Standard name
Human Ortholog
Description Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-binding protein involved in mRNA poly(A) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II) and 2-oxoglutarate
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.12 0.05 0 0 0 0.05 0.05 0 0.05 0 0 0.05 0.16 0.16 0.11 0.15 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 0.07 0.07 0.11 0.1 0.25 0.13 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.96 0.8 0.93 0.96 0.92 0.9 0.89 0.9 0.9 0.87 0.84 0.85 0.91 0.8 0.79 0.76 0.72 0.75 0.95 0.9 0.92 0.9 0.78 0.71
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.05 0 0 0 0.05 0.07 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0.1 0 0.05 0 0 0.11 0.15
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Bud 0 2 0 0 0 1 0 0 2 1 0 2 0 0 0 0 1 0 0 4 3 0 2 3
Bud Neck 0 0 0 0 1 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 1 1 4 2 3 4 4 8 0 1 0 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0
Cytoplasm 6 50 14 7 10 7 20 16 10 17 8 16 13 39 45 23 32 31 0 2 0 1 2 1
Endoplasmic Reticulum 2 0 0 0 0 0 0 0 0 0 0 0 1 1 0 2 5 10 0 0 1 0 2 0
Endosome 1 1 1 0 1 2 2 1 0 1 0 2 0 0 4 1 0 1 2 5 1 0 0 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 3 0 1 0 3 2 0
Mitochondria 7 6 0 0 0 18 27 24 35 32 71 56 0 0 0 6 2 6 2 1 0 0 1 5
Nucleus 386 348 264 207 233 257 336 310 275 278 244 359 216 190 227 154 150 185 382 437 278 166 260 205
Nuclear Periphery 1 5 0 3 2 0 1 1 1 0 2 4 1 1 3 2 2 1 1 1 0 0 1 1
Nucleolus 3 9 2 2 2 14 8 4 13 15 20 18 2 3 10 7 6 5 1 3 1 2 17 17
Peroxisomes 0 0 1 0 0 0 0 0 0 0 0 0 2 1 3 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 2 6 4 1 0 1 1 5 9 1 1 0 0 2 1 0 4 2
Vac/Vac Membrane 2 33 8 2 6 7 6 4 2 5 5 15 5 5 6 14 17 26 7 24 10 6 35 42
Unique Cell Count 401 433 284 215 253 285 376 345 307 321 289 421 237 237 287 203 207 248 402 487 303 185 332 288
Labelled Cell Count 408 456 290 221 256 307 407 368 345 355 354 481 241 246 308 212 218 269 402 487 303 185 332 288


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.5 11.5 9.6 9.8 8.7 6.9 6.5 6.7 5.7 6.0 5.3 5.5 12.6 10.7 10.0 13.1 12.9 12.9 10.1 10.2 9.6
Std Deviation (1e-4) 1.4 4.3 1.8 2.2 1.6 1.6 1.8 1.8 1.4 1.6 1.3 1.3 3.1 3.6 3.3 5.4 5.1 4.7 2.3 2.3 1.8
Intensity Change (Log2) – – – 0.03 -0.13 -0.48 -0.55 -0.51 -0.75 -0.68 -0.84 -0.81 0.39 0.16 0.06 0.45 0.42 0.42 0.08 0.08 -0.0

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.9 -0.5 -1.6 0.2 -0.2 -1.0 0.2 -1.3 -0.7 0.3 4.3 4.2 2.6 4.0 3.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.3 4.6 4.5 5.9 5.5 8.9 6.4 0 0 0 0 0 0
Nucleus 1.6 -0.4 -1.2 -1.6 -1.4 -1.4 -2.6 -3.2 -3.1 -0.8 -4.3 -4.8 -5.3 -6.2 -5.8
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 3.0 0 0 2.7 2.9 3.9 2.8 0 0 2.3 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 -0.3 -0.3 -1.1 -1.5 0 -1.1 -0.9 0.5 -0.5 -0.5 -0.6 2.1 2.7 3.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.4019 9.4859 8.2212 6.7307 6.0771 8.567 7.083 8.2557 7.0838 7.0639 5.8625 7.1759 7.1324 9.522 8.0705 8.1092 5.676 8.4925
Actin 0.0242 0 0.0004 0.0216 0.0054 0.0118 0.0095 0 0.0024 0.0092 0.0107 0.0027 0.0336 0 0.0195 0 0.0472 0.0113
Bud 0.0004 0 0.0003 0.0004 0.0006 0.0006 0.0001 0 0.0003 0.0006 0.001 0.0002 0.0009 0 0.0002 0 0.005 0.0002
Bud Neck 0.0004 0 0.0001 0.0027 0.0008 0.0009 0.0001 0 0.0046 0.0004 0.0005 0.0004 0.0008 0 0.0012 0 0.0011 0.0016
Bud Periphery 0.0004 0 0.0008 0.0005 0.002 0.0014 0.0002 0 0.0004 0.0013 0.0018 0.0002 0.0017 0 0.0004 0 0.0097 0.0003
Bud Site 0.0026 0 0.0005 0.002 0.0009 0.0008 0.0003 0.0001 0.0015 0.0012 0.0021 0.0001 0.0063 0 0.0027 0 0.0032 0.0003
Cell Periphery 0.0002 0 0.0004 0.0004 0.001 0.0003 0.0001 0 0.0001 0.0003 0.0001 0 0.0009 0 0.0002 0 0.0003 0.0001
Cytoplasm 0.0217 0 0.0004 0.0012 0.0006 0.0013 0.005 0.0003 0.0004 0.0014 0.0018 0.0033 0.0045 0 0.0004 0 0.003 0.0001
Cytoplasmic Foci 0.0262 0 0.0011 0.014 0.0044 0.0009 0.0063 0 0.0008 0.0011 0.0179 0.0006 0.0169 0 0.0076 0 0.0494 0.0014
Eisosomes 0.0002 0 0 0.0001 0.0001 0 0.0001 0 0 0.0003 0.0001 0 0.0007 0 0.0001 0 0.0003 0.0001
Endoplasmic Reticulum 0.003 0 0.0005 0.0002 0.0026 0.0003 0.0013 0 0.0001 0.0028 0.001 0.0006 0.0071 0 0.0002 0 0.0039 0.0002
Endosome 0.0263 0 0.0007 0.0079 0.0738 0.0034 0.0067 0.0001 0.0011 0.0088 0.0164 0.0026 0.0222 0 0.0033 0 0.041 0.0044
Golgi 0.0082 0 0.0008 0.0401 0.0421 0.0019 0.0012 0 0.001 0.0018 0.0152 0.0015 0.0069 0 0.0055 0 0.0416 0.0039
Lipid Particles 0.0305 0 0.0055 0.005 0.0237 0.004 0.0068 0 0.0007 0.0025 0.022 0.0007 0.0094 0 0.0062 0 0.0149 0.0024
Mitochondria 0.0039 0.0001 0.003 0.005 0.0487 0.0089 0.0029 0.0001 0.0016 0.0434 0.041 0.001 0.0371 0.0001 0.0054 0.0001 0.0232 0.0031
None 0.0026 0 0.0002 0.0003 0.0007 0.0002 0.0073 0 0.0003 0.0011 0.0015 0.0004 0.003 0 0.0002 0 0.0008 0.0001
Nuclear Periphery 0.0047 0.001 0.0126 0.0062 0.0174 0.0018 0.0148 0.0013 0.0022 0.0269 0.0158 0.0044 0.0152 0.0006 0.001 0.0003 0.0049 0.0009
Nucleolus 0.032 0.0062 0.0221 0.0886 0.111 0.0492 0.0149 0.0071 0.0065 0.0182 0.0385 0.0316 0.0198 0.0056 0.0058 0.01 0.056 0.0228
Nucleus 0.7776 0.9926 0.9392 0.7789 0.6294 0.9032 0.8992 0.9889 0.9668 0.8684 0.7823 0.9453 0.792 0.9935 0.9211 0.9894 0.6367 0.9402
Peroxisomes 0.013 0 0.0045 0.0162 0.0014 0.0009 0.0022 0 0.0006 0.0008 0.0149 0.0001 0.0061 0 0.0092 0 0.0476 0.0011
Punctate Nuclear 0.0184 0 0.0015 0.0052 0.001 0.0013 0.0166 0.0006 0.0082 0.0023 0.013 0.0022 0.0061 0 0.0006 0.0001 0.0039 0.0043
Vacuole 0.0019 0 0.0028 0.0026 0.0086 0.0051 0.0019 0.0011 0.0004 0.003 0.001 0.0013 0.0041 0.0001 0.0038 0 0.0035 0.0007
Vacuole Periphery 0.0016 0 0.0027 0.0008 0.0238 0.0019 0.0023 0.0004 0.0002 0.0042 0.0014 0.0005 0.0047 0.0002 0.0053 0 0.0028 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 73.8454 82.0706 100.239 67.6756 79.1088 59.2716 78.2139 65.9212 58.1071 71.3651
Translational Efficiency 1.372 1.4187 1.0251 1.3245 1.0548 1.1687 1.2073 1.1928 1.1871 1.0308

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2413 1309 511 105 1640 1851 192 176 4053 3160 703 281

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 736.26 1037.44 1350.91 1632.22 969.01 1018.40 1606.44 1731.02 830.44 1026.29 1420.70 1694.10
Standard Deviation 108.46 173.25 227.92 322.96 160.79 173.80 246.24 324.33 174.68 173.83 259.39 327.33
Intensity Change Log 2 — 0.494741 0.875644 1.148548 — 0.071721 0.729284 0.837039 — 0.269728 0.794305 0.979852

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000182 0.000355 0.000676 0.000997 0.000284 0.000459 0.000680 0.000798 0.000223 0.000416 0.000677 0.000872
Bud Neck 0.003570 0.007354 0.010085 0.013835 0.003250 0.011827 0.005984 0.017487 0.003440 0.009974 0.008965 0.016123
Bud Site 0.000936 0.000751 0.000769 0.002275 0.000293 0.001734 0.000438 0.003227 0.000676 0.001327 0.000679 0.002871
Cell Periphery 0.000909 0.000119 0.000038 0.000053 0.000143 0.000350 0.000022 0.000065 0.000599 0.000254 0.000034 0.000061
Cytoplasm 0.003835 0.000374 0.000157 0.000335 0.000153 0.000860 0.000044 0.000367 0.002345 0.000659 0.000126 0.000355
Cytoplasmic Foci 0.000588 0.000253 0.000020 0.002107 0.000007 0.001261 0.000047 0.002779 0.000353 0.000844 0.000028 0.002528
Eisosomes 0.000033 0.000043 0.000053 0.000074 0.000051 0.000064 0.000083 0.000058 0.000040 0.000056 0.000061 0.000064
Endoplasmic Reticulum 0.008385 0.003711 0.001673 0.001179 0.004013 0.006677 0.001290 0.000582 0.006616 0.005448 0.001568 0.000805
Endosome 0.000625 0.000236 0.000037 0.000211 0.000068 0.001111 0.000018 0.001089 0.000400 0.000749 0.000032 0.000761
Golgi 0.000144 0.000191 0.000040 0.000291 0.000016 0.000839 0.000031 0.000445 0.000092 0.000571 0.000038 0.000387
Lipid Particles 0.000125 0.000039 0.000027 0.000076 0.000009 0.000229 0.000017 0.000120 0.000078 0.000150 0.000025 0.000104
Mitochondria 0.000489 0.000733 0.001205 0.002484 0.000360 0.001830 0.001347 0.002832 0.000437 0.001375 0.001244 0.002702
Mitotic Spindle 0.000193 0.001144 0.000063 0.047120 0.000073 0.003878 0.000026 0.025704 0.000145 0.002745 0.000053 0.033707
None 0.010478 0.002145 0.000689 0.001134 0.001079 0.001904 0.000334 0.002403 0.006674 0.002004 0.000592 0.001929
Nuclear Periphery 0.000858 0.000166 0.000108 0.001773 0.000077 0.001110 0.000062 0.000275 0.000542 0.000719 0.000096 0.000835
Nuclear Periphery Foci 0.000487 0.000055 0.000015 0.004153 0.000036 0.000531 0.000005 0.000500 0.000305 0.000334 0.000012 0.001865
Nucleolus 0.008061 0.005785 0.006278 0.056949 0.006601 0.007298 0.011691 0.091408 0.007470 0.006671 0.007756 0.078532
Nucleus 0.958452 0.975544 0.976952 0.847910 0.982860 0.952416 0.975961 0.837740 0.968328 0.961997 0.976681 0.841540
Peroxisomes 0.000208 0.000288 0.000494 0.015819 0.000145 0.000992 0.001280 0.009367 0.000182 0.000700 0.000709 0.011778
Vacuole 0.001153 0.000560 0.000546 0.001018 0.000408 0.003066 0.000572 0.002118 0.000852 0.002028 0.000553 0.001707
Vacuole Periphery 0.000290 0.000153 0.000076 0.000207 0.000076 0.001562 0.000068 0.000635 0.000203 0.000978 0.000073 0.000475

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.30 -13.02 -9.55 -8.04 -4.52 -5.66 -9.01 -6.68 -5.26 -3.27 -9.31 -15.18 -10.59 -8.44 -4.88
Bud Neck -4.51 -9.84 -4.78 -3.80 -3.01 -8.58 -5.90 -6.41 -3.91 -5.47 -9.37 -11.46 -7.97 -5.44 -5.63
Bud Site 0.60 0.25 -3.24 -3.34 -3.29 -5.83 -3.49 -5.71 -4.30 -5.49 -3.47 -0.88 -6.25 -5.49 -6.17
Cell Periphery 4.60 5.09 4.74 0.91 -4.48 -2.19 4.59 2.09 2.88 -5.85 2.98 5.50 4.96 3.00 -6.27
Cytoplasm 5.58 6.07 5.03 -0.91 -1.99 -4.16 2.64 -3.70 2.63 -5.70 4.25 6.10 4.97 1.40 -3.80
Cytoplasmic Foci 1.32 2.89 -2.43 -2.68 -2.84 -3.09 -2.23 -2.85 -2.12 -2.81 -1.46 2.74 -3.56 -3.19 -3.87
Eisosomes -2.63 -6.76 -6.65 -5.42 -4.23 -2.21 -5.99 -3.71 -1.76 0.79 -4.05 -7.84 -7.77 -4.69 -3.64
Endoplasmic Reticulum 8.76 13.22 10.72 4.22 0.22 -6.60 10.55 14.02 16.12 2.70 3.07 15.55 16.14 15.23 2.74
Endosome 1.79 3.00 1.26 -0.77 -2.97 -4.55 6.25 -1.19 0.85 -1.28 -1.99 3.13 -0.43 0.63 -1.60
Golgi -0.36 1.58 -4.20 -2.59 -5.26 -2.24 -3.52 -5.45 0.03 -5.27 -2.12 1.28 -6.38 -0.94 -7.17
Lipid Particles 2.05 2.66 -1.62 -2.85 -3.11 -1.95 -2.29 -2.96 0.40 -2.80 -1.22 2.24 -2.75 -0.48 -3.82
Mitochondria -1.30 -9.22 -7.02 -5.57 -4.58 -5.14 -12.70 -4.20 -1.69 -2.54 -5.04 -13.99 -6.03 -3.43 -3.89
Mitotic Spindle -1.27 1.07 -3.96 -3.91 -3.96 -3.82 0.27 -4.57 -4.25 -4.57 -3.93 0.98 -6.04 -5.79 -6.05
None 5.44 7.92 6.67 0.53 -1.60 -1.71 3.49 -2.86 -0.77 -4.68 5.33 8.14 5.65 -0.15 -4.32
Nuclear Periphery 2.74 2.91 -0.66 -1.75 -1.81 -3.11 0.60 -4.26 1.95 -4.33 -0.75 2.87 -0.78 -0.14 -2.61
Nuclear Periphery Foci 2.26 2.45 -1.11 -1.40 -1.42 -3.03 1.28 -1.80 -0.68 -1.88 -0.06 2.53 -1.59 -1.59 -2.07
Nucleolus 2.14 1.39 -5.72 -5.81 -5.77 -0.90 -2.02 -8.61 -8.56 -7.88 0.99 -1.36 -10.30 -10.35 -10.13
Nucleus -5.21 -6.41 6.91 7.38 7.37 9.15 2.39 10.55 9.31 9.91 2.71 -2.40 12.31 11.95 12.54
Peroxisomes -0.78 -3.48 -3.75 -3.73 -3.69 -2.02 -3.92 -4.64 -4.38 -4.30 -2.08 -5.44 -5.97 -5.76 -5.78
Vacuole 3.17 2.36 -1.31 -1.45 -1.42 -4.58 -2.43 -2.74 0.46 -2.45 -3.36 1.35 -2.01 -1.23 -2.12
Vacuole Periphery 2.40 4.45 -1.13 -3.36 -5.12 -4.40 -0.16 -2.36 2.28 -2.36 -3.86 4.35 -2.19 1.81 -3.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-binding protein involved in mRNA poly(A) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II) and 2-oxoglutarate
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Tpa1

Tpa1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tpa1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available