Standard name
Human Ortholog
Description Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 – 0 0 0 0 0 0.05 0.07 0.06 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 – 0.1 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0.06 0.05 0 0.07 0.05 0 0.09 0.07 0.1 0.1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 – 0 0 0 0 0 0 0 0 0 0 0.08 0.1 0.14 0 0.08 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 – 0 0 0 0 0 0 0 0 0 0 0.1 0.05 0 0.1 0.16 0.08 0 0.06 0 0.05 0.06 0.05
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.1 – 0.12 0.11 0 0.11 0.07 0.09 0.13 0.1 0.18 0.13 0 0 0.09 0 0 0 0 0 0 0 0 0
Nucleus 0 – 0.05 0 0 0 0 0.05 0.05 0 0 0.05 0.06 0.06 0.05 0.05 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.67 – 0.41 0.39 0.36 0.44 0.37 0.33 0.4 0.4 0.43 0.35 0.59 0.64 0.61 0.61 0.6 0.56 0 0 0 0 0.06 0
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.69 – 0.81 0.9 0.89 0.82 0.85 0.81 0.81 0.83 0.77 0.82 0.72 0.66 0.54 0.84 0.79 0.85 0.94 0.82 0.84 0.79 0.76 0.78
Vac/Vac Membrane 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 1 1 1
Bud 0 – 6 11 13 19 32 45 32 47 24 39 1 0 1 6 5 7 0 0 0 0 1 4
Bud Neck 2 – 18 13 10 17 12 26 19 20 22 17 2 1 6 2 0 2 0 0 1 0 2 2
Bud Site 1 – 11 19 16 33 42 30 44 56 43 68 4 3 13 5 0 11 – – – – – –
Cell Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 – 4 4 13 6 14 13 8 5 9 4 14 47 69 23 26 25 0 0 0 0 1 1
Endoplasmic Reticulum 0 – 1 1 0 0 0 0 0 0 0 0 0 0 2 2 1 3 0 0 0 0 1 1
Endosome 0 – 0 2 4 2 8 5 5 2 1 1 17 22 20 67 53 42 3 1 6 3 21 18
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 2 1 1 4
Mitochondria 5 – 23 45 16 50 59 84 62 76 76 90 7 12 44 17 6 14 0 0 0 0 3 2
Nucleus 2 – 9 12 18 21 29 42 22 31 10 33 10 28 23 34 14 14 0 0 1 1 6 3
Nuclear Periphery 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2
Nucleolus 34 – 77 152 183 204 303 292 191 320 185 238 104 291 296 400 200 294 1 0 8 1 21 11
Peroxisomes 1 – 1 6 5 9 22 14 15 29 5 17 3 7 11 21 13 10 0 0 2 1 9 7
SpindlePole 35 – 153 354 453 383 699 729 391 658 332 559 126 298 262 553 264 441 74 22 161 57 250 270
Vac/Vac Membrane 0 – 0 0 1 0 1 1 0 0 1 0 1 2 1 7 2 5 0 0 1 1 2 5
Unique Cell Count 51 189 394 510 468 819 895 482 791 429 679 176 454 483 658 336 521 79 27 193 73 331 347
Labelled Cell Count 80 303 619 732 744 1221 1281 790 1244 710 1066 289 712 748 1138 586 868 79 27 193 73 331 347


SpindlePole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 – 3.8 3.6 4.1 3.7 3.7 3.7 3.3 3.3 3.4 3.1 5.5 5.3 4.6 6.9 7.3 7.8 4.9 5.1 5.5
Std Deviation (1e-4) 0.8 – 0.9 0.7 1.0 0.9 1.2 0.9 0.7 0.8 0.9 0.7 1.3 1.2 1.2 1.3 1.8 1.5 0.9 1.4 1.5
Intensity Change (Log2) – – – -0.07 0.12 -0.02 -0.03 -0.02 -0.21 -0.18 -0.16 -0.29 0.53 0.47 0.27 0.87 0.93 1.03 0.37 0.41 0.54


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 -3.5 -6.3 0 0 -5.8 -6.5
Bud Site 0 0 0 0 0 0 0 0 0 -1.7 0 0 0 0 -2.5
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 2.6 3.5 4.6 1.0 2.7 1.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 4.4 3.1 0 4.6 5.8 4.0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 -2.8 -4.9 0 -5.5 -5.0 -5.0
Nucleus -1.0 -0.8 -0.2 -0.8 0 -0.1 -0.5 -1.6 0.1 0.4 0.7 0 0.2 -0.3 -1.4
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 3.5 5.5 0 4.9 4.1 3.7
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 2.3 0
SpindlePole 0 0 0 0 0 0 0 0 0 -2.1 -3.9 0 1.0 -0.6 1.2
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.3516 1.3903 1.4313 4.0945 0.8275 1.0849 2.4821 2.5317 2.2913 2.3025 1.5849 2.025 0.3868 0.3923 0.4692 0.5993 0.1796 0.0848
Actin 0.0062 0.0002 0.0011 0.0056 0.0232 0.0002 0.0058 0.0002 0.0021 0.0104 0.0048 0.0083 0.0444 0 0.0012 0.0001 0.0014 0
Bud 0.0001 0.0001 0.0002 0 0.0001 0 0.0004 0.0002 0.0001 0.0005 0.0001 0 0.0002 0 0.0001 0 0 0
Bud Neck 0.0004 0.0005 0.0026 0.0002 0.0007 0.0001 0.001 0.0008 0.0006 0.0065 0.0033 0.0002 0.0008 0.0011 0.0016 0.0026 0.0003 0.0001
Bud Periphery 0.0003 0.0001 0.0002 0 0.0003 0 0.0004 0.0002 0.0001 0.0006 0.0002 0.0001 0.0002 0 0.0001 0 0 0
Bud Site 0.0005 0.0042 0.0043 0.0004 0.0004 0 0.0031 0.0068 0.0018 0.002 0.0003 0.0001 0.0011 0.0005 0.0007 0.0001 0.0001 0
Cell Periphery 0.0001 0 0.0002 0 0.0001 0 0.0002 0.0001 0 0 0 0 0.0001 0 0 0 0 0
Cytoplasm 0.0007 0.0034 0.0007 0.0001 0.0002 0 0.0147 0.0003 0.0029 0.0004 0.0003 0.0001 0.0034 0.0001 0.0002 0.0001 0.0004 0
Cytoplasmic Foci 0.0162 0.0067 0.0229 0.0166 0.0188 0.0122 0.0214 0.0211 0.0199 0.0313 0.0674 0.0037 0.0284 0.0189 0.0108 0.0541 0.0362 0.006
Eisosomes 0.0003 0 0 0.0001 0.0004 0 0.0001 0 0 0.0001 0.0001 0 0.0005 0 0 0 0 0
Endoplasmic Reticulum 0.0014 0.0002 0.0003 0 0.0015 0 0.0032 0.0001 0.0007 0.0001 0.0013 0.0002 0.0013 0 0.0001 0 0.0001 0
Endosome 0.0074 0.0006 0.0016 0.002 0.0137 0.0003 0.0295 0.0018 0.0043 0.0051 0.0263 0.005 0.0088 0.0003 0.0011 0.0012 0.0032 0
Golgi 0.0028 0.0003 0.001 0.0052 0.0099 0.0003 0.0049 0.0015 0.0012 0.0057 0.0316 0.004 0.0047 0.0004 0.0009 0.002 0.0021 0.0001
Lipid Particles 0.0203 0.0024 0.0153 0.0354 0.0503 0.0066 0.016 0.0078 0.0026 0.0226 0.0666 0.0045 0.0245 0.0139 0.0066 0.044 0.0603 0.0009
Mitochondria 0.0073 0.0002 0.001 0.0387 0.0099 0.0005 0.0144 0.0005 0.0085 0.0288 0.0303 0.0149 0.0014 0.0001 0.0012 0 0 0
None 0.002 0.0009 0.0005 0.0001 0.0006 0 0.009 0.0017 0.0007 0.001 0.0003 0.0001 0.0122 0.0003 0.0018 0.0003 0.0005 0.0001
Nuclear Periphery 0.0102 0.0011 0.0038 0.0004 0.0055 0.0002 0.0151 0.0006 0.0052 0.001 0.0015 0.0005 0.0025 0.0003 0.0005 0.0013 0.0009 0.0002
Nucleolus 0.0068 0.0335 0.0162 0.0024 0.0124 0.0104 0.0151 0.0749 0.0509 0.0024 0.0068 0.0114 0.0081 0.0218 0.0183 0.002 0.0032 0.0051
Nucleus 0.002 0.009 0.0026 0.0004 0.001 0.002 0.013 0.0399 0.0078 0.0007 0.0007 0.0016 0.0025 0.0199 0.003 0.0006 0.0003 0.001
Peroxisomes 0.0091 0.0004 0.0029 0.016 0.0028 0.0024 0.0042 0.0022 0.0064 0.0181 0.0052 0.0011 0.01 0.0052 0.0012 0.0051 0.0054 0.0002
Punctate Nuclear 0.9036 0.9359 0.9218 0.8762 0.8436 0.9647 0.8256 0.8376 0.8828 0.8621 0.7507 0.944 0.8447 0.9168 0.9503 0.8867 0.8853 0.9863
Vacuole 0.0009 0.0002 0.0005 0.0001 0.0012 0 0.0017 0.0014 0.0007 0.0003 0.0006 0.0002 0.0002 0.0002 0.0001 0 0.0001 0
Vacuole Periphery 0.0015 0 0.0002 0.0001 0.0035 0 0.0013 0.0002 0.0005 0.0003 0.0015 0.0002 0.0002 0.0001 0 0 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.0377 15.7591 7.4416 10.3667 18.4411 18.0195 19.827 14.4206 13.9705 22.4724
Translational Efficiency 1.3176 1.2882 0.7697 0.8563 1.0629 1.5061 0.8153 0.8459 0.7575 0.7781

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1618 336 352 585 683 999 426 356 2301 1335 778 941

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 612.30 796.49 958.16 871.62 571.39 760.63 933.09 898.80 600.16 769.66 944.43 881.90
Standard Deviation 75.00 118.42 107.26 125.19 106.04 103.82 112.75 125.00 87.42 108.80 111.01 125.81
Intensity Change Log 2 — 0.379418 0.646028 0.509461 — 0.412719 0.707540 0.653524 — 0.395589 0.676049 0.580800

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000774 0.002815 0.000244 0.000206 0.000595 0.000482 0.000155 0.000093 0.000721 0.001069 0.000195 0.000163
Bud Neck 0.011475 0.003751 0.001562 0.003735 0.005039 0.006675 0.000445 0.001192 0.009564 0.005939 0.000951 0.002773
Bud Site 0.013215 0.005437 0.002029 0.008288 0.006508 0.008935 0.000705 0.006021 0.011224 0.008054 0.001304 0.007430
Cell Periphery 0.000529 0.000165 0.000037 0.000095 0.000478 0.000153 0.000017 0.000020 0.000514 0.000156 0.000026 0.000067
Cytoplasm 0.055065 0.013416 0.000813 0.028602 0.041071 0.018569 0.000599 0.002214 0.050911 0.017272 0.000696 0.018619
Cytoplasmic Foci 0.215669* 0.038161 0.002882 0.006266 0.129793 0.044251 0.000429 0.002983 0.190178* 0.042719 0.001539 0.005024
Eisosomes 0.000160 0.000085 0.000026 0.000019 0.000193 0.000087 0.000005 0.000008 0.000170 0.000086 0.000014 0.000015
Endoplasmic Reticulum 0.002202 0.001883 0.000874 0.000583 0.002448 0.001820 0.000134 0.000223 0.002275 0.001836 0.000468 0.000447
Endosome 0.019204 0.007567 0.000788 0.001441 0.017253 0.015861 0.000251 0.000447 0.018625 0.013773 0.000494 0.001065
Golgi 0.030259 0.018870 0.000843 0.000605 0.028791 0.011027 0.000324 0.000366 0.029823 0.013001 0.000559 0.000514
Lipid Particles 0.030634 0.008108 0.000546 0.001483 0.025276 0.012236 0.000137 0.000274 0.029044 0.011197 0.000322 0.001026
Mitochondria 0.003152 0.004603 0.000114 0.000277 0.003268 0.004263 0.000419 0.000093 0.003187 0.004348 0.000281 0.000208
Mitotic Spindle 0.171718* 0.712626* 0.926116* 0.890792* 0.301671* 0.674375* 0.983457* 0.966338* 0.210292* 0.684002* 0.957513* 0.919373*
None 0.063113 0.004432 0.000247 0.003929 0.067017 0.003722 0.000318 0.000151 0.064272 0.003901 0.000286 0.002500
Nuclear Periphery 0.000379 0.000540 0.000257 0.000984 0.000483 0.000551 0.000078 0.000146 0.000410 0.000548 0.000159 0.000667
Nuclear Periphery Foci 0.166318 0.069774 0.019976 0.006334 0.155305 0.070252 0.003170 0.005001 0.163049 0.070132 0.010774 0.005830
Nucleolus 0.107063 0.037183 0.016287 0.014554 0.122158 0.069487 0.004776 0.007013 0.111543 0.061357 0.009984 0.011701
Nucleus 0.028664 0.048851 0.019705 0.026450 0.053856 0.027213 0.003203 0.004249 0.036142 0.032659 0.010669 0.018051
Peroxisomes 0.078175 0.018791 0.003945 0.002346 0.036951 0.023694 0.000840 0.002656 0.065938 0.022460 0.002245 0.002463
Vacuole 0.001934 0.002233 0.002644 0.002864 0.001564 0.004804 0.000428 0.000465 0.001824 0.004157 0.001430 0.001956
Vacuole Periphery 0.000296 0.000712 0.000066 0.000148 0.000284 0.001542 0.000108 0.000046 0.000293 0.001333 0.000089 0.000109

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.08 -2.41 -0.78 1.01 1.98 1.71 1.75 1.72 0.34 -0.38 -0.64 -0.73 0.40 0.74 0.94
Bud Neck 0.21 -0.31 -2.83 -3.46 -2.98 -1.45 1.24 -1.67 -0.56 -2.46 -0.18 0.87 -3.01 -3.32 -4.28
Bud Site -0.11 -0.52 -3.40 -3.02 -2.87 -1.21 1.94 -1.91 -1.38 -2.54 0.17 1.73 -3.72 -3.61 -4.38
Cell Periphery 7.24 11.15 9.14 1.40 -0.68 7.09 10.18 9.98 6.80 -0.62 11.92 16.26 13.38 3.23 -1.69
Cytoplasm 4.28 11.18 0.33 -2.61 -5.07 4.08 6.84 5.17 1.60 -1.42 6.85 12.40 2.24 -2.37 -5.13
Cytoplasmic Foci 16.20 30.29 29.29 6.62 -1.63 9.08 16.20 15.17 10.70 -2.08 21.70 34.35 32.74 12.64 -3.19
Eisosomes 10.83 15.92 26.58 8.21 3.71 5.24 14.14 13.73 17.10 -1.02 13.12 25.48 29.95 17.97 2.03
Endoplasmic Reticulum 0.11 -0.82 3.40 2.27 2.41 1.92 6.52 5.26 4.11 -1.05 2.27 3.03 5.78 3.57 1.11
Endosome 5.87 14.71 14.21 5.27 -0.35 1.18 6.87 6.61 8.07 -0.84 3.97 16.43 15.38 8.70 -1.33
Golgi 6.00 23.81 25.36 3.97 3.64 6.68 11.72 11.67 13.79 -0.47 13.31 26.66 27.20 11.36 2.15
Lipid Particles 7.19 13.35 12.99 4.50 0.28 4.70 9.21 9.14 8.76 -1.10 8.84 16.36 15.90 9.09 -0.41
Mitochondria -0.51 7.31 5.60 1.40 -3.69 0.65 3.80 5.34 2.80 0.32 -0.17 6.20 7.82 2.87 -0.72
Mitotic Spindle -20.29* -33.40* -38.74* -6.80 0.22 -15.77* -34.30* -28.70* -15.33 2.84 -31.08 -54.47 -49.50 -14.87 3.01
None 10.85 13.27 9.99 -0.00 -2.51 7.95 8.75 8.77 6.33 0.12 14.01 15.86 13.54 0.98 -2.47
Nuclear Periphery -2.94 -3.29 -2.40 -1.88 -1.73 -2.10 2.46 -1.30 -0.48 -2.52 -5.09 -0.71 -2.64 -1.94 -2.45
Nuclear Periphery Foci 9.76 19.79 27.63* 8.74 4.11 6.76 18.26 18.04 15.99 -0.19 12.52 29.64 33.26 17.99 3.05
Nucleolus 7.64 10.80 16.21 3.60 2.42 4.42 13.21 11.32 8.48 -1.90 7.74 19.04 19.98 9.40 0.19
Nucleus -2.76 -3.29 -5.87 -1.85 -1.55 2.62 2.81 1.43 -0.53 -1.08 -1.07 -1.45 -4.74 -3.73 -2.71
Peroxisomes 9.26 17.24 21.02 6.49 3.38 4.67 12.26 11.56 9.78 -1.30 11.94 22.51 23.89 11.95 1.71
Vacuole -2.52 -3.15 -3.57 -2.95 -0.88 -2.84 -1.92 -2.49 -2.12 -1.94 -3.61 -3.68 -4.33 -3.65 -2.25
Vacuole Periphery -1.34 -2.35 -3.00 0.75 -0.65 -1.94 0.38 1.64 2.20 0.33 -2.32 -0.58 -1.89 2.02 -0.44
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation
Localization
Cell Percentages spindle pole (78%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Spc105

Spc105


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Spc105-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available