 -3.37 0.37 -3.51 -1.58 1.11 -3.62 -0.95 -3.75
Nuclear Periphery Foci -2.21 2.54 -3.04 -0.46 -3.29 -1.91 2.09 -1.71 0.61 -2.30 -2.85 2.42 -3.45 0.13 -3.93
Nucleolus -3.46 -4.29 -7.03 -4.34 -2.87 -1.88 5.66 -1.89 0.02 -5.43 -3.71 3.46 -6.84 -3.23 -8.83
Nucleus -1.65 -5.14 7.02 7.39 9.55 3.22 -2.60 4.64 1.69 6.63 1.42 -5.99 8.18 6.31 11.70
Peroxisomes -2.12 -8.27 -5.04 -0.69 4.30 0.07 1.42 0.50 0.69 -3.14 -1.79 -1.85 -2.92 -0.48 -1.95
Vacuole 2.84 7.65 3.62 0.45 -3.54 -3.49 3.32 -0.91 2.32 -2.81 -0.67 7.63 2.17 2.37 -3.90
Vacuole Periphery -1.78 4.93 -2.67 -1.48 -3.03 -3.24 2.56 -2.09 0.33 -2.79 -3.82 3.86 -3.37 -0.50 -4.09
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-2

Chz1

Chz1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Chz1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available