Standard name | |
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Human Ortholog | |
Description | GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 4 | 1 | 5 | 2 | 2 | 1 | 1 | 2 | – | 1 | 1 | 0 | 0 | 0 | 2 | – | 0 | 0 | 1 | 4 | 7 | 0 | 1 | 5 |
Bud | 0 | 4 | 4 | 5 | 3 | 10 | 9 | 25 | – | 27 | 22 | 28 | 0 | 0 | 0 | – | 0 | 0 | 0 | 2 | 1 | 0 | 5 | 4 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 2 | 5 | 2 | 1 | 3 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | – | 0 | 1 | 1 | 0 | 0 | 0 | – | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 2 | 3 | 3 | 1 | 1 | – | 5 | 4 | 3 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 290 | 212 | 240 | 197 | 252 | 385 | 483 | 614 | – | 518 | 412 | 480 | 38 | 38 | 170 | – | 34 | 14 | 52 | 77 | 27 | 35 | 108 | 82 |
Endoplasmic Reticulum | 19 | 7 | 12 | 7 | 3 | 4 | 7 | 4 | – | 2 | 1 | 1 | 1 | 1 | 3 | – | 1 | 1 | 111 | 57 | 132 | 47 | 83 | 100 |
Endosome | 20 | 4 | 28 | 18 | 22 | 27 | 17 | 26 | – | 6 | 1 | 9 | 1 | 1 | 3 | – | 1 | 1 | 22 | 22 | 30 | 12 | 11 | 10 |
Golgi | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 3 | 3 | 12 | 1 | 2 | 2 |
Mitochondria | 2 | 5 | 6 | 5 | 9 | 53 | 70 | 137 | – | 176 | 148 | 198 | 2 | 2 | 0 | – | 1 | 0 | 36 | 15 | 44 | 29 | 36 | 24 |
Nucleus | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 5 | – | 2 | 1 | 3 | 1 | 1 | 0 | – | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | – | 2 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 2 | 0 | 3 | 1 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 3 | – | 3 | 1 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Peroxisomes | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 0 |
SpindlePole | 2 | 0 | 7 | 1 | 4 | 4 | 5 | 7 | – | 4 | 5 | 4 | 0 | 0 | 2 | – | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 0 |
Vac/Vac Membrane | 22 | 7 | 20 | 6 | 24 | 19 | 17 | 15 | – | 16 | 14 | 24 | 0 | 0 | 2 | – | 6 | 3 | 162 | 83 | 82 | 75 | 144 | 176 |
Unique Cell Count | 341 | 231 | 298 | 228 | 307 | 455 | 565 | 749 | 631 | 499 | 599 | 43 | 43 | 176 | 43 | 18 | 398 | 278 | 352 | 210 | 407 | 416 | ||
Labelled Cell Count | 360 | 241 | 323 | 244 | 330 | 507 | 614 | 842 | 763 | 611 | 752 | 43 | 43 | 182 | 45 | 20 | 398 | 278 | 352 | 210 | 407 | 416 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.6 | 5.6 | 5.2 | 5.3 | 5.2 | 4.2 | 4.1 | 4.1 | – | 3.4 | 3.5 | 3.4 | 5.4 | 5.4 | 6.6 | 4.8 | 5.5 | 6.4 | 6.7 | 6.8 | 7.0 |
Std Deviation (1e-4) | 0.7 | 1.1 | 1.5 | 1.4 | 1.8 | 1.2 | 1.1 | 1.3 | – | 1.1 | 0.8 | 0.9 | 1.0 | 1.0 | 1.5 | 1.0 | 1.4 | 1.3 | 1.2 | 1.5 | 1.3 |
Intensity Change (Log2) | – | – | – | 0.02 | 0.02 | -0.29 | -0.34 | -0.34 | – | -0.6 | -0.55 | -0.63 | 0.05 | 0.05 | 0.34 | -0.1 | 0.08 | 0.3 | 0.36 | 0.39 | 0.44 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Cytoplasm | 1.8 | 0.5 | 1.5 | 1.9 | 0.5 | – | 0.6 | 0.7 | -0.1 | 1.2 | 1.2 | 4.9 | – | -0.2 | -0.3 |
Endoplasmic Reticulum | -0.6 | -2.4 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | -1.4 | – | 0 | 0 |
Endosome | -0.6 | -1.0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | -3.3 | – | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Mitochondria | 0 | 0.7 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
SpindlePole | 0 | -1.0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Vacuole | -2.1 | 0.5 | -1.5 | -2.6 | -3.8 | – | -3.1 | -2.6 | -1.8 | 0 | 0 | -2.8 | – | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.3322 | 1.6508 | 1.4507 | 1.5757 | 1.9094 | 1.39 | 1.8994 | 2.7634 | 2.553 | 2.2454 | 2.4187 | 2.3644 | 2.5651 | 2.0997 | 2.3453 | 1.8154 | 2.1117 | 2.0801 |
Actin | 0.0258 | 0.001 | 0.0083 | 0.0789 | 0.0526 | 0.0063 | 0.0346 | 0.0008 | 0.0142 | 0.003 | 0.0155 | 0.0085 | 0.0023 | 0.0003 | 0.0296 | 0.0149 | 0.0011 | 0.0021 |
Bud | 0.0007 | 0.0004 | 0.0005 | 0.0007 | 0.0008 | 0.0001 | 0.0006 | 0.0004 | 0.0004 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0003 | 0.0002 | 0.0003 | 0.0001 |
Bud Neck | 0.0036 | 0.0002 | 0.0019 | 0.0023 | 0.0018 | 0.0007 | 0.0018 | 0.0002 | 0.0009 | 0.0018 | 0.0007 | 0.0016 | 0.0004 | 0.0002 | 0.0003 | 0.0003 | 0.0012 | 0.0006 |
Bud Periphery | 0.0012 | 0.0006 | 0.0007 | 0.0009 | 0.001 | 0.0002 | 0.0006 | 0.0004 | 0.0005 | 0.0006 | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0002 | 0.0002 | 0.0002 | 0.0001 |
Bud Site | 0.0054 | 0.0018 | 0.0018 | 0.0012 | 0.0038 | 0.0002 | 0.0041 | 0.0022 | 0.0055 | 0.0008 | 0.0004 | 0.0005 | 0.0003 | 0.0003 | 0.0008 | 0.0003 | 0.001 | 0.0001 |
Cell Periphery | 0.0009 | 0.0005 | 0.0003 | 0.0002 | 0.0003 | 0.0001 | 0.0005 | 0.0006 | 0.0006 | 0.0004 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0003 | 0.0004 | 0.0001 | 0.0002 |
Cytoplasm | 0.314 | 0.4714 | 0.4837 | 0.2948 | 0.4133 | 0.5002 | 0.2395 | 0.4741 | 0.3599 | 0.2562 | 0.2449 | 0.4055 | 0.1376 | 0.2858 | 0.3843 | 0.4408 | 0.3872 | 0.4231 |
Cytoplasmic Foci | 0.0802 | 0.0695 | 0.0875 | 0.1156 | 0.1067 | 0.0743 | 0.1454 | 0.1272 | 0.118 | 0.1446 | 0.1811 | 0.1284 | 0.0243 | 0.0448 | 0.0794 | 0.0817 | 0.1232 | 0.0835 |
Eisosomes | 0.0005 | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.0406 | 0.0529 | 0.0411 | 0.0343 | 0.0202 | 0.0371 | 0.0563 | 0.031 | 0.0548 | 0.0117 | 0.0076 | 0.0495 | 0.1061 | 0.077 | 0.0451 | 0.0707 | 0.0306 | 0.073 |
Endosome | 0.2131 | 0.1382 | 0.175 | 0.2686 | 0.1955 | 0.1406 | 0.3256 | 0.1461 | 0.2195 | 0.3761 | 0.3689 | 0.2026 | 0.2891 | 0.2272 | 0.1901 | 0.1207 | 0.2392 | 0.1382 |
Golgi | 0.0176 | 0.0076 | 0.0141 | 0.0432 | 0.0344 | 0.0056 | 0.0466 | 0.0144 | 0.0204 | 0.0222 | 0.032 | 0.0135 | 0.0102 | 0.0082 | 0.0285 | 0.0244 | 0.0077 | 0.0085 |
Lipid Particles | 0.0316 | 0.0085 | 0.0107 | 0.0124 | 0.0328 | 0.0118 | 0.0406 | 0.0122 | 0.0225 | 0.0169 | 0.0125 | 0.0187 | 0.0318 | 0.0132 | 0.0216 | 0.0061 | 0.0533 | 0.0079 |
Mitochondria | 0.0093 | 0.0028 | 0.0047 | 0.0113 | 0.0087 | 0.005 | 0.0097 | 0.0084 | 0.0159 | 0.0196 | 0.0027 | 0.0052 | 0.0025 | 0.0006 | 0.0049 | 0.0027 | 0.0013 | 0.002 |
None | 0.1718 | 0.1906 | 0.1288 | 0.0683 | 0.0876 | 0.1833 | 0.05 | 0.1551 | 0.1286 | 0.0944 | 0.0792 | 0.1339 | 0.16 | 0.3112 | 0.1744 | 0.1752 | 0.1113 | 0.2393 |
Nuclear Periphery | 0.0295 | 0.0124 | 0.0085 | 0.0159 | 0.006 | 0.0065 | 0.0076 | 0.0028 | 0.0052 | 0.0024 | 0.0014 | 0.0048 | 0.0741 | 0.0078 | 0.0025 | 0.0156 | 0.0053 | 0.0042 |
Nucleolus | 0.0019 | 0.0007 | 0.0005 | 0.0003 | 0.0007 | 0.0005 | 0.0011 | 0.0002 | 0.0003 | 0.0003 | 0.0002 | 0.0002 | 0.0064 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0001 |
Nucleus | 0.0127 | 0.0047 | 0.004 | 0.0033 | 0.0021 | 0.0034 | 0.0017 | 0.002 | 0.0015 | 0.0012 | 0.0019 | 0.0013 | 0.0875 | 0.001 | 0.0008 | 0.0023 | 0.0021 | 0.0016 |
Peroxisomes | 0.0042 | 0.0009 | 0.0067 | 0.0171 | 0.008 | 0.0022 | 0.0139 | 0.0039 | 0.0117 | 0.0054 | 0.0332 | 0.0101 | 0.0007 | 0.0003 | 0.0241 | 0.0033 | 0.0066 | 0.0014 |
Punctate Nuclear | 0.0083 | 0.0037 | 0.005 | 0.006 | 0.0084 | 0.0066 | 0.0058 | 0.0014 | 0.0027 | 0.0023 | 0.0014 | 0.0024 | 0.0417 | 0.0007 | 0.0014 | 0.0007 | 0.002 | 0.0019 |
Vacuole | 0.0215 | 0.0283 | 0.0136 | 0.0202 | 0.0121 | 0.0129 | 0.0116 | 0.015 | 0.0145 | 0.0328 | 0.0139 | 0.0105 | 0.0203 | 0.0194 | 0.0088 | 0.0354 | 0.022 | 0.0106 |
Vacuole Periphery | 0.0058 | 0.0034 | 0.0026 | 0.0042 | 0.0031 | 0.0023 | 0.0022 | 0.0015 | 0.0024 | 0.0068 | 0.0022 | 0.0022 | 0.0038 | 0.0015 | 0.0024 | 0.0039 | 0.0042 | 0.0018 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 16.6046 | 8.938 | 9.4749 | 9.1913 | 14.5839 | 14.9894 | 12.2648 | 10.4563 | 8.1303 | 17.1051 |
Translational Efficiency | 0.5373 | 0.611 | 0.4186 | 0.3536 | 0.3883 | 0.5906 | 0.4765 | 0.3406 | 0.4945 | 0.3803 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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