Standard name
Human Ortholog
Description Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0.05 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.11 – – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0 0 0.1 0 0 0 0 – – – 0 0 0 0 0 0
Nucleus 0.88 0.88 0.76 0.82 0.84 0.83 0.75 – 0.68 0.62 0.51 0.66 0.69 0.65 0.57 – – – 0.74 0.79 0.67 0.57 0.63 0.67
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0.49 0.32 0.53 0.34 0.2 0.32 0.35 – 0.68 0.62 0.74 0.66 0.5 0.53 0.34 – – – 0.22 0.16 0.24 0.35 0.25 0.25
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0.06 0 0 – – – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 1 0 0 0 1 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 1 1 – 0 1 3 2 0 1 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 1 2 0 2 5 1 10 – 0 3 0 2 0 3 14 – – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – 0 0 1 0 0 0
Endosome 0 0 1 1 1 0 0 – 0 0 0 2 0 0 2 – – – 1 1 0 0 0 1
Golgi 0 0 0 0 0 0 0 – 0 1 0 0 0 0 2 – – – 0 0 0 0 0 0
Mitochondria 0 1 0 0 1 1 2 – 0 0 10 4 0 0 0 – – – 0 0 0 0 0 0
Nucleus 131 136 39 116 168 199 200 – 62 81 49 105 11 51 73 – – – 112 128 54 12 31 60
Nuclear Periphery 0 0 0 0 1 0 1 – 0 1 0 1 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 73 50 27 48 41 78 93 – 62 80 72 104 8 42 43 – – – 32 26 19 7 12 22
Peroxisomes 0 0 0 1 0 1 1 – 0 0 0 0 0 0 3 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 0 0 – 0 1 1 0 0 1 3 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 1 0 3 4 0 3 – 0 1 1 0 1 0 3 – – – 2 3 3 0 0 2
Unique Cell Count 149 155 51 142 201 241 268 91 130 97 158 16 79 127 152 162 81 22 50 91
Labelled Cell Count 205 190 67 171 222 282 311 124 169 137 220 20 98 144 152 162 81 22 50 91


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.9 23.6 15.4 16.8 16.8 14.9 14.3 – 11.7 11.6 10.4 11.9 18.0 17.2 17.7 – – – – 10.9 13.7
Std Deviation (1e-4) 4.7 5.7 4.5 4.4 4.7 3.9 4.1 – 4.9 3.3 2.9 4.1 6.3 5.8 6.0 – – – – 4.3 4.3
Intensity Change (Log2) – – – 0.13 0.12 -0.05 -0.11 – -0.4 -0.41 -0.57 -0.37 0.22 0.16 0.2 – – – – -0.5 -0.18


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Bud 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Cytoplasm 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Nucleus 0.8 1.2 1.0 -0.3 – -1.1 -1.8 -3.1 -1.3 -0.6 -1.4 -2.4 – – –
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Nucleolus -2.4 -4.7 -2.8 -2.5 – 1.8 1.1 2.6 1.7 -0.2 0 -2.4 – – –
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 – – –
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 15.543 14.5381 13.5536 13.0076 14.1809 13.7022 15.6357 15.0166 14.6133 13.3777 13.3496 14.1408 14.5158 14.3423 13.5206 11.9967 11.489 13.5823
Actin 0.0107 0 0.0065 0 0 0 0.0101 0 0.0137 0.0108 0.0078 0.0013 0.0009 0 0.0078 0 0.0339 0.0042
Bud 0.0004 0 0.0002 0 0.0001 0 0.0003 0 0.0001 0.0003 0.0002 0.0001 0.0002 0 0.0002 0.0001 0.0008 0.0001
Bud Neck 0.0001 0 0.0001 0 0.0002 0.0002 0.0001 0 0.0001 0 0.0003 0.0002 0.0001 0 0 0 0.0006 0.0002
Bud Periphery 0.0004 0 0.0003 0 0.0001 0.0001 0.0002 0 0.0002 0.0004 0.0003 0.0001 0.0003 0 0.0003 0.0001 0.0009 0.0004
Bud Site 0.0017 0 0.0006 0.0001 0.0001 0.0001 0.0008 0 0.0004 0.0008 0.0004 0.0001 0.0004 0 0.0006 0 0.0016 0.0001
Cell Periphery 0.0001 0 0.0002 0.0001 0.0001 0.0001 0 0 0 0 0.0002 0.0001 0.0001 0 0 0.0001 0.0001 0.0001
Cytoplasm 0.001 0 0.0004 0.0001 0 0.0001 0.0033 0 0.0012 0.0003 0.0018 0.0002 0.0007 0 0.001 0 0.0024 0
Cytoplasmic Foci 0.0194 0 0.0033 0.0043 0 0.0065 0.0064 0 0.0016 0.0138 0.0032 0.0024 0.0063 0 0.0005 0 0.01 0.0004
Eisosomes 0.0001 0 0.0001 0 0 0 0.0003 0 0.0001 0 0 0 0 0 0.0001 0 0.0001 0.0001
Endoplasmic Reticulum 0.0004 0 0.0001 0 0 0 0.0014 0 0.0008 0.0002 0.0023 0.0009 0.0001 0 0.0001 0 0.0059 0.0002
Endosome 0.0063 0 0.0006 0.0001 0 0.0002 0.0047 0 0.0022 0.0051 0.0209 0.0102 0.0005 0 0.0007 0 0.0565 0.0022
Golgi 0.0015 0 0.001 0.0001 0 0.0001 0.001 0 0.001 0.0046 0.0028 0.0031 0.0001 0 0.0014 0 0.0277 0.0023
Lipid Particles 0.0053 0 0.0019 0.0082 0.0001 0.0011 0.0045 0 0.0016 0.0097 0.0045 0.0011 0.0008 0 0.0004 0 0.0095 0.0041
Mitochondria 0.0021 0.0002 0.0212 0.0041 0.0025 0.0002 0.0013 0.0002 0.0016 0.0025 0.0064 0.0041 0.0053 0.0004 0.0097 0.0007 0.0132 0.0121
None 0.0013 0 0.001 0.0003 0 0.0001 0.0194 0 0.0006 0.0006 0.0011 0.0001 0.0009 0 0.0007 0 0.0007 0.0002
Nuclear Periphery 0.0086 0.0055 0.0011 0.0005 0.0002 0.0002 0.0115 0.0001 0.014 0.0011 0.0596 0.0023 0.0056 0 0.0013 0.0001 0.0203 0.0014
Nucleolus 0.1038 0.0568 0.0527 0.0959 0.5317 0.2599 0.0788 0.0534 0.0758 0.0263 0.552 0.2059 0.1104 0.0751 0.0423 0.0729 0.3774 0.184
Nucleus 0.8131 0.9291 0.8993 0.8821 0.4632 0.7255 0.8246 0.9462 0.8632 0.8904 0.3175 0.7539 0.8269 0.9243 0.9266 0.9251 0.4253 0.7858
Peroxisomes 0.0116 0 0.0058 0.0003 0 0 0.0037 0 0.006 0.0262 0.0015 0.0009 0.0002 0 0.0008 0 0.0034 0.0009
Punctate Nuclear 0.0112 0.008 0.0028 0.001 0.0002 0.0054 0.0268 0.0001 0.0152 0.0064 0.014 0.0114 0.0392 0 0.0054 0 0.0065 0.0003
Vacuole 0.0004 0 0.0004 0.0005 0.0004 0.0002 0.0003 0 0.0002 0.0001 0.001 0.0005 0.0004 0 0.0001 0.0004 0.0013 0.0002
Vacuole Periphery 0.0005 0.0002 0.0005 0.002 0.0011 0.0001 0.0004 0 0.0003 0.0002 0.0021 0.0012 0.0006 0 0.0001 0.0004 0.0019 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.5147 52.4417 54.2173 55.8131 64.5228 54.0198 58.8326 63.1307 67.7965 58.7326
Translational Efficiency 2.5074 2.0732 1.7691 1.8975 1.756 1.7888 1.6175 1.4715 1.3097 1.5586

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
44 93 1891 14 113 1724 2123 36 157 1817 4014 50

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1112.59 1486.45 1763.05 2012.55 1403.24 1352.24 1717.17 2095.08 1321.78 1359.11 1738.78 2071.97
Standard Deviation 292.49 348.68 376.69 515.68 294.72 305.90 376.19 496.46 321.76 309.65 377.12 503.28
Intensity Change Log 2 — 0.417949 0.664151 0.855103 — -0.053411 0.291271 0.578244 — 0.174191 0.468144 0.707272

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000953 0.000588 0.000798 0.001088 0.000635 0.000807 0.000803 0.001261 0.000724 0.000796 0.000800 0.001212
Bud Neck 0.006760 0.002683 0.009406 0.010780 0.003735 0.005748 0.013036 0.028961 0.004583 0.005591 0.011326 0.023870
Bud Site 0.000558 0.000475 0.000895 0.000878 0.000389 0.000967 0.001435 0.004980 0.000436 0.000942 0.001181 0.003831
Cell Periphery 0.000022 0.000029 0.000026 0.000068 0.000017 0.000078 0.000198 0.000238 0.000019 0.000075 0.000117 0.000190
Cytoplasm 0.000044 0.005774 0.000035 0.000700 0.000126 0.000924 0.000343 0.000639 0.000103 0.001172 0.000198 0.000656
Cytoplasmic Foci 0.000055 0.000951 0.000192 0.000170 0.000639 0.001097 0.000752 0.001695 0.000475 0.001089 0.000488 0.001268
Eisosomes 0.000050 0.000096 0.000161 0.000103 0.000097 0.000140 0.000146 0.000162 0.000084 0.000137 0.000153 0.000145
Endoplasmic Reticulum 0.000777 0.000321 0.000225 0.000498 0.000367 0.000697 0.000457 0.000435 0.000482 0.000677 0.000348 0.000453
Endosome 0.000026 0.000078 0.000008 0.000030 0.000012 0.000228 0.000253 0.000106 0.000016 0.000220 0.000138 0.000085
Golgi 0.000091 0.000079 0.000072 0.000129 0.000079 0.000146 0.000206 0.000281 0.000082 0.000143 0.000143 0.000238
Lipid Particles 0.000012 0.000037 0.000004 0.000036 0.000012 0.000273 0.000293 0.000039 0.000012 0.000261 0.000157 0.000038
Mitochondria 0.002051 0.001936 0.001967 0.003172 0.001406 0.001562 0.002044 0.004034 0.001587 0.001581 0.002008 0.003793
Mitotic Spindle 0.000224 0.004249 0.000600 0.000445 0.002389 0.004341 0.002596 0.003276 0.001782 0.004336 0.001656 0.002483
None 0.000817 0.000732 0.000675 0.001795 0.000707 0.001456 0.001253 0.001374 0.000738 0.001419 0.000981 0.001492
Nuclear Periphery 0.000233 0.000085 0.000051 0.000351 0.000103 0.000115 0.000282 0.000218 0.000140 0.000114 0.000173 0.000255
Nuclear Periphery Foci 0.000034 0.000073 0.000014 0.000029 0.000036 0.000457 0.000251 0.000042 0.000036 0.000437 0.000139 0.000038
Nucleolus 0.103379 0.162153 0.110970 0.045583 0.141117 0.117094 0.072326 0.136914 0.130541 0.119400 0.090531 0.111341
Nucleus 0.878537* 0.806315* 0.863603* 0.930226* 0.827119* 0.858660* 0.896956* 0.783716* 0.841529* 0.855981* 0.881243* 0.824739*
Peroxisomes 0.004892 0.012760 0.009877 0.002469 0.018825 0.004044 0.004445 0.029870 0.014921 0.004490 0.007004 0.022198
Vacuole 0.000189 0.000215 0.000137 0.001218 0.000532 0.000576 0.001047 0.001034 0.000436 0.000557 0.000619 0.001086
Vacuole Periphery 0.000298 0.000372 0.000282 0.000234 0.001657 0.000591 0.000878 0.000726 0.001276 0.000580 0.000597 0.000588

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin NaN NaN NaN NaN NaN -1.42 -4.03 -3.49 -2.22 -2.43 -0.55 -1.99 -3.47 -2.83 -3.06
Bud Neck NaN NaN NaN NaN NaN -2.14 -10.37 -1.55 -1.45 -0.98 -1.08 -9.76 -1.82 -1.76 -1.26
Bud Site NaN NaN NaN NaN NaN -2.85 -5.99 -1.65 -1.42 -1.25 -2.87 -6.39 -1.82 -1.52 -1.43
Cell Periphery NaN NaN NaN NaN NaN -3.56 -2.75 -1.50 -1.05 -0.30 -3.65 -2.79 -1.63 -1.04 -0.72
Cytoplasm NaN NaN NaN NaN NaN -2.17 -0.76 -0.93 1.31 -0.64 -2.41 -0.25 -1.56 1.59 -1.53
Cytoplasmic Foci NaN NaN NaN NaN NaN -1.29 -0.59 -1.64 -0.76 -1.40 -1.75 -0.38 -1.65 -0.25 -1.58
Eisosomes NaN NaN NaN NaN NaN -2.97 -4.37 -1.74 -0.78 -0.61 -4.27 -8.59 -2.05 -0.44 0.13
Endoplasmic Reticulum NaN NaN NaN NaN NaN -3.20 -2.08 -0.70 1.89 0.34 -1.81 2.40 -1.14 -0.42 -1.65
Endosome NaN NaN NaN NaN NaN -2.75 -2.79 -1.23 1.29 1.20 -2.75 -2.62 -1.62 1.36 0.30
Golgi NaN NaN NaN NaN NaN -1.80 -1.63 -2.80 -1.86 -1.16 -1.83 -1.36 -3.32 -2.10 -2.25
Lipid Particles NaN NaN NaN NaN NaN -1.94 -1.24 -1.57 1.74 1.10 -1.95 -1.20 -1.85 1.31 0.42
Mitochondria NaN NaN NaN NaN NaN -0.29 -3.09 -3.59 -3.38 -2.73 0.19 -2.29 -4.07 -4.03 -3.44
Mitotic Spindle NaN NaN NaN NaN NaN -0.42 0.50 -0.05 0.35 -0.56 -1.02 0.71 -0.11 0.89 -0.84
None NaN NaN NaN NaN NaN -1.03 -0.88 -0.93 0.33 -0.33 -1.12 -0.26 -1.40 0.19 -1.56
Nuclear Periphery NaN NaN NaN NaN NaN 0.31 -1.32 -0.82 -1.62 0.58 0.72 -0.07 -1.59 -2.41 -1.79
Nuclear Periphery Foci NaN NaN NaN NaN NaN -1.94 -1.03 0.63 2.10 1.31 -2.01 -0.76 0.18 2.05 0.90
Nucleolus NaN NaN NaN NaN NaN 1.65 4.17 -0.41 -1.36 -2.73 1.09 3.03 0.23 -0.37 -1.48
Nucleus NaN NaN NaN NaN NaN -1.67 -3.38 1.47 2.37 3.14 -1.05 -2.46 1.15 1.76 2.42
Peroxisomes NaN NaN NaN NaN NaN 2.03 1.90 -1.30 -2.77 -2.69 1.97 1.34 -1.19 -2.57 -2.19
Vacuole NaN NaN NaN NaN NaN -0.39 -1.02 -0.94 -0.80 -0.13 -0.75 -0.59 -1.59 -1.47 -1.49
Vacuole Periphery NaN NaN NaN NaN NaN 0.70 0.53 0.55 -0.64 0.06 0.63 0.64 0.52 -0.42 -0.54
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
Localization
Cell Percentages nucleus (84%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-2

Rsc8

Rsc8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rsc8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available