Standard name
Human Ortholog
Description Ubiquitin-specific protease involved in transport and osmotic response; negatively regulates Ras/PKA signaling; interacts with Bre5p to coregulate anterograde, retrograde transport between ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; role in ribophagy; cleaves ubiquitin fusions but not polyubiquitin; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0.07 0 0.07 0 0.05 0 0 0.06 0.06 0 0 0 0 0.09 0 0 0 0 0 0 0
Cytoplasm 0.97 0.95 0.92 0.87 0.87 0.78 0.7 0.66 0.66 0.58 0.55 0.55 0.97 0.95 0.95 0.88 0.92 0.93 0.93 0.95 0.88 0.71 0.61 0.54
Endoplasmic Reticulum 0 0.05 0.08 0.11 0.1 0.17 0.17 0.23 0.18 0.17 0.14 0.15 0 0 0 0 0 0 0 0 0.05 0.17 0.24 0.26
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.12 0 0.16 0.23 0.32 0.23 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.05 0.05 0.06 0 0.1 0 0 0 0.11 0 0.05 0 0 0 0 0 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 1 1 2 10 12 14 7 11 17 18 0 0 1 2 2 0 0 0 0 1 3 1
Bud 0 0 1 0 0 0 3 2 2 1 2 1 0 0 0 0 0 0 0 4 1 1 4 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 19 22 17 14 24 15 18 10 12 17 14 6 8 11 17 31 12 0 0 0 0 0 0
Cytoplasm 296 498 439 218 278 269 247 230 153 159 151 136 271 290 327 369 314 342 277 501 438 147 245 155
Endoplasmic Reticulum 8 26 37 27 33 59 60 79 42 46 39 38 5 13 15 13 12 12 9 7 25 35 97 73
Endosome 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 1 1 1 0 0 1 2 6
Golgi 0 0 1 1 1 3 5 8 2 1 0 4 0 0 1 8 2 1 0 0 3 2 12 10
Mitochondria 0 1 0 1 2 15 42 15 37 63 87 57 2 1 0 5 0 2 0 2 6 3 9 4
Nucleus 0 0 2 0 1 0 3 5 5 3 2 3 2 1 2 1 5 4 1 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 1 1 0 1 1 0 0 0 0 0 0 1 0 0 0 2 0
Nucleolus 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Vac/Vac Membrane 2 2 3 1 6 5 13 16 11 15 8 25 0 0 1 48 13 17 2 9 15 8 17 21
Unique Cell Count 305 522 476 250 318 346 353 351 231 272 273 246 280 305 343 420 342 369 300 531 497 207 401 285
Labelled Cell Count 310 547 506 266 338 385 400 389 270 311 324 297 286 313 358 464 380 391 300 531 497 207 401 285


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.8 17.1 13.5 12.5 13.5 11.8 11.7 12.0 11.0 10.2 9.2 10.0 15.3 16.3 16.4 16.4 18.0 17.1 14.1 15.1 16.0
Std Deviation (1e-4) 3.0 2.8 1.8 1.7 1.6 1.9 1.9 1.8 2.0 1.8 1.9 1.9 2.4 2.3 2.6 4.0 3.7 3.8 2.8 2.5 3.0
Intensity Change (Log2) – – – -0.11 0.0 -0.19 -0.2 -0.17 -0.29 -0.4 -0.55 -0.43 0.19 0.27 0.29 0.28 0.42 0.35 0.07 0.17 0.25


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 3.7 4.0 0 0 5.2 5.7 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1.2 -0.1 1.4 -0.3 0.3 -0.2 -0.1 1.0 0.6 -1.7 -1.4 -1.0 -0.4 2.5 -1.0
Cytoplasm -2.2 -2.2 -5.9 -8.4 -9.7 -8.8 -11.1 -11.9 -11.7 2.5 1.6 1.8 -2.2 -0.2 0.2
Endoplasmic Reticulum 1.4 1.3 4.1 4.1 6.0 4.1 3.8 2.8 3.2 -3.5 -2.0 -2.0 -3.0 -2.5 -2.8
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.6 7.7 4.6 9.0 11.0 13.1 10.9 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.2 3.7 0 4.2 0 6.3 0 0 0 7.0 3.2 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.1607 15.734 13.4232 11.5687 11.1686 13.6283 11.7596 16.1865 14.7565 12.2784 12.6342 14.516 10.8645 14.3946 13.2516 13.2177 11.5316 13.0438
Actin 0.0094 0.0023 0.0055 0.0235 0.0199 0.0073 0.0148 0.0006 0.0016 0.0229 0.0032 0.0014 0.0193 0.0043 0.0104 0.0323 0.0298 0.0055
Bud 0.001 0.0006 0.0014 0.0015 0.0014 0.001 0.0025 0.0033 0.0014 0.0029 0.0006 0.001 0.0098 0.0119 0.0145 0.0117 0.0072 0.005
Bud Neck 0.0036 0.0006 0.001 0.0014 0.0015 0.0035 0.0018 0.0004 0.0007 0.0014 0.0006 0.0011 0.0011 0.0007 0.0011 0.0012 0.001 0.002
Bud Periphery 0.0012 0.0004 0.0013 0.0012 0.0018 0.001 0.0022 0.0008 0.0006 0.0036 0.0004 0.001 0.0057 0.0038 0.006 0.0069 0.0028 0.0018
Bud Site 0.0042 0.0016 0.0043 0.0021 0.0139 0.001 0.0062 0.0068 0.0011 0.0078 0.0006 0.0002 0.0093 0.0415 0.0158 0.0082 0.0014 0.0033
Cell Periphery 0.002 0.0012 0.0013 0.0006 0.0005 0.0005 0.0012 0.0003 0.0004 0.0013 0.0001 0.0003 0.0015 0.001 0.0009 0.0007 0.0004 0.0004
Cytoplasm 0.6016 0.918 0.7614 0.6415 0.549 0.7196 0.7055 0.9028 0.863 0.6056 0.6994 0.7974 0.7169 0.8475 0.8207 0.7941 0.6896 0.8001
Cytoplasmic Foci 0.023 0.0096 0.0215 0.0255 0.0341 0.033 0.0183 0.0135 0.0198 0.0238 0.0357 0.0218 0.0305 0.0299 0.0221 0.0359 0.0362 0.0305
Eisosomes 0.0003 0 0.0005 0.0002 0.0003 0 0.0004 0 0 0.0002 0.0001 0 0.0002 0 0 0.0002 0.0002 0
Endoplasmic Reticulum 0.1374 0.0226 0.0343 0.0416 0.0606 0.078 0.0771 0.0155 0.0248 0.0271 0.0119 0.0444 0.0352 0.0108 0.0163 0.0061 0.007 0.0346
Endosome 0.1034 0.0242 0.078 0.0848 0.1462 0.0847 0.0821 0.0339 0.0508 0.1564 0.1682 0.0825 0.0714 0.0247 0.0468 0.0475 0.1492 0.0752
Golgi 0.0188 0.0076 0.0116 0.0389 0.0277 0.0185 0.0173 0.006 0.0085 0.0256 0.0205 0.0189 0.0105 0.0031 0.0069 0.0097 0.0116 0.01
Lipid Particles 0.0088 0.0002 0.0071 0.0078 0.03 0.0006 0.004 0.0001 0.0003 0.0048 0.004 0.0001 0.0046 0.0009 0.0007 0.0147 0.0024 0.0008
Mitochondria 0.0172 0.0024 0.0126 0.0414 0.0324 0.0269 0.0274 0.0026 0.0041 0.0542 0.0133 0.0177 0.0188 0.002 0.005 0.0016 0.0021 0.0086
None 0.0036 0.0005 0.0026 0.0006 0.0007 0.0011 0.0019 0.0005 0.0008 0.0015 0.002 0.0007 0.0109 0.0035 0.003 0.0064 0.0066 0.0022
Nuclear Periphery 0.0116 0.0011 0.004 0.0044 0.007 0.0035 0.0069 0.0008 0.0013 0.0032 0.0152 0.001 0.0076 0.001 0.0022 0.0017 0.003 0.0041
Nucleolus 0.001 0 0.0008 0.0001 0.0004 0.0009 0.0003 0 0 0.0003 0.0003 0 0.0038 0.0005 0.0028 0.0002 0.0003 0.0003
Nucleus 0.0059 0.0009 0.0075 0.0015 0.0026 0.0021 0.0028 0.0008 0.0009 0.0019 0.0026 0.0007 0.0079 0.0031 0.0041 0.0017 0.0033 0.0029
Peroxisomes 0.0018 0.0001 0.0037 0.0286 0.0384 0.0002 0.0014 0.0001 0.0002 0.0064 0.0009 0.0001 0.0013 0.0005 0.0005 0.0092 0.0029 0.0004
Punctate Nuclear 0.0056 0.0001 0.0005 0.0003 0.0011 0.0006 0.0007 0.0001 0.0001 0.0016 0.0007 0 0.0038 0.0009 0.0008 0.0027 0.0026 0.0028
Vacuole 0.0319 0.0047 0.0318 0.0417 0.019 0.0114 0.0195 0.0091 0.016 0.0331 0.0124 0.006 0.0253 0.007 0.0164 0.0056 0.0332 0.0069
Vacuole Periphery 0.0066 0.0012 0.0072 0.0109 0.0112 0.0045 0.0059 0.0019 0.0037 0.0145 0.0073 0.0037 0.0045 0.0014 0.003 0.0017 0.0073 0.0026

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 40.4864 33.8515 25.6538 42.8157 43.8742 30.5996 49.1562 51.9775 38.1641 50.9308
Translational Efficiency 1.3224 1.6973 1.6755 0.8687 1.0396 1.4217 1.1567 0.8779 1.0431 0.9098

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1744 1738 474 1938 2381 2187 592 1129 4125 3925 1066 3067

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1267.36 1495.68 1853.05 1587.81 1334.52 1377.30 1597.42 1478.10 1306.13 1429.72 1711.09 1547.42
Standard Deviation 186.04 241.15 241.96 211.76 212.27 206.83 204.03 248.49 204.31 230.31 255.51 232.09
Intensity Change Log 2 — 0.238975 0.548075 0.325212 — 0.045522 0.259423 0.147423 — 0.142994 0.407238 0.236761

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000219 0.000183 0.000366 0.000254 0.000091 0.000108 0.000428 0.000449 0.000145 0.000141 0.000400 0.000326
Bud Neck 0.000158 0.000220 0.003168 0.000901 0.000120 0.000150 0.002026 0.001162 0.000136 0.000181 0.002534 0.000997
Bud Site 0.021109 0.016186 0.021168 0.020373 0.013299 0.013243 0.024843 0.042052 0.016601 0.014546 0.023209 0.028353
Cell Periphery 0.000565 0.000569 0.001679 0.001954 0.000590 0.000361 0.001025 0.001364 0.000579 0.000453 0.001315 0.001737
Cytoplasm 0.677910* 0.760681* 0.647127* 0.797180* 0.730529* 0.742739* 0.732085* 0.694988* 0.708282* 0.750684* 0.694308* 0.759562*
Cytoplasmic Foci 0.197320* 0.122394 0.047997 0.033270 0.143116 0.149014 0.062726 0.080244 0.166033 0.137226 0.056176 0.050562
Eisosomes 0.000003 0.000003 0.000003 0.000003 0.000002 0.000002 0.000004 0.000004 0.000003 0.000003 0.000004 0.000004
Endoplasmic Reticulum 0.009229 0.006962 0.002732 0.001163 0.006860 0.003940 0.004907 0.001916 0.007861 0.005278 0.003940 0.001440
Endosome 0.005499 0.005439 0.014358 0.004992 0.004247 0.006303 0.014456 0.011548 0.004776 0.005921 0.014413 0.007405
Golgi 0.032728 0.037431 0.044701 0.019795 0.029185 0.035667 0.025520 0.033976 0.030683 0.036448 0.034049 0.025015
Lipid Particles 0.000654 0.001111 0.005566 0.006596 0.000779 0.000673 0.007489 0.006997 0.000726 0.000867 0.006634 0.006744
Mitochondria 0.000811 0.000495 0.000089 0.000264 0.000963 0.000879 0.000042 0.000185 0.000899 0.000709 0.000063 0.000235
Mitotic Spindle 0.001386 0.003025 0.025112 0.001589 0.000971 0.001721 0.005578 0.002815 0.001147 0.002298 0.014264 0.002040
None 0.000286 0.000528 0.000359 0.000111 0.001052 0.000250 0.000245 0.000107 0.000728 0.000373 0.000296 0.000109
Nuclear Periphery 0.000025 0.000042 0.001030 0.000024 0.000030 0.000032 0.000145 0.000030 0.000028 0.000036 0.000538 0.000026
Nuclear Periphery Foci 0.000792 0.001618 0.016857 0.001443 0.000756 0.000781 0.007333 0.001940 0.000772 0.001151 0.011568 0.001626
Nucleolus 0.000017 0.000025 0.000089 0.000108 0.000022 0.000025 0.000053 0.000061 0.000020 0.000025 0.000069 0.000091
Nucleus 0.000648 0.000758 0.004329 0.001912 0.001091 0.001047 0.002968 0.001571 0.000903 0.000919 0.003573 0.001787
Peroxisomes 0.000120 0.000118 0.000144 0.000459 0.000108 0.000128 0.000249 0.000700 0.000113 0.000124 0.000202 0.000548
Vacuole 0.010119 0.013236 0.108356 0.088398 0.011936 0.015019 0.092967 0.094294 0.011168 0.014230 0.099810 0.090569
Vacuole Periphery 0.040403 0.028975 0.054770 0.019210 0.054254 0.027916 0.014911 0.023595 0.048398 0.028385 0.032635 0.020824

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.59 -1.78 -0.74 -2.69 1.62 -1.40 -8.04 -7.66 -7.19 -0.29 0.14 -5.85 -5.95 -8.06 1.75
Bud Neck -2.80 -7.75 -11.24 -10.16 5.84 -2.30 -8.91 -12.53 -12.19 3.66 -3.68 -11.30 -16.63 -15.72 7.10
Bud Site 4.02 -0.22 0.32 -3.57 0.39 0.05 -5.32 -10.65 -10.78 -5.02 2.81 -4.13 -9.27 -11.20 -2.51
Cell Periphery -0.09 -4.27 -5.07 -5.03 -0.68 2.41 -3.47 -4.14 -5.11 -1.53 2.18 -5.42 -6.17 -6.73 -1.79
Cytoplasm -8.67 2.41 -13.12 -4.06 -10.26 -1.51 0.24 3.92 5.11 2.49 -6.87 1.96 -7.65 -0.99 -6.73
Cytoplasmic Foci 11.71 25.90 31.09 21.39 5.00 -1.12 16.66 13.61 14.17 -3.48 7.06 29.58 34.50 27.62 2.53
Eisosomes 1.08 0.31 -0.17 -1.23 -0.45 -0.03 -5.78 -6.29 -5.95 0.31 0.81 -4.19 -4.76 -4.47 0.66
Endoplasmic Reticulum 1.83 6.10 9.75 6.18 2.20 4.23 1.50 8.24 4.18 2.41 3.87 4.51 13.26 7.85 3.30
Endosome 0.12 -7.15 1.11 0.89 7.40 -5.71 -8.94 -11.13 -7.44 2.45 -4.23 -11.48 -7.41 -3.75 8.04
Golgi -2.58 -3.49 8.38 9.88 7.64 -4.12 1.85 -1.78 1.32 -2.85 -4.84 -1.47 5.25 8.86 4.53
Lipid Particles -4.33 -7.12 -12.47 -11.34 -1.02 1.23 -9.10 -8.50 -8.65 0.52 -2.10 -11.54 -14.88 -14.49 -0.01
Mitochondria 2.46 6.41 4.52 2.95 -3.36 0.32 13.98 9.60 2.80 -2.86 1.25 13.70 9.49 3.34 -4.61
Mitotic Spindle -2.32 -7.08 -0.64 1.68 6.95 -3.52 -5.27 -3.10 -2.02 2.34 -3.44 -8.26 -2.79 0.11 7.43
None -1.21 -1.98 7.95 2.08 7.03 2.41 2.42 2.84 6.05 2.93 1.68 2.22 3.22 2.95 6.33
Nuclear Periphery -1.75 -3.02 -0.14 1.77 3.02 -0.56 -3.93 -1.11 -0.19 3.83 -1.78 -3.44 -0.28 1.70 3.44
Nuclear Periphery Foci -3.78 -8.81 -5.49 0.70 8.42 -0.24 -7.78 -8.29 -7.63 6.28 -3.35 -11.41 -9.52 -3.81 10.44
Nucleolus -1.15 -5.29 -16.60 -10.54 -0.62 -1.11 -5.08 -10.42 -9.15 -1.34 -1.46 -6.99 -20.43 -15.17 -2.21
Nucleus -2.22 -4.23 -10.75 -9.84 2.86 0.17 -6.13 -3.14 -3.83 4.17 -0.16 -6.16 -7.57 -8.52 4.04
Peroxisomes 0.10 -1.52 -10.76 -10.89 -9.06 -1.68 -6.08 -8.18 -7.92 -5.90 -1.15 -5.88 -13.14 -12.90 -9.59
Vacuole -2.40 -12.94 -24.30 -23.07 2.61 -2.94 -12.17 -19.05 -18.26 -0.44 -3.74 -17.70 -30.90 -29.45 1.64
Vacuole Periphery 4.31 -2.74 9.60 4.98 7.79 9.91 13.23 11.36 2.52 -3.32 10.49 5.95 15.62 5.87 4.78
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ubiquitin-specific protease involved in transport and osmotic response; negatively regulates Ras/PKA signaling; interacts with Bre5p to coregulate anterograde, retrograde transport between ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; role in ribophagy; cleaves ubiquitin fusions but not polyubiquitin; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Ubp3

Ubp3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ubp3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available