ORF
Human Ortholog
Description Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.68 0.61 0.7 0.72 0.62 0.6 0.55 0.49 0.49 – 0.44 0.49 0.44 0.2 0.31 – – – 0.2 0.31 0.22 0.33 0.27 0.23
Bud 0.05 0.07 0.12 0.08 0.13 0.09 0.12 0.11 0.08 – 0.08 0.07 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0.63 0.65 0.61 0.67 0.43 0.45 0.4 0.33 0.42 – 0.35 0.41 0.6 0.68 0.66 – – – 0.74 0.57 0.67 0.58 0.44 0.29
Cytoplasm 0 0.05 0.08 0.12 0.09 0.15 0.15 0.12 0.08 – 0.11 0.08 0.34 0.43 0.27 – – – 0 0 0 0 0.1 0.24
Endoplasmic Reticulum 0 0.16 0 0 0.13 0.09 0.09 0.12 0.07 – 0.08 0.09 0.09 0.09 0.15 – – – 0 0.06 0 0 0.13 0.17
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0.13 0 0.13 0 0.06 0.23 0 – 0 0.11 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0.59 0.2 0.07 0.19 0.09 0.28 0.33 0.2 0.59 – 0.63 0.48 0 0 0 – – – 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0.09 0 0.06 0.06 0 0.05 0 0 0.05 – 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 89 127 287 143 186 205 198 188 172 – 128 156 101 73 106 – – – 29 68 103 38 89 66
Bud 6 14 50 15 38 30 44 43 29 – 23 21 3 5 7 – – – 0 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 4 0 3 2
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – – – – –
Cell Periphery 82 135 249 132 128 154 144 128 147 – 103 131 140 248 225 – – – 107 127 314 68 144 83
Cytoplasm 3 10 34 23 27 50 53 45 28 – 31 25 80 157 94 – – – 1 1 3 1 31 70
Endoplasmic Reticulum 4 33 12 7 40 30 34 45 23 – 23 30 22 32 52 – – – 3 12 10 3 42 50
Endosome 0 0 1 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 1 3 0 0 1
Golgi 4 9 52 7 39 8 22 90 2 – 8 36 2 1 1 – – – 1 4 3 0 7 5
Mitochondria 77 42 30 37 26 96 120 79 204 – 184 154 4 0 1 – – – 0 1 14 2 4 1
Nucleus 0 0 2 0 2 1 0 3 1 – 0 1 0 0 2 – – – 0 0 1 0 0 0
Nuclear Periphery 0 1 0 0 0 0 0 2 0 – 1 2 0 0 0 – – – 0 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 12 5 24 12 9 18 14 9 18 – 0 7 5 0 2 – – – 0 0 2 0 0 0
SpindlePole 0 0 6 1 2 0 1 3 1 – 0 2 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 1 3 1 0 3 0 8 1 – 1 3 0 0 0 – – – 0 1 3 0 0 0
Unique Cell Count 130 208 411 198 298 343 361 386 348 292 319 232 365 342 145 223 470 118 328 290
Labelled Cell Count 277 377 750 378 497 595 630 643 626 502 568 357 516 490 145 223 470 118 328 290


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.1 13.7 10.2 9.5 11.1 9.5 10.5 11.1 9.3 – 9.5 11.1 14.7 19.2 18.9 – – – 10.9 12.9 14.2
Std Deviation (1e-4) 1.9 3.1 1.6 1.4 1.6 1.7 1.6 2.0 2.1 – 2.4 2.7 2.4 4.4 5.1 – – – 2.2 2.3 2.6
Intensity Change (Log2) – – – -0.1 0.12 -0.1 0.04 0.12 -0.13 – -0.11 0.13 0.53 0.91 0.89 – – – 0.1 0.34 0.47

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70005101520WT3HU80HU120HU16005101520WT305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.6 -2.1 -2.9 -4.3 -6.1 -5.7 – -6.9 -5.7 -6.5 -13.9 -10.6 – – –
Bud -1.7 0.2 -1.5 0 -0.5 -1.7 – -1.8 -2.5 -4.8 -5.8 -5.2 – – –
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Cell Periphery 1.5 -4.6 -4.3 -5.7 -7.7 -5.0 – -6.6 -5.2 -0.1 2.1 1.5 – – –
Cytoplasm 1.3 0.4 2.7 2.8 1.6 -0.1 – 1.1 -0.2 8.4 11.2 7.0 – – –
Endoplasmic Reticulum 0.4 5.3 3.5 3.8 4.8 2.4 – 3.0 3.7 3.6 3.5 6.0 – – –
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Golgi -3.6 0.2 -5.2 -3.1 3.9 -6.4 – -4.6 -0.6 -5.2 -6.8 -6.6 – – –
Mitochondria 4.2 0.7 7.6 9.1 5.4 15.3 – 15.8 12.6 -3.0 -5.3 -4.8 – – –
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Peroxisomes 0.1 -1.8 -0.4 -1.3 -2.5 -0.4 – -4.2 -2.4 -2.2 -4.7 -3.9 – – –
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Vacuole 0 0 0 0 1.6 0 – 0 0 0 0 0 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.5907 17.2879 14.5766 13.4583 9.8424 14.0388 13.8493 17.24 15.0858 14.9492 12.621 16.0362 13.3364 15.3022 13.6455 12.9274 12.6583 13.0282
Actin 0.1217 0.0151 0.0368 0.0031 0.2426 0.0415 0.0651 0.0353 0.0576 0.0369 0.1068 0.0322 0.1546 0.0504 0.1058 0.0665 0.1331 0.0692
Bud 0.0004 0.0003 0.0003 0.0001 0.0005 0.0004 0.0007 0.0001 0.0006 0.0004 0.0021 0.0002 0.0008 0.0003 0.0011 0.0008 0.0004 0.0004
Bud Neck 0.0051 0.0032 0.0061 0.0029 0.0118 0.0033 0.0027 0.003 0.0034 0.0047 0.0118 0.0012 0.0041 0.0086 0.0127 0.0206 0.0077 0.0042
Bud Periphery 0.0017 0.0008 0.0016 0.0016 0.0027 0.0048 0.0041 0.0007 0.0027 0.0034 0.0049 0.0017 0.0025 0.0014 0.0039 0.0057 0.0027 0.0027
Bud Site 0.0075 0.1013 0.0192 0.0031 0.002 0.0012 0.0114 0.0175 0.0081 0.0041 0.0256 0.0007 0.0103 0.0474 0.0358 0.0172 0.0034 0.004
Cell Periphery 0.0537 0.2105 0.2387 0.2755 0.1816 0.2138 0.1349 0.1356 0.1816 0.2499 0.1197 0.1832 0.0632 0.1294 0.1612 0.3247 0.1067 0.1465
Cytoplasm 0.0037 0.0722 0.0048 0.0031 0.0013 0.0019 0.0107 0.0026 0.0099 0.0064 0.0042 0.0017 0.0052 0.0064 0.0096 0.0112 0.0057 0.0101
Cytoplasmic Foci 0.0066 0.0016 0.0004 0.0001 0.0041 0.014 0.0057 0.0001 0.0067 0.0056 0.0142 0.0005 0.0218 0.0002 0.0033 0.0142 0.0042 0.0015
Eisosomes 0.7344 0.5826 0.6731 0.7031 0.3463 0.6681 0.7024 0.7987 0.6844 0.6271 0.6139 0.7516 0.6916 0.7523 0.6354 0.4787 0.6817 0.7392
Endoplasmic Reticulum 0.0015 0.0029 0.0008 0.0032 0.0013 0.0021 0.0061 0.0034 0.005 0.0181 0.0042 0.0038 0.0047 0.0013 0.0035 0.0089 0.0036 0.0027
Endosome 0.006 0.0012 0.0001 0 0.0059 0.0037 0.007 0 0.0126 0.0028 0.0223 0.0014 0.0081 0 0.0029 0.0134 0.0073 0.0007
Golgi 0.0051 0.0006 0.0007 0.0003 0.0069 0.0048 0.0059 0.001 0.0046 0.0097 0.0238 0.0025 0.0068 0.0006 0.0042 0.0082 0.0047 0.0016
Lipid Particles 0.0142 0.0003 0.0005 0.0001 0.0406 0.0084 0.0122 0.0001 0.004 0.0053 0.0123 0.0007 0.0058 0.0002 0.0043 0.0069 0.0082 0.0005
Mitochondria 0.0154 0.0012 0.0137 0.0018 0.1386 0.005 0.0107 0.0002 0.0029 0.0158 0.014 0.0159 0.0029 0.0002 0.0096 0.0021 0.0116 0.0127
None 0.0137 0.0038 0.0006 0.0009 0.001 0.008 0.0039 0.0004 0.0009 0.0005 0.0016 0.001 0.0034 0.0004 0.0012 0.006 0.0051 0.0007
Nuclear Periphery 0.0017 0.0005 0.0002 0.0003 0.0008 0.0004 0.0017 0.0007 0.0033 0.0015 0.0055 0.0005 0.0016 0.0004 0.0009 0.0037 0.004 0.0008
Nucleolus 0.0003 0.0001 0.0001 0 0.0003 0.0002 0.0014 0 0.0004 0.0001 0.0005 0 0.0002 0 0.0001 0.0006 0.0003 0
Nucleus 0.0003 0.0004 0.0001 0 0.0002 0.0001 0.0009 0 0.0054 0.0001 0.0008 0.0001 0.0004 0.0001 0.0002 0.0011 0.0004 0.0004
Peroxisomes 0.0036 0.0002 0.0015 0.0002 0.0078 0.016 0.0076 0.0001 0.0024 0.0068 0.0071 0.0003 0.0058 0.0001 0.0026 0.0043 0.002 0.0005
Punctate Nuclear 0.0026 0.0001 0 0 0.0007 0.0008 0.0035 0 0.0022 0.0001 0.0023 0.0001 0.005 0 0.0004 0.0034 0.0067 0.0012
Vacuole 0.0005 0.001 0.0007 0.0004 0.0015 0.0013 0.0011 0.0003 0.0008 0.0007 0.0015 0.0005 0.001 0.0003 0.0009 0.0017 0.0003 0.0003
Vacuole Periphery 0.0003 0.0001 0 0 0.0016 0.0002 0.0003 0 0.0003 0.0001 0.0008 0.0001 0.0002 0 0.0002 0.0004 0.0003 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 21.6089 20.9268 24.4874 44.2066 28.6006 39.1444 36.1128 45.5891 54.6188 35.4943
Translational Efficiency 2.2054 2.1371 2.6099 2.2673 2.1852 1.7884 1.5023 2.0978 1.8926 1.8986

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2054 1639 2481 1773 1691 1470 557 2794 3745 3109 3038 4567

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 976.47 1173.09 2187.62 1868.32 1078.18 1027.66 1626.82 1920.69 1022.40 1104.33 2084.80 1900.36
Standard Deviation 139.57 186.96 447.66 430.77 161.59 182.98 319.70 443.23 158.23 198.82 479.05 439.18
Intensity Change Log 2 — 0.264666 1.163715 0.936094 — -0.069235 0.593457 0.833027 — 0.099103 0.892579 0.882928

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.139898 0.091459 0.033236 0.063835 0.086100 0.124523 0.127769 0.066565 0.115606 0.107092 0.050568 0.065505
Bud Neck 0.003862 0.005440 0.005287 0.004109 0.004281 0.004634 0.006633 0.003294 0.004051 0.005059 0.005534 0.003611
Bud Site 0.001403 0.003614 0.002597 0.007929 0.002295 0.004464 0.002723 0.004798 0.001806 0.004016 0.002620 0.006013
Cell Periphery 0.194810 0.378051 0.445996 0.532816 0.233235 0.305894 0.079178 0.538167 0.212161 0.343934 0.378742 0.536089
Cytoplasm 0.000254 0.000351 0.000830 0.001269 0.000194 0.000968 0.000338 0.003128 0.000227 0.000643 0.000739 0.002406
Cytoplasmic Foci 0.005524 0.001285 0.000491 0.000625 0.002359 0.002519 0.001959 0.000975 0.004095 0.001868 0.000760 0.000839
Eisosomes 0.618291 0.494445 0.384209 0.369330 0.653320 0.491734 0.444638 0.334592 0.634108 0.493163 0.395289 0.348078
Endoplasmic Reticulum 0.003365 0.007397 0.033531 0.006300 0.005702 0.011513 0.120801 0.008382 0.004420 0.009343 0.049532 0.007574
Endosome 0.002195 0.003236 0.005603 0.002211 0.002374 0.009536 0.027894 0.004106 0.002276 0.006215 0.009690 0.003371
Golgi 0.003915 0.001911 0.005658 0.001957 0.001628 0.011833 0.084894 0.003841 0.002882 0.006603 0.020185 0.003109
Lipid Particles 0.005623 0.001442 0.055542 0.004019 0.000702 0.009950 0.093687 0.010503 0.003401 0.005465 0.062536 0.007986
Mitochondria 0.001117 0.001751 0.000788 0.001735 0.001046 0.002008 0.000375 0.002637 0.001085 0.001873 0.000712 0.002287
Mitotic Spindle 0.001800 0.001634 0.001556 0.000577 0.002424 0.001393 0.000358 0.000827 0.002082 0.001520 0.001336 0.000730
None 0.001770 0.000449 0.000262 0.000166 0.001087 0.000582 0.000250 0.000227 0.001462 0.000512 0.000260 0.000203
Nuclear Periphery 0.000258 0.000426 0.002212 0.000354 0.000361 0.000361 0.000350 0.000637 0.000304 0.000395 0.001870 0.000527
Nuclear Periphery Foci 0.000015 0.000096 0.000083 0.000032 0.000028 0.000156 0.000097 0.000032 0.000021 0.000125 0.000085 0.000032
Nucleolus 0.000005 0.000042 0.000014 0.000012 0.000007 0.000031 0.000003 0.000010 0.000006 0.000037 0.000012 0.000011
Nucleus 0.000169 0.000320 0.000246 0.000153 0.000180 0.000382 0.000097 0.000173 0.000174 0.000349 0.000219 0.000165
Peroxisomes 0.015628 0.006391 0.019735 0.000988 0.002490 0.017061 0.007076 0.016062 0.009696 0.011436 0.017414 0.010210
Vacuole 0.000068 0.000170 0.001985 0.001165 0.000126 0.000213 0.000792 0.000820 0.000094 0.000191 0.001766 0.000954
Vacuole Periphery 0.000031 0.000090 0.000139 0.000419 0.000059 0.000243 0.000090 0.000225 0.000044 0.000162 0.000130 0.000300

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 6.57 18.40 11.38 4.36 -6.95 -4.92 -4.09 3.37 8.31 6.40 1.57 14.67 11.21 8.91 -4.29
Bud Neck -4.42 -4.30 -0.77 3.31 3.10 -1.04 -3.81 3.25 3.79 5.34 -4.07 -5.24 1.99 5.41 6.39
Bud Site -4.63 -5.46 -5.10 -3.22 -4.19 -2.76 -0.93 -4.23 -0.43 -3.47 -4.95 -3.71 -6.96 -2.85 -5.69
Cell Periphery -18.89 -28.21 -34.17 -13.66 -8.14 -6.83 16.28 -32.76 -22.29 -49.77 -18.31 -21.74 -48.68 -25.20 -19.50
Cytoplasm -1.48 -3.41 -2.68 -2.40 -1.15 -2.72 -1.94 -4.97 -3.32 -4.73 -3.01 -3.65 -5.60 -4.30 -4.07
Cytoplasmic Foci 5.68 7.44 6.93 1.75 -0.65 -0.30 0.77 3.74 3.46 2.31 4.67 8.16 7.75 3.58 -0.55
Eisosomes 11.72 25.01 24.46 11.48 1.54 13.72 11.63 33.37 14.90 6.41 17.90 30.34 41.71 19.44 6.33
Endoplasmic Reticulum -3.93 -15.74 -3.09 0.91 13.44 -4.14 -14.36 -2.75 2.22 14.02 -5.76 -20.22 -4.71 1.93 18.59
Endosome -2.90 -13.39 -0.07 2.46 10.29 -7.10 -11.80 -5.45 5.38 11.00 -7.65 -15.60 -5.17 5.39 12.94
Golgi 3.33 -2.64 2.61 -0.09 5.17 -6.76 -12.55 -2.87 5.21 12.21 -4.73 -12.13 -0.43 4.28 11.83
Lipid Particles 6.12 -15.71 1.31 -2.44 15.72 -6.64 -12.89 -9.57 -0.34 11.42 -2.71 -20.41 -5.57 -2.53 18.36
Mitochondria -0.93 0.92 -1.47 0.02 -3.97 -1.72 6.21 -3.71 -0.91 -5.33 -1.75 1.86 -3.57 -0.86 -5.74
Mitotic Spindle 1.05 1.72 8.32 9.12 10.50 5.07 11.99 9.25 4.75 -9.56 4.44 6.46 12.31 9.83 9.85
None 12.85 14.97 16.02 10.76 6.05 5.88 6.45 12.88 6.41 0.21 13.76 17.99 20.00 10.39 2.33
Nuclear Periphery -5.78 -25.55 -4.76 2.43 24.22 -0.03 0.31 -10.41 -8.62 -7.17 -4.64 -24.53 -12.30 -5.71 20.69
Nuclear Periphery Foci -1.20 -15.19 -2.87 0.95 6.97 -1.07 -5.07 -0.70 1.03 4.97 -1.55 -13.30 -2.88 1.38 10.23
Nucleolus -1.02 -15.43 -7.43 0.82 1.80 -1.05 6.00 -4.14 0.91 -15.55 -1.40 -11.48 -9.13 1.17 1.56
Nucleus -0.85 -7.56 -0.03 0.82 1.69 -0.89 8.62 0.67 0.92 -9.22 -1.23 -5.47 0.12 1.24 2.51
Peroxisomes 5.82 -2.03 11.88 5.24 11.58 -8.65 -3.87 -10.36 0.48 -5.31 -1.48 -5.13 -0.49 1.00 4.66
Vacuole -5.24 -6.10 -2.57 -2.34 1.44 -1.69 -7.01 -4.09 -3.51 -0.24 -3.70 -6.49 -4.40 -3.89 2.40
Vacuole Periphery -1.57 -6.57 -1.68 -1.41 -1.22 -1.75 -1.31 -2.70 0.14 -2.34 -2.23 -6.27 -2.62 -1.28 -1.77
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
Localization
Cell Percentages cell periphery (28%), actin (10%), mixed (36%)
Cell Cycle Regulation No
Subcompartmental Group N/A

YGR130C

YGR130C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ygr130c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available