Standard name
Human Ortholog
Description Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.06 0 – 0 0 0 0 0 0.07 0.12 0.15 0.05 0.13 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.07 0.07 0.06 0.08 – 0.08 0.17 0.13 0.15 0.16 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.94 0.92 0.9 0.9 0.8 0.83 – 0.73 0.74 0.75 0.74 0.74 0.88 0.82 0.77 0.87 0.78 0.88 0.94 0.91 0.88 0.8 0.72 0.64
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.08 0.09 0.15 0.11 0.16 0.25 – 0.34 0.39 0.39 0.38 0.34 0.06 0.06 0.06 0.06 0.05 0 0 0 0 0.07 0.12 0.13
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.12 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 1 0 1 1 – 1 0 3 2 2 0 2 1 0 0 0 3 1 1 2 1 6
Bud Neck 0 0 0 0 0 0 – 3 0 3 0 0 0 0 1 0 0 0 0 0 1 0 0 0
Bud Site 0 0 0 1 2 5 – 15 6 20 12 23 0 4 0 2 2 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 10 8 12 17 30 10 – 21 6 7 7 8 25 66 85 15 25 21 0 2 2 0 2 2
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 3 1 3 0 0 0 0 0 1
Endosome 1 0 1 0 3 0 – 0 0 0 0 0 2 0 4 3 1 1 4 0 5 2 2 2
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 1 1 0 2 0 1 1 0 1
Mitochondria 13 1 36 29 28 60 – 70 69 95 67 80 1 3 0 8 8 5 4 2 0 0 4 5
Nucleus 518 209 494 354 408 591 – 631 299 538 323 369 306 456 450 275 149 271 550 221 500 200 287 301
Nuclear Periphery 1 1 3 4 4 8 – 8 3 12 4 8 1 4 3 2 2 0 1 0 0 0 0 1
Nucleolus 43 21 83 42 80 177 – 291 156 284 168 169 22 36 36 18 10 9 7 5 24 18 46 63
Peroxisomes 1 0 0 0 0 0 – 0 0 0 0 0 0 5 10 2 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 0 1 1 – 1 0 0 0 1 2 15 18 0 0 0 1 0 3 1 1 1
Vac/Vac Membrane 2 4 7 0 11 4 – 11 1 7 5 5 5 2 11 8 6 11 12 5 17 20 47 80
Unique Cell Count 551 228 546 394 508 712 863 405 721 439 500 346 554 584 315 192 309 588 243 567 250 398 471
Labelled Cell Count 589 244 638 447 568 857 1052 540 969 588 665 365 593 620 337 205 322 588 243 567 250 398 471


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.0 12.9 8.1 9.4 9.9 8.0 – 8.5 7.9 7.9 8.1 7.9 11.3 12.2 11.8 12.8 12.0 12.5 11.7 12.6 12.7
Std Deviation (1e-4) 2.8 3.5 2.6 3.9 4.7 2.8 – 3.2 3.3 3.0 3.2 2.9 3.8 4.5 4.8 4.7 4.6 4.8 2.8 3.1 2.9
Intensity Change (Log2) – – – 0.22 0.29 -0.02 – 0.07 -0.04 -0.04 0.0 -0.04 0.48 0.59 0.54 0.66 0.57 0.63 0.54 0.64 0.64

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 3.1 0 3.9 3.9 5.1 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.9 3.1 -1.1 – 0.3 -0.8 -1.8 -0.7 -0.7 3.7 6.3 7.4 2.1 5.9 3.4
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.5 -0.7 1.2 – 1.1 5.1 3.8 4.4 4.8 -4.6 -5.4 -6.3 -2.6 -1.2 -3.3
Nucleus -0.3 -4.7 -3.8 – -7.9 -6.8 -7.2 -7.0 -7.1 -1.0 -3.9 -6.1 -1.5 -4.6 -1.3
Nuclear Periphery 0 0 0 – 0 0 1.8 0 1.7 0 0 0 0 0 0
Nucleolus -2.0 0.2 4.2 – 7.7 8.2 9.4 8.3 7.0 -4.0 -4.6 -4.9 -4.2 -3.6 -5.6
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 3.5 3.8 0 0 0
Vacuole 0 1.1 0 – 0 0 -0.5 -0.2 -0.4 0 0 0.8 1.4 0 2.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.6943 11.3169 9.7532 9.6872 8.7125 9.477 9.1754 8.2872 7.9874 7.762 7.232 7.8676 10.8895 11.3334 10.7167 10.0933 9.8181 10.5995
Actin 0.0039 0.0008 0.0119 0.0026 0.0072 0 0.0001 0 0 0.0001 0 0 0.0091 0 0.0001 0.0016 0.0004 0
Bud 0.0008 0.0001 0.0003 0.0001 0.0002 0.0001 0 0 0 0.0001 0 0 0.0002 0 0.0001 0.0005 0.0007 0
Bud Neck 0.0014 0.0001 0.0002 0 0.0003 0.0004 0 0 0 0.0002 0.0001 0.0004 0.0006 0 0.0001 0.0002 0.0005 0.0003
Bud Periphery 0.0013 0.0001 0.0005 0.0002 0.0004 0.0001 0 0 0 0.0001 0 0.0001 0.0002 0 0.0001 0.0006 0.0005 0
Bud Site 0.0019 0.0008 0.0008 0.0003 0.0004 0.0001 0 0 0 0.0001 0 0 0.0008 0 0.0002 0.0008 0.0019 0
Cell Periphery 0.0007 0 0.0002 0.0001 0.0001 0.0001 0 0 0 0 0 0 0.0002 0 0.0002 0.0004 0.0006 0
Cytoplasm 0.0154 0.0003 0.0088 0.0001 0.0003 0 0 0 0 0.0001 0 0 0.0039 0 0.0077 0.0018 0.0075 0
Cytoplasmic Foci 0.022 0.0002 0.0047 0.009 0.0106 0.0001 0.0014 0 0 0 0 0 0.0144 0 0.0029 0.0017 0.0058 0
Eisosomes 0.0002 0 0.0001 0 0.0001 0 0 0 0 0 0 0 0.0002 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0013 0.0002 0.0004 0.0001 0.0005 0 0 0 0 0 0 0 0.0013 0 0.0006 0.0007 0.0011 0
Endosome 0.0172 0.0013 0.0028 0.005 0.0383 0 0.0003 0 0 0 0 0 0.0079 0 0.002 0.0059 0.001 0
Golgi 0.0059 0.0006 0.0034 0.0089 0.0215 0 0.0003 0 0 0 0 0 0.0019 0 0.0002 0.0007 0.0002 0
Lipid Particles 0.0217 0.0012 0.0066 0.0325 0.0213 0 0.0043 0 0 0 0 0 0.0163 0 0.0027 0.0014 0.0052 0
Mitochondria 0.0171 0.0035 0.0055 0.0152 0.0653 0.0003 0.0007 0 0 0.0005 0.0002 0.0005 0.0021 0.0001 0.0011 0.003 0.0021 0.0001
None 0.0018 0 0.0008 0.0002 0.0002 0 0 0 0 0 0 0 0.006 0 0.0007 0.0005 0.0041 0
Nuclear Periphery 0.0097 0.0016 0.0037 0.0009 0.0035 0.0003 0.0007 0.0015 0.0003 0.0009 0.0006 0.0004 0.0149 0.0008 0.0057 0.0106 0.0055 0.0002
Nucleolus 0.0553 0.0113 0.0209 0.0094 0.117 0.1076 0.0199 0.0151 0.0086 0.0162 0.1459 0.0909 0.0522 0.011 0.0279 0.0418 0.1452 0.0639
Nucleus 0.7905 0.9771 0.9129 0.9079 0.7053 0.8877 0.9532 0.9831 0.9909 0.9808 0.8494 0.9073 0.836 0.9876 0.9373 0.9076 0.8065 0.9351
Peroxisomes 0.0054 0.0002 0.008 0.0043 0.0039 0 0.015 0 0 0 0 0 0.0035 0 0.0001 0.001 0.0002 0
Punctate Nuclear 0.0168 0.0002 0.0041 0.0005 0.0009 0.0028 0.0029 0.0001 0.0001 0.0003 0.0036 0.0002 0.0251 0.0004 0.006 0.0143 0.007 0.0001
Vacuole 0.0054 0.0002 0.0014 0.0008 0.0012 0.0002 0.0005 0 0 0.0002 0.0001 0.0001 0.0017 0 0.0024 0.0026 0.0025 0.0001
Vacuole Periphery 0.0041 0.0003 0.0019 0.002 0.0016 0.0001 0.0004 0 0 0.0002 0.0001 0.0001 0.0014 0 0.0018 0.0023 0.0013 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 36.2797 40.2603 28.2151 26.1877 22.7081 55.0146 39.5763 28.2377 29.4797 27.0034
Translational Efficiency 1.552 1.7647 1.5759 2.065 2.3029 0.9734 1.506 2.1073 1.8741 1.9075

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
424 1638 87 201 146 2060 440 1588 570 3698 527 1789

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 957.57 1193.99 1301.11 1404.08 1119.44 1104.12 1377.21 1456.44 999.03 1143.93 1364.65 1450.56
Standard Deviation 159.22 224.38 241.10 301.79 255.27 207.47 203.07 284.24 201.34 219.71 211.72 286.74
Intensity Change Log 2 — 0.318341 0.442293 0.552175 — -0.019880 0.298971 0.379669 — 0.145940 0.366820 0.461769

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000370 0.000487 0.000973 0.000790 0.000777 0.000513 0.000622 0.000620 0.000474 0.000502 0.000680 0.000639
Bud Neck 0.001630 0.006035 0.007329 0.008851 0.003725 0.006917 0.009171 0.013125 0.002167 0.006526 0.008867 0.012645
Bud Site 0.000125 0.000460 0.000738 0.000675 0.000313 0.000959 0.000563 0.001189 0.000173 0.000738 0.000592 0.001132
Cell Periphery 0.000016 0.000060 0.000019 0.000043 0.000048 0.000146 0.000022 0.000095 0.000024 0.000108 0.000021 0.000090
Cytoplasm 0.000039 0.000333 0.000021 0.000490 0.000079 0.000349 0.000029 0.000778 0.000050 0.000342 0.000028 0.000745
Cytoplasmic Foci 0.000085 0.000094 0.000064 0.000025 0.000027 0.000411 0.000016 0.000660 0.000070 0.000271 0.000024 0.000589
Eisosomes 0.000037 0.000080 0.000089 0.000034 0.000071 0.000103 0.000065 0.000041 0.000046 0.000093 0.000069 0.000041
Endoplasmic Reticulum 0.001904 0.001850 0.001028 0.001031 0.001498 0.002788 0.000791 0.001034 0.001800 0.002373 0.000830 0.001034
Endosome 0.000165 0.000211 0.000021 0.000035 0.000021 0.000228 0.000015 0.000685 0.000128 0.000221 0.000016 0.000612
Golgi 0.000049 0.000107 0.000078 0.000059 0.000040 0.000091 0.000035 0.000781 0.000047 0.000098 0.000042 0.000700
Lipid Particles 0.000154 0.000038 0.000020 0.000011 0.000014 0.000243 0.000009 0.000120 0.000118 0.000152 0.000011 0.000108
Mitochondria 0.000444 0.001199 0.001520 0.002235 0.001365 0.001374 0.001164 0.003002 0.000680 0.001296 0.001223 0.002916
Mitotic Spindle 0.000214 0.002084 0.000089 0.000431 0.000025 0.001151 0.000027 0.001505 0.000165 0.001564 0.000038 0.001384
None 0.000714 0.000622 0.000517 0.002353 0.001648 0.001201 0.000491 0.000520 0.000953 0.000945 0.000496 0.000726
Nuclear Periphery 0.000023 0.000259 0.000044 0.000372 0.000041 0.000234 0.000047 0.000741 0.000028 0.000245 0.000046 0.000700
Nuclear Periphery Foci 0.000792 0.000344 0.000009 0.000025 0.000010 0.000300 0.000003 0.000399 0.000591 0.000319 0.000004 0.000357
Nucleolus 0.036466 0.031102 0.070414 0.019210 0.030824 0.030564 0.024533 0.016991 0.035021 0.030802 0.032107 0.017240
Nucleus 0.955480 0.953108 0.910997 0.961968 0.956721 0.950566 0.960895 0.954297 0.955798 0.951692 0.952658 0.955159
Peroxisomes 0.001057 0.000509 0.005542 0.000963 0.002396 0.000746 0.001187 0.000496 0.001400 0.000641 0.001906 0.000549
Vacuole 0.000134 0.000634 0.000334 0.000274 0.000252 0.000677 0.000223 0.001777 0.000164 0.000658 0.000241 0.001608
Vacuole Periphery 0.000101 0.000383 0.000155 0.000125 0.000103 0.000438 0.000092 0.001143 0.000102 0.000413 0.000103 0.001029

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.55 -7.12 -7.25 -5.65 1.18 4.11 1.82 1.80 -3.11 0.04 -0.79 -6.43 -5.41 -4.93 0.80
Bud Neck -8.30 -5.11 -5.85 -2.88 -1.72 -3.34 -6.24 -8.03 -6.05 -3.44 -9.59 -11.33 -11.41 -6.95 -3.83
Bud Site -4.58 -4.67 -3.23 -1.85 -0.61 -2.77 -3.94 -4.06 -1.00 -2.75 -4.32 -8.27 -5.14 -2.07 -2.77
Cell Periphery -3.48 -1.29 -3.62 0.93 -2.93 -2.01 0.80 -1.47 1.07 -4.05 -3.59 0.15 -3.77 0.51 -4.22
Cytoplasm -1.30 0.60 -3.40 -0.56 -3.53 -1.31 0.69 -1.18 -0.50 -1.26 -1.89 0.73 -1.33 -0.61 -1.36
Cytoplasmic Foci -0.01 0.36 0.75 1.72 2.42 -1.71 1.76 -2.38 -0.75 -2.40 -1.33 0.80 -2.07 -1.20 -2.38
Eisosomes -7.91 -6.28 0.16 7.85 6.30 -3.29 0.72 4.75 8.89 6.22 -9.27 -5.85 1.68 11.30 8.01
Endoplasmic Reticulum 0.26 3.73 4.52 4.38 0.03 -6.23 4.98 3.25 10.04 -3.15 -3.51 7.26 5.78 10.75 -2.73
Endosome -0.06 0.94 0.82 2.07 -1.76 -3.11 0.44 -2.58 -1.68 -2.59 -0.44 0.98 -1.65 -1.62 -2.60
Golgi -0.95 -0.73 -0.73 0.61 -0.03 -1.30 -0.25 -1.60 -1.48 -1.59 -1.23 0.11 -1.58 -1.45 -1.59
Lipid Particles 0.82 0.91 0.94 1.29 0.72 -1.48 1.37 -2.07 0.68 -2.14 -0.02 0.98 0.21 0.35 -2.11
Mitochondria -2.71 -7.46 -6.68 -3.22 -2.75 0.03 0.75 -3.30 -2.81 -3.75 -2.46 -7.19 -5.32 -3.49 -3.94
Mitotic Spindle -1.97 0.63 -1.08 0.12 -1.22 -2.11 -0.87 -2.43 -0.21 -2.41 -2.64 0.78 -2.27 0.04 -2.64
None 0.54 1.60 -2.88 -3.02 -3.25 0.42 1.15 1.14 2.46 -0.15 -0.03 1.60 0.73 1.17 -2.59
Nuclear Periphery -2.44 -2.58 -3.60 -1.17 -3.36 -3.02 -1.37 -4.09 -2.82 -4.02 -3.90 -3.93 -4.45 -2.88 -4.29
Nuclear Periphery Foci 0.63 1.01 0.97 1.41 -1.76 -2.09 0.43 -2.85 -0.42 -2.86 0.55 1.01 0.52 -0.13 -2.89
Nucleolus 1.65 -3.05 2.73 1.83 4.10 0.14 0.89 3.31 6.01 2.99 1.69 0.26 6.32 6.92 4.82
Nucleus 0.58 3.76 0.33 -0.02 -3.27 1.28 -0.16 0.95 -0.27 1.32 1.30 1.40 1.02 -0.01 -0.41
Peroxisomes 1.85 -3.33 -0.02 -3.06 3.39 4.25 2.99 5.31 0.78 4.03 2.86 -1.55 3.02 0.08 5.06
Vacuole -2.67 -3.12 -4.15 1.55 0.41 -3.00 0.19 -3.42 -2.37 -3.44 -4.27 -3.12 -3.67 -2.30 -3.41
Vacuole Periphery -4.59 -2.39 -1.53 4.05 0.92 -4.89 0.42 -2.94 -1.94 -2.95 -6.50 -0.44 -2.96 -1.92 -2.94
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-2

Smd1

Smd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Smd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available