Standard name
Human Ortholog
Description Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.06 0 0 0 0 0 0 0 0 0 0 0 0.12 0.05 0.06 0 0 0 0.05 0.07 0.09 0.07 0.07 0.16
Bud 0 0 0.06 0.06 0.05 0.06 0.06 0.05 0 0.05 0.07 0.06 0.06 0 0.06 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0 0.08 0.05 0 0 0 0 0 0.05 0.05 0.25 0.23 0.18 0.16 0.14 0.18 0 0 0.06 0.05 0.05 0.08
Cytoplasm 0.19 0.69 0.75 0.67 0.71 0.66 0.68 0.65 0.54 0.56 0.6 0.47 0.5 0.76 0.79 0.89 0.84 0.86 0 0.23 0.12 0.12 0.14 0.07
Endoplasmic Reticulum 0.81 0.38 0.08 0.05 0.06 0.05 0 0 0 0 0 0 0.25 0.13 0.06 0 0 0 0.75 0.42 0.39 0.46 0.46 0.51
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.11 0.31 0.21 0.34 0.38 0.41 0.54 0.54 0.53 0.64 0.06 0 0.08 0 0 0 0 0.09 0.21 0.1 0.12 0.08
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Nuclear Periphery 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.15 0.06 0 0.08 0.05 0.08 0.08 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 6 10 3 2 2 3 3 0 0 0 2 5 9 3 0 1 3 5 20 2 9 24
Bud 0 0 11 14 17 23 26 29 9 25 22 27 1 2 8 0 0 0 0 0 1 0 1 0
Bud Neck 0 0 2 0 2 2 0 1 0 0 0 1 0 0 0 0 0 0 2 3 7 2 4 5
Bud Site 0 0 1 0 1 0 1 2 2 2 2 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 6 21 17 16 13 13 14 15 15 20 4 26 26 63 40 50 0 1 14 1 6 12
Cytoplasm 3 11 138 166 228 237 309 374 210 284 186 209 8 84 113 347 231 241 3 16 27 4 19 10
Endoplasmic Reticulum 13 6 14 12 20 17 13 6 13 14 3 10 4 14 8 4 5 11 54 29 87 18 65 80
Endosome 0 0 2 0 8 1 2 2 1 0 0 0 0 0 0 2 0 0 0 0 2 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1
Mitochondria 0 0 21 77 68 121 174 235 212 275 165 280 1 1 11 4 2 1 2 6 46 4 16 13
Nucleus 0 0 0 1 0 2 2 3 2 2 0 0 0 0 0 9 8 14 0 0 0 0 0 0
Nuclear Periphery 1 0 1 1 0 0 1 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 4 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 3 1 1 1 2 3 0 1 0 0 2 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 3 3 3 3 10 17 3 12 6 16 0 0 0 19 42 17 3 5 10 3 10 4
Unique Cell Count 16 16 185 249 319 359 457 573 392 510 309 440 16 111 143 392 276 279 73 72 223 39 141 156
Labelled Cell Count 18 18 205 305 374 425 554 687 471 634 399 568 20 132 177 452 328 336 73 72 223 39 141 156


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 5.8 4.3 4.1 4.5 4.0 3.8 3.9 3.4 3.5 3.5 3.3 5.4 5.8 5.0 10.0 10.9 11.4 – 5.6 6.7
Std Deviation (1e-4) 0.7 1.9 0.6 0.9 1.2 1.2 1.1 1.3 0.9 0.9 1.1 1.0 0.4 0.8 0.6 1.5 1.5 1.7 – 0.9 1.6
Intensity Change (Log2) – – – -0.06 0.05 -0.1 -0.17 -0.14 -0.36 -0.31 -0.29 -0.41 0.31 0.43 0.22 1.21 1.33 1.4 – 0.37 0.63

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 1.3 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 -0.1 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 5.4 4.5 4.4 4.0 4.8
Cytoplasm -1.8 -0.8 -2.0 -1.7 -2.4 -4.8 -4.5 -3.3 -6.2 -2.1 0.2 0.9 4.3 2.4 3.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 1.4 -0.7 -4.2 -3.0 -1.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 -3.3 -1.1 -5.7 -5.1 -5.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 1.3 0 0 0 1.9 4.8 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8855 2.2839 1.9203 1.7866 1.56 2.13 2.4321 3.1906 3.3319 3.1749 2.9301 3.3489 2.0959 2.4753 2.3783 2.3825 2.1197 2.2434
Actin 0.031 0.012 0.0233 0.0588 0.052 0.024 0.0277 0.0034 0.0073 0.0065 0.0147 0.0055 0.0059 0.0149 0.0136 0.0065 0.0123 0.0075
Bud 0.0005 0.0003 0.0009 0.0002 0.0086 0.0004 0.0009 0.0002 0.0002 0.0015 0.0005 0.0011 0.0013 0.0279 0.003 0.0029 0.0002 0.0004
Bud Neck 0.0102 0.0018 0.0047 0.0034 0.0166 0.0395 0.0119 0.0012 0.0017 0.0036 0.015 0.0301 0.0054 0.0023 0.0027 0.0009 0.0053 0.0184
Bud Periphery 0.0015 0.0008 0.004 0.0012 0.0158 0.003 0.0018 0.0004 0.0008 0.0025 0.0008 0.0043 0.0007 0.007 0.0047 0.0023 0.0009 0.0006
Bud Site 0.0094 0.0156 0.0126 0.0006 0.0379 0.0012 0.0182 0.0139 0.002 0.0016 0.0073 0.0007 0.0082 0.0561 0.0239 0.0014 0.0007 0.0004
Cell Periphery 0.0244 0.024 0.0226 0.008 0.0084 0.0161 0.0101 0.0123 0.0136 0.0095 0.0065 0.0073 0.0222 0.0202 0.023 0.0071 0.0117 0.0101
Cytoplasm 0.375 0.533 0.4392 0.2087 0.297 0.5019 0.3908 0.5764 0.6149 0.5119 0.4685 0.5745 0.4624 0.5779 0.4906 0.3762 0.5479 0.6038
Cytoplasmic Foci 0.0317 0.0248 0.0262 0.0287 0.0378 0.0219 0.0367 0.0153 0.0162 0.0174 0.0912 0.0217 0.0299 0.0158 0.0215 0.0148 0.0342 0.0178
Eisosomes 0.0018 0.001 0.0008 0.0006 0.0013 0.0007 0.0005 0.0004 0.0003 0.0002 0.0003 0.0002 0.0011 0.0013 0.0012 0.001 0.0004 0.0005
Endoplasmic Reticulum 0.3133 0.2393 0.3235 0.5055 0.3094 0.3088 0.2082 0.1719 0.2295 0.3019 0.219 0.2589 0.2332 0.0925 0.2121 0.3525 0.2407 0.1814
Endosome 0.0396 0.0204 0.0271 0.036 0.032 0.0179 0.0343 0.0127 0.0165 0.0267 0.0568 0.0188 0.0151 0.0099 0.0116 0.0125 0.0217 0.01
Golgi 0.0173 0.0068 0.0123 0.0092 0.0193 0.0056 0.0149 0.003 0.0091 0.0061 0.0146 0.0066 0.0057 0.0037 0.0061 0.0049 0.0056 0.0042
Lipid Particles 0.0442 0.0736 0.034 0.0693 0.0519 0.0173 0.052 0.0147 0.017 0.0054 0.0189 0.0164 0.0369 0.0178 0.0218 0.0178 0.0339 0.0161
Mitochondria 0.0045 0.0006 0.012 0.0445 0.0593 0.001 0.0038 0.0006 0.0012 0.0017 0.0016 0.0025 0.0027 0.0029 0.0011 0.0009 0.0017 0.0007
None 0.046 0.0291 0.0321 0.0015 0.0121 0.0271 0.1625 0.1611 0.0541 0.092 0.0608 0.0421 0.1409 0.1371 0.149 0.1725 0.0719 0.1181
Nuclear Periphery 0.0242 0.0048 0.0049 0.0052 0.0082 0.0041 0.0026 0.0024 0.0033 0.0038 0.0031 0.0017 0.0032 0.0027 0.0036 0.0063 0.0022 0.0017
Nucleolus 0.0008 0.0003 0.0003 0.0001 0.0016 0.0002 0.0011 0.0009 0.0001 0.0001 0.0005 0.0001 0.0032 0.0007 0.0006 0.0005 0.0001 0.0002
Nucleus 0.0041 0.0017 0.0014 0.001 0.008 0.0016 0.0016 0.002 0.0011 0.0013 0.0014 0.001 0.0064 0.0023 0.0018 0.0028 0.0013 0.0015
Peroxisomes 0.0064 0.0005 0.0085 0.0084 0.0053 0.0006 0.0071 0.0002 0.005 0.0007 0.0087 0.0026 0.0022 0.0005 0.001 0.0005 0.0005 0.0003
Punctate Nuclear 0.0059 0.0018 0.0017 0.0009 0.0032 0.0015 0.0055 0.0011 0.0006 0.0006 0.0038 0.0007 0.0075 0.0019 0.0024 0.0104 0.0021 0.0029
Vacuole 0.0066 0.0075 0.0073 0.007 0.0126 0.0053 0.0072 0.0056 0.0054 0.0045 0.0052 0.0028 0.0056 0.0044 0.0043 0.0048 0.0044 0.003
Vacuole Periphery 0.0017 0.0003 0.0007 0.0012 0.0016 0.0004 0.0005 0.0003 0.0003 0.0005 0.0006 0.0003 0.0003 0.0003 0.0003 0.0005 0.0003 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.1498 18.5976 13.8002 19.0433 15.5225 13.3387 23.4164 17.0018 17.8746 21.3489
Translational Efficiency 0.6943 0.4913 0.5534 0.3033 0.3787 0.497 0.3646 0.447 0.4149 0.3953

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
269 260 167 971 1586 1715 770 220 1855 1975 937 1191

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 717.56 906.89 1219.72 925.19 704.07 801.07 1045.61 1017.05 706.03 815.00 1076.64 942.16
Standard Deviation 80.38 145.50 136.43 109.94 121.93 114.49 122.00 122.08 116.92 124.30 141.38 117.80
Intensity Change Log 2 — 0.337828 0.765379 0.366650 — 0.186209 0.570554 0.530600 — 0.264728 0.672175 0.450175

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003703 0.018917 0.016413 0.014749 0.002659 0.004320 0.018945 0.106726 0.002811 0.006241 0.018494 0.031739
Bud Neck 0.021004 0.028112 0.007460 0.024491 0.007315 0.023824 0.012864 0.033894 0.009300 0.024389 0.011901 0.026228
Bud Site 0.018075 0.035984 0.051992 0.057799 0.007321 0.024356 0.035548 0.134200 0.008881 0.025887 0.038479 0.071912
Cell Periphery 0.008768 0.011063 0.003027 0.002429 0.003556 0.004625 0.007859 0.018952 0.004312 0.005473 0.006998 0.005481
Cytoplasm 0.260751 0.243560 0.266440 0.263604 0.344190 0.333707 0.218733 0.203092 0.332090 0.321840 0.227236 0.252427
Cytoplasmic Foci 0.162365 0.183014 0.092549 0.145180 0.153447 0.146248 0.053154 0.060228 0.154740 0.151088 0.060176 0.129488
Eisosomes 0.007942 0.009223 0.000282 0.002533 0.006244 0.005632 0.004935 0.010977 0.006491 0.006105 0.004106 0.004093
Endoplasmic Reticulum 0.178564 0.162800 0.220201 0.052675 0.159532 0.130073 0.320200 0.116437 0.162292 0.134382 0.302377 0.064453
Endosome 0.027460 0.031675 0.028249 0.034831 0.019721 0.034382 0.014290 0.013731 0.020843 0.034025 0.016777 0.030934
Golgi 0.072014 0.050759 0.005061 0.009408 0.069138 0.052234 0.007113 0.014605 0.069555 0.052040 0.006747 0.010368
Lipid Particles 0.114715 0.073446 0.059175 0.058992 0.120165 0.099382 0.064135 0.047501 0.119374 0.095968 0.063251 0.056869
Mitochondria 0.035378 0.007724 0.000070 0.002554 0.022756 0.022323 0.000810 0.001373 0.024586 0.020401 0.000678 0.002336
Mitotic Spindle 0.000606 0.000783 0.001683 0.009262 0.000275 0.001596 0.001229 0.000502 0.000323 0.001489 0.001310 0.007644
None 0.001807 0.000588 0.000377 0.000324 0.007157 0.003332 0.001144 0.000087 0.006381 0.002971 0.001007 0.000280
Nuclear Periphery 0.000851 0.000331 0.001116 0.001837 0.001024 0.001260 0.002633 0.000285 0.000999 0.001138 0.002362 0.001550
Nuclear Periphery Foci 0.002002 0.004093 0.079352 0.010995 0.002516 0.002037 0.037635 0.010208 0.002442 0.002307 0.045070 0.010850
Nucleolus 0.000376 0.003458 0.000053 0.000432 0.000913 0.000801 0.000192 0.000090 0.000835 0.001151 0.000167 0.000369
Nucleus 0.020280 0.025582 0.014547 0.041326 0.033027 0.035372 0.058581 0.029507 0.031179 0.034084 0.050733 0.039143
Peroxisomes 0.028595 0.025989 0.000959 0.014079 0.017556 0.016961 0.003892 0.011092 0.019156 0.018149 0.003370 0.013527
Vacuole 0.029430 0.079983 0.150548 0.250897 0.018096 0.052589 0.135636 0.185652 0.019739 0.056195 0.138294 0.238845
Vacuole Periphery 0.005312 0.002917 0.000448 0.001604 0.003392 0.004946 0.000472 0.000860 0.003670 0.004679 0.000468 0.001466

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.16 -2.02 -5.44 1.33 0.38 -2.64 -6.56 -7.81 -7.67 -6.40 -4.67 -6.73 -9.39 -8.02 -3.15
Bud Neck -1.14 3.92 -0.52 0.91 -7.07 -9.95 -4.32 -6.35 -1.90 -4.75 -9.06 -2.15 -8.23 -0.10 -6.45
Bud Site -3.09 -3.32 -6.30 -2.93 -0.30 -8.27 -7.98 -10.38 -8.77 -7.60 -8.68 -8.67 -13.60 -9.04 -5.49
Cell Periphery -0.64 3.21 3.65 2.95 1.64 -1.80 -4.62 -5.84 -5.32 -4.01 -1.65 -3.10 -1.02 0.63 2.01
Cytoplasm 1.01 -0.49 0.33 -0.85 0.74 1.32 13.13 10.22 9.54 1.51 1.40 11.71 10.07 8.93 -1.77
Cytoplasmic Foci -1.49 5.47 1.89 3.41 -4.87 1.35 20.17 12.86 12.26 -1.14 0.73 20.11 4.76 4.24 -12.84
Eisosomes -0.66 5.57 4.05 5.27 -8.27 1.12 2.37 -2.58 -3.09 -3.66 0.73 4.39 5.18 5.21 0.38
Endoplasmic Reticulum 0.80 -1.04 8.26 7.34 7.47 3.97 -11.35 3.77 1.59 11.58 3.99 -10.83 15.62 11.84 20.79
Endosome -1.00 0.02 -1.50 -0.42 -1.66 -7.83 3.96 2.70 7.70 0.52 -7.68 3.20 -4.08 2.08 -6.26
Golgi 2.95 12.79 11.86 8.04 -2.73 5.77 27.46 10.77 7.66 -1.29 6.46 30.34 25.08 18.94 -2.04
Lipid Particles 4.04 5.20 6.71 2.42 0.19 4.09 10.53 9.24 6.90 1.72 5.08 11.72 13.47 9.74 1.54
Mitochondria 4.60 6.23 5.74 2.32 -2.12 0.22 15.31 13.85 13.29 -0.60 2.17 16.19 13.30 11.84 -1.60
Mitotic Spindle -0.55 -1.12 -4.35 -4.22 -3.59 -2.47 -2.48 -2.32 1.80 1.56 -2.52 -2.76 -4.62 -3.77 -3.93
None 1.15 1.41 1.47 0.68 0.12 2.80 5.04 6.33 4.64 2.08 2.88 5.23 6.30 4.40 1.68
Nuclear Periphery 2.88 -0.74 -2.81 -4.44 -1.98 -1.15 -4.65 4.73 5.67 7.01 -0.77 -4.66 -2.16 -1.72 1.62
Nuclear Periphery Foci -3.28 -9.91 -10.01 -6.77 8.63 1.61 -13.60 -6.40 -6.79 8.70 0.51 -16.46 -11.06 -11.42 12.37
Nucleolus -0.97 4.49 -0.64 0.95 -3.90 0.27 2.37 2.71 5.54 2.88 -0.66 2.56 1.64 1.79 -2.52
Nucleus -1.31 0.99 -6.13 -4.44 -8.15 -1.11 -7.55 0.43 0.97 5.63 -1.53 -6.91 -3.88 -2.45 3.80
Peroxisomes 0.44 10.20 4.82 3.05 -7.56 0.34 13.83 3.71 3.50 -3.49 0.62 16.94 3.93 3.37 -6.70
Vacuole -6.54 -9.48 -27.25 -17.58 -7.24 -14.35 -19.11 -12.55 -10.35 -3.71 -15.59 -21.37 -32.48 -26.73 -10.98
Vacuole Periphery 3.01 7.60 4.63 2.01 -1.83 -3.21 8.65 6.32 7.83 -0.77 -2.31 10.72 4.71 5.83 -1.78
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
Localization
Cell Percentages ER (71%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Nnf2

Nnf2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nnf2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available