Standard name
Human Ortholog
Description Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0.05 0.05 0 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.05 0 0.05 0.06 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.98 0.97 0.99 0.95 0.95 0.82 0.77 0.81 0.75 0.75 0.76 0.99 0.98 0.96 0.98 0.99 0.99 0.99 0.95 0.92 0.93 0.93 0.89
Endoplasmic Reticulum 0 0 0 0 0 0 0.14 0.17 0.09 0.15 0.15 0.05 0 0 0 0.06 0.08 0.07 0 0 0.05 0 0.05 0.07
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.05 0.06 0.05 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 8 7 12 16 4 12 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 3 2 2 0 0 2 0 1 0 1 0 0 0 2 0 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 2 2 5 5 20 10 12 19 5 6 0 0 2 3 6 3 0 0 0 0 0 0
Cytoplasm 128 193 299 182 294 234 328 303 210 241 76 87 94 197 238 717 384 303 120 184 276 82 204 140
Endoplasmic Reticulum 0 3 9 0 11 9 55 69 22 50 15 6 1 4 11 45 31 21 0 2 16 3 9 10
Endosome 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 1 1 0 0 3 7 6 7 3 2 0 0 0 3 1 0 0 0 0 0 1 0
Mitochondria 0 0 0 0 0 0 2 3 13 19 5 8 0 0 0 5 1 0 0 0 1 0 1 1
Nucleus 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 1 3 0 1 6 2 0 2 2 0 0 0 2 1 0 0 1 1 0 0 2
Unique Cell Count 128 196 308 184 309 246 402 395 258 323 102 115 95 200 248 728 388 306 122 195 302 89 220 158
Labelled Cell Count 128 196 311 186 314 249 421 409 280 352 111 126 95 202 251 776 424 327 122 195 302 89 220 158


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 89.2 101.5 86.0 85.3 72.5 64.2 51.4 43.8 41.6 38.4 33.8 36.7 91.1 88.6 86.2 115.0 133.8 142.1 80.3 84.3 86.6
Std Deviation (1e-4) 19.5 24.0 20.6 23.6 20.5 15.9 13.2 12.9 13.5 11.9 10.8 13.4 16.6 18.5 17.1 28.6 35.8 41.1 23.6 17.7 19.1
Intensity Change (Log2) – – – -0.01 -0.25 -0.42 -0.74 -0.97 -1.05 -1.16 -1.35 -1.23 0.08 0.04 0.0 0.42 0.64 0.73 -0.1 -0.03 0.01


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 3.8 4.0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 3.3 1.9 3.1 3.7 0 0 0 0 0 0 0 0
Cytoplasm 1.3 -1.2 -1.2 -6.4 -7.6 -6.2 -8.0 -7.1 -6.9 1.0 1.0 -0.7 1.5 1.8 1.7
Endoplasmic Reticulum 0 0.4 0.5 5.0 6.1 2.9 5.4 4.4 0 0 -0.6 1.0 2.2 2.9 2.3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 4.0 4.3 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 85.059 117.4392 104.1007 104.882 89.5673 115.8765 84.2606 122.0421 107.0797 94.5135 107.7273 114.6937 90.1508 127.4035 109.1946 113.357 87.742 110.7711
Actin 0.0028 0.0006 0.0024 0.0001 0.0026 0.0005 0.0141 0.0005 0.0083 0.014 0.0002 0.0048 0.0119 0.0003 0.002 0.0001 0.0347 0.0028
Bud 0.0024 0.0009 0.0017 0.0016 0.0011 0.0009 0.0022 0.0006 0.0017 0.0025 0.0005 0.0073 0.0015 0.0003 0.0013 0.0015 0.0016 0.0024
Bud Neck 0.001 0.0009 0.0011 0.0011 0.0009 0.0017 0.0009 0.0003 0.0005 0.0011 0.0006 0.0025 0.0007 0.0003 0.0006 0.0006 0.0006 0.0018
Bud Periphery 0.0041 0.0011 0.0019 0.0016 0.0005 0.0006 0.003 0.0003 0.0012 0.0034 0.0001 0.0051 0.0018 0.0001 0.0012 0.0007 0.0025 0.0019
Bud Site 0.0012 0.0008 0.0007 0.0003 0.0002 0.0002 0.0032 0.0011 0.0035 0.0004 0 0.0029 0.0017 0.0003 0.0007 0.0003 0.0014 0.0022
Cell Periphery 0.0312 0.018 0.0239 0.0305 0.0032 0.0035 0.0087 0.0036 0.0091 0.0062 0.0005 0.003 0.0127 0.0124 0.0102 0.0164 0.0031 0.0303
Cytoplasm 0.5924 0.8324 0.6933 0.4857 0.7095 0.8081 0.8388 0.9573 0.9024 0.7594 0.9644 0.7686 0.7421 0.9558 0.8429 0.7721 0.6614 0.8158
Cytoplasmic Foci 0.0041 0.0007 0.0018 0.001 0.0046 0.0026 0.0099 0.0041 0.0023 0.0019 0.002 0.0128 0.0142 0.0006 0.0115 0.0029 0.0212 0.0161
Eisosomes 0.0002 0.0005 0.0004 0 0.0001 0 0.0018 0 0 0.0002 0 0 0.0004 0 0.0002 0 0.0004 0.0006
Endoplasmic Reticulum 0.0493 0.0267 0.017 0.0177 0.0082 0.0089 0.0283 0.0062 0.0047 0.0085 0.0037 0.0188 0.0374 0.0024 0.0101 0.0018 0.0085 0.0231
Endosome 0.0083 0.0018 0.005 0.0055 0.0111 0.0284 0.0073 0.0009 0.008 0.0134 0.0036 0.0312 0.0108 0.0007 0.0077 0.0083 0.0105 0.0063
Golgi 0.0015 0.0006 0.0008 0.0001 0.0043 0.0026 0.0032 0.0004 0.0007 0.0051 0.0001 0.0086 0.0044 0.0001 0.0055 0.0003 0.0056 0.0017
Lipid Particles 0.0044 0.0011 0.0017 0.0005 0.0342 0.0006 0.0039 0.0008 0.0005 0.0008 0.0002 0.0018 0.01 0.0006 0.0041 0.0018 0.0083 0.0062
Mitochondria 0.0094 0.0007 0.0068 0.0004 0.009 0.0023 0.0101 0.0015 0.0006 0.0608 0.0001 0.0609 0.0143 0.0001 0.0075 0.0005 0.0641 0.0032
None 0.0028 0.0002 0.0006 0.0002 0.0008 0.0003 0.006 0.0003 0.0035 0.0006 0.0003 0.0016 0.0046 0.0001 0.0043 0.0004 0.0138 0.0102
Nuclear Periphery 0.0443 0.0085 0.0112 0.0169 0.0272 0.0109 0.0091 0.0009 0.0047 0.0092 0.0051 0.0026 0.0203 0.0024 0.0064 0.0038 0.0074 0.0037
Nucleolus 0.0018 0.0003 0.0009 0.0007 0.0007 0.0002 0.0008 0.0002 0.0002 0.0002 0 0.0014 0.0018 0.0001 0.0007 0.0006 0.0022 0.0073
Nucleus 0.012 0.0027 0.005 0.0065 0.004 0.0041 0.005 0.0009 0.0027 0.0035 0.0026 0.0055 0.0054 0.0011 0.0026 0.0037 0.0039 0.0078
Peroxisomes 0.0017 0 0.0035 0 0.0099 0.0001 0.0005 0.0003 0.0001 0.0001 0 0.0008 0.0025 0 0.0008 0.0001 0.0049 0.0004
Punctate Nuclear 0.0088 0 0.0001 0 0.0016 0.0001 0.0011 0.0001 0.0006 0.0001 0.0001 0.0002 0.0013 0 0.0006 0 0.0009 0.0068
Vacuole 0.1594 0.0866 0.178 0.3374 0.1135 0.0759 0.0371 0.0184 0.0396 0.0856 0.0128 0.0444 0.0814 0.021 0.0682 0.1577 0.077 0.0414
Vacuole Periphery 0.057 0.015 0.0421 0.092 0.0527 0.0476 0.0049 0.0012 0.0051 0.023 0.0028 0.015 0.019 0.0013 0.011 0.0264 0.0662 0.0079

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 91.9504 71.6119 70.6981 108.3308 104.3155 93.9881 92.0825 104.5386 91.6126 108.77
Translational Efficiency 1.3987 1.7981 1.6568 1.1541 1.316 1.3581 1.4304 1.161 1.3864 1.2402

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2088 827 331 1392 1630 1548 2012 1216 3718 2375 2343 2608

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 4060.95 7427.61 5331.85 3179.19 5493.05 6467.79 3520.98 3157.25 4688.79 6802.01 3776.80 3168.96
Standard Deviation 1116.21 1841.32 935.45 619.50 1172.64 1601.93 594.71 647.98 1344.43 1749.94 908.38 633.03
Intensity Change Log 2 — 0.871081 0.392819 -0.353158 — 0.235665 -0.641630 -0.798939 — 0.540431 -0.109966 -0.592432

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000057 0.000100 0.000287 0.000424 0.000048 0.000112 0.000079 0.000316 0.000053 0.000108 0.000109 0.000374
Bud Neck 0.000246 0.000795 0.005999 0.001785 0.000323 0.000777 0.000764 0.001770 0.000280 0.000783 0.001503 0.001778
Bud Site 0.003589 0.003240 0.004763 0.013836 0.001460 0.003637 0.003396 0.012444 0.002655 0.003499 0.003589 0.013187
Cell Periphery 0.006020 0.029047 0.048967 0.026670 0.014011 0.012768 0.004133 0.016917 0.009523 0.018436 0.010466 0.022123
Cytoplasm 0.871099* 0.743365* 0.440009* 0.715445* 0.812131* 0.820730* 0.854555* 0.702120* 0.845247* 0.793791* 0.795991* 0.709232*
Cytoplasmic Foci 0.009313 0.007101 0.030175 0.005601 0.005140 0.008824 0.004375 0.009444 0.007483 0.008224 0.008020 0.007392
Eisosomes 0.000001 0.000003 0.000012 0.000005 0.000001 0.000002 0.000001 0.000004 0.000001 0.000002 0.000003 0.000004
Endoplasmic Reticulum 0.000801 0.000363 0.000313 0.000551 0.000592 0.000450 0.000216 0.000462 0.000709 0.000420 0.000230 0.000509
Endosome 0.000659 0.000397 0.001163 0.001067 0.000393 0.000483 0.000575 0.002316 0.000543 0.000453 0.000658 0.001650
Golgi 0.035555 0.039365 0.062128 0.015838 0.040084 0.030982 0.011934 0.018118 0.037541 0.033901 0.019025 0.016901
Lipid Particles 0.005186 0.018881 0.035866 0.032751 0.012822 0.013418 0.006973 0.022026 0.008533 0.015320 0.011055 0.027750
Mitochondria 0.000138 0.000274 0.000182 0.000387 0.000092 0.000260 0.000086 0.000090 0.000118 0.000265 0.000099 0.000249
Mitotic Spindle 0.001015 0.000943 0.003307 0.000771 0.000526 0.001227 0.000738 0.001568 0.000800 0.001128 0.001101 0.001143
None 0.002200 0.002731 0.001811 0.000577 0.001905 0.003608 0.000729 0.000510 0.002071 0.003302 0.000882 0.000546
Nuclear Periphery 0.000182 0.001292 0.003362 0.000185 0.000614 0.000838 0.000172 0.000162 0.000371 0.000996 0.000623 0.000174
Nuclear Periphery Foci 0.006914 0.014268 0.026954 0.005196 0.013089 0.011617 0.004652 0.004944 0.009621 0.012540 0.007803 0.005078
Nucleolus 0.000047 0.000371 0.000135 0.000146 0.000054 0.000180 0.000064 0.000169 0.000050 0.000246 0.000074 0.000156
Nucleus 0.004798 0.015313 0.034180 0.005577 0.006415 0.016669 0.008835 0.008247 0.005507 0.016197 0.012415 0.006822
Peroxisomes 0.000028 0.000028 0.000021 0.000196 0.000015 0.000449 0.000030 0.000174 0.000022 0.000302 0.000029 0.000186
Vacuole 0.020218 0.079194 0.239082* 0.158747 0.052899 0.051944 0.082977 0.182375 0.034546 0.061433 0.105030 0.169764
Vacuole Periphery 0.031932 0.042930 0.061286 0.014247 0.037387 0.021025 0.014717 0.015826 0.034323 0.028653 0.021296 0.014983

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.41 -8.23 -4.32 -3.76 -0.88 -3.30 -2.06 -3.08 -2.29 -2.76 -4.72 -6.90 -5.29 -4.25 -4.16
Bud Neck -5.75 -9.90 -10.24 -5.96 7.30 -4.90 -6.71 -9.80 -6.91 -6.27 -7.61 -11.87 -14.19 -9.04 -1.35
Bud Site 0.38 -2.68 -8.96 -8.84 -7.28 -4.89 -5.80 -9.43 -7.28 -7.56 -2.55 -3.50 -12.90 -11.31 -11.20
Cell Periphery -10.48 -11.60 -11.26 1.46 5.74 1.01 10.55 -0.72 -1.56 -8.60 -8.58 -0.90 -9.53 -1.40 -8.23
Cytoplasm 11.02 23.16 17.55 2.43 -13.83 -0.50 -3.51 10.82 11.49 14.82 7.83 8.51 20.21 10.90 9.91
Cytoplasmic Foci 2.47 -6.92 4.98 1.97 7.85 -5.35 0.72 -4.24 -0.50 -4.64 -1.95 -2.39 -0.50 1.15 1.66
Eisosomes -5.64 -8.61 -8.81 -4.05 5.57 -2.35 -0.04 -6.83 -2.80 -7.11 -4.84 -7.69 -11.16 -4.89 -3.47
Endoplasmic Reticulum 3.09 3.60 1.62 -2.13 -3.01 1.67 5.63 1.75 0.02 -3.64 3.20 5.80 2.23 -1.27 -5.18
Endosome 4.01 -5.82 -3.21 -5.43 0.93 -2.00 -2.90 -6.09 -5.74 -5.17 1.80 -2.31 -6.81 -7.33 -5.37
Golgi -1.33 -5.80 9.59 9.88 11.60 3.74 14.39 10.20 6.76 -3.02 2.01 12.31 13.85 11.51 2.26
Lipid Particles -7.25 -10.52 -12.61 -4.72 1.34 -0.54 4.68 -4.91 -4.32 -9.54 -6.38 -3.67 -13.35 -7.15 -10.64
Mitochondria -1.71 -2.72 -1.09 -0.41 -0.76 -1.94 0.58 0.57 2.03 0.07 -2.35 1.24 -1.05 0.31 -1.17
Mitotic Spindle 0.25 -5.81 0.94 0.92 6.86 -4.54 -2.60 -1.54 -0.25 -0.98 -2.41 -2.64 -0.99 0.26 0.37
None -1.37 1.76 7.08 6.75 8.28 -3.46 9.73 11.78 6.40 3.06 -3.46 8.61 11.05 8.19 4.69
Nuclear Periphery -4.96 -12.40 -0.28 4.91 12.35 -1.00 6.68 7.09 2.98 1.44 -3.73 -5.48 5.89 4.89 10.06
Nuclear Periphery Foci -4.91 -8.21 2.48 6.03 8.91 0.97 8.03 7.53 7.32 -0.24 -3.54 2.34 7.50 9.57 5.08
Nucleolus -2.22 -10.01 -7.32 1.48 -0.20 -2.09 -1.17 -6.31 0.16 -6.75 -3.08 -4.38 -9.63 1.31 -8.00
Nucleus -5.30 -10.19 -2.85 4.36 9.62 -8.77 -5.10 -4.17 4.46 -0.45 -10.61 -11.55 -5.14 7.21 6.77
Peroxisomes 0.06 0.79 -7.28 -7.35 -7.58 -1.42 -3.70 -6.03 1.02 -5.42 -1.40 -1.68 -9.39 0.77 -8.98
Vacuole -11.47 -17.85 -24.39 -11.01 5.72 -0.10 -7.96 -18.59 -18.26 -12.88 -9.21 -18.84 -30.34 -21.97 -11.09
Vacuole Periphery -2.98 -5.09 8.98 8.73 9.30 6.41 9.77 9.54 3.57 -0.05 2.81 7.83 13.04 8.93 5.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Hom3

Hom3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hom3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available