Standard name
Human Ortholog
Description B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm – 0.91 0.95 0.85 0.84 0.76 0.7 0.66 0.58 0.63 0.45 0.46 0.7 0.81 0.87 0.93 0.89 0.93 0.39 0.63 0.63 0.89 0.84 0.77
Endoplasmic Reticulum – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.13 0.09 0.24 0 0 0 0 0
Endosome – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria – 0.05 0 0.14 0.07 0.38 0.38 0.37 0.6 0.54 0.66 0.71 0 0 0 0 0 0 0.12 0.1 0.19 0 0 0
Nucleus – 0 0 0 0 0 0 0 0 0 0 0 0.13 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – 0.06 0 0.05 0.09 0 0 0 0 0 0 0 0.18 0.17 0.14 0 0.09 0.05 0.05 0.07 0 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 3 4 5 1 3 5
Bud – 0 2 2 0 1 1 6 2 5 7 4 0 0 0 0 0 0 0 3 1 0 6 5
Bud Neck – 0 1 0 1 1 0 1 2 3 0 0 0 0 0 0 1 0 0 0 1 0 1 4
Bud Site – 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 1 2 1 3 1 2 0 4 3 0 0 0 4 7 4 0 1 1 0 0 1
Cytoplasm – 158 195 138 202 233 366 314 173 219 156 198 124 260 306 253 214 179 37 123 136 97 251 180
Endoplasmic Reticulum – 3 1 0 0 4 1 3 2 2 3 6 1 0 1 20 31 17 23 1 1 0 1 1
Endosome – 0 3 2 6 2 8 12 1 2 1 0 5 11 9 6 3 1 3 4 6 2 3 1
Golgi – 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 2 2 0 1 2
Mitochondria – 8 8 22 17 116 199 174 179 190 232 305 0 0 0 6 2 0 11 20 40 4 13 7
Nucleus – 0 0 2 2 0 8 16 8 5 14 10 23 9 2 3 3 2 0 8 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 2 1 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Nucleolus – 0 0 1 2 0 0 0 0 1 0 0 2 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0 0 1 0 0 3 2 0 0 3 1 0 0 0 1 0 0 0 0 0 0 1 0
SpindlePole – 1 0 0 2 4 6 8 1 6 5 4 0 0 0 1 0 1 0 4 3 0 5 2
Vac/Vac Membrane – 10 2 8 21 5 16 10 7 10 13 8 31 53 49 10 22 10 5 13 9 0 4 13
Unique Cell Count 174 205 162 241 307 522 475 298 349 349 432 176 320 351 273 241 192 97 195 217 110 300 233
Labelled Cell Count 181 212 177 255 368 613 548 377 444 440 540 186 333 367 305 284 215 97 195 217 110 300 233


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 4.1 3.8 3.7 4.0 3.2 2.9 3.2 3.0 2.8 2.9 2.9 4.9 4.4 4.4 4.9 5.7 5.5 4.2 4.2 5.1
Std Deviation (1e-4) – 1.1 1.1 1.7 1.9 1.0 1.1 1.1 1.1 1.2 0.6 1.6 1.6 1.1 1.2 1.4 1.2 1.5 1.7 1.6 2.0
Intensity Change (Log2) – – – -0.05 0.06 -0.24 -0.39 -0.25 -0.35 -0.46 -0.4 -0.39 0.34 0.19 0.21 0.35 0.56 0.52 0.11 0.11 0.42

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 1.9 3.8 2.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -1.144 -0.4624 -0.5799 -0.3061 -0.5342 -0.8507 2.005 1.6163 2.0598 2.1598 2.1241 1.4704 2.9538 2.9836 2.9849 3.3805 3.0031 2.4226
Actin 0.0243 0.0035 0.0018 0.0298 0.003 0.0017 0.0301 0.0005 0.0506 0.0202 0.0187 0.0021 0.0597 0.0015 0.0088 0.0122 0.0064 0.0029
Bud 0.0023 0.0011 0.0002 0.0002 0.0002 0.0001 0.0014 0.0013 0.0058 0.0098 0.0019 0.0009 0.0028 0.0047 0.0011 0.0142 0.0098 0.0017
Bud Neck 0.0061 0.0003 0.0003 0.0011 0.0012 0.0007 0.0028 0.0001 0.0017 0.0011 0.0116 0.0001 0.0035 0.0005 0.0025 0.0007 0.0006 0.0004
Bud Periphery 0.0049 0.0013 0.0008 0.0002 0.0001 0.0001 0.0033 0.0049 0.0039 0.0248 0.0025 0.0033 0.0029 0.0046 0.0013 0.0082 0.0064 0.0042
Bud Site 0.0058 0.0036 0.0004 0.0008 0.0003 0.0001 0.0121 0.0031 0.0098 0.0152 0.0346 0.0001 0.0057 0.0064 0.0151 0.0022 0.0009 0.0002
Cell Periphery 0.0003 0.0001 0.0002 0.0002 0.0001 0 0.0008 0.0003 0.0006 0.0009 0.0006 0.0001 0.0005 0.0008 0.0011 0.0005 0.0003 0.0001
Cytoplasm 0.0369 0.1295 0.1007 0.2393 0.2248 0.0834 0.0631 0.0761 0.0836 0.1821 0.2139 0.0514 0.0514 0.09 0.1097 0.1925 0.1305 0.076
Cytoplasmic Foci 0.0138 0.0074 0.0078 0.0026 0.0231 0.011 0.0615 0.0046 0.0265 0.0053 0.0379 0.0054 0.0162 0.0101 0.0196 0.0247 0.0206 0.011
Eisosomes 0.0008 0.0002 0.0004 0.0002 0.0001 0.0002 0.0009 0.0003 0.0005 0.0005 0.0002 0.0001 0.0006 0.0015 0.0002 0.0003 0.0002 0.0001
Endoplasmic Reticulum 0.0037 0.0024 0.0032 0.0036 0.0041 0.0005 0.0063 0.0009 0.0034 0.0016 0.0038 0.0005 0.006 0.0012 0.0031 0.0026 0.0102 0.0007
Endosome 0.014 0.0016 0.0044 0.0027 0.0112 0.0013 0.0252 0.0012 0.0107 0.0052 0.0146 0.001 0.01 0.0046 0.0076 0.0084 0.0102 0.0038
Golgi 0.004 0.0004 0.0004 0.0009 0.0011 0.0006 0.0167 0.0001 0.0098 0.0034 0.008 0.0018 0.0054 0.0035 0.002 0.0017 0.0008 0.0029
Lipid Particles 0.0075 0.0006 0.0021 0.0005 0.0018 0.0043 0.0164 0.0007 0.0067 0.003 0.0042 0.0017 0.0096 0.0012 0.0034 0.0045 0.003 0.007
Mitochondria 0.0071 0.0007 0.0132 0.0007 0.001 0.0039 0.0158 0.0008 0.0063 0.0326 0.005 0.0088 0.0051 0.0011 0.0016 0.0034 0.0024 0.0012
None 0.822 0.7064 0.7164 0.4476 0.6614 0.8624 0.6961 0.8647 0.6466 0.4487 0.5064 0.9094 0.772 0.8385 0.6439 0.5137 0.7303 0.8635
Nuclear Periphery 0.0107 0.0113 0.0086 0.0121 0.0192 0.0005 0.0034 0.0011 0.0078 0.0033 0.031 0.0004 0.0118 0.0011 0.0096 0.0059 0.0145 0.0011
Nucleolus 0.0016 0.0016 0.0022 0.0007 0.0008 0.0006 0.0055 0.0005 0.0024 0.0019 0.0011 0.0006 0.001 0.0007 0.0012 0.0042 0.0013 0.0003
Nucleus 0.0112 0.1112 0.1147 0.2458 0.0224 0.0128 0.0039 0.0353 0.0856 0.2258 0.0425 0.0102 0.0058 0.0131 0.1499 0.1609 0.0421 0.0153
Peroxisomes 0.0131 0.0043 0.0032 0.001 0.0012 0.0076 0.0215 0.0004 0.021 0.0029 0.042 0.0011 0.0169 0.0023 0.0053 0.0024 0.0006 0.0036
Punctate Nuclear 0.0054 0.01 0.0169 0.0076 0.021 0.0079 0.0084 0.0018 0.011 0.0067 0.0163 0.0003 0.0097 0.0013 0.0104 0.0333 0.0037 0.0033
Vacuole 0.0029 0.0022 0.0017 0.0018 0.0015 0.0004 0.0039 0.001 0.0048 0.0039 0.0019 0.0004 0.002 0.0107 0.0019 0.0025 0.0038 0.0005
Vacuole Periphery 0.0015 0.0003 0.0006 0.0004 0.0006 0.0001 0.001 0.0001 0.0007 0.0013 0.0014 0.0002 0.0012 0.0005 0.0007 0.001 0.0014 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1.5585 25.0774 21.7099 19.1822 10.6084 1.5576 33.6315 35.6529 27.0473 12.4699
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1738 1330 1656 538 1015 1633 1601 113 2753 2963 3257 651

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 644.18 658.24 777.71 810.23 650.31 667.16 842.77 743.17 646.44 663.16 809.69 798.59
Standard Deviation 68.77 95.50 94.23 106.78 75.83 88.33 97.59 108.39 71.52 91.73 101.26 110.04
Intensity Change Log 2 — 0.031150 0.271768 0.330868 — 0.036905 0.374011 0.192565 — 0.034044 0.324037 0.263046

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000029 0.000223 0.000150 0.000683 0.000047 0.000399 0.000232 0.003436 0.000035 0.000320 0.000191 0.001161
Bud Neck 0.006073 0.020762 0.007088 0.014710 0.002258 0.039970 0.004379 0.009721 0.004666 0.031348 0.005756 0.013844
Bud Site 0.002380 0.009014 0.006082 0.021301 0.000827 0.015441 0.005690 0.093542 0.001808 0.012556 0.005890 0.033841
Cell Periphery 0.000176 0.000140 0.000126 0.000269 0.000131 0.000176 0.000138 0.000825 0.000159 0.000160 0.000132 0.000366
Cytoplasm 0.546135 0.460841 0.192531 0.344331 0.511197 0.412982 0.299304 0.474084 0.533254 0.434465 0.245016 0.366853
Cytoplasmic Foci 0.107562 0.174337 0.002402 0.022250 0.083714 0.226377 0.005617 0.099983 0.098769 0.203018 0.003982 0.035743
Eisosomes 0.000129 0.000089 0.000016 0.000057 0.000056 0.000167 0.000029 0.000164 0.000102 0.000132 0.000022 0.000076
Endoplasmic Reticulum 0.000581 0.001168 0.002250 0.006280 0.000332 0.000858 0.003357 0.002037 0.000489 0.000997 0.002794 0.005543
Endosome 0.004142 0.018753 0.000673 0.008415 0.001660 0.018491 0.002159 0.014035 0.003227 0.018608 0.001403 0.009391
Golgi 0.000842 0.003507 0.000038 0.010558 0.000865 0.006099 0.000718 0.002139 0.000851 0.004935 0.000372 0.009097
Lipid Particles 0.005365 0.007535 0.000445 0.001574 0.002939 0.008566 0.000798 0.004030 0.004471 0.008103 0.000619 0.002001
Mitochondria 0.001793 0.007375 0.000767 0.004563 0.001133 0.017909 0.001023 0.008109 0.001550 0.013181 0.000893 0.005178
Mitotic Spindle 0.000841 0.001813 0.002740 0.036365 0.000557 0.015175 0.005855 0.012465 0.000736 0.009177 0.004272 0.032216
None 0.011009 0.016956 0.006390 0.008978 0.013278 0.005239 0.009124 0.012723 0.011846 0.010498 0.007734 0.009628
Nuclear Periphery 0.000535 0.000857 0.001866 0.006550 0.000359 0.000526 0.002273 0.000749 0.000470 0.000674 0.002066 0.005543
Nuclear Periphery Foci 0.000280 0.000801 0.000325 0.005787 0.000185 0.000425 0.000909 0.005061 0.000245 0.000594 0.000612 0.005661
Nucleolus 0.001221 0.004218 0.000740 0.000761 0.001311 0.003528 0.000881 0.001011 0.001254 0.003838 0.000809 0.000805
Nucleus 0.284816 0.210857 0.763556 0.363465 0.369103 0.156364 0.625008 0.155570 0.315891 0.180824 0.695452 0.327379
Peroxisomes 0.001306 0.008834 0.000107 0.001566 0.000865 0.019413 0.000216 0.004097 0.001143 0.014664 0.000161 0.002005
Vacuole 0.024416 0.049629 0.011568 0.129060 0.008881 0.049998 0.031939 0.094516 0.018688 0.049832 0.021582 0.123064
Vacuole Periphery 0.000370 0.002292 0.000138 0.012477 0.000300 0.001897 0.000351 0.001702 0.000345 0.002074 0.000243 0.010607

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.90 -10.14 -8.32 -6.44 -6.72 -5.99 -9.56 -2.93 -2.56 -2.65 -8.36 -14.27 -6.67 -5.12 -5.48
Bud Neck -7.99 -1.79 -3.64 3.94 -2.09 -15.19 -5.39 -2.60 9.43 -1.09 -16.46 -3.32 -4.90 9.93 -3.07
Bud Site -6.09 -2.87 -5.66 -2.75 -3.68 -10.35 -4.71 -5.30 -4.21 -4.97 -11.09 -4.55 -7.55 -4.04 -6.18
Cell Periphery 3.65 3.52 -0.11 -1.87 -2.38 -3.54 0.67 -4.54 -4.15 -4.59 0.14 3.85 -3.66 -3.68 -4.92
Cytoplasm 8.94 46.25 25.63 16.52 -4.71 8.83 24.23 2.85 -0.41 -5.66 13.80 49.24 22.97 13.84 -4.57
Cytoplasmic Foci -10.34 31.88 25.62 27.93 -5.69 -21.19 20.64 0.74 12.01 -6.35 -22.17 37.69 20.98 38.16 -7.64
Eisosomes 2.03 5.91 2.34 1.14 -13.86 -12.34 3.88 -3.78 0.93 -4.38 -2.34 6.01 0.61 5.11 -11.24
Endoplasmic Reticulum -4.75 -13.06 -13.80 -12.65 -9.33 -3.41 -18.86 -5.61 -4.10 5.18 -4.82 -22.24 -14.40 -13.16 -6.79
Endosome -10.06 9.71 0.10 9.47 -5.12 -14.60 -0.79 -3.27 2.77 -3.14 -16.69 6.80 -2.58 11.79 -5.23
Golgi -3.49 3.59 -1.17 0.56 -1.74 -5.69 0.66 -0.78 5.24 -1.84 -7.29 2.12 -1.24 1.95 -1.79
Lipid Particles -2.74 11.17 6.91 7.80 -12.55 -8.22 8.74 -0.14 3.19 -1.42 -6.70 13.02 5.07 10.42 -5.75
Mitochondria -5.01 1.80 -0.17 5.12 -2.52 -9.52 0.66 -0.95 2.38 -0.99 -10.43 1.88 -1.06 7.60 -1.85
Mitotic Spindle -1.77 -2.82 -5.74 -5.54 -5.10 -6.91 -4.16 -1.62 -0.19 -1.06 -7.02 -4.93 -5.91 -3.74 -4.86
None -3.06 4.70 4.26 5.82 -0.02 6.15 4.62 0.49 -0.68 -0.42 1.12 6.36 3.38 2.44 -0.15
Nuclear Periphery -1.56 -12.39 -5.53 -5.10 -3.54 -2.74 -12.64 -2.44 -1.88 4.90 -1.91 -16.34 -5.76 -5.45 -2.61
Nuclear Periphery Foci -5.64 -1.89 -4.46 -3.64 -4.26 -2.79 -4.28 -3.86 -3.58 -2.48 -5.46 -4.52 -5.38 -4.75 -4.18
Nucleolus -7.90 0.21 1.38 8.17 0.75 -4.43 -0.31 1.37 4.60 1.31 -8.02 -0.17 1.96 8.45 1.54
Nucleus 8.05 -59.41 -7.49 -12.11 26.55 21.02 -23.46 6.13 -1.21 15.49 20.73 -56.68 -3.11 -13.51 26.57
Peroxisomes -7.92 5.03 1.59 8.40 -2.52 -14.62 5.93 -2.05 10.27 -2.77 -16.31 6.61 -0.05 15.74 -3.71
Vacuole -10.06 5.23 -19.70 -17.28 -20.44 -18.11 -16.71 -7.39 -5.36 -4.52 -17.78 -10.96 -21.14 -18.03 -18.88
Vacuole Periphery -7.76 4.46 -1.70 -0.51 -1.85 -8.09 0.69 -1.23 0.85 -1.31 -11.05 3.03 -1.83 -0.53 -1.95
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (40%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Clb1

Clb1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Clb1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available