Standard name
Human Ortholog
Description Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0.08 0.09 0.06 0.08 0.07 0 0.05 0.06 0.05 0 0.08 0.22 0.26 0.12 0.19 0.15 0 0 0 0.4 0.35 0.36
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0.05 0.05 0.06
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.23 0 0 0 0 0.16 0.35 0.19 0.47 0.21 0.5 0.23 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.87 0.81 0.84 0.84 0.79 0.79 0.7 0.84 0.71 0.81 0.73 0.83 0.82 0.61 0.62 0.57 0.49 0.53 0.78 0.74 0.7 0.22 0.2 0.18
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0 0 0 0 0 0 0 0.05 0 0.1 0 0 0 0 0 0 0 0.07 0.06 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0
Vac/Vac Membrane 0 0.15 0.1 0.07 0.13 0.07 0.05 0 0 0 0 0 0 0.11 0.09 0.31 0.32 0.38 0 0.07 0.1 0.09 0.13 0.15
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 2 5 6
Bud 0 1 0 0 0 2 8 6 3 4 4 4 0 0 0 0 0 0 4 6 3 6 12 11
Bud Neck 0 0 1 0 0 1 1 0 0 3 2 1 0 0 0 0 0 0 0 0 0 1 4 6
Bud Site 0 0 0 0 3 4 6 10 13 12 16 12 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 8 10 13 21 24 28 32 21 19 22 17 9 10 37 39 13 23 5 2 4 3 38 58 75
Endoplasmic Reticulum 0 0 0 1 2 0 0 0 0 0 0 0 0 0 0 1 7 0 1 0 1 0 3 6
Endosome 0 3 0 1 9 4 2 3 1 0 0 0 4 7 8 1 0 0 4 4 3 4 8 11
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 2 2 2 1 2 5
Mitochondria 64 5 3 9 13 54 154 95 172 81 155 85 3 1 1 1 5 1 5 4 6 0 3 1
Nucleus 237 169 138 200 316 273 307 421 259 315 227 304 99 103 93 59 59 18 232 189 133 20 33 36
Nuclear Periphery 0 0 0 0 0 0 2 1 0 1 2 0 0 0 1 0 0 0 1 1 0 0 1 0
Nucleolus 13 7 1 0 0 5 13 17 20 16 30 16 5 7 0 1 2 0 20 16 7 2 1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1
SpindlePole 0 0 3 5 5 2 1 4 3 4 0 1 1 3 2 0 0 0 3 3 4 5 5 7
Vac/Vac Membrane 10 31 16 17 53 24 22 12 7 11 7 9 5 18 13 32 38 13 12 17 19 8 21 31
Unique Cell Count 273 208 165 239 399 345 437 499 365 388 312 365 120 168 149 104 120 34 296 255 190 96 167 208
Labelled Cell Count 332 226 176 254 425 398 548 590 497 469 460 441 127 177 159 109 135 37 296 255 190 96 167 208


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.1 7.4 6.4 6.4 6.4 5.5 5.2 5.8 4.7 5.6 4.8 5.5 7.9 8.2 7.7 9.5 10.0 9.0 7.8 8.6 9.1
Std Deviation (1e-4) 0.6 1.2 1.2 1.3 1.1 1.3 1.3 1.3 1.1 1.4 1.1 1.0 3.3 2.9 2.4 1.5 2.4 1.5 2.6 3.2 3.5
Intensity Change (Log2) – – – -0.01 -0.02 -0.23 -0.31 -0.15 -0.45 -0.19 -0.41 -0.23 0.29 0.36 0.25 0.56 0.64 0.48 0.28 0.41 0.5


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.3 -0.8 0.1 -0.2 -1.9 -1.2 -1.0 -1.0 -2.9 0.1 3.6 4.4 1.2 2.8 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.6 8.3 5.4 0 5.7 0 6.2 0 0 0 0 0 0
Nucleus 0 -1.2 -1.2 -3.3 0.2 -3.1 -0.7 -2.7 -0.1 -0.3 -4.6 -4.3 -4.9 -6.2 -4.0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 2.2 0 2.3 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.9 1.2 -1.1 -2.1 -4.0 -4.1 -3.4 -3.6 -3.6 -1.8 0.3 -0.3 4.4 4.7 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9692 4.6383 4.0759 3.6245 3.7475 4.2944 3.5978 4.2293 3.7272 3.4116 2.9619 3.6498 3.8872 3.4847 3.1963 2.942 3.2753 2.9013
Actin 0.0376 0 0.0008 0.0476 0.0578 0.0025 0.0147 0.0003 0.0071 0.0077 0.0003 0.0015 0.017 0 0.02 0.0023 0.0045 0.001
Bud 0.0005 0 0.0001 0.0041 0.0009 0.0002 0.001 0.0003 0.0004 0.0006 0.0004 0.0001 0.0008 0 0.0001 0.0002 0.0003 0.0002
Bud Neck 0.0008 0.0001 0.0007 0.0023 0.002 0.0034 0.003 0.0004 0.0018 0.0093 0.0014 0.0018 0.003 0.0001 0.0007 0.0002 0.0008 0.0019
Bud Periphery 0.0006 0 0.0003 0.0099 0.0011 0.0003 0.002 0.0003 0.0005 0.0012 0.001 0.0002 0.0036 0 0.0001 0.0002 0.0005 0.0003
Bud Site 0.0025 0.0001 0.0007 0.0069 0.0042 0.0007 0.0116 0.0005 0.0027 0.0013 0.0006 0.0002 0.0011 0.0001 0.0004 0.0002 0.0005 0.0002
Cell Periphery 0.0002 0 0.0001 0.0003 0.0001 0.0001 0.0004 0 0.0001 0.0003 0.0001 0 0.0004 0 0 0 0.0001 0
Cytoplasm 0.006 0.0009 0.006 0.001 0.0056 0.0017 0.0032 0.0008 0.0073 0.0157 0.0074 0.0018 0.0165 0.0006 0.0043 0.0044 0.0042 0.0011
Cytoplasmic Foci 0.0115 0 0.0014 0.0231 0.0137 0.0027 0.0144 0.0003 0.0056 0.0058 0.0032 0.0013 0.0047 0 0.0003 0.0021 0.0015 0.0029
Eisosomes 0.0005 0 0 0.0003 0.0001 0 0.0002 0 0.0001 0.0001 0 0 0.0002 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0019 0 0.001 0.001 0.0029 0.0018 0.002 0.0002 0.0015 0.0025 0.0005 0.0003 0.0051 0 0.0008 0.0009 0.002 0.0008
Endosome 0.0234 0 0.0043 0.0069 0.088 0.0206 0.0183 0.0009 0.0129 0.0176 0.0032 0.0035 0.0168 0 0.0017 0.0054 0.0139 0.0031
Golgi 0.011 0 0.0005 0.0106 0.0256 0.005 0.0061 0.0001 0.0021 0.0105 0.0003 0.0024 0.0032 0 0.0004 0.0005 0.0085 0.0006
Lipid Particles 0.0171 0 0.001 0.0125 0.0082 0.0033 0.0109 0.0001 0.0058 0.0051 0.002 0.0024 0.0016 0 0.0002 0.0003 0.0062 0.0002
Mitochondria 0.0093 0.0001 0.0061 0.0164 0.0269 0.0146 0.0087 0.0005 0.0029 0.0113 0.0022 0.0084 0.004 0.0002 0.0004 0.0011 0.0155 0.001
None 0.0047 0 0.0002 0.0005 0.0516 0.0015 0.0017 0.0001 0.0005 0.0021 0.0145 0.0002 0.002 0 0.0005 0.0283 0.0006 0.0032
Nuclear Periphery 0.0081 0.0022 0.0028 0.0034 0.0096 0.0054 0.014 0.0032 0.0071 0.0096 0.0082 0.0022 0.0297 0.0021 0.012 0.0075 0.0437 0.0053
Nucleolus 0.0055 0.0107 0.0059 0.0052 0.0435 0.018 0.0117 0.0057 0.0071 0.0101 0.0207 0.0165 0.0085 0.0054 0.0068 0.0023 0.0086 0.0103
Nucleus 0.8365 0.9848 0.9579 0.8057 0.6189 0.9117 0.8361 0.9716 0.9026 0.8387 0.9084 0.9489 0.8556 0.9771 0.9367 0.939 0.8755 0.9517
Peroxisomes 0.0076 0 0.0056 0.0332 0.0268 0.0007 0.0091 0.0001 0.0098 0.0024 0.0017 0.0012 0.0005 0 0.0001 0.0007 0.0005 0.0001
Punctate Nuclear 0.0122 0.0007 0.0007 0.0065 0.007 0.0042 0.0206 0.014 0.0126 0.0456 0.0221 0.0064 0.0169 0.0141 0.0138 0.0039 0.0082 0.015
Vacuole 0.0014 0.0001 0.0031 0.0016 0.0034 0.0011 0.0083 0.0004 0.0072 0.0016 0.0013 0.0003 0.0063 0.0001 0.0003 0.0003 0.002 0.0008
Vacuole Periphery 0.0009 0 0.0006 0.0009 0.0021 0.0006 0.0022 0.0001 0.0022 0.0008 0.0005 0.0003 0.0025 0 0.0004 0.0003 0.0024 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.948 4.4552 11.9014 16.6562 17.4465 7.9696 14.64 12.7693 15.0767 19.7661
Translational Efficiency 0.6671 2.2799 0.8284 0.732 0.8082 1.1287 0.7339 0.6862 0.686 0.7134

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
36 695 2936 1124 1948 1804 1164 1366 1984 2499 4100 2490

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1194.16 895.19 987.88 927.81 769.38 846.88 978.08 999.02 777.09 860.32 985.10 966.88
Standard Deviation 725.92 135.73 126.78 146.02 104.55 118.35 119.20 137.35 153.33 125.31 124.75 145.70
Intensity Change Log 2 — -0.415730 -0.273588 -0.364095 — 0.138461 0.346256 0.376817 — -0.172654 0.001777 -0.027228

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002029 0.001117 0.000507 0.001050 0.000247 0.000695 0.000863 0.002553 0.000280 0.000812 0.000608 0.001875
Bud Neck 0.048090 0.014384 0.023847 0.021251 0.004733 0.013644 0.011399 0.030510 0.005519 0.013850 0.020313 0.026330
Bud Site 0.026721 0.005738 0.002987 0.013085 0.000557 0.001949 0.001964 0.039057 0.001032 0.003003 0.002696 0.027333
Cell Periphery 0.000323 0.000249 0.000099 0.000260 0.000089 0.000102 0.000138 0.000192 0.000093 0.000143 0.000110 0.000223
Cytoplasm 0.020473 0.020184 0.010933 0.079481 0.016434 0.013673 0.027136 0.037873 0.016507 0.015483 0.015533 0.056655
Cytoplasmic Foci 0.011447 0.001940 0.000180 0.004831 0.001228 0.002991 0.000910 0.010206 0.001414 0.002699 0.000387 0.007780
Eisosomes 0.000079 0.000030 0.000019 0.000042 0.000016 0.000025 0.000036 0.000038 0.000017 0.000026 0.000024 0.000040
Endoplasmic Reticulum 0.023000 0.006998 0.003260 0.007905 0.002486 0.004526 0.007128 0.007073 0.002858 0.005213 0.004358 0.007448
Endosome 0.004435 0.001084 0.000472 0.009377 0.000352 0.001439 0.000662 0.021400 0.000426 0.001340 0.000526 0.015973
Golgi 0.000852 0.000343 0.000091 0.002999 0.000170 0.001533 0.000091 0.013654 0.000183 0.001202 0.000091 0.008844
Lipid Particles 0.020346 0.001221 0.000089 0.000951 0.000577 0.000712 0.000513 0.001106 0.000936 0.000853 0.000210 0.001036
Mitochondria 0.004360 0.002720 0.001615 0.006854 0.001234 0.003509 0.001618 0.010096 0.001290 0.003290 0.001616 0.008632
Mitotic Spindle 0.005130 0.009418 0.002886 0.046983 0.002143 0.008312 0.003549 0.158001* 0.002198 0.008620 0.003074 0.107887*
None 0.019180 0.008173 0.004466 0.011788 0.006356 0.005660 0.007693 0.010404 0.006589 0.006359 0.005382 0.011028
Nuclear Periphery 0.002681 0.001527 0.001127 0.002792 0.000918 0.001232 0.001204 0.004392 0.000950 0.001314 0.001149 0.003670
Nuclear Periphery Foci 0.018553 0.001696 0.000164 0.001980 0.000887 0.000959 0.000468 0.004268 0.001207 0.001164 0.000250 0.003235
Nucleolus 0.036848 0.017883 0.005495 0.008655 0.016962 0.023564 0.005299 0.007460 0.017323 0.021984 0.005440 0.008000
Nucleus 0.733126* 0.901271* 0.939856* 0.752293* 0.943526* 0.912592* 0.921446* 0.599146* 0.939708* 0.909444* 0.934629* 0.668277*
Peroxisomes 0.001778 0.001481 0.000103 0.001423 0.000416 0.001074 0.000212 0.001970 0.000441 0.001187 0.000134 0.001723
Vacuole 0.016883 0.002265 0.001691 0.022352 0.000549 0.001335 0.007520 0.033340 0.000845 0.001593 0.003346 0.028380
Vacuole Periphery 0.003666 0.000279 0.000114 0.003645 0.000118 0.000475 0.000153 0.007261 0.000182 0.000421 0.000125 0.005629

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.31 2.25 0.50 -3.37 -11.44 -6.10 -14.64 -8.32 -5.56 -3.72 -8.25 -12.27 -12.48 -7.02 -8.15
Bud Neck 1.25 0.62 0.41 -7.07 -1.92 -8.87 -9.48 -20.60 -15.86 -14.57 -9.20 -20.29 -23.26 -17.03 -10.85
Bud Site 1.16 1.33 0.66 -3.89 -7.14 -7.01 -9.18 -12.59 -11.82 -11.27 -4.04 -4.48 -14.73 -12.85 -13.09
Cell Periphery 0.68 2.73 1.28 0.70 -9.29 -1.28 -4.08 -7.93 -6.40 -3.98 -2.79 -1.08 -9.63 -2.53 -11.16
Cytoplasm 1.20 1.59 0.50 -5.17 -10.02 1.67 -0.94 -6.02 -7.28 -4.15 1.02 3.54 -8.05 -9.29 -12.34
Cytoplasmic Foci 1.15 1.37 1.12 -0.33 -4.19 -2.19 2.44 -3.91 -0.63 -5.30 -1.95 4.46 -3.15 -0.36 -7.21
Eisosomes 2.60 3.17 0.64 -8.98 -14.88 -5.66 -13.24 -18.05 -12.75 -2.96 -6.61 -10.20 -22.68 -16.23 -15.83
Endoplasmic Reticulum 2.23 2.77 1.73 -4.26 -13.18 -8.67 -16.32 -16.46 -9.81 0.40 -9.59 -13.05 -21.00 -11.55 -11.74
Endosome 1.71 2.13 -0.09 -3.38 -4.34 -3.36 -7.00 -6.45 -5.04 -5.84 -3.70 -1.97 -7.73 -5.91 -7.45
Golgi 1.30 2.00 -0.68 -2.10 -2.78 -3.06 0.68 -3.06 -1.51 -3.11 -3.13 1.09 -3.70 -1.63 -3.82
Lipid Particles 1.74 1.85 1.77 0.88 -10.11 -1.04 -0.10 -4.36 -3.37 -5.82 0.06 2.98 -0.90 -1.53 -12.39
Mitochondria 0.71 1.17 -0.20 -2.12 -3.96 -3.27 -1.44 -5.53 -2.44 -5.41 -3.35 -1.55 -5.97 -2.87 -6.78
Mitotic Spindle -1.63 0.12 -9.29 -8.32 -10.75 -3.72 -3.01 -19.23 -18.10 -18.18 -4.56 -2.89 -21.71 -19.73 -21.22
None 0.67 0.91 0.59 -0.97 -5.78 1.28 0.83 -2.54 -3.74 -3.09 0.73 2.94 -2.73 -3.95 -6.88
Nuclear Periphery 0.51 0.78 -1.53 -6.06 -10.89 -2.22 -6.66 -13.54 -11.64 -10.28 -3.21 -6.76 -17.85 -13.88 -14.73
Nuclear Periphery Foci 1.70 1.94 1.52 -1.78 -5.13 -0.72 -0.32 -5.78 -5.57 -5.76 -0.68 2.14 -5.79 -5.80 -8.26
Nucleolus 1.78 2.87 1.66 -0.40 -5.18 -2.89 6.43 -5.35 -3.31 -9.80 -2.20 6.68 -4.09 -2.38 -10.86
Nucleus -2.99 -3.58 -0.59 12.95 19.73 6.26 6.55 33.78 29.49 28.77 6.80 4.27 36.22 31.14 35.90
Peroxisomes 0.28 1.96 1.04 0.92 -3.01 -2.90 1.28 -4.15 -1.38 -5.71 -3.05 1.25 -3.92 -0.17 -5.77
Vacuole 2.06 2.15 -2.02 -11.08 -11.40 -4.49 -8.28 -15.09 -14.66 -9.14 -4.92 -9.25 -19.11 -18.41 -16.00
Vacuole Periphery 1.64 1.72 1.12 -2.44 -2.88 -4.61 -3.25 -3.68 -2.79 -3.56 -3.65 1.16 -4.44 -3.56 -4.62
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Kss1

Kss1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kss1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available