Standard name
Human Ortholog
Description Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 0.09 0 0.08 0.06 0 0.05 – 0 0 0.05 0.07 0.11 0.14 0.19 0.22 0.24 0.1 0 0 0 0.06 0.09
Bud – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – – 0 0.05 0 0 0 0 – 0 0 0.05 0.05 0.1 0.2 0.21 0.25 0.16 0.08 0 0 0 0 0
Cytoplasm – – 0.09 0.12 0.13 0.14 0.09 0.09 – 0.08 0.08 0.06 0.1 0.08 0.14 0.2 0.16 0.18 0 0 0 0 0 0
Endoplasmic Reticulum – – 0.75 0.59 0.56 0.68 0.55 0.47 – 0.38 0.33 0.36 0.83 0.75 0.65 0 0 0.06 0.62 0.81 0.82 0.78 0.75 0.68
Endosome – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0.26 0.28 0.23 0 0 0 0 0 0
Mitochondria – – 0.21 0.17 0.14 0.18 0.32 0.28 – 0.32 0.46 0.5 0 0 0 0.1 0.07 0.11 0.07 0.06 0 0 0 0
Nucleus – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery – – 0.09 0.1 0.05 0.06 0.11 0.11 – 0.1 0.05 0.09 0 0 0 0 0.05 0.07 0 0.05 0 0 0 0
Nucleolus – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – – 0 0.18 0.22 0.08 0.21 0.25 – 0.23 0.26 0.22 0.07 0.14 0.06 0.2 0.19 0.14 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 5 6 19 7 9 11 – 14 7 17 12 25 34 38 36 29 1 0 3 2 10 18
Bud – – 1 0 3 4 2 5 – 11 7 4 2 3 4 5 4 3 0 0 0 0 2 1
Bud Neck – – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2
Bud Site – – 0 0 0 0 0 0 – 2 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery – – 0 7 9 0 8 6 – 8 3 18 9 21 47 43 41 19 0 0 0 1 1 7
Cytoplasm – – 5 16 32 16 27 21 – 25 22 20 19 17 32 40 27 22 0 0 0 0 6 5
Endoplasmic Reticulum – – 43 79 135 76 165 113 – 120 94 125 151 164 152 9 2 7 6 26 65 46 138 147
Endosome – – 0 2 8 0 2 2 – 11 0 5 2 1 2 3 0 0 0 0 0 0 1 4
Golgi – – 0 1 0 0 0 1 – 2 1 1 0 2 4 52 47 27 0 0 0 1 4 8
Mitochondria – – 12 23 34 20 95 67 – 99 132 176 2 1 4 19 11 13 0 1 1 2 5 6
Nucleus – – 0 0 2 1 3 2 – 1 2 1 0 0 1 1 1 1 0 0 0 0 0 1
Nuclear Periphery – – 5 14 11 7 33 26 – 30 15 32 2 2 0 5 9 8 0 1 3 2 3 0
Nucleolus – – 0 1 0 0 2 2 – 2 4 4 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – – 0 0 0 1 0 0 – 1 0 0 0 1 2 0 1 1 0 0 0 0 0 0
SpindlePole – – 0 0 0 0 0 0 – 2 0 0 0 0 0 2 3 0 0 0 0 0 0 0
Vac/Vac Membrane – – 1 24 54 9 62 60 – 72 74 78 13 30 14 40 31 17 0 0 2 0 3 8
Unique Cell Count 57 134 241 112 298 243 314 287 351 183 220 235 200 167 119 11 33 80 59 184 218
Labelled Cell Count 72 173 307 141 408 316 400 362 482 213 267 296 257 213 147 11 33 80 59 184 218


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – – 7.3 8.5 8.6 7.9 7.5 7.6 – 7.4 7.4 7.3 10.0 10.1 9.8 13.4 14.0 13.8 – 12.1 12.7
Std Deviation (1e-4) – – 0.8 1.3 1.6 1.5 1.5 1.3 – 1.5 1.3 1.4 1.3 1.4 1.6 2.8 2.9 3.0 – 2.4 2.5
Intensity Change (Log2) – – – 0.22 0.24 0.12 0.05 0.07 – 0.03 0.03 0.0 0.46 0.48 0.43 0.88 0.95 0.93 – 0.73 0.8

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0.6 1.1 1.8 2.2 2.5
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 3.7 3.8 4.1 3.2
Cytoplasm 0.6 0.9 1.0 0.1 0 – 0 0 0 0.4 0 1.0 2.0 1.4 1.7
Endoplasmic Reticulum -2.2 -2.7 -1.0 -2.8 -3.9 – -5.2 -6.0 -5.7 1.2 -0.1 -1.5 -11.8 -12.1 -9.6
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 4.3 4.5 3.9
Mitochondria -0.6 -1.3 -0.5 1.6 1.0 – 1.6 3.5 4.1 0 0 0 -2.4 -3.1 -1.8
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.4 0 0 0.5 0.4 – 0.2 0 0.1 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 3.0 3.6 0 3.4 3.9 – 3.7 4.0 3.6 0 2.5 0 3.3 3.1 2.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.642 11.1904 9.9783 9.9299 8.8132 9.8811 10.6504 12.6851 11.7336 11.0117 10.4666 11.9566 9.2289 10.4267 9.7157 9.1784 8.3527 10.1024
Actin 0.0711 0.0592 0.0592 0.0542 0.0228 0.027 0.0513 0.0218 0.0231 0.0017 0.0326 0.0055 0.065 0.0416 0.03 0.0212 0.0028 0.0323
Bud 0.0016 0.0003 0.0005 0.0002 0.0003 0.0002 0.0004 0.0002 0.0003 0.0001 0.0004 0.0001 0.0004 0.0006 0.0003 0.0001 0.0002 0.0001
Bud Neck 0.0052 0.003 0.004 0.0149 0.0008 0.001 0.0013 0.0005 0.001 0.0004 0.0005 0.0015 0.0016 0.0029 0.0015 0.003 0.0003 0.0021
Bud Periphery 0.0044 0.0008 0.0008 0.0004 0.0005 0.0007 0.0016 0.0003 0.0007 0.0005 0.0005 0.0003 0.0014 0.0021 0.0006 0.0003 0.0003 0.0005
Bud Site 0.0103 0.0058 0.0056 0.0031 0.0006 0.0002 0.0025 0.0007 0.0009 0.0009 0.0015 0 0.0014 0.0023 0.004 0.0002 0.0013 0.0002
Cell Periphery 0.0215 0.0186 0.0188 0.0036 0.0016 0.0073 0.0108 0.0162 0.01 0.0024 0.0011 0.0063 0.0116 0.0164 0.008 0.0011 0.0005 0.008
Cytoplasm 0.0248 0.0174 0.0444 0.0044 0.0036 0.0035 0.0296 0.0276 0.0026 0.001 0.0019 0.0038 0.0061 0.0075 0.0135 0.0016 0.001 0.0044
Cytoplasmic Foci 0.0377 0.0074 0.0147 0.0121 0.0078 0.0063 0.0254 0.0026 0.0064 0.0007 0.0102 0.003 0.0182 0.0076 0.0066 0.0027 0.0184 0.0027
Eisosomes 0.005 0.0053 0.006 0.001 0.0005 0.0024 0.0088 0.0054 0.0112 0.0009 0.0002 0.0014 0.012 0.0061 0.0139 0.0002 0.0001 0.0042
Endoplasmic Reticulum 0.5067 0.7102 0.6658 0.817 0.6712 0.7634 0.6685 0.8701 0.8263 0.8891 0.792 0.8734 0.6255 0.7289 0.8092 0.8678 0.7851 0.8463
Endosome 0.0422 0.0145 0.0206 0.0079 0.0256 0.0237 0.0287 0.0051 0.0116 0.0177 0.0213 0.0105 0.0356 0.0207 0.0128 0.0156 0.018 0.0103
Golgi 0.0542 0.0576 0.0884 0.0161 0.069 0.0388 0.0641 0.0214 0.0325 0.0133 0.0298 0.026 0.0904 0.0554 0.0379 0.0253 0.0089 0.0503
Lipid Particles 0.0921 0.0729 0.0347 0.0067 0.0437 0.0502 0.0279 0.0168 0.0389 0.0068 0.0197 0.0359 0.0784 0.071 0.0337 0.0286 0.0214 0.0103
Mitochondria 0.0056 0.007 0.0034 0.0006 0.0336 0.0207 0.0323 0.0004 0.0133 0.0019 0.0212 0.0015 0.0105 0.0049 0.0044 0.0021 0.0069 0.0013
None 0.0032 0.0005 0.0021 0.0068 0.0017 0.001 0.0082 0.0003 0.0003 0.0004 0.0003 0.0002 0.007 0.0076 0.0054 0.0002 0.0007 0.0004
Nuclear Periphery 0.0675 0.0136 0.0116 0.0345 0.0724 0.0418 0.0137 0.0077 0.0084 0.021 0.0488 0.0257 0.0207 0.0129 0.0085 0.0229 0.099 0.0206
Nucleolus 0.0041 0.0001 0.0039 0.0016 0.0023 0.0003 0.0004 0 0 0.0011 0.0001 0 0.0003 0.0002 0.0004 0.0001 0.0003 0
Nucleus 0.0042 0.0004 0.0029 0.0013 0.008 0.0027 0.0013 0.0002 0.0002 0.0014 0.0008 0.0004 0.0012 0.0009 0.0006 0.0006 0.003 0.0004
Peroxisomes 0.0101 0.0009 0.004 0.0027 0.0086 0.0013 0.0109 0.0001 0.0085 0.0002 0.0112 0.0001 0.0029 0.0005 0.0034 0.0003 0.0198 0.0009
Punctate Nuclear 0.015 0.0009 0.0048 0.0068 0.0015 0.0009 0.0056 0.0001 0.0003 0.0001 0.0003 0.0001 0.0037 0.0026 0.0021 0.0002 0.0061 0.0009
Vacuole 0.0091 0.0026 0.0029 0.0021 0.0095 0.0036 0.0044 0.002 0.0022 0.0331 0.0028 0.0022 0.0038 0.0055 0.0018 0.0036 0.0024 0.0022
Vacuole Periphery 0.0044 0.0009 0.0011 0.002 0.0143 0.0029 0.0024 0.0006 0.0013 0.0052 0.0028 0.0019 0.0024 0.0019 0.0012 0.0023 0.0037 0.0014

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 200.4143 240.2195 234.0196 188.2817 201.4535 190.5507 244.921 209.7224 189.7857 181.4945
Translational Efficiency 2.0498 2.0579 1.8279 1.991 2.132 2.3202 1.7816 1.8905 2.0287 1.9477

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1494 1360 1780 112 1947 1671 2423 2266 3441 3031 4203 2378

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 887.62 1079.57 1474.05 1745.75 1040.26 1038.87 1842.55 1564.32 973.99 1057.13 1686.49 1572.87
Standard Deviation 132.19 184.25 236.01 329.76 152.09 163.22 324.02 336.05 162.48 174.15 342.44 337.95
Intensity Change Log 2 — 0.282443 0.731771 0.975833 — -0.001929 0.824760 0.588592 — 0.135987 0.782690 0.779846

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.008759 0.012198 0.021787 0.091145 0.015595 0.015142 0.123570 0.158037 0.012627 0.013821 0.080464 0.154886
Bud Neck 0.000780 0.000946 0.004122 0.029284 0.000690 0.000910 0.011184 0.014170 0.000729 0.000926 0.008193 0.014882
Bud Site 0.003994 0.006031 0.006624 0.022393 0.004126 0.006749 0.009999 0.022987 0.004068 0.006427 0.008570 0.022959
Cell Periphery 0.007156 0.010441 0.003439 0.004034 0.011686 0.012420 0.009560 0.009228 0.009719 0.011532 0.006968 0.008983
Cytoplasm 0.032614 0.019583 0.002397 0.004142 0.015986 0.015511 0.001199 0.001681 0.023205 0.017339 0.001706 0.001797
Cytoplasmic Foci 0.008208 0.005392 0.000909 0.017619 0.006490 0.009289 0.001447 0.005106 0.007236 0.007541 0.001219 0.005695
Eisosomes 0.002311 0.002773 0.001785 0.007010 0.003260 0.004489 0.024836 0.012976 0.002848 0.003719 0.015074 0.012695
Endoplasmic Reticulum 0.812238 0.841971 0.855568 0.364878 0.844778 0.807300 0.608430 0.462487 0.830650 0.822857 0.713094 0.457890
Endosome 0.010136 0.012324 0.021441 0.069492 0.011741 0.014880 0.020599 0.041763 0.011044 0.013733 0.020956 0.043069
Golgi 0.019199 0.011393 0.002763 0.022571 0.011303 0.015938 0.015280 0.013936 0.014732 0.013899 0.009979 0.014342
Lipid Particles 0.047580 0.047312 0.062605 0.313549 0.043359 0.052547 0.149544 0.236807 0.045192 0.050198 0.112725 0.240422
Mitochondria 0.005420 0.003194 0.000532 0.000757 0.002272 0.007328 0.003787 0.002413 0.003639 0.005473 0.002408 0.002335
Mitotic Spindle 0.000225 0.000825 0.000541 0.011528 0.000301 0.001013 0.000577 0.000658 0.000268 0.000929 0.000561 0.001170
None 0.004045 0.003831 0.001646 0.000042 0.004762 0.004401 0.007111 0.001320 0.004451 0.004145 0.004797 0.001260
Nuclear Periphery 0.000616 0.000575 0.001781 0.000964 0.000482 0.000932 0.000769 0.000592 0.000540 0.000772 0.001198 0.000609
Nuclear Periphery Foci 0.009958 0.004889 0.008237 0.018820 0.004655 0.006037 0.000714 0.002979 0.006957 0.005522 0.003900 0.003725
Nucleolus 0.000217 0.000084 0.000018 0.000021 0.000018 0.000110 0.000021 0.000026 0.000104 0.000099 0.000020 0.000026
Nucleus 0.001244 0.001082 0.000209 0.000263 0.000666 0.000978 0.000302 0.000205 0.000917 0.001025 0.000263 0.000208
Peroxisomes 0.023438 0.013580 0.001012 0.001095 0.016728 0.020225 0.008552 0.007669 0.019641 0.017243 0.005359 0.007359
Vacuole 0.001245 0.001040 0.002348 0.019609 0.000657 0.001774 0.001877 0.003632 0.000912 0.001445 0.002076 0.004384
Vacuole Periphery 0.000616 0.000536 0.000238 0.000785 0.000446 0.002024 0.000640 0.001328 0.000520 0.001357 0.000470 0.001303

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.58 -4.99 -4.62 -4.42 -3.84 0.18 -20.47 -23.93 -23.97 -4.54 -0.71 -20.39 -25.35 -25.06 -11.74
Bud Neck -0.73 -6.61 -4.20 -4.18 -3.69 -1.39 -13.07 -12.91 -12.66 -2.29 -1.48 -14.56 -13.54 -13.31 -5.74
Bud Site -1.84 -2.61 -3.77 -3.34 -3.16 -2.54 -6.26 -11.09 -8.67 -7.13 -3.12 -6.40 -11.65 -9.72 -8.46
Cell Periphery -2.17 3.92 2.49 4.27 -0.63 -0.44 1.58 1.82 2.45 0.35 -1.58 3.17 0.72 2.50 -3.10
Cytoplasm 5.28 17.15 4.57 2.18 -1.03 0.32 14.02 13.46 12.22 -2.69 4.20 21.95 21.22 14.79 -0.68
Cytoplasmic Foci 2.41 7.81 -1.97 -2.53 -3.43 -2.12 6.37 1.35 3.29 -5.36 -0.34 9.95 1.66 1.86 -6.65
Eisosomes -0.97 1.05 -1.23 -1.10 -1.37 -1.99 -13.01 -8.34 -6.84 6.03 -2.16 -12.30 -8.90 -7.92 1.67
Endoplasmic Reticulum -2.97 -4.37 11.94 12.72 13.07 4.05 24.49 37.48 31.10 12.82 1.16 16.64 39.93 37.81 25.78
Endosome -1.96 -8.52 -5.93 -5.70 -4.75 -2.70 -8.44 -18.18 -15.15 -12.40 -3.30 -12.01 -20.14 -17.85 -13.31
Golgi 4.44 11.91 -0.53 -1.95 -3.59 -2.90 -3.36 -1.94 1.33 1.22 0.69 5.28 0.38 -0.29 -4.39
Lipid Particles 0.07 -3.12 -8.31 -8.30 -7.79 -2.16 -19.40 -29.00 -26.53 -11.24 -1.62 -17.62 -30.86 -29.39 -18.56
Mitochondria 1.75 4.81 4.40 2.96 -0.65 -4.20 -3.10 -0.35 3.99 2.49 -2.12 2.33 2.20 3.85 0.15
Mitotic Spindle -1.35 -1.80 -2.87 -2.73 -2.78 -1.70 -2.20 -2.87 0.82 -0.68 -2.17 -2.77 -4.04 -0.91 -2.53
None 0.19 2.95 5.71 3.75 3.86 0.29 -1.95 4.03 3.33 6.33 0.35 -0.43 5.34 4.08 6.03
Nuclear Periphery 0.14 -3.50 -1.82 -1.27 2.25 -1.70 -3.59 -1.12 1.23 1.87 -1.18 -4.44 -0.80 0.75 3.72
Nuclear Periphery Foci 3.40 0.99 -1.41 -2.16 -1.65 -1.40 6.51 2.10 3.19 -4.35 1.67 3.78 3.55 2.14 0.20
Nucleolus 0.74 1.18 1.16 1.13 -0.23 -1.92 -0.78 -1.40 1.72 -1.03 0.08 1.15 1.06 1.96 -0.89
Nucleus 0.52 3.41 2.69 2.68 -0.87 -0.84 2.72 3.40 2.21 4.40 -0.34 4.29 4.64 3.73 2.00
Peroxisomes 3.93 10.94 10.99 8.21 -0.17 -1.62 5.25 5.88 6.63 0.74 1.47 11.35 8.84 7.07 -2.10
Vacuole 0.73 -3.08 -3.64 -3.68 -3.42 -2.89 -3.35 -7.11 -3.43 -3.32 -2.03 -4.49 -7.28 -5.79 -4.47
Vacuole Periphery 0.44 2.74 -0.66 -0.91 -2.26 -3.07 -1.57 -2.14 1.06 -1.65 -2.83 0.50 -2.00 0.10 -2.13
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
Localization
Cell Percentages ER (99%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Scs2

Scs2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Scs2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available