Standard name
Human Ortholog
Description Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.23 0.22 0.23 0.19 0.11 0.1 0 0 0 0 0 0.23 0.25 0.13 0.05 0.15 0.13 0.15 0.14 0.26 0.17 0.18 0.15
Bud 0 0.06 0.15 0.09 0.11 0.11 0.1 0.09 0.08 0.1 0.09 0.11 0.09 0 0 0 0 0.06 0.11 0 0.18 0.21 0.16
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.12 0.06 0.15 0.12 0.1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0.05 0 0 0 0 0 0 0 0 0
Cytoplasm 0.35 0.52 0.42 0.59 0.65 0.68 0.7 0.74 0.74 0.78 0.75 0.46 0.47 0.59 0.44 0.42 0.38 0 0.06 0 0 0 0
Endoplasmic Reticulum 0.24 0.27 0.22 0.13 0.06 0.08 0 0 0 0 0 0.27 0.27 0.26 0 0 0 0.27 0.24 0.23 0.07 0.08 0.12
Endosome 0.06 0 0.05 0 0.1 0 0.05 0 0 0 0 0 0.05 0.06 0.05 0.06 0 0.06 0 0.1 0.06 0.06 0.06
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Mitochondria 0 0 0.08 0 0 0.09 0.15 0.14 0.13 0.23 0.22 0 0 0 0.07 0.07 0 0 0 0.06 0.06 0.06 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.07 0.07 0 0.07 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.18 0 0 0 0.07 0 0.05 0.05 0.08 0 0.05 0 0 0.07 0.44 0.41 0.4 0.28 0.24 0.17 0.2 0.23 0.28
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 54 30 74 64 52 68 30 11 19 17 14 30 38 22 4 12 7 47 25 104 21 47 35
Bud 10 8 47 32 53 75 87 74 62 61 65 14 14 2 0 3 0 17 20 14 22 53 35
Bud Neck 0 0 0 1 2 1 3 0 3 1 1 0 0 0 0 0 0 28 21 22 18 31 22
Bud Site 7 6 9 11 7 14 10 5 1 4 3 1 1 0 0 0 0
Cell Periphery 4 1 3 3 2 1 7 8 11 7 5 6 12 8 0 0 1 1 0 4 0 0 0
Cytoplasm 83 72 133 202 320 452 586 617 595 452 551 60 72 101 32 34 21 6 10 7 3 5 5
Endoplasmic Reticulum 57 37 70 45 29 51 28 19 20 5 12 36 41 44 3 2 2 84 43 93 8 20 28
Endosome 14 2 17 6 49 28 39 24 35 5 8 1 7 11 4 5 1 18 6 40 7 14 14
Golgi 0 0 0 1 0 0 0 0 0 0 0 0 1 1 2 0 3 10 1 13 1 1 4
Mitochondria 1 2 26 11 13 62 124 121 107 133 163 1 0 0 5 6 2 4 3 24 8 14 8
Nucleus 1 0 0 2 3 3 4 10 5 2 3 0 0 0 0 0 0 0 0 0 0 2 1
Nuclear Periphery 0 0 1 2 1 5 2 4 4 0 0 0 0 0 0 0 0 0 0 1 0 1 1
Nucleolus 0 1 1 0 1 0 3 10 3 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 18 10 11 24 23 9 14 4 3 3 2 1 2 0 0 1 0 1 0 3 3 2 1
SpindlePole 3 2 7 8 13 13 19 13 10 2 9 1 2 1 0 1 0 2 2 0 0 0 1
Vac/Vac Membrane 44 5 11 8 32 30 40 42 61 23 37 2 4 12 32 33 22 88 42 70 25 60 64
Unique Cell Count 240 139 318 342 492 667 835 836 800 583 733 131 154 172 73 81 55 315 181 407 125 258 232
Labelled Cell Count 296 176 410 420 600 812 996 962 939 715 874 153 194 202 82 97 59 315 181 407 125 258 232


Bud Neck, Cell Periphery, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.2 8.6 6.0 6.0 5.8 5.5 4.6 4.9 4.5 4.3 4.3 7.6 8.1 8.5 10.9 10.2 10.7 8.7 9.0 8.8
Std Deviation (1e-4) 1.1 1.5 1.0 1.4 1.2 1.5 1.1 1.2 1.3 0.9 0.9 1.1 1.4 1.7 2.4 2.4 2.4 1.4 1.7 2.1
Intensity Change (Log2) 0.01 -0.03 -0.11 -0.38 -0.3 -0.39 -0.47 -0.48 0.34 0.44 0.51 0.86 0.78 0.84 0.55 0.59 0.56

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.4 -4.9 -5.5 0 0 0 0 0 -0.1 0.3 -2.8 -3.4 -1.7 -1.8
Bud -2.1 -1.7 -1.6 0 0 0 0 0 -1.2 -1.7 -4.8 -3.5 -2.7 -3.0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0.3 -1.4 -0.7 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4.4 6.5 7.8 8.9 10.2 10.3 10.7 10.4 0.8 1.0 3.6 0.3 0 -0.5
Endoplasmic Reticulum -3.0 -6.8 -6.4 0 0 0 0 0 1.2 1.1 0.9 -3.5 -4.1 -3.2
Endosome -2.5 2.3 -0.8 0 0 0 0 0 -2.3 -0.4 0.5 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -2.8 -3.6 0.6 0 0 0 0 0 -3.0 -3.7 -3.9 -0.4 -0.2 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 2.0 0.8 -2.2 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.1 0.4 -0.3 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.9 1.9 0.8 1.0 1.1 2.6 0.4 1.1 0 0 1.8 9.9 9.6 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.0525 4.2213 4.1998 3.6234 3.4248 3.9813 4.8054 6.4902 6.1237 5.6107 6.0095 5.9961 2.7454 4.0586 3.8538 3.2662 3.3877 3.786
Actin 0.072 0.0424 0.0692 0.0571 0.0694 0.0313 0.0813 0.0221 0.0714 0.0356 0.0302 0.0639 0.0542 0.0229 0.0518 0.0396 0.0088 0.0193
Bud 0.0269 0.0265 0.1371 0.0522 0.0291 0.0086 0.0203 0.0188 0.0687 0.0105 0.0036 0.0037 0.0303 0.0165 0.1022 0.0216 0.0185 0.0025
Bud Neck 0.0396 0.0088 0.0075 0.0117 0.0103 0.514 0.0332 0.0165 0.0097 0.003 0.007 0.5015 0.0315 0.0138 0.0069 0.0093 0.0343 0.5666
Bud Periphery 0.057 0.0487 0.3031 0.1738 0.076 0.0186 0.0609 0.0346 0.205 0.1057 0.0128 0.008 0.0771 0.021 0.204 0.1 0.0486 0.0061
Bud Site 0.1616 0.2373 0.0665 0.0273 0.0375 0.0083 0.1246 0.2839 0.0563 0.0026 0.0078 0.0073 0.1017 0.2627 0.0593 0.0115 0.0042 0.0067
Cell Periphery 0.013 0.0045 0.0049 0.0051 0.0115 0.0053 0.0363 0.0087 0.0073 0.0076 0.013 0.0054 0.0187 0.003 0.0048 0.0047 0.0034 0.0045
Cytoplasm 0.1658 0.2754 0.1279 0.1329 0.2074 0.1303 0.2165 0.156 0.1351 0.2668 0.222 0.1094 0.1888 0.149 0.1039 0.1326 0.1828 0.0834
Cytoplasmic Foci 0.0797 0.0525 0.0367 0.0408 0.0894 0.0583 0.0704 0.0647 0.0473 0.0481 0.0826 0.044 0.07 0.0572 0.0404 0.0373 0.0778 0.0457
Eisosomes 0.0006 0.0001 0.0002 0.0002 0.0006 0.0002 0.0012 0.0002 0.0012 0.0001 0.0002 0.0003 0.0005 0.0001 0.0004 0.0003 0.0001 0.0001
Endoplasmic Reticulum 0.0155 0.0188 0.0064 0.0126 0.0106 0.0114 0.026 0.0292 0.0156 0.014 0.0203 0.0138 0.0218 0.0142 0.0111 0.026 0.0191 0.0096
Endosome 0.1517 0.1487 0.1125 0.2486 0.2046 0.1039 0.1356 0.1886 0.1837 0.2443 0.3457 0.1221 0.1933 0.2633 0.2228 0.3484 0.3297 0.1298
Golgi 0.0591 0.0389 0.0434 0.0744 0.0925 0.0428 0.0504 0.0518 0.069 0.1681 0.1178 0.0445 0.0544 0.0466 0.057 0.0572 0.0978 0.052
Lipid Particles 0.0329 0.0112 0.0055 0.0077 0.0111 0.0125 0.0345 0.0169 0.0096 0.0068 0.0225 0.0087 0.0202 0.006 0.0049 0.0286 0.0172 0.0059
Mitochondria 0.0272 0.0071 0.0127 0.0396 0.0311 0.0163 0.0112 0.0066 0.0228 0.0056 0.0086 0.0064 0.0092 0.0106 0.0172 0.0121 0.011 0.0069
None 0.008 0.0123 0.0066 0.0031 0.0121 0.003 0.0158 0.0162 0.0034 0.002 0.0022 0.012 0.0078 0.0047 0.0058 0.0058 0.0045 0.007
Nuclear Periphery 0.0092 0.0029 0.0022 0.0029 0.003 0.0007 0.0036 0.003 0.0042 0.0019 0.0021 0.0006 0.0037 0.0026 0.0027 0.0052 0.0093 0.0013
Nucleolus 0.0014 0.0008 0.0011 0.0006 0.006 0.0005 0.0013 0.0025 0.0008 0.0003 0.0002 0.0008 0.0014 0.0012 0.0011 0.0004 0.0005 0.0005
Nucleus 0.0039 0.0029 0.0032 0.0025 0.0219 0.0016 0.0022 0.0121 0.0019 0.001 0.0012 0.0011 0.0025 0.0027 0.0026 0.0018 0.0022 0.0013
Peroxisomes 0.0144 0.0021 0.0057 0.0018 0.0071 0.0047 0.0093 0.0018 0.0119 0.0011 0.0037 0.0027 0.0032 0.002 0.0022 0.0095 0.0077 0.0032
Punctate Nuclear 0.0034 0.0016 0.002 0.0005 0.004 0.0024 0.0044 0.0047 0.001 0.0003 0.0004 0.0004 0.0024 0.0012 0.0008 0.0019 0.0023 0.0017
Vacuole 0.0509 0.0511 0.0384 0.088 0.0592 0.0219 0.0559 0.0564 0.0617 0.0664 0.0875 0.0383 0.1006 0.0895 0.082 0.1272 0.1044 0.0403
Vacuole Periphery 0.0062 0.0052 0.0072 0.0164 0.0055 0.0034 0.0052 0.0048 0.0121 0.0082 0.0085 0.005 0.0067 0.009 0.0161 0.0189 0.0156 0.0054

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 50.4728 33.0579 18.5635 28.3296 41.467 28.9683 22.8102 24.3886 19.8917 48.1946
Translational Efficiency 1.4383 1.1306 1.3043 0.852 1.1742 2.1978 1.5949 0.8982 1.0371 1.0158

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1298 2238 326 957 1878 1329 277 1506 3176 3567 603 2463

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 787.64 947.37 1054.28 1156.76 840.63 871.19 1168.66 1243.69 818.97 918.99 1106.82 1209.91
Standard Deviation 96.51 128.09 120.54 174.57 109.91 115.72 119.97 189.88 107.84 129.00 133.10 188.90
Intensity Change Log 2 0.266392 0.420650 0.554481 0.051516 0.475312 0.565084 0.159457 0.449129 0.559965

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.015255 0.032130 0.003077 0.055029 0.033038 0.020279 0.032057 0.041405 0.025770 0.027714 0.016390 0.046699
Bud Neck 0.157892 0.101106 0.014120 0.048921 0.165953 0.139996 0.058915 0.061843 0.162659 0.115596 0.034697 0.056822
Bud Site 0.155629 0.226763 0.048573 0.364800 0.181107 0.217089 0.295771 0.408651 0.170695 0.223159 0.162128 0.391613
Cell Periphery 0.011861 0.011064 0.000489 0.074716 0.031094 0.030885 0.018313 0.098868 0.023234 0.018449 0.008677 0.089484
Cytoplasm 0.259527 0.173446 0.047779 0.057795 0.243391 0.168717 0.038355 0.069045 0.249985 0.171684 0.043450 0.064674
Cytoplasmic Foci 0.118796 0.119269 0.088515 0.030718 0.062822 0.070850 0.052594 0.031029 0.085698 0.101229 0.072014 0.030909
Eisosomes 0.007715 0.004420 0.000128 0.003350 0.013280 0.007596 0.000679 0.003384 0.011005 0.005603 0.000381 0.003371
Endoplasmic Reticulum 0.024345 0.036520 0.044433 0.044075 0.029789 0.052911 0.070592 0.039950 0.027564 0.042627 0.056450 0.041553
Endosome 0.062481 0.085604 0.148413 0.060812 0.060950 0.077560 0.098657 0.053488 0.061576 0.082607 0.125556 0.056334
Golgi 0.037454 0.060684 0.008780 0.020314 0.040422 0.045560 0.021036 0.025561 0.039209 0.055049 0.014410 0.023522
Lipid Particles 0.025355 0.028205 0.024702 0.016040 0.029963 0.025404 0.015034 0.024235 0.028080 0.027161 0.020261 0.021051
Mitochondria 0.013890 0.021475 0.000904 0.003389 0.015974 0.014668 0.000871 0.006059 0.015122 0.018939 0.000889 0.005022
Mitotic Spindle 0.000301 0.000245 0.005215 0.002116 0.000085 0.000793 0.000749 0.000887 0.000173 0.000449 0.003164 0.001364
None 0.000580 0.000211 0.000141 0.000063 0.000120 0.000139 0.000012 0.000163 0.000308 0.000184 0.000081 0.000124
Nuclear Periphery 0.000130 0.000063 0.005654 0.000098 0.000055 0.000107 0.000117 0.000082 0.000086 0.000079 0.003111 0.000088
Nuclear Periphery Foci 0.000848 0.000387 0.018899 0.001240 0.000305 0.000545 0.002275 0.000691 0.000527 0.000446 0.011263 0.000904
Nucleolus 0.000573 0.000193 0.003835 0.000129 0.000159 0.000141 0.000200 0.000264 0.000328 0.000173 0.002165 0.000212
Nucleus 0.007190 0.002272 0.036965 0.001130 0.003053 0.002308 0.001074 0.001461 0.004744 0.002285 0.020477 0.001332
Peroxisomes 0.018495 0.017117 0.005443 0.003759 0.024298 0.019934 0.006834 0.005491 0.021926 0.018166 0.006082 0.004818
Vacuole 0.073568 0.064226 0.465419 0.188925 0.056467 0.090575 0.270457 0.110977 0.063456 0.074043 0.375860 0.141264
Vacuole Periphery 0.008115 0.014602 0.028516 0.022581 0.007674 0.013940 0.015408 0.016464 0.007855 0.014355 0.022495 0.018841

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.97 6.84 -7.93 -4.40 -10.59 4.92 0.16 -2.42 -6.67 -1.45 -1.01 3.02 -7.30 -6.63 -8.07
Bud Neck 7.35 20.10 14.98 10.39 -8.32 3.10 11.83 16.56 11.40 -0.39 8.58 22.64 22.21 14.59 -5.13
Bud Site -8.73 11.30 -17.00 -11.38 -24.36 -3.94 -5.77 -22.41 -16.75 -5.36 -8.79 0.68 -28.17 -20.79 -17.92
Cell Periphery 0.61 11.26 -11.41 -11.63 -13.75 0.08 3.90 -12.68 -12.35 -13.92 3.25 8.38 -16.93 -18.36 -20.32
Cytoplasm 11.65 27.08 28.25 22.10 -1.75 10.24 29.70 29.26 16.38 -5.66 15.50 40.01 40.44 27.36 -5.37
Cytoplasmic Foci -0.07 4.33 19.00 23.20 9.41 -2.13 1.54 10.63 10.98 3.42 -5.01 2.84 20.78 26.15 9.24
Eisosomes 5.16 13.22 6.06 2.10 -7.16 5.57 15.70 10.98 5.49 -6.04 8.93 20.04 12.48 5.22 -9.29
Endoplasmic Reticulum -4.35 -3.08 -4.73 -1.76 0.00 -6.20 -4.71 -3.17 3.05 3.44 -6.85 -5.42 -5.49 0.41 2.64
Endosome -6.27 -10.08 0.39 6.03 10.04 -4.37 -4.86 2.13 6.05 5.77 -8.04 -10.84 1.94 9.36 11.57
Golgi -7.76 11.96 6.21 13.66 -4.90 -1.59 5.67 5.56 6.10 -1.31 -7.20 12.11 8.04 14.21 -4.40
Lipid Particles -1.48 0.17 4.12 5.44 2.83 2.03 3.44 2.23 0.44 -1.99 0.63 3.03 3.90 3.37 -0.26
Mitochondria -4.98 11.37 8.11 14.79 -3.57 1.01 17.95 8.98 6.97 -6.87 -3.80 20.80 11.96 15.31 -7.68
Mitotic Spindle 0.71 -2.25 -2.23 -2.32 1.37 -2.04 -2.96 -3.89 -0.24 -0.47 -2.00 -2.51 -3.51 -2.53 1.49
None 1.91 2.29 2.73 3.29 2.03 -0.38 6.34 -0.59 -0.32 -1.92 1.48 2.82 1.95 0.94 -0.86
Nuclear Periphery 2.69 -4.80 1.42 -2.49 4.83 -6.42 -3.77 -4.17 2.48 1.99 0.58 -4.79 -0.23 -1.00 4.79
Nuclear Periphery Foci 1.68 -6.82 -1.05 -8.58 6.74 -5.39 -7.66 -7.14 -2.26 6.04 0.81 -7.30 -2.66 -8.39 7.08
Nucleolus 1.60 -3.22 1.86 1.54 3.81 0.99 -0.34 -0.79 -0.92 -0.35 1.57 -3.36 0.99 -0.44 3.62
Nucleus 9.30 -5.51 11.40 8.04 6.66 3.34 6.61 4.63 2.54 -1.33 9.71 -5.24 11.42 4.80 6.36
Peroxisomes 1.07 10.20 13.33 14.90 2.22 2.34 12.33 15.32 9.38 1.43 3.45 16.26 19.93 16.46 2.14
Vacuole 2.11 -25.98 -13.22 -14.78 16.36 -6.61 -12.67 -10.22 -3.25 9.14 -3.35 -26.27 -16.31 -13.74 18.66
Vacuole Periphery -6.60 -5.50 -7.03 -3.91 1.28 -5.79 -3.89 -7.27 -1.68 -0.51 -9.59 -6.65 -10.06 -3.85 1.35
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
Localization
Cell Percentages ER (14%), cell periphery (7%), mixed (39%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sho1

Sho1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sho1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available