Standard name
Human Ortholog
Description C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.09 0 0 0 0.07 0.06 0.05 0.1 0.08 0.08 0 0 0 0 – – 0 0 0 0.05 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0 0.1 0.06 0.13 0.16 0.11 0.07 0 0.05 0.11 0.08 0.1 0.13 0.23 0.39 – – 0 0 0 0 0 0
Cytoplasm 0.08 0.27 0.33 0.23 0.2 0.23 0.17 0.17 0.15 0.13 0.19 0.13 0.25 0.29 0.1 0.28 – – 0 0.07 0 0 0 0
Endoplasmic Reticulum 0.8 0.77 0.33 0.59 0.49 0.54 0.52 0.48 0.62 0.46 0.43 0.46 0.7 0.62 0.82 0 – – 0.86 0.83 0.77 0.81 0.79 0.81
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 – – 0 0 0 0 0 0
Mitochondria 0.1 0 0 0.12 0.06 0.06 0.15 0.09 0.28 0.22 0.22 0.15 0 0 0 0 – – 0 0 0 0.05 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 – – 0 0 0 0 0 0
Nuclear Periphery 0 0.05 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0 0.3 0.15 0.32 0.2 0.23 0.31 0.06 0.26 0.13 0.25 0 0.07 0 0.39 – – 0 0 0 0 0.06 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 1 12 4 6 8 15 13 7 17 7 12 3 4 2 0 – – 3 3 2 6 4 6
Bud 1 0 3 2 1 3 4 4 0 4 1 3 1 1 0 0 – – 0 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 1 0 2 0 2 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 2 3 13 8 26 29 25 15 3 9 10 13 10 15 30 7 – – 0 0 3 4 10 10
Cytoplasm 15 27 42 29 41 43 39 36 21 22 17 20 24 34 13 5 – – 3 7 6 3 5 9
Endoplasmic Reticulum 146 78 42 75 100 100 115 98 90 78 39 72 68 74 107 0 – – 179 89 124 111 186 235
Endosome 1 0 3 0 2 0 2 1 0 0 0 0 1 0 0 0 – – 3 0 0 0 0 1
Golgi 1 0 0 0 4 3 2 1 0 1 0 0 0 1 0 1 – – 1 0 2 0 0 1
Mitochondria 19 1 5 15 13 12 33 19 41 37 20 23 1 2 0 0 – – 7 2 6 6 7 6
Nucleus 2 0 1 0 0 1 0 3 0 1 1 0 2 0 1 1 – – 0 0 0 0 0 0
Nuclear Periphery 4 5 2 0 1 3 8 1 2 7 2 8 1 0 1 0 – – 1 0 1 0 1 0
Nucleolus 0 0 1 0 0 1 0 0 0 0 0 1 0 1 0 0 – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Vac/Vac Membrane 10 1 39 19 66 37 52 63 9 45 12 39 4 8 4 7 – – 5 2 2 1 13 11
Unique Cell Count 183 101 129 128 204 186 223 206 144 171 91 156 97 119 131 18 208 108 161 138 236 289
Labelled Cell Count 204 116 163 152 260 240 295 254 173 221 109 191 115 140 158 22 208 108 161 138 236 289


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.6 11.2 9.1 9.1 10.4 9.6 9.4 10.4 8.9 9.0 9.1 9.8 9.8 10.6 10.5 9.9 – – 9.7 9.5 10.1
Std Deviation (1e-4) 1.2 2.0 1.7 1.7 1.9 1.8 1.8 2.1 1.7 1.8 1.8 2.0 2.0 1.6 1.5 1.7 – – 1.7 1.7 1.8
Intensity Change (Log2) – – – -0.0 0.19 0.08 0.05 0.2 -0.02 -0.01 -0.0 0.11 0.1 0.23 0.21 0.13 – – 0.09 0.07 0.15


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.0 -2.5 -1.8 -0.9 -1.0 -1.4 0.2 -0.4 -0.5 -1.9 -1.9 -2.8 0 – –
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Cell Periphery -1.1 0.7 1.4 0.3 -0.9 -2.8 -1.6 0.2 -0.5 0.1 0.6 2.8 0 – –
Cytoplasm -1.8 -2.6 -1.9 -3.2 -3.2 -3.5 -4.1 -2.3 -4.0 -1.3 -0.7 -4.5 -0.4 – –
Endoplasmic Reticulum 4.2 3.0 3.7 3.5 2.7 4.9 2.3 1.6 2.3 5.6 4.7 8.0 -2.9 – –
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Mitochondria 2.3 1.0 1.0 3.2 1.8 5.4 4.4 4.2 3.1 0 0 0 0 – –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Vacuole -3.0 0.4 -2.1 -1.4 0.1 -5.2 -0.7 -3.0 -1.0 -4.9 -4.7 -5.9 0.7 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.6897 6.4083 6.2842 5.8058 5.632 6.5429 4.8306 5.5751 5.1035 4.7624 4.7537 5.2775 4.3307 4.7867 4.5679 2.85 2.9026 3.8696
Actin 0.0193 0.0013 0.0025 0.0372 0.0069 0.0011 0.0081 0.0003 0.003 0.005 0.0037 0.0008 0.0265 0.0113 0.0021 0.0014 0.0006 0.042
Bud 0.0003 0.0001 0.0001 0.0003 0.0002 0 0.0002 0.0001 0.0001 0.0008 0.0002 0 0.0009 0.0004 0.0001 0 0.0001 0.0005
Bud Neck 0.0016 0.0001 0.0053 0.0013 0.0004 0.0002 0.0007 0.0003 0.0033 0.001 0.0042 0.0005 0.0017 0.0018 0.0004 0.0004 0.0004 0.001
Bud Periphery 0.0005 0.0003 0.0003 0.0006 0.0005 0.0001 0.0005 0.0001 0.0002 0.0023 0.0007 0.0002 0.0015 0.0003 0.0001 0.0002 0.0001 0.0013
Bud Site 0.008 0.0002 0.0021 0.0026 0.0005 0 0.0015 0.0113 0.006 0.0064 0.0005 0.0001 0.0117 0.0057 0.0006 0.0002 0.0002 0.0005
Cell Periphery 0.0015 0.0009 0.002 0.0014 0.0012 0.0003 0.001 0.0021 0.0012 0.0044 0.0048 0.0008 0.0008 0.0044 0.0013 0.0018 0.003 0.0004
Cytoplasm 0.0611 0.0515 0.0468 0.0377 0.0296 0.0278 0.0609 0.0911 0.0804 0.0332 0.1001 0.0762 0.0652 0.092 0.0777 0.0689 0.0513 0.0516
Cytoplasmic Foci 0.0142 0.0165 0.0087 0.0079 0.0039 0.0015 0.0094 0.0011 0.0097 0.0125 0.0211 0.0022 0.0246 0.0109 0.0169 0.0019 0.0021 0.0069
Eisosomes 0.0003 0 0.0001 0.0003 0.0003 0 0.0003 0 0.0001 0 0.0001 0 0.0005 0.0001 0 0 0 0.0004
Endoplasmic Reticulum 0.7745 0.8409 0.8905 0.7928 0.8257 0.9298 0.7896 0.8596 0.8183 0.8878 0.7054 0.8773 0.6393 0.8131 0.8474 0.8422 0.8505 0.7481
Endosome 0.0352 0.0262 0.0074 0.0293 0.0412 0.0106 0.0337 0.0064 0.0248 0.0059 0.0536 0.0054 0.0506 0.0067 0.0204 0.0206 0.0492 0.0118
Golgi 0.0108 0.0054 0.0019 0.0338 0.0256 0.0022 0.0085 0.0002 0.0067 0.0023 0.0163 0.0012 0.0204 0.0045 0.009 0.0017 0.0014 0.0114
Lipid Particles 0.0087 0.0095 0.0042 0.0083 0.0121 0.0023 0.0152 0.0029 0.0108 0.003 0.0568 0.0083 0.0258 0.0044 0.0058 0.0104 0.0087 0.0243
Mitochondria 0.0061 0.007 0.0022 0.0029 0.0123 0.0024 0.011 0.0002 0.0109 0.0005 0.0062 0.0033 0.0295 0.0014 0.0026 0.0008 0.001 0.0384
None 0.0074 0.0071 0.0044 0.0053 0.0066 0.0021 0.0138 0.0018 0.0051 0.0016 0.0009 0.0083 0.0025 0.0085 0.0007 0.0005 0.0012 0.0009
Nuclear Periphery 0.0326 0.0217 0.0089 0.0204 0.0193 0.0107 0.0219 0.0137 0.0088 0.0144 0.0092 0.0101 0.055 0.0157 0.0079 0.0191 0.019 0.0361
Nucleolus 0.0002 0 0.0002 0.0003 0.0001 0.0005 0.001 0.0001 0.0003 0.0002 0.0002 0 0.0006 0.0009 0 0.0002 0 0.0001
Nucleus 0.0038 0.0018 0.0009 0.0038 0.0042 0.0021 0.0026 0.0018 0.0017 0.0028 0.0019 0.0014 0.0093 0.0037 0.0007 0.0018 0.0016 0.002
Peroxisomes 0.0032 0.0029 0.0067 0.0016 0.0004 0.0012 0.0076 0 0.0022 0.0052 0.0077 0.0005 0.0199 0.0012 0.0027 0.0001 0 0.0158
Punctate Nuclear 0.0024 0.0008 0.0007 0.0015 0.0012 0.0022 0.0038 0.0006 0.0006 0.0064 0.0013 0.0005 0.003 0.0098 0.0006 0.0004 0.0003 0.0028
Vacuole 0.0065 0.0043 0.0037 0.0081 0.0057 0.0024 0.0067 0.0057 0.0049 0.0037 0.0043 0.0026 0.0066 0.003 0.0025 0.025 0.0068 0.0022
Vacuole Periphery 0.0018 0.0014 0.0004 0.0025 0.0019 0.0006 0.0021 0.0004 0.0011 0.0006 0.0011 0.0003 0.0042 0.0003 0.0003 0.0023 0.0025 0.0016

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 71.984 73.2737 57.1605 68.8725 57.9057 84.0224 75.2742 76.9287 79.6431 83.9712
Translational Efficiency 1.7213 1.2182 1.5164 1.346 1.3913 1.5134 1.4954 1.2382 1.2702 1.2265

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1820 661 323 1694 1831 1670 226 1363 3651 2331 549 3057

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1045.66 1108.58 1512.07 1345.97 1108.63 1057.61 1580.27 1373.71 1077.24 1072.06 1540.15 1358.34
Standard Deviation 159.52 176.87 230.39 259.20 197.53 157.10 217.45 252.09 182.33 164.56 227.64 256.42
Intensity Change Log 2 — 0.084299 0.532111 0.364232 — -0.067970 0.511393 0.309300 — 0.007947 0.521486 0.336224

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000708 0.002326 0.002071 0.003700 0.000479 0.001501 0.001122 0.003314 0.000593 0.001735 0.001680 0.003528
Bud Neck 0.000662 0.002076 0.006543 0.003696 0.000194 0.001180 0.005605 0.004093 0.000427 0.001434 0.006157 0.003873
Bud Site 0.005865 0.014036 0.016914 0.024497 0.002426 0.005474 0.011503 0.027711 0.004140 0.007902 0.014687 0.025930
Cell Periphery 0.004166 0.003170 0.004548 0.016018 0.003752 0.002373 0.003133 0.019330 0.003958 0.002599 0.003966 0.017495
Cytoplasm 0.041250 0.035711 0.022078 0.048770 0.016256 0.049747 0.020674 0.052903 0.028715 0.045766 0.021500 0.050613
Cytoplasmic Foci 0.006272 0.015374 0.004821 0.006204 0.002366 0.010576 0.005982 0.006139 0.004313 0.011937 0.005299 0.006175
Eisosomes 0.000417 0.000813 0.000189 0.000314 0.000175 0.000476 0.000064 0.000438 0.000295 0.000572 0.000138 0.000369
Endoplasmic Reticulum 0.911621* 0.871983* 0.747474* 0.804196* 0.957562* 0.884740* 0.764539* 0.808880* 0.934661* 0.881123* 0.754499* 0.806284*
Endosome 0.003209 0.010568 0.022093 0.011076 0.003017 0.005145 0.019879 0.011116 0.003113 0.006683 0.021182 0.011094
Golgi 0.003977 0.007508 0.001479 0.008461 0.001524 0.008640 0.001204 0.005644 0.002747 0.008319 0.001366 0.007205
Lipid Particles 0.005991 0.010665 0.023849 0.025660 0.003686 0.009114 0.016734 0.026928 0.004835 0.009554 0.020920 0.026225
Mitochondria 0.003135 0.002978 0.000534 0.001577 0.000939 0.003479 0.000153 0.001069 0.002034 0.003336 0.000377 0.001350
Mitotic Spindle 0.000385 0.000488 0.002662 0.002901 0.000101 0.000865 0.002273 0.001547 0.000242 0.000758 0.002501 0.002297
None 0.002446 0.001055 0.000059 0.001442 0.001670 0.003113 0.000039 0.001341 0.002057 0.002529 0.000051 0.001397
Nuclear Periphery 0.000275 0.000842 0.019087 0.000476 0.000405 0.000333 0.010250 0.000445 0.000340 0.000477 0.015449 0.000462
Nuclear Periphery Foci 0.002946 0.006403 0.076665 0.009097 0.002267 0.003774 0.083354 0.006766 0.002605 0.004519 0.079419 0.008058
Nucleolus 0.000030 0.000083 0.000025 0.000152 0.000010 0.000039 0.000017 0.000031 0.000020 0.000051 0.000022 0.000098
Nucleus 0.001518 0.002780 0.002316 0.002583 0.000406 0.002662 0.001786 0.002576 0.000960 0.002695 0.002098 0.002580
Peroxisomes 0.002437 0.001593 0.000099 0.000714 0.001031 0.001946 0.000133 0.000914 0.001731 0.001846 0.000113 0.000803
Vacuole 0.001746 0.007250 0.045266 0.025960 0.001156 0.003477 0.050374 0.017038 0.001450 0.004547 0.047369 0.021982
Vacuole Periphery 0.000944 0.002299 0.001227 0.002507 0.000580 0.001347 0.001184 0.001776 0.000762 0.001617 0.001209 0.002181

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.70 -3.09 -7.09 -2.30 -2.57 -2.38 -2.51 -6.07 -3.15 -3.91 -3.25 -3.91 -9.40 -4.35 -4.19
Bud Neck -2.22 -4.32 -5.97 -2.29 2.11 -2.93 -3.74 -6.71 -4.44 1.19 -3.24 -5.75 -9.04 -5.35 2.40
Bud Site -3.04 -2.87 -8.31 -3.64 -1.66 -3.03 -2.49 -9.35 -7.99 -3.14 -3.41 -3.90 -12.64 -9.76 -3.22
Cell Periphery 1.20 -0.51 -7.77 -8.51 -6.44 2.26 0.52 -9.85 -11.18 -9.05 2.81 -0.19 -12.34 -14.14 -10.64
Cytoplasm 1.31 3.26 -3.15 -3.78 -5.21 -11.11 -1.44 -9.58 -1.13 -4.68 -6.70 1.15 -9.12 -2.59 -7.01
Cytoplasmic Foci -4.19 0.61 -0.20 4.11 -0.78 -6.54 -2.32 -4.02 2.93 0.16 -6.84 -1.52 -2.92 4.74 -0.41
Eisosomes -0.75 1.77 0.83 0.96 -1.83 -3.45 1.87 -3.08 0.37 -5.40 -1.67 2.15 -1.07 1.26 -4.65
Endoplasmic Reticulum 3.76 9.71 13.76 6.63 -3.01 11.82 9.83 18.02 8.40 -2.49 9.81 14.07 22.54 11.62 -3.94
Endosome -6.06 -8.86 -10.20 -0.52 5.05 -3.14 -7.99 -9.06 -5.72 3.99 -5.98 -11.86 -13.71 -5.83 6.42
Golgi -2.38 4.51 -3.26 -0.45 -5.38 -6.37 1.08 -4.06 2.04 -4.38 -6.05 4.34 -5.09 0.99 -6.88
Lipid Particles -2.24 -3.96 -9.75 -5.67 -0.18 -5.11 -4.49 -9.69 -7.14 -2.06 -4.86 -5.58 -13.87 -9.91 -1.15
Mitochondria 0.18 4.70 2.54 1.56 -1.83 -4.64 4.73 -0.96 4.30 -5.93 -2.66 5.34 1.94 3.86 -2.98
Mitotic Spindle -0.34 -2.98 -3.13 -3.02 0.14 -1.82 -2.40 -2.32 -1.05 1.00 -1.59 -3.87 -3.93 -2.70 0.80
None 2.16 4.55 1.57 -0.82 -4.12 -1.68 4.27 0.57 2.00 -3.04 -0.73 6.19 1.54 1.79 -5.07
Nuclear Periphery -3.82 -5.93 -3.88 2.20 5.85 0.79 -5.00 -0.63 -2.52 4.98 -2.05 -7.40 -2.68 -0.14 7.33
Nuclear Periphery Foci -3.37 -9.62 -5.52 -2.42 8.69 -2.01 -7.63 -5.78 -3.14 7.19 -3.02 -12.24 -7.72 -4.52 11.27
Nucleolus -1.13 -0.46 -1.11 -0.58 -1.04 -2.97 -1.66 -4.21 0.63 -1.37 -2.07 -1.11 -1.29 -0.75 -1.10
Nucleus -0.94 -2.16 -4.37 -0.33 -0.50 -6.23 -2.36 -5.53 -0.87 0.04 -3.69 -3.37 -7.29 -0.97 -0.27
Peroxisomes 1.23 4.40 3.20 1.96 -4.26 -2.92 4.51 0.53 3.62 -5.02 -0.33 5.71 3.17 4.43 -6.54
Vacuole -4.78 -7.42 -12.65 -9.21 2.89 -3.96 -6.63 -11.73 -9.60 4.39 -5.76 -9.97 -16.69 -13.73 5.13
Vacuole Periphery -2.61 -0.87 -2.89 -0.29 -2.20 -2.36 -0.89 -3.41 -0.99 -0.87 -3.02 -1.36 -4.25 -1.42 -2.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456
Localization
Cell Percentages ER (100%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Erg26

Erg26


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Erg26-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available