Standard name
Human Ortholog
Description Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0.05 0 0 0 – 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.05 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0.08 0.1 0.11 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.08 0 0.06 – 0 0 0 0 0 0 0 0.15 0.09 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.06 0.07 0.13 0 0.09 – 0 0 0.07 0 0.1 0.09 0.08 0.11 0.07 0.08 0 0.07 0 0.06 0.08 0.06
Golgi 0 0.06 0.2 0.09 0.08 0 0 – 0 0 0 0 0.16 0.21 0.31 0.36 0.48 0.36 0.05 0.08 0.05 0.07 0.08 0.09
Mitochondria 0.86 0.89 0.77 0.82 0.64 0.9 0.69 – 0.9 0.88 0.9 0.93 0.8 0.76 0.65 0.14 0.1 0.07 0.78 0.74 0.81 0.71 0.65 0.64
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0.06 0 0 0 – 0 0 0 0 0.06 0.05 0.07 0.05 0.07 0.07 0.05 0 0.06 0.07 0.06 0.07
SpindlePole 0 0 0.06 0 0.07 0 0.06 – 0 0.09 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0.17 0.09 0.08 0.16 0.09 0.17 – 0.09 0.05 0.1 0.05 0.12 0.1 0.11 0.19 0.2 0.22 0 0 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 4 9 3 3 1 0 – 0 0 0 0 1 0 2 4 2 4 1 10 0 3 7 9
Bud 3 7 3 10 6 11 5 – 13 22 18 10 2 3 1 2 2 3 0 2 0 0 1 3
Bud Neck 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 1 1 0 0 3 2
Bud Site 0 1 1 2 0 3 1 – 2 2 3 4 0 0 1 0 1 0 – – – – – –
Cell Periphery 3 31 13 6 3 0 1 – 3 6 9 2 3 5 6 8 14 13 1 1 1 0 0 0
Cytoplasm 5 7 6 4 21 4 17 – 12 9 6 1 11 10 8 15 12 11 0 1 0 0 0 1
Endoplasmic Reticulum 3 10 4 0 3 4 1 – 4 2 0 3 2 5 3 4 1 3 0 2 0 0 0 5
Endosome 11 17 16 14 32 3 27 – 6 9 35 17 30 30 24 11 9 10 15 49 12 12 29 22
Golgi 13 38 55 18 21 1 5 – 1 2 0 2 49 71 90 37 64 43 15 59 15 13 28 32
Mitochondria 286 603 208 158 162 259 201 – 380 360 466 482 251 251 189 14 14 8 263 543 256 142 239 229
Nucleus 3 5 1 1 0 11 11 – 7 10 6 7 0 0 2 2 2 4 0 1 0 1 0 1
Nuclear Periphery 11 11 5 0 6 7 10 – 23 5 8 10 7 8 6 0 1 1 6 5 0 1 4 5
Nucleolus 14 10 1 1 4 10 5 – 15 8 17 7 13 5 16 0 0 3 1 1 0 0 3 1
Peroxisomes 4 13 3 11 4 0 4 – 4 7 11 6 19 15 21 5 9 9 16 17 18 13 22 25
SpindlePole 7 6 16 8 18 10 18 – 15 35 18 23 5 3 8 5 4 4 2 2 0 0 3 1
Vac/Vac Membrane 53 117 23 15 41 26 50 – 36 21 51 25 36 33 33 19 27 27 10 31 6 7 16 15
Unique Cell Count 331 681 270 192 255 289 292 422 411 517 521 313 331 290 102 134 121 339 733 316 201 366 359
Labelled Cell Count 416 880 364 251 324 350 356 521 499 648 599 429 439 410 126 162 143 339 733 316 201 366 359


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 6.5 6.7 6.6 7.3 4.8 5.9 – 5.3 5.1 5.3 5.3 7.9 8.0 8.0 8.7 9.8 8.7 6.6 6.9 7.0
Std Deviation (1e-4) 1.0 0.9 0.9 1.0 2.0 1.1 1.4 – 1.3 0.9 1.1 0.9 1.3 1.4 1.2 1.8 2.2 1.6 1.5 1.4 1.5
Intensity Change (Log2) – – – -0.03 0.11 -0.5 -0.19 – -0.34 -0.39 -0.35 -0.35 0.24 0.25 0.24 0.36 0.54 0.36 -0.02 0.03 0.05


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 -1.7 0 0 – 0 0 0 0 0 0 -2.3 0 0 0
Bud 2.6 0 0 0 – 1.7 2.9 2.0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.9 -2.4 0 -3.4 – -3.5 -2.6 -2.5 -4.3 -2.8 -2.4 -1.8 1.1 2.1 2.2
Cytoplasm 0 3.1 0 2.2 – 0.5 0 0 0 0.9 0.6 0.4 4.7 3.1 3.1
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0.6 2.6 0 1.5 – -3.3 -2.5 0.5 -1.8 1.6 1.4 1.1 1.6 0.3 0.9
Golgi -3.2 -3.9 0 -7.2 – -9.5 -9.2 -10.6 -10.3 -1.5 0.3 2.9 3.2 5.7 3.2
Mitochondria 1.4 -3.4 0 -2.2 – 4.7 3.6 5.0 6.2 0.9 -0.3 -3.1 -11.1 -12.7 -12.9
Nucleus 0 0 2.8 2.8 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0.4 0 1.2 – 2.3 0 0 0.1 0.3 0.5 0.2 0 0 0
Nucleolus 0 0 0 0 – 2.7 0 2.6 0 3.0 0 3.5 0 0 0
Peroxisomes 2.9 0 0 0 – 0 0 0 0 3.1 2.4 3.6 0 0 0
SpindlePole -0.8 0.5 0 0.1 – -1.5 1.3 -1.6 -0.9 -2.8 -3.5 -1.8 -0.4 -1.3 -1.1
Vacuole -0.3 2.6 0.2 3.0 – 0 -1.8 0.6 -2.1 1.2 0.6 1.1 2.7 3.3 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.6653 3.306 3.1733 2.7569 2.8222 2.9914 3.7998 4.6744 4.2043 3.4393 4.4111 4.2801 8.2049 8.1915 7.9475 8.0623 7.6847 8.2116
Actin 0.0401 0.0035 0.0115 0.0007 0.001 0.0005 0.0414 0.0132 0.0388 0.0014 0.002 0.0106 0.01 0.0064 0.006 0.0349 0.0054 0.0017
Bud 0.0004 0.0001 0.0007 0.0001 0.0001 0.0001 0.0009 0.0008 0.0006 0.0002 0.0006 0.0002 0.0034 0.0008 0.0002 0.0012 0.0001 0.0001
Bud Neck 0.0005 0.0001 0.0002 0.0001 0.0001 0.0001 0.0005 0.0003 0.0003 0.0003 0.0002 0.0005 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001
Bud Periphery 0.001 0.0002 0.0022 0.0001 0.0002 0.0005 0.0016 0.0009 0.0011 0.0005 0.0011 0.0004 0.0085 0.0011 0.0004 0.0022 0.0004 0.0004
Bud Site 0.001 0.0004 0.0027 0.0001 0.0001 0.0001 0.0033 0.003 0.0029 0.0003 0.002 0.0013 0.0006 0.0044 0.0003 0.0009 0.0003 0.0001
Cell Periphery 0.0004 0.0001 0.0005 0.0001 0.0001 0.0001 0.0004 0.0002 0.0011 0.0001 0.0002 0.0002 0.0003 0.0003 0.0001 0.0001 0.0001 0.0001
Cytoplasm 0.0007 0.0001 0.0005 0.0002 0 0.0001 0.0007 0.0003 0.0001 0.0001 0.0001 0.0002 0.0003 0.0003 0.0001 0.0002 0.0001 0.0001
Cytoplasmic Foci 0.0166 0.004 0.0064 0.0087 0.0054 0.0017 0.0323 0.0109 0.0049 0.0076 0.0119 0.0071 0.004 0.0083 0.0053 0.002 0.0033 0.0027
Eisosomes 0.0007 0.0001 0.0003 0.0001 0.0001 0.0001 0.0006 0.0003 0.0002 0.0001 0.0001 0.0002 0.0004 0.0002 0.0001 0.0002 0.0002 0.0001
Endoplasmic Reticulum 0.0024 0.0002 0.0008 0.0002 0 0.0001 0.0009 0.0003 0.0001 0 0.0001 0.0003 0.0002 0.0003 0.0001 0.0001 0.0001 0.0001
Endosome 0.028 0.0204 0.0227 0.0488 0.0136 0.0105 0.0319 0.0177 0.009 0.012 0.0058 0.029 0.0233 0.019 0.0103 0.0159 0.0057 0.007
Golgi 0.0382 0.0375 0.0282 0.0314 0.0212 0.0339 0.0293 0.0405 0.0117 0.023 0.0081 0.0506 0.0196 0.033 0.02 0.0328 0.0301 0.0191
Lipid Particles 0.0487 0.012 0.0226 0.0302 0.0412 0.0042 0.0642 0.0232 0.0105 0.0074 0.0328 0.0093 0.0212 0.0243 0.0086 0.0022 0.0042 0.0047
Mitochondria 0.7523 0.8923 0.8673 0.8621 0.8978 0.9386 0.7141 0.843 0.8748 0.9295 0.8634 0.8509 0.8817 0.8614 0.9243 0.903 0.9308 0.9447
None 0.0012 0 0.0009 0 0.0001 0 0.001 0.0001 0.0001 0 0.0001 0.0001 0.0002 0.0001 0 0.0001 0 0.0001
Nuclear Periphery 0.0087 0.0002 0.0018 0.0001 0.0001 0.0001 0.0025 0.0014 0 0 0.0001 0.0001 0.0014 0.0004 0 0 0.0001 0.0005
Nucleolus 0.0016 0.0002 0.0008 0.0002 0.0002 0.0001 0.0023 0.0036 0.0005 0.0001 0.0017 0.0003 0.0022 0.0003 0.0001 0 0 0.0001
Nucleus 0.0017 0.0001 0.0009 0.0001 0.0001 0.0001 0.002 0.0009 0.0002 0.0001 0.0005 0.0002 0.0002 0.0002 0.0001 0 0 0.0002
Peroxisomes 0.0424 0.0186 0.0134 0.0103 0.0139 0.0025 0.0543 0.0326 0.031 0.0151 0.0661 0.0312 0.0093 0.0342 0.0191 0.0019 0.0179 0.0135
Punctate Nuclear 0.0028 0 0.0035 0.0003 0.0003 0 0.0048 0.001 0.0001 0 0.0004 0.0002 0.0001 0.0001 0 0 0 0
Vacuole 0.0043 0.0044 0.0041 0.0022 0.0014 0.0021 0.0049 0.0021 0.0092 0.001 0.0014 0.0039 0.0046 0.0016 0.0015 0.0006 0.0002 0.0021
Vacuole Periphery 0.0063 0.0054 0.008 0.0042 0.0031 0.0047 0.0062 0.0034 0.0028 0.0012 0.0014 0.0033 0.0085 0.0033 0.0031 0.0015 0.0007 0.0026

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.7151 30.1393 28.4641 33.3879 26.824 24.5065 37.0534 35.5261 36.6007 44.2413
Translational Efficiency 1.13 1.139 1.1769 0.8264 1.2506 1.6742 0.8817 1.0411 0.8821 0.8782

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1742 661 615 1390 559 1889 229 1421 2301 2550 844 2811

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 684.99 905.12 1007.16 827.42 766.66 884.55 926.26 906.67 704.83 889.88 985.21 867.48
Standard Deviation 84.17 137.13 117.96 115.76 90.07 131.89 120.33 138.01 92.53 133.57 123.94 133.51
Intensity Change Log 2 — 0.402026 0.556138 0.272537 — 0.206357 0.272830 0.241991 — 0.302000 0.413461 0.256485

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000988 0.003928 0.001776 0.005233 0.000854 0.001015 0.004490 0.000879 0.000956 0.001770 0.002513 0.003032
Bud Neck 0.002234 0.002808 0.002883 0.021808 0.003029 0.001474 0.017359 0.013566 0.002427 0.001820 0.006811 0.017642
Bud Site 0.006249 0.007853 0.018690 0.050736 0.004837 0.003797 0.076936 0.039074 0.005906 0.004849 0.034494 0.044841
Cell Periphery 0.000428 0.000368 0.000184 0.000982 0.000410 0.000365 0.000909 0.000433 0.000424 0.000365 0.000381 0.000704
Cytoplasm 0.001020 0.003607 0.002824 0.016473 0.001813 0.001439 0.006362 0.014957 0.001213 0.002001 0.003784 0.015706
Cytoplasmic Foci 0.013668 0.032038 0.105865 0.036175 0.029380 0.020383 0.047759 0.057313 0.017485 0.023404 0.090099 0.046860
Eisosomes 0.000042 0.000075 0.000059 0.000112 0.000057 0.000048 0.000111 0.000079 0.000046 0.000055 0.000073 0.000095
Endoplasmic Reticulum 0.000382 0.000338 0.001004 0.002334 0.000630 0.000211 0.001938 0.001885 0.000442 0.000244 0.001258 0.002107
Endosome 0.025030 0.058377 0.149133 0.116431 0.058389 0.041530 0.111372 0.138286 0.033134 0.045897 0.138887 0.127479
Golgi 0.034337 0.060716 0.185112* 0.058249 0.065965 0.034924 0.088376 0.088992 0.042020 0.041609 0.158865* 0.073790
Lipid Particles 0.002674 0.003722 0.001009 0.008251 0.004552 0.002848 0.000749 0.003301 0.003130 0.003074 0.000938 0.005749
Mitochondria 0.874726* 0.759704* 0.295108* 0.443326* 0.758091* 0.857355* 0.438607* 0.377355* 0.846391* 0.832042* 0.334043* 0.409977*
Mitotic Spindle 0.002489 0.005427 0.092932 0.037996 0.006065 0.002391 0.052865 0.056961 0.003358 0.003178 0.082061 0.047583
None 0.000363 0.000325 0.000194 0.001762 0.000322 0.000224 0.000385 0.001592 0.000353 0.000250 0.000246 0.001676
Nuclear Periphery 0.000046 0.000079 0.001014 0.001558 0.000187 0.000156 0.000266 0.000913 0.000080 0.000136 0.000811 0.001232
Nuclear Periphery Foci 0.000138 0.000278 0.001933 0.001939 0.000574 0.000261 0.000626 0.001605 0.000244 0.000265 0.001578 0.001770
Nucleolus 0.000197 0.000567 0.000352 0.004165 0.000927 0.000417 0.000736 0.003167 0.000374 0.000456 0.000456 0.003660
Nucleus 0.000362 0.000427 0.000564 0.006195 0.000666 0.000625 0.001336 0.004184 0.000436 0.000573 0.000773 0.005178
Peroxisomes 0.027427 0.044964 0.021902 0.023559 0.042598 0.017325 0.076233 0.023091 0.031113 0.024490 0.036643 0.023322
Vacuole 0.003175 0.007737 0.066161 0.108070 0.006453 0.006574 0.042668 0.107211 0.003972 0.006876 0.059786 0.107636
Vacuole Periphery 0.004024 0.006665 0.051302 0.054646 0.014201 0.006639 0.029918 0.065158 0.006497 0.006645 0.045500 0.059960

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.11 -1.73 -3.38 -0.72 -2.80 -0.53 -2.46 -0.13 0.58 2.46 -1.73 -2.96 -3.15 -1.79 -0.66
Bud Neck -0.73 -1.18 -9.40 -8.99 -9.15 2.11 -3.93 -7.31 -9.28 0.98 1.26 -4.01 -12.09 -12.98 -6.85
Bud Site -0.89 -5.07 -12.48 -11.38 -7.69 0.90 -7.08 -12.70 -13.40 3.65 1.05 -8.39 -17.24 -17.92 -2.52
Cell Periphery 0.83 5.08 -3.50 -3.82 -5.28 0.36 -2.09 -0.21 -0.86 2.20 0.84 0.60 -3.15 -3.59 -3.33
Cytoplasm -1.82 -6.22 -9.40 -6.05 -8.27 0.49 -3.94 -7.84 -8.26 -4.83 -1.49 -6.84 -12.58 -11.14 -10.17
Cytoplasmic Foci -6.19 -18.27 -10.62 -1.41 13.12 3.20 -3.69 -8.28 -13.26 -1.86 -3.56 -18.08 -16.02 -11.91 10.24
Eisosomes -5.71 -4.65 -11.89 -4.87 -8.39 2.02 -5.60 -4.12 -7.16 3.40 -3.09 -7.21 -13.33 -10.01 -4.78
Endoplasmic Reticulum 0.26 -3.42 -5.76 -6.26 -4.04 1.91 -1.67 -4.13 -7.81 0.10 1.59 -3.23 -7.51 -9.88 -2.86
Endosome -7.20 -19.49 -19.40 -9.39 4.29 3.28 -5.21 -12.30 -19.18 -2.68 -4.86 -19.53 -26.20 -21.78 1.87
Golgi -5.07 -17.81 -5.88 0.47 14.41 5.54 -1.98 -3.45 -12.50 -0.04 0.15 -16.63 -9.38 -10.02 11.92
Lipid Particles -0.93 2.71 -4.06 -2.93 -5.80 0.93 2.08 0.50 -1.11 -4.82 0.08 3.41 -3.02 -3.67 -7.23
Mitochondria 8.25 40.86* 39.58* 20.25 -9.18 -6.97 11.68 24.20 45.47* 2.40 1.87 39.68* 51.52* 50.29* -5.56
Mitotic Spindle -2.68 -13.13 -11.90 -10.33 7.27 3.93 -6.28 -12.97 -14.21 -0.55 0.37 -14.46 -18.03 -18.03 5.71
None 0.35 1.55 -3.11 -3.29 -3.62 1.11 -0.68 -3.91 -4.32 -3.82 1.17 1.26 -4.71 -5.33 -5.37
Nuclear Periphery -0.80 -3.46 -5.44 -5.32 -1.37 0.24 -0.65 -3.88 -4.12 -3.59 -0.79 -3.54 -7.08 -6.38 -1.62
Nuclear Periphery Foci -1.28 -2.69 -6.13 -5.54 0.00 1.11 -0.49 -3.01 -5.77 -2.70 -0.22 -2.77 -7.68 -7.98 -0.34
Nucleolus -0.85 -1.15 -6.81 -5.02 -6.54 1.18 0.38 -3.25 -4.59 -3.82 -0.41 -0.52 -7.66 -7.31 -7.55
Nucleus -0.23 -1.06 -7.59 -7.45 -7.36 0.12 -1.49 -6.20 -5.94 -4.42 -0.49 -1.75 -9.91 -9.10 -9.16
Peroxisomes -3.36 1.61 1.16 4.09 -0.57 4.70 -2.84 3.54 -2.44 4.88 2.39 -1.35 2.96 0.45 3.43
Vacuole -3.81 -14.44 -24.19 -22.58 -6.76 -0.12 -6.63 -25.46 -25.69 -9.66 -4.61 -15.84 -35.42 -34.33 -10.39
Vacuole Periphery -2.18 -12.17 -21.26* -18.38 -0.69 3.51 -3.43 -14.77 -21.00 -7.16 -0.19 -12.58 -28.06 -28.45* -4.02
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity
Localization
Cell Percentages mitochondrion (97%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Tim21

Tim21


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tim21-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available