Standard name
Human Ortholog
Description Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of yeast cdc14-1 mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0.06 0.05 0.05 0 0.07 0.06 0.06 0.07 0.06 0.07 0.06 0 0 0 0 0 0 0 0 0 0.05
Bud Site 0 0 0 0 0 0 0 0 0.05 0.08 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.07 0 0 0 0 0 0 0 0.16 0.19 0.23 0.14 0.14 0.14 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.05 0.05 0.07 0 0 0 0 0 0 0 0 0 0 0 0.07 0.07 0.06 0.06 0.07 0.05 0.05 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.13 0 0.05 0.06 0.06 0.08 0.08 0.09 0.11 0.11 0.15 0.12 0 0 0 0.06 0 0 0 0 0 0 0 0
Nucleus 0.19 0.2 0.12 0.09 0.06 0 0 0.06 0 0 0.05 0.05 0.06 0 0.06 0.07 0.07 0.07 0.12 0.13 0.05 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.73 0.73 0.68 0.64 0.5 0.66 0.63 0.59 0.69 0.68 0.65 0.68 0.65 0.6 0.57 0.64 0.65 0.7 0.42 0.53 0.29 0.23 0.25 0.34
Peroxisomes 0 0 0 0.07 0.09 0.1 0.09 0.05 0 0.05 0.08 0.09 0 0.05 0.06 0.05 0 0 0 0 0 0 0 0
SpindlePole 0.22 0.27 0.44 0.45 0.47 0.47 0.55 0.59 0.53 0.55 0.49 0.5 0.41 0.42 0.44 0.44 0.49 0.35 0.29 0.18 0.44 0.62 0.57 0.4
Vac/Vac Membrane 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 3
Bud 2 0 1 2 1 3 4 8 5 8 1 4 0 0 1 0 1 0 4 2 7 1 4 11
Bud Neck 9 4 14 14 13 17 18 38 21 28 14 11 24 30 11 5 0 1 2 1 7 3 15 21
Bud Site 1 1 4 3 3 5 10 18 19 34 9 6 1 0 0 2 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Cytoplasm 4 7 8 9 20 11 10 10 10 10 5 6 55 90 108 45 34 21 0 1 0 1 1 1
Endoplasmic Reticulum 0 0 1 0 1 2 0 0 0 0 0 0 0 1 0 4 5 3 0 0 0 3 1 2
Endosome 5 11 16 11 19 12 15 12 7 9 4 3 6 12 16 13 17 10 15 17 28 11 27 16
Golgi 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 2 2 3 4
Mitochondria 35 10 16 14 18 29 34 52 40 50 31 23 6 6 4 20 2 4 2 5 6 1 3 2
Nucleus 49 57 43 22 18 14 15 32 15 20 10 10 21 20 28 22 17 10 33 40 18 2 11 10
Nuclear Periphery 2 1 2 7 7 2 8 8 6 8 6 3 3 1 1 2 5 0 1 2 2 1 5 2
Nucleolus 192 205 240 155 138 241 262 330 249 305 139 132 222 276 267 205 160 102 113 162 113 54 147 137
Peroxisomes 0 1 15 18 25 35 38 30 14 21 16 17 5 24 28 17 1 2 0 0 6 2 1 2
SpindlePole 57 76 156 109 132 172 231 330 192 247 104 98 140 195 206 142 120 51 79 54 170 148 332 163
Vac/Vac Membrane 10 16 6 5 5 2 4 3 2 1 3 2 1 2 4 10 6 7 8 8 8 0 4 5
Unique Cell Count 264 282 354 244 278 367 417 564 363 449 213 195 339 462 471 320 246 146 272 305 387 241 579 406
Labelled Cell Count 366 389 523 370 400 545 649 871 580 741 342 315 484 657 674 488 370 211 272 305 387 241 579 406


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 7.8 7.7 7.9 7.7 7.1 6.5 6.2 6.5 5.7 6.2 6.3 8.6 8.0 7.8 9.6 11.4 11.1 7.0 7.2 8.4
Std Deviation (1e-4) 1.2 1.5 2.5 3.2 3.7 2.8 3.0 2.5 2.6 2.3 2.6 2.6 4.1 3.5 3.2 2.7 3.4 3.3 1.7 2.2 2.8
Intensity Change (Log2) – – – 0.03 -0.01 -0.12 -0.25 -0.31 -0.25 -0.44 -0.32 -0.3 0.15 0.06 0.02 0.32 0.55 0.52 -0.13 -0.1 0.12

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 1.0 0.4 0.4 0.3 1.8 1.1 1.4 1.4 0.9 1.8 1.6 -1.3 -1.9 -3.2 0
Bud Site 0 0 0 1.3 2.0 3.1 4.3 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 3.0 0.6 0.1 -0.5 0.4 0 0 0 6.4 7.5 8.5 5.7 5.5 5.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 1.3 -0.9 -0.6 -2.1 -2.0 -2.0 -1.7 -1.8 -2.1 -1.5 -0.8 -0.3 1.3 1.1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.7 1.1 1.9 2.0 2.6 3.2 3.4 4.2 3.2 -2.1 -2.8 -3.4 1.0 -2.6 -0.9
Nucleus -1.2 -2.4 -4.1 -4.5 -3.5 -3.9 -4.0 -3.0 -2.7 -2.7 -4.1 -3.1 -2.3 -2.1 -1.7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -1.1 -4.6 -0.6 -1.4 -2.8 0.2 0 -0.6 0 -0.6 -2.4 -3.2 -1.0 -0.7 0.5
Peroxisomes 1.7 2.4 2.8 2.7 0.7 -0.3 0.3 1.7 2.1 -2.2 0.6 1.1 0.7 -2.9 0
SpindlePole 0.1 0.9 0.8 3.1 4.3 2.4 3.1 1.1 1.4 -0.7 -0.5 -0.1 0.1 1.1 -1.9
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 1.2 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.8391 4.5814 4.4849 4.1149 3.3214 3.9603 6.6246 7.5413 6.356 6.7487 6.9168 6.5345 7.7163 8.2616 7.6485 8.187 7.9357 7.9023
Actin 0 0 0 0 0.0002 0.0002 0.032 0 0.0108 0.0002 0.0232 0.0029 0.0151 0 0.0042 0.0138 0.001 0.0008
Bud 0 0 0.0005 0 0 0 0.0007 0.0001 0 0.0001 0.0006 0.0001 0.0005 0 0.0001 0.0001 0.0002 0.0001
Bud Neck 0.0001 0.0007 0.0017 0.0011 0.0005 0.0044 0.0029 0.0007 0.0008 0.0011 0.0014 0.0027 0.0036 0.0008 0.0013 0.0044 0.0013 0.0361
Bud Periphery 0 0.0001 0.0003 0.0001 0.0002 0.0001 0.0011 0.0001 0.0001 0.0002 0.0007 0.0002 0.0005 0 0.0002 0.0002 0.0002 0.0002
Bud Site 0.0001 0.0005 0.0016 0.0002 0.0003 0.0003 0.0114 0.0009 0.0003 0.0005 0.0036 0.0004 0.006 0.0007 0.0011 0.0004 0.0025 0.0005
Cell Periphery 0.0001 0.0002 0.0018 0.0005 0.0001 0.0002 0.0008 0.0001 0.0002 0.0017 0.0001 0.0001 0.001 0.0001 0.0002 0.0008 0.0001 0.0002
Cytoplasm 0 0 0 0 0.0001 0.0006 0.0039 0 0.0016 0.0001 0.0004 0.0037 0.0763 0 0.0005 0.0014 0.0095 0.0137
Cytoplasmic Foci 0.0059 0.0099 0.0128 0.004 0.0027 0.0285 0.0715 0.0154 0.0158 0.0129 0.0113 0.0181 0.0453 0.011 0.0434 0.0356 0.0418 0.0362
Eisosomes 0 0 0 0 0.0001 0 0.0005 0 0 0 0.0001 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0.0001 0.006 0 0.0094 0 0.0004 0.0011 0.0096 0 0.0005 0.0007 0.0007 0.0018
Endosome 0.0001 0.0004 0.0004 0.0003 0.0002 0.0015 0.0298 0.0005 0.0038 0.0008 0.0038 0.0071 0.0258 0.0002 0.0126 0.0094 0.0252 0.0155
Golgi 0.0001 0.0007 0.0005 0.0002 0.0007 0.0014 0.0085 0.0003 0.0035 0.001 0.0045 0.0024 0.0125 0.0003 0.0066 0.1213 0.0025 0.0133
Lipid Particles 0.0172 0.0314 0.0532 0.0167 0.0672 0.0728 0.092 0.0161 0.0217 0.1007 0.0241 0.0412 0.0829 0.0117 0.0622 0.0143 0.0185 0.0593
Mitochondria 0.0003 0.0005 0.0031 0.0001 0.0084 0.0002 0.0167 0.0001 0.0005 0.0005 0.0011 0.0046 0.0036 0.0001 0.0032 0.0004 0.0003 0.0063
None 0 0.0001 0.0001 0 0.0001 0.0001 0.0147 0 0.0002 0.0002 0.0004 0.0042 0.0036 0 0.0006 0.0001 0.0004 0.0019
Nuclear Periphery 0 0.0003 0.0003 0 0.0483 0.0009 0.0383 0.0004 0.0005 0.003 0.0018 0.0073 0.0078 0.0001 0.0044 0.0001 0.0017 0.0051
Nucleolus 0.947 0.702 0.8613 0.9467 0.4662 0.7008 0.448 0.8236 0.8005 0.6563 0.4317 0.5822 0.5128 0.7647 0.7055 0.645 0.4696 0.5785
Nucleus 0.0247 0.0345 0.0213 0.0229 0.0478 0.061 0.0305 0.0482 0.0389 0.0894 0.0889 0.0693 0.0267 0.0525 0.0469 0.0193 0.1155 0.0504
Peroxisomes 0.0005 0.0015 0.0011 0.0003 0.0019 0.0012 0.0113 0.0005 0.0015 0.001 0.0042 0.0018 0.0112 0.0003 0.0054 0.0005 0.0011 0.0035
Punctate Nuclear 0.0038 0.2165 0.0368 0.0055 0.3529 0.1251 0.17 0.092 0.0893 0.1206 0.3968 0.2488 0.1531 0.1573 0.0992 0.1294 0.3061 0.1752
Vacuole 0.0001 0.0006 0.0024 0.0011 0.0003 0.0005 0.0052 0.0007 0.0005 0.0088 0.0004 0.001 0.0013 0.0002 0.0009 0.0027 0.0016 0.0009
Vacuole Periphery 0.0001 0.0002 0.0007 0.0002 0.0019 0.0002 0.0042 0.0001 0.0001 0.0009 0.0003 0.0006 0.0007 0 0.0006 0.0002 0.0003 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.9817 38.7165 34.4751 36.9048 36.2836 16.6485 41.8563 45.7287 33.3119 40.7378
Translational Efficiency 0.7563 0.9126 0.701 0.6253 0.739 1.1952 0.7596 0.5309 0.6644 0.7278

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2275 1298 498 1594 1690 1824 1688 210 3965 3122 2186 1804

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 732.60 873.12 1042.58 1107.53 788.05 907.25 1079.75 1339.18 756.23 893.06 1071.28 1134.50
Standard Deviation 102.23 161.55 154.66 188.93 112.06 147.97 161.57 1644.59 110.00 154.68 160.78 593.22
Intensity Change Log 2 — 0.253154 0.509060 0.596248 — 0.203213 0.454338 0.764991 — 0.227489 0.480961 0.686155

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000421 0.000631 0.000581 0.000690 0.000398 0.005599 0.000502 0.001581 0.000411 0.003533 0.000520 0.000794
Bud Neck 0.021474 0.015342 0.012790 0.021372 0.006793 0.022056 0.009692 0.023165 0.015216 0.019264 0.010398 0.021581
Bud Site 0.011678 0.006550 0.004036 0.007102 0.002476 0.026512 0.003726 0.009896 0.007756 0.018212 0.003797 0.007427
Cell Periphery 0.000401 0.000231 0.000072 0.000157 0.000131 0.000391 0.000078 0.000145 0.000286 0.000325 0.000077 0.000155
Cytoplasm 0.015485 0.003824 0.000783 0.001401 0.002217 0.009328 0.000753 0.006159 0.009830 0.007040 0.000760 0.001955
Cytoplasmic Foci 0.023564 0.016722 0.002191 0.007215 0.007238 0.043565 0.002938 0.027110 0.016605 0.032405 0.002768 0.009531
Eisosomes 0.000216 0.000338 0.000109 0.000125 0.000249 0.000211 0.000105 0.000124 0.000230 0.000264 0.000106 0.000125
Endoplasmic Reticulum 0.003248 0.003351 0.001583 0.000840 0.003084 0.003624 0.000857 0.000978 0.003178 0.003510 0.001022 0.000856
Endosome 0.007707 0.007274 0.000685 0.001891 0.002716 0.028212 0.000307 0.006115 0.005580 0.019507 0.000393 0.002383
Golgi 0.006029 0.004943 0.000907 0.001545 0.003492 0.024831 0.000722 0.010292 0.004947 0.016562 0.000764 0.002563
Lipid Particles 0.001720 0.002376 0.000218 0.000371 0.002039 0.006811 0.000096 0.000287 0.001856 0.004967 0.000124 0.000362
Mitochondria 0.001932 0.005235 0.001380 0.004617 0.001584 0.005912 0.001721 0.004220 0.001784 0.005631 0.001643 0.004571
Mitotic Spindle 0.101375 0.158406 0.084863 0.200137 0.166002 0.171337 0.083780 0.222768 0.128921 0.165961 0.084026 0.202772
None 0.011590 0.002713 0.001011 0.001464 0.002232 0.002528 0.000740 0.001121 0.007601 0.002605 0.000801 0.001424
Nuclear Periphery 0.000889 0.001474 0.000487 0.002256 0.001144 0.001962 0.000562 0.002215 0.000998 0.001759 0.000545 0.002251
Nuclear Periphery Foci 0.067183 0.040481 0.001581 0.003043 0.060749 0.026292 0.001172 0.002667 0.064441 0.032191 0.001265 0.002999
Nucleolus 0.543247 0.512451 0.600260 0.547964 0.545668 0.418343 0.669912 0.479346 0.544279 0.457469 0.654044 0.539976
Nucleus 0.153293 0.150729 0.235761 0.163438 0.152922 0.157996 0.184499 0.129411 0.153135 0.154975 0.196178 0.159477
Peroxisomes 0.025956 0.059787 0.047946 0.027228 0.036784 0.033749 0.036481 0.051988 0.030571 0.044574 0.039093 0.030110
Vacuole 0.001824 0.004911 0.002133 0.003789 0.001529 0.007784 0.000813 0.013508 0.001698 0.006589 0.001114 0.004920
Vacuole Periphery 0.000769 0.002232 0.000624 0.003356 0.000554 0.002957 0.000543 0.006904 0.000677 0.002656 0.000561 0.003769

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.94 -3.60 -6.38 -3.31 -2.17 -4.65 -3.07 -1.67 3.21 -1.32 -4.78 -3.88 -5.79 3.84 -3.21
Bud Neck 3.97 3.38 -4.63 -7.77 -6.25 -12.50 -4.58 -7.01 -2.46 -5.46 -4.71 2.64 -9.72 -6.22 -10.63
Bud Site 5.47 7.13 0.63 -3.93 -5.55 -11.24 -2.84 -6.45 4.00 -5.16 -7.32 5.29 -3.67 3.83 -7.06
Cell Periphery 4.46 11.01 6.91 1.81 -5.95 -6.97 3.00 -1.67 4.81 -3.35 -1.58 11.19 4.65 5.34 -6.80
Cytoplasm 6.81 10.13 9.07 2.14 -3.68 -5.71 2.39 -1.48 0.39 -1.87 2.40 10.34 6.95 4.70 -3.98
Cytoplasmic Foci 4.50 13.91 9.70 4.74 -5.58 -12.72 4.59 -3.94 1.04 -4.70 -6.40 14.21 4.86 10.13 -7.04
Eisosomes -5.33 14.36 11.82 9.69 -0.87 2.34 18.28 10.49 4.56 -1.94 -2.12 24.67 15.31 9.91 -2.21
Endoplasmic Reticulum -0.85 4.70 11.30 10.90 2.23 -1.68 11.47 4.38 4.82 -1.06 -1.80 12.83 13.15 11.27 -0.21
Endosome 0.45 10.77 8.58 6.44 -3.85 -12.32 5.92 -1.09 9.15 -2.74 -10.53 12.81 6.89 13.63 -6.13
Golgi 2.94 19.47 14.27 6.62 -2.69 -9.28 9.63 -1.21 4.72 -2.32 -8.13 21.75 7.54 10.40 -3.81
Lipid Particles -1.94 6.04 6.18 6.46 -0.88 -4.71 6.20 5.23 6.93 -4.93 -5.23 9.55 7.81 8.21 -4.49
Mitochondria -3.19 1.66 -8.10 0.15 -9.95 -7.22 -2.22 -2.98 1.99 -2.46 -6.87 -0.86 -9.37 1.09 -9.15
Mitotic Spindle -6.08 1.86 -11.11 -4.31 -10.17 -0.82 10.07 -1.92 -1.58 -5.78 -5.82 8.12 -8.95 -4.24 -14.32
None 7.16 9.09 8.47 2.73 -1.64 -0.41 5.36 2.29 2.72 -2.17 6.97 10.03 8.52 3.40 -2.60
Nuclear Periphery -6.03 5.71 -5.64 -3.05 -7.00 -3.82 7.09 -2.74 -0.33 -4.12 -5.79 7.58 -5.72 -1.90 -7.37
Nuclear Periphery Foci 7.42 23.63 23.07 13.69 -2.29 10.00 19.77 19.11 13.34 -2.26 13.12 30.97 29.71 18.75 -4.03
Nucleolus 2.66 -4.57 1.40 -1.05 5.19 13.06 -13.18 4.62 -1.01 9.97 12.11 -15.23 3.09 -6.13 14.38
Nucleus -1.02 -8.36 -4.33 -3.12 5.67 -0.94 -6.17 -0.35 0.04 2.32 -1.62 -10.24 -4.09 -2.72 4.75
Peroxisomes -12.43 -7.79 -0.44 12.23 7.60 1.06 0.07 -3.54 -3.98 -3.60 -9.20 -6.18 0.47 8.91 6.07
Vacuole -4.80 -0.93 -4.47 -0.56 -2.64 -8.87 1.75 -2.88 -1.98 -2.95 -10.15 1.34 -5.18 -0.72 -5.42
Vacuole Periphery -3.46 0.80 -3.99 -1.16 -4.09 -8.47 -0.55 -2.68 -1.25 -2.66 -8.17 1.09 -4.79 -1.10 -4.89
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of yeast cdc14-1 mutant
Localization
Cell Percentages nucleolus (42%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-1

Cdc14

Cdc14


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cdc14-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available