Standard name
Human Ortholog
Description Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0.06
Bud 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0.09 0.07 0 0.1 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 0.63 0.72 0.8 0.92 0.92 0.84 0.87 – 0.65 0.79 0.57 0.64 – – – 0.7 0.57 0.57 0.39 0.5 0.48 0.47 0.22 0.42
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0.05 0.07 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0.07
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0 0 0 0 0.08 0.1 – 0.52 0.22 0.52 0.39 – – – 0 0.05 0 0 0 0.06 0 0 0
Nucleus 0.24 0.18 0.15 0 0 0.05 0 – 0 0.06 0 0 – – – 0.06 0.08 0.1 0.23 0.22 0.15 0.18 0.31 0.08
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0.06 0.06 0.07 0.08 0 0.07
Vac/Vac Membrane 0.13 0.12 0.05 0 0 0 0 – 0 0 0 0 – – – 0.16 0.28 0.3 0.11 0.08 0.12 0.1 0 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 1 1 0 – – – 1 0 0 1 2 1 0 0 2
Bud 0 0 0 0 0 0 0 – 3 0 3 1 – – – 0 1 0 18 21 3 1 0 0
Bud Neck 0 1 1 0 1 0 2 – 1 6 3 4 – – – 0 1 0 3 2 1 0 0 0
Bud Site 0 0 0 0 0 0 0 – 1 0 1 1 – – – 0 0 0 – – – – – –
Cell Periphery 2 1 1 0 2 1 0 – 0 0 0 0 – – – 1 2 0 0 0 0 0 0 0
Cytoplasm 113 207 67 77 47 80 104 – 57 115 82 83 – – – 44 74 52 80 155 54 7 2 15
Endoplasmic Reticulum 1 0 0 1 1 0 0 – 0 2 3 2 – – – 3 9 6 0 0 0 0 0 0
Endosome 0 4 1 1 0 2 0 – 0 0 0 0 – – – 2 5 1 2 4 1 0 0 2
Golgi 0 1 0 0 0 0 0 – 0 0 0 0 – – – 1 2 3 3 0 0 0 0 0
Mitochondria 13 4 0 3 0 8 12 – 46 32 76 50 – – – 2 7 2 7 6 6 0 0 1
Nucleus 44 53 13 2 2 5 4 – 3 9 6 5 – – – 4 11 9 46 67 17 2 4 2
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 1 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 – – – 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 0 0 3 0 – 0 2 2 1 – – – 1 1 0 11 19 8 1 0 2
Vac/Vac Membrane 23 36 4 3 2 3 2 – 2 2 1 0 – – – 10 36 27 21 26 13 1 0 3
Unique Cell Count 180 289 84 84 51 95 120 88 146 145 129 63 130 91 204 313 113 16 13 37
Labelled Cell Count 196 308 87 87 55 102 124 113 169 178 147 70 150 100 204 313 113 16 13 37


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 4.8 5.4 4.9 5.9 4.1 4.4 – 3.3 3.8 3.2 3.3 – – – 6.2 6.6 6.6 – – –
Std Deviation (1e-4) 1.0 0.9 1.1 1.4 2.7 1.7 2.0 – 0.8 1.4 1.0 0.4 – – – 2.0 2.1 2.2 – – –
Intensity Change (Log2) – – – -0.14 0.12 -0.4 -0.31 – -0.7 -0.51 -0.77 -0.7 – – – 0.19 0.29 0.28 – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.3 4.2 4.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.4175 -0.581 -0.6322 -0.1948 1.3251 -0.2543 2.3077 -0.7002 -0.22 -0.3195 0.9932 -0.5445 4.7745 -0.5942 -0.5022 -0.2096 0.8885 -0.6606
Actin 0.2209 0.0004 0.0041 0.0123 0.067 0.0131 0.1459 0.0003 0.0206 0.0003 0.0229 0.0189 0.209 0.0006 0.0236 0.0019 0.0496 0.0003
Bud 0.0048 0.0063 0.0059 0.0009 0.006 0.0039 0.0032 0.0015 0.0059 0 0.0009 0.0011 0.0141 0.002 0.0027 0.0003 0.002 0.0009
Bud Neck 0.0115 0.0004 0.002 0.0008 0.0039 0.0033 0.0099 0.0005 0.0083 0.0004 0.0157 0.0077 0.0312 0.0008 0.0011 0.0006 0.004 0.0031
Bud Periphery 0.022 0.0024 0.0084 0.0012 0.0103 0.007 0.0085 0.002 0.0112 0 0.0017 0.002 0.0292 0.0023 0.0026 0.0003 0.0039 0.0015
Bud Site 0.0186 0.011 0.017 0.0004 0.0286 0.0003 0.0254 0.0055 0.0102 0.0001 0.003 0.0006 0.0451 0.005 0.0098 0.0002 0.0027 0.0002
Cell Periphery 0.002 0.0002 0.0004 0.0001 0.0007 0.0001 0.0013 0.0005 0.0005 0 0.0003 0.0001 0.0041 0.0007 0.0014 0 0.0003 0.0001
Cytoplasm 0.0312 0.0396 0.0482 0.0578 0.0163 0.0814 0.0326 0.0536 0.0323 0.0415 0.0361 0.0627 0.0219 0.0931 0.1372 0.1036 0.0095 0.2019
Cytoplasmic Foci 0.06 0.0051 0.0104 0.0037 0.0285 0.0059 0.0671 0.0042 0.0179 0.0017 0.0314 0.0029 0.0414 0.0021 0.009 0.0065 0.0103 0.0034
Eisosomes 0.0022 0.0001 0.0006 0.0002 0.0011 0.0002 0.0017 0.0001 0.0003 0.0001 0.0005 0.0002 0.0013 0.0002 0.0002 0 0.0002 0
Endoplasmic Reticulum 0.0359 0.0011 0.0026 0.0024 0.007 0.0016 0.0142 0.001 0.0028 0.0007 0.0049 0.0014 0.0141 0.0022 0.0065 0.0011 0.0004 0.0016
Endosome 0.0452 0.0013 0.0036 0.0053 0.0333 0.0074 0.0709 0.0005 0.0051 0.0012 0.0379 0.0068 0.1463 0.0013 0.0031 0.0237 0.0104 0.0015
Golgi 0.0273 0.0001 0.0014 0.0012 0.0228 0.0031 0.0143 0 0.0032 0 0.0113 0.0021 0.0441 0.0001 0.0011 0.0086 0.0291 0
Lipid Particles 0.0607 0.0004 0.0053 0.0046 0.0435 0.0102 0.04 0.0002 0.005 0.0002 0.0375 0.0032 0.0537 0.0002 0.0015 0.0018 0.0098 0.0001
Mitochondria 0.0431 0.0031 0.0022 0.0011 0.0237 0.0085 0.0844 0.0006 0.0018 0.0008 0.0118 0.0024 0.0323 0.0009 0.0009 0.0049 0.0126 0.0007
None 0.1895 0.7418 0.754 0.269 0.0857 0.6911 0.3172 0.8231 0.7644 0.4099 0.1653 0.7502 0.0648 0.7261 0.6768 0.2241 0.0961 0.5253
Nuclear Periphery 0.0306 0.0049 0.0078 0.0248 0.0272 0.0106 0.034 0.002 0.0039 0.02 0.0315 0.0076 0.0524 0.0048 0.0074 0.009 0.0028 0.0035
Nucleolus 0.0044 0.0037 0.0028 0.0053 0.01 0.004 0.0074 0.0018 0.0032 0.0047 0.0092 0.0034 0.0246 0.0011 0.0012 0.0024 0.0097 0.0041
Nucleus 0.0954 0.1578 0.1004 0.559 0.436 0.107 0.0258 0.099 0.0473 0.4887 0.4843 0.1073 0.0308 0.1441 0.0827 0.5787 0.6971 0.2432
Peroxisomes 0.0447 0.0004 0.0067 0.0011 0.0407 0.0061 0.0239 0.0004 0.029 0.0001 0.0291 0.0026 0.0154 0.0001 0.0082 0.0007 0.0081 0.0001
Punctate Nuclear 0.0121 0.0185 0.0138 0.0469 0.1014 0.033 0.0629 0.0021 0.0244 0.0286 0.0574 0.0158 0.0648 0.0028 0.0192 0.0301 0.0388 0.0058
Vacuole 0.026 0.0011 0.0016 0.0012 0.0043 0.0011 0.0063 0.0012 0.0024 0.0006 0.0048 0.0006 0.0502 0.0077 0.0035 0.001 0.002 0.0023
Vacuole Periphery 0.0118 0.0002 0.0005 0.0007 0.0021 0.0009 0.003 0.0002 0.0004 0.0003 0.0024 0.0005 0.0093 0.0019 0.0005 0.0005 0.0006 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 3.3108 8.6099 28.7503 26.9866 8.195 9.0245 20.1315 36.7227 22.4277 9.8571
Translational Efficiency 0.621 1.709 1.3587 0.8524 0.775 0.289 1.2131 0.9034 1.3122 1.0164

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
742 1099 1377 13 1640 1329 714 19 2382 2428 2091 32

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 584.31 703.44 944.23 337.50 676.48 693.88 839.59 311.83 647.77 698.21 908.50 322.26
Standard Deviation 92.98 91.61 132.45 62.92 78.47 89.94 176.52 3.31 93.57 90.83 157.02 42.11
Intensity Change Log 2 — 0.267693 0.692404 -0.791846 — 0.036639 0.311638 -1.117288 — 0.148334 0.500642 -0.957304

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000038 0.000313 0.000528 0.000450 0.000132 0.000203 0.003078 0.000206 0.000102 0.000253 0.001398 0.000305
Bud Neck 0.010719 0.016341 0.022120 0.000060 0.003395 0.019691 0.014115 0.000012 0.005677 0.018175 0.019387 0.000031
Bud Site 0.003038 0.007389 0.023982 0.000606 0.001275 0.009349 0.037057 0.000044 0.001824 0.008462 0.028447 0.000272
Cell Periphery 0.000239 0.000179 0.000220 0.001279 0.000108 0.000205 0.000930 0.000547 0.000149 0.000194 0.000462 0.000844
Cytoplasm 0.395910* 0.349303* 0.094349 0.030303 0.403506* 0.376157* 0.255526* 0.000078 0.401140* 0.364002* 0.149385* 0.012357
Cytoplasmic Foci 0.069176 0.091762 0.000499 0.000141 0.054168 0.078911 0.029232 0.000020 0.058843 0.084728 0.010310 0.000069
Eisosomes 0.000149 0.000067 0.000019 0.004386 0.000043 0.000074 0.000122 0.002051 0.000076 0.000071 0.000054 0.002999
Endoplasmic Reticulum 0.000621 0.001550 0.002701 0.000432 0.000507 0.000967 0.002725 0.000001 0.000542 0.001231 0.002709 0.000176
Endosome 0.002810 0.006772 0.000443 0.000233 0.001523 0.004658 0.037938 0.000000 0.001924 0.005614 0.013246 0.000095
Golgi 0.000248 0.001250 0.000122 0.000093 0.000290 0.002876 0.044283 0.000004 0.000277 0.002140 0.015202 0.000040
Lipid Particles 0.002441 0.002974 0.000201 0.000111 0.001376 0.003305 0.007023 0.000023 0.001708 0.003155 0.002530 0.000059
Mitochondria 0.000622 0.005554 0.002060 0.000129 0.001276 0.004851 0.014759 0.000020 0.001072 0.005169 0.006396 0.000064
Mitotic Spindle 0.002299 0.006100 0.043644 0.001820 0.001653 0.006970 0.108478* 0.000298 0.001854 0.006576 0.065782 0.000916
None 0.027215 0.010301 0.011774 0.944610* 0.006524 0.009488 0.047496 0.996283* 0.012969 0.009856 0.023972 0.975291*
Nuclear Periphery 0.000441 0.000851 0.001344 0.000032 0.000603 0.000977 0.001228 0.000000 0.000552 0.000920 0.001304 0.000013
Nuclear Periphery Foci 0.000547 0.000445 0.000170 0.000524 0.000252 0.000626 0.003396 0.000002 0.000344 0.000544 0.001272 0.000214
Nucleolus 0.002640 0.002857 0.001757 0.000658 0.001138 0.002575 0.003282 0.000003 0.001606 0.002703 0.002278 0.000269
Nucleus 0.443683* 0.453968* 0.782710* 0.012256 0.504926* 0.448257* 0.272846* 0.000009 0.485849* 0.450842* 0.608610* 0.004984
Peroxisomes 0.001005 0.006853 0.000532 0.001777 0.001820 0.004694 0.007966 0.000400 0.001566 0.005671 0.003071 0.000960
Vacuole 0.035909 0.034254 0.010664 0.000081 0.015301 0.024369 0.082432 0.000000 0.021720 0.028843 0.035170 0.000033
Vacuole Periphery 0.000252 0.000919 0.000160 0.000022 0.000184 0.000796 0.026089 0.000000 0.000205 0.000852 0.009014 0.000009

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin NaN NaN NaN NaN NaN -1.27 -4.43 -0.75 0.00 4.09 -3.72 -7.73 -1.54 -0.38 3.91
Bud Neck NaN NaN NaN NaN NaN -8.24 -6.74 10.06 10.16 9.82 -8.77 -11.04 8.20 14.51 20.33
Bud Site NaN NaN NaN NaN NaN -5.66 -6.99 5.69 6.61 7.56 -7.52 -8.33 3.99 9.37 9.60
Cell Periphery NaN NaN NaN NaN NaN -5.65 -4.07 -2.21 -1.72 -0.87 -2.68 -2.86 -2.95 -2.76 -2.64
Cytoplasm NaN NaN NaN NaN NaN 2.37 16.98 53.40 44.41 21.01 4.35 38.75 25.83 23.31 6.68
Cytoplasmic Foci NaN NaN NaN NaN NaN -5.01 15.19 21.25 20.30 8.26 -6.64 24.26 26.57 27.90 8.56
Eisosomes NaN NaN NaN NaN NaN -6.58 -3.08 -1.89 -1.86 -1.85 0.46 2.26 -2.67 -2.68 -2.69
Endoplasmic Reticulum NaN NaN NaN NaN NaN -4.10 -13.17 7.90 10.79 15.53 -6.08 -22.18 1.84 5.35 18.16
Endosome NaN NaN NaN NaN NaN -5.25 -4.93 5.61 9.26 5.89 -6.97 -3.01 7.53 11.77 6.18
Golgi NaN NaN NaN NaN NaN -2.83 -4.05 3.67 3.17 4.15 -3.57 -3.93 3.43 4.05 4.18
Lipid Particles NaN NaN NaN NaN NaN -4.17 -1.10 12.79 7.74 2.72 -5.10 1.88 15.31 12.06 3.43
Mitochondria NaN NaN NaN NaN NaN -4.14 -2.63 3.44 6.14 3.63 -5.58 -3.73 3.91 7.43 6.28
Mitotic Spindle NaN NaN NaN NaN NaN -3.15 -10.26 1.61 4.21 10.48 -3.98 -12.85 1.07 4.87 13.21
None NaN NaN NaN NaN NaN -2.38 -7.10 -671.18* -557.27* -286.15* 2.06 -2.89 -46.12* -46.31* -45.89*
Nuclear Periphery NaN NaN NaN NaN NaN -1.99 -11.84 18.26 5.42 16.05 -3.61 -22.32 19.49 8.93 28.44
Nuclear Periphery Foci NaN NaN NaN NaN NaN -1.19 -4.13 3.52 3.01 4.80 -1.18 -3.46 0.79 1.60 3.40
Nucleolus NaN NaN NaN NaN NaN -4.05 -4.35 7.17 8.36 6.73 -3.66 -3.21 4.08 6.81 5.70
Nucleus NaN NaN NaN NaN NaN 4.59 2.34 62.54* 48.14* 35.33 3.61 -21.22 54.92 50.16 77.25*
Peroxisomes NaN NaN NaN NaN NaN -3.49 -0.30 3.49 5.88 1.34 -6.38 1.32 1.10 6.11 -0.10
Vacuole NaN NaN NaN NaN NaN -4.32 -13.55 14.63 14.84 15.77 -3.80 -11.52 16.51 20.52 19.57
Vacuole Periphery NaN NaN NaN NaN NaN -2.64 -4.03 3.14 3.56 4.15 -4.11 -3.88 4.48 5.61 4.23
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
Localization
Cell Percentages nucleus (26%), cytoplasm (10%), mixed (52%)
Cell Cycle Regulation Yes
cytoplasm - T/G1 (3.9e-06)
nucleus - MA (3.9e-08)
Subcompartmental Group N/A

Cdc20

Cdc20


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cdc20-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available