Standard name
Human Ortholog
Description Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 – 0 0 0 0 0.05 0.07 0.13 0.07 0.06 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.07 0 0 0 0 0 – 0.07 0.06 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0
Nucleus 0.58 0.65 0.66 0.95 0.97 0.9 0.89 – 0.82 0.87 0.82 0.83 0.72 0.82 0.74 0.68 0.63 0.69 0.41 0.5 0.49 0.71 0.57 0.39
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.5 0.36 0.37 0.07 0 0.06 0.06 – 0.18 0.1 0.14 0.19 0.29 0.17 0.14 0.26 0.25 0.18 0.51 0.4 0.45 0.19 0.21 0.25
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0.07 0.09 0.05 0 0 0.05 0.17 0.27
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 1 0 0 0 – 2 0 1 0 0 0 0 0 0 0 3 2 3 3 3 3
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 1 0 0 0 – 0 2 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 4 5 1 3 7 10 – 8 7 7 3 12 22 46 17 12 17 0 2 0 3 2 3
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 2 2 4 9 0 0 0 0 0 1
Endosome 1 1 1 0 0 0 2 – 0 0 2 0 2 0 4 1 3 5 0 3 2 3 0 3
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 1 0 1 1 1 0
Mitochondria 1 15 1 0 0 0 3 – 18 17 8 10 0 0 0 11 10 6 0 1 0 0 0 5
Nucleus 120 138 149 186 250 207 244 – 213 265 211 257 177 257 260 161 132 188 92 116 135 193 193 134
Nuclear Periphery 0 0 2 1 6 1 2 – 1 1 0 5 0 0 1 3 1 1 0 0 1 1 2 5
Nucleolus 104 76 85 13 3 13 16 – 46 32 37 60 72 52 48 61 52 49 114 93 123 53 71 86
Peroxisomes 1 0 0 0 0 0 0 – 0 0 0 0 1 0 1 0 0 1 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 1 0 – 1 1 1 1 1 2 4 0 0 1 1 1 1 0 4 1
Vac/Vac Membrane 7 3 4 1 1 7 6 – 3 5 9 4 3 7 11 14 15 26 10 8 4 13 56 94
Unique Cell Count 206 211 227 196 257 230 273 260 305 257 311 245 313 352 236 211 274 226 233 275 274 339 346
Labelled Cell Count 236 237 247 204 264 236 283 293 330 277 340 268 340 377 270 229 304 226 233 275 274 339 346


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.0 9.5 12.7 12.6 11.1 9.8 9.2 – 8.2 8.3 8.9 8.7 13.6 12.5 11.9 10.9 14.2 14.1 13.7 13.5 13.4
Std Deviation (1e-4) 2.7 2.0 2.9 2.4 2.4 2.1 1.9 – 1.9 2.0 2.1 2.0 3.4 3.4 3.7 3.2 4.6 4.5 3.2 2.7 2.8
Intensity Change (Log2) – – – -0.01 -0.2 -0.37 -0.47 – -0.64 -0.61 -0.51 -0.55 0.1 -0.03 -0.1 -0.23 0.16 0.15 0.11 0.09 0.08


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.6 1.0 – 0.6 0.1 0.4 0 1.6 2.5 4.5 2.5 1.9 2.2
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 3.7 3.2 0 0 0 0 0 2.9 2.9 0
Nucleus 7.4 9.1 6.3 6.4 – 4.1 5.8 4.1 4.5 1.6 4.4 2.1 0.6 -0.7 0.7
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus -7.5 -10.3 -8.3 -8.8 – -4.9 -7.4 -5.8 -4.7 -1.9 -5.5 -6.6 -2.7 -2.9 -4.9
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0.9 0 – 0 0 1.2 0 0 0 1.0 2.3 2.7 3.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.9038 8.2944 7.829 6.9196 6.2197 7.9171 10.4508 11.6365 11.665 10.6424 11.0061 11.348 7.9769 9.7598 9.3119 8.556 7.5994 8.8657
Actin 0.0068 0.0033 0.0081 0.0026 0.0227 0.0006 0.0095 0.0004 0.0045 0 0 0.0028 0.0412 0.0036 0.0007 0.0735 0.013 0
Bud 0.0003 0.0001 0.0005 0.0001 0.0002 0.0001 0.0007 0.0002 0.0002 0.0001 0 0.0001 0.0006 0.0003 0 0.0004 0.0003 0.0001
Bud Neck 0.0006 0.0003 0.0017 0.0002 0.0007 0.0007 0.0008 0.0004 0.0004 0.0003 0.0003 0.0007 0.0012 0.0003 0.0002 0.0003 0.0006 0.0006
Bud Periphery 0.0005 0.0001 0.001 0.0001 0.0005 0.0002 0.0016 0.0003 0.0003 0.0001 0.0001 0.0002 0.0009 0.0004 0.0001 0.0004 0.0004 0.0001
Bud Site 0.0012 0.0009 0.0074 0.0001 0.0005 0.0001 0.0016 0.0005 0.0007 0.0002 0.0001 0.0002 0.0043 0.0055 0.0002 0.0007 0.0009 0.0001
Cell Periphery 0.0004 0.0002 0.0004 0 0.0002 0.0001 0.0005 0.0001 0.0002 0.0001 0 0.0001 0.0003 0.0003 0.0001 0.0001 0.0002 0.0001
Cytoplasm 0.0097 0.0053 0.0019 0.0003 0.0031 0.0003 0.01 0.0006 0.0058 0.0001 0 0.0004 0.0059 0.0001 0.0011 0.0002 0.0056 0
Cytoplasmic Foci 0.0183 0.0006 0.0027 0.0088 0.0039 0.0052 0.0225 0.0011 0.0067 0.0181 0 0.0019 0.0103 0.0001 0.0095 0.0009 0.0023 0
Eisosomes 0.0003 0 0.0001 0 0.0002 0 0.0004 0 0.0001 0 0 0 0.0005 0.0001 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.0034 0.0006 0.0005 0.0001 0.0136 0 0.0073 0.0002 0.0052 0 0 0.0002 0.0028 0 0.0002 0.0003 0.0095 0
Endosome 0.0114 0.0005 0.0034 0.0026 0.0254 0.0012 0.0125 0.0024 0.0108 0.0003 0 0.0043 0.01 0.0002 0.0025 0.0013 0.0115 0
Golgi 0.0029 0.0012 0.0021 0.0021 0.0051 0.0004 0.003 0.0008 0.0042 0.0003 0 0.0037 0.0154 0.0002 0.0005 0.0024 0.0018 0
Lipid Particles 0.0055 0.0001 0.0021 0.0359 0.0094 0.0013 0.0043 0.0007 0.0018 0.0245 0 0.0023 0.0126 0.0002 0.0012 0.0005 0.0019 0.0001
Mitochondria 0.0084 0.0004 0.0134 0.0048 0.0056 0.0002 0.0073 0.0009 0.0078 0.0002 0.0002 0.0015 0.0283 0.0028 0.0002 0.0014 0.0022 0.0001
None 0.0066 0.0003 0.0019 0.0006 0.0017 0.0002 0.0168 0.0001 0.0056 0 0 0.0002 0.0015 0.0001 0.0021 0.0002 0.0053 0
Nuclear Periphery 0.0125 0.0008 0.0078 0.0013 0.0389 0.0009 0.0346 0.0028 0.0018 0.0004 0.0008 0.0022 0.0122 0.0008 0.0006 0.0005 0.0134 0.0002
Nucleolus 0.3299 0.2673 0.375 0.2752 0.2398 0.4227 0.3625 0.3787 0.4596 0.3754 0.2679 0.4661 0.2987 0.3366 0.5059 0.4252 0.3353 0.4396
Nucleus 0.5651 0.7164 0.5499 0.6509 0.6057 0.554 0.4617 0.6004 0.4712 0.5771 0.7295 0.5062 0.5309 0.6441 0.466 0.4901 0.5905 0.558
Peroxisomes 0.0026 0.0001 0.0046 0.0114 0.0026 0.0032 0.0086 0.0002 0.0006 0.0005 0 0.0006 0.0148 0.0005 0.0052 0.0008 0.0006 0
Punctate Nuclear 0.008 0.0006 0.0101 0.0021 0.0129 0.0081 0.0251 0.0071 0.009 0.002 0.0005 0.0056 0.0029 0.0003 0.0036 0.0005 0.0028 0.0008
Vacuole 0.0031 0.0006 0.003 0.0002 0.0041 0.0004 0.0046 0.0015 0.0028 0.0003 0.0003 0.0004 0.0028 0.0022 0.0002 0.0002 0.0009 0.0001
Vacuole Periphery 0.0025 0.0004 0.0022 0.0005 0.0031 0.0002 0.0039 0.0005 0.0008 0.0001 0.0001 0.0002 0.002 0.0013 0.0001 0.0002 0.001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 46.9059 55.908 46.4249 39.3314 41.509 29.765 38.6951 33.1567 32.7183 41.6417
Translational Efficiency 1.6439 1.3717 1.4006 1.4725 1.4544 1.9999 1.4147 1.6576 1.5181 1.5039

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1546 162 2209 747 1683 2017 2321 953 3229 2179 4530 1700

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 962.00 1340.68 1324.52 1427.70 1059.09 1238.99 1416.79 1412.59 1012.60 1246.55 1371.80 1419.23
Standard Deviation 160.28 285.26 214.80 261.39 170.54 213.50 228.84 298.41 172.66 221.26 226.84 282.84
Intensity Change Log 2 — 0.478856 0.461361 0.569584 — 0.226339 0.419801 0.415518 — 0.352053 0.439732 0.490905

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000287 0.000754 0.000556 0.002004 0.000297 0.000311 0.000419 0.000698 0.000293 0.000344 0.000486 0.001272
Bud Neck 0.003317 0.020054 0.018529 0.041302 0.003999 0.003986 0.012821 0.016550 0.003672 0.005180 0.015605 0.027426
Bud Site 0.000434 0.001245 0.001050 0.009525 0.000376 0.000545 0.000648 0.001351 0.000404 0.000597 0.000844 0.004942
Cell Periphery 0.000080 0.000077 0.000038 0.000359 0.000030 0.000055 0.000026 0.000067 0.000054 0.000056 0.000032 0.000196
Cytoplasm 0.000685 0.000291 0.000284 0.003134 0.000153 0.001081 0.000123 0.001328 0.000408 0.001023 0.000201 0.002122
Cytoplasmic Foci 0.000099 0.000082 0.000030 0.004989 0.000211 0.000463 0.000106 0.001895 0.000157 0.000435 0.000069 0.003254
Eisosomes 0.000042 0.000049 0.000052 0.000057 0.000047 0.000060 0.000068 0.000061 0.000045 0.000059 0.000060 0.000059
Endoplasmic Reticulum 0.001459 0.001468 0.000868 0.002063 0.001307 0.001019 0.000623 0.000861 0.001379 0.001052 0.000742 0.001390
Endosome 0.000231 0.000129 0.000082 0.006434 0.000132 0.000485 0.000239 0.001969 0.000180 0.000459 0.000162 0.003931
Golgi 0.000174 0.000095 0.000143 0.006319 0.000156 0.000249 0.000128 0.003388 0.000165 0.000237 0.000135 0.004676
Lipid Particles 0.000033 0.000024 0.000014 0.001676 0.000026 0.000504 0.000016 0.000072 0.000029 0.000469 0.000015 0.000777
Mitochondria 0.000450 0.001594 0.001197 0.008544 0.000521 0.001128 0.000889 0.002365 0.000487 0.001162 0.001039 0.005080
Mitotic Spindle 0.000659 0.000453 0.001227 0.032621 0.000145 0.002013 0.001081 0.005583 0.000391 0.001897 0.001152 0.017464
None 0.002928 0.000952 0.001698 0.002730 0.000710 0.000901 0.000531 0.002943 0.001772 0.000905 0.001100 0.002849
Nuclear Periphery 0.000198 0.000239 0.000554 0.004015 0.000107 0.000178 0.000148 0.000465 0.000151 0.000182 0.000346 0.002025
Nuclear Periphery Foci 0.000863 0.000087 0.000174 0.002512 0.000442 0.000616 0.000058 0.001460 0.000644 0.000576 0.000115 0.001922
Nucleolus 0.397048* 0.293162* 0.308658* 0.310059* 0.301314* 0.354159* 0.397208* 0.371544* 0.347150* 0.349624* 0.354028* 0.344527*
Nucleus 0.589467* 0.676036* 0.662236* 0.535099* 0.687660* 0.629709* 0.582296* 0.580286* 0.640647* 0.633153* 0.621278* 0.560430*
Peroxisomes 0.001022 0.002232 0.001462 0.002422 0.001190 0.001297 0.001762 0.002112 0.001110 0.001367 0.001616 0.002248
Vacuole 0.000307 0.000502 0.000386 0.012759 0.000593 0.000620 0.000367 0.002886 0.000456 0.000611 0.000376 0.007225
Vacuole Periphery 0.000217 0.000474 0.000764 0.011375 0.000583 0.000621 0.000443 0.002116 0.000408 0.000610 0.000599 0.006184

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.93 -14.52 -3.82 -2.56 -2.93 -0.63 -8.16 -14.20 -12.85 -9.54 -2.40 -16.38 -5.38 -5.07 -3.94
Bud Neck -5.07 -23.96 -18.85 -7.37 -12.10 -0.12 -18.28 -12.76 -12.65 -4.45 -4.34 -29.95 -21.87 -20.27 -11.90
Bud Site -2.87 -8.68 -5.95 -5.13 -5.33 -0.83 -2.71 -6.91 -6.23 -5.68 -1.37 -7.04 -7.09 -6.73 -6.12
Cell Periphery -0.09 1.29 -2.02 -1.96 -2.50 -1.29 0.34 -3.36 -0.95 -4.47 -0.14 1.32 -2.46 -2.38 -3.06
Cytoplasm -0.34 1.16 -3.05 -2.63 -3.40 -1.62 -0.58 -2.89 -1.37 -2.79 -1.20 0.86 -4.13 -2.66 -4.39
Cytoplasmic Foci 0.49 1.79 -3.08 -3.11 -3.19 -0.83 0.69 -2.45 -1.96 -2.91 -1.22 1.04 -3.95 -3.12 -4.32
Eisosomes -1.57 -4.58 -3.16 -0.90 -0.90 -3.93 -4.12 -2.26 0.62 1.68 -6.02 -5.42 -3.72 1.01 0.84
Endoplasmic Reticulum -0.10 3.32 -1.84 -1.67 -3.63 1.87 3.85 1.91 0.09 -2.92 2.85 5.06 -0.53 -2.82 -4.49
Endosome 1.46 2.56 -4.04 -4.18 -4.26 -2.36 -0.56 -2.88 -2.13 -2.61 -2.01 0.31 -4.92 -4.12 -4.92
Golgi 2.03 0.41 -2.34 -2.41 -2.36 -1.07 0.63 -2.41 -2.32 -2.43 -0.88 0.73 -3.36 -3.26 -3.38
Lipid Particles 1.17 2.01 -1.73 -1.75 -1.76 -1.77 0.69 -3.05 1.54 -3.42 -1.75 1.78 -1.87 -0.04 -1.91
Mitochondria -5.42 -14.75 -6.38 -4.94 -5.37 -1.71 -4.26 -3.90 -2.25 -2.99 -2.12 -10.81 -7.45 -5.21 -6.06
Mitotic Spindle 0.34 -2.25 -6.84 -6.86 -6.62 -3.05 -2.08 -4.32 -3.54 -3.83 -2.51 -3.07 -8.03 -7.36 -7.58
None 1.48 1.41 -0.02 -2.04 -2.17 -0.95 0.92 -3.01 -2.72 -3.14 2.05 1.50 -2.16 -4.11 -3.64
Nuclear Periphery -1.01 -1.22 -3.86 -3.72 -3.17 -1.13 -1.19 -4.30 -3.77 -4.03 -0.68 -1.44 -4.69 -4.57 -3.79
Nuclear Periphery Foci 3.72 3.25 -1.27 -3.10 -2.93 -0.69 2.74 -1.34 -1.11 -1.88 0.49 4.21 -1.75 -1.91 -3.01
Nucleolus 4.69 10.83 11.79 1.35 3.83 -6.37 -10.05 -3.28 1.09 3.92 -0.26 0.27 5.09 4.97 4.90
Nucleus -3.81 -8.60 0.54 3.81 6.46 6.98 11.68 7.54 2.76 -0.82 1.01 2.45 5.61 4.49 3.92
Peroxisomes -2.45 -5.32 -6.19 -0.23 -3.62 -0.76 -4.36 -4.75 -4.50 -1.35 -2.37 -6.52 -7.84 -5.43 -3.66
Vacuole -1.29 -0.91 -6.55 -6.48 -6.49 -0.01 0.61 -3.13 -3.19 -3.45 -0.59 0.08 -7.22 -7.07 -7.27
Vacuole Periphery -5.02 -1.30 -3.60 -3.44 -3.23 -0.13 0.47 -2.62 -2.86 -3.29 -1.18 -0.73 -4.34 -4.09 -4.07
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
Localization
Cell Percentages nucleus (46%), nucleolus (24%), mixed (30%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ski6

Ski6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ski6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available