Standard name | |
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Human Ortholog | |
Description | Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 |
Bud | 0 | 0 | 2 | 1 | 2 | 2 | 2 | 5 | 10 | 9 | 12 | 9 | 1 | 0 | 0 | 0 | 0 | 0 | 10 | 1 | 0 | 8 | 22 | 17 |
Bud Neck | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 4 | 4 |
Bud Site | 0 | 0 | 0 | 0 | 2 | 5 | 5 | 12 | 17 | 12 | 11 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 50 | 9 | 36 | 68 | 49 | 34 | 48 | 50 | 20 | 33 | 14 | 25 | 22 | 37 | 50 | 37 | 31 | 31 | 36 | 8 | 26 | 11 | 19 | 7 |
Endoplasmic Reticulum | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 9 | 2 | 4 | 1 | 0 | 4 | 0 | 0 | 2 |
Endosome | 17 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 4 | 2 | 7 | 4 | 2 | 0 | 0 | 0 | 4 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 4 |
Mitochondria | 18 | 23 | 81 | 131 | 125 | 218 | 311 | 341 | 277 | 344 | 193 | 245 | 2 | 7 | 35 | 10 | 7 | 8 | 3 | 1 | 5 | 1 | 1 | 3 |
Nucleus | 268 | 36 | 104 | 75 | 198 | 270 | 356 | 407 | 306 | 342 | 204 | 258 | 105 | 205 | 213 | 114 | 76 | 102 | 302 | 66 | 115 | 53 | 99 | 121 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 3 | 1 | 4 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 7 | 1 | 0 | 0 | 0 | 3 | 6 | 10 | 7 | 10 | 3 | 5 | 0 | 1 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 2 | 1 | 1 | 0 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 8 | 1 | 4 | 2 | 4 | 7 |
Vac/Vac Membrane | 116 | 10 | 16 | 15 | 42 | 30 | 22 | 21 | 13 | 14 | 10 | 13 | 17 | 20 | 18 | 42 | 23 | 34 | 153 | 18 | 65 | 28 | 38 | 60 |
Unique Cell Count | 423 | 62 | 202 | 220 | 342 | 404 | 539 | 620 | 441 | 526 | 298 | 366 | 140 | 262 | 281 | 194 | 130 | 168 | 533 | 102 | 234 | 109 | 200 | 244 |
Labelled Cell Count | 477 | 79 | 242 | 293 | 419 | 566 | 752 | 850 | 655 | 766 | 451 | 576 | 149 | 274 | 322 | 221 | 144 | 190 | 533 | 102 | 234 | 109 | 200 | 244 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.1 | 4.3 | 3.8 | 3.7 | 4.2 | 4.0 | 3.9 | 4.1 | 3.9 | 3.9 | 3.8 | 3.8 | 5.6 | 5.6 | 4.7 | 6.8 | 7.6 | 7.7 | 5.3 | 6.1 | 7.2 |
Std Deviation (1e-4) | 0.7 | 0.6 | 0.7 | 0.9 | 1.0 | 1.0 | 1.0 | 1.1 | 1.0 | 1.1 | 0.8 | 1.1 | 1.4 | 1.3 | 1.1 | 1.6 | 2.1 | 2.1 | 1.4 | 2.0 | 2.0 |
Intensity Change (Log2) | – | – | – | -0.05 | 0.13 | 0.07 | 0.03 | 0.09 | 0.02 | 0.04 | 0.0 | -0.02 | 0.55 | 0.54 | 0.3 | 0.82 | 0.98 | 0.99 | 0.47 | 0.67 | 0.91 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 3.9 | 2.7 | 3.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.8242 | 1.7768 | 1.5432 | 1.2256 | 1.1846 | 1.6888 | 1.9337 | 2.2326 | 2.1921 | 1.8085 | 2.1246 | 2.168 | -0.1296 | 1.0557 | 0.5515 | 1.2266 | 0.5875 | 0.7079 |
Actin | 0.0006 | 0.0003 | 0.0007 | 0.0005 | 0.0014 | 0.0002 | 0.0256 | 0.0011 | 0.0122 | 0.0005 | 0.008 | 0.0018 | 0.0004 | 0.0018 | 0.0005 | 0.0006 | 0.0017 | 0.0003 |
Bud | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0008 | 0.0002 | 0.0004 | 0.0001 | 0.0006 | 0.0002 | 0.0024 | 0.0216 | 0.0001 | 0.0001 | 0.0002 | 0.0002 |
Bud Neck | 0.0012 | 0.0005 | 0.0016 | 0.0016 | 0.0025 | 0.007 | 0.0024 | 0.0007 | 0.0026 | 0.0008 | 0.0021 | 0.0098 | 0.0007 | 0.001 | 0.0015 | 0.0007 | 0.0045 | 0.0075 |
Bud Periphery | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0012 | 0.0001 | 0.0005 | 0.0001 | 0.0007 | 0.0003 | 0.0011 | 0.0127 | 0.0001 | 0.0001 | 0.0002 | 0.0002 |
Bud Site | 0.0013 | 0.0026 | 0.0018 | 0.0011 | 0.0014 | 0.0003 | 0.0144 | 0.0021 | 0.0081 | 0.0003 | 0.0027 | 0.0004 | 0.0024 | 0.0112 | 0.001 | 0.0005 | 0.0014 | 0.0007 |
Cell Periphery | 0.0003 | 0.0004 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0006 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0003 | 0.0009 | 0.0002 | 0.0002 | 0.0002 | 0.0002 |
Cytoplasm | 0.3713 | 0.3849 | 0.3012 | 0.339 | 0.2173 | 0.232 | 0.1176 | 0.1876 | 0.11 | 0.077 | 0.0807 | 0.0769 | 0.3694 | 0.1936 | 0.3131 | 0.2674 | 0.1227 | 0.1903 |
Cytoplasmic Foci | 0.0052 | 0.0022 | 0.0056 | 0.0124 | 0.0153 | 0.0017 | 0.0449 | 0.0018 | 0.006 | 0.0113 | 0.0404 | 0.004 | 0.0145 | 0.0024 | 0.0041 | 0.0025 | 0.0043 | 0.0049 |
Eisosomes | 0.0001 | 0.0001 | 0 | 0 | 0.0003 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0179 | 0.0081 | 0.0088 | 0.0093 | 0.0095 | 0.0026 | 0.0047 | 0.0045 | 0.0051 | 0.0024 | 0.0051 | 0.0031 | 0.0089 | 0.0068 | 0.0097 | 0.0051 | 0.008 | 0.0031 |
Endosome | 0.0074 | 0.002 | 0.0042 | 0.014 | 0.0274 | 0.0013 | 0.0287 | 0.0059 | 0.0151 | 0.0128 | 0.0794 | 0.0116 | 0.0043 | 0.0034 | 0.0035 | 0.0017 | 0.003 | 0.0022 |
Golgi | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0006 | 0 | 0.0116 | 0.0003 | 0.0122 | 0.0096 | 0.0342 | 0.0052 | 0.0002 | 0.0008 | 0.0001 | 0.0001 | 0.0002 | 0.0001 |
Lipid Particles | 0.0011 | 0.0004 | 0.0004 | 0.0009 | 0.0044 | 0.0002 | 0.0259 | 0.0007 | 0.009 | 0.01 | 0.031 | 0.002 | 0.0007 | 0.0003 | 0.0007 | 0.0002 | 0.0006 | 0.0006 |
Mitochondria | 0.0006 | 0.0002 | 0.0007 | 0.0005 | 0.0014 | 0.0003 | 0.0146 | 0.0017 | 0.0173 | 0.0222 | 0.0486 | 0.0094 | 0.0005 | 0.0033 | 0.0007 | 0.0006 | 0.0008 | 0.0004 |
None | 0.2118 | 0.1928 | 0.082 | 0.1368 | 0.249 | 0.074 | 0.0358 | 0.0697 | 0.0347 | 0.078 | 0.07 | 0.0231 | 0.3252 | 0.1986 | 0.2012 | 0.3637 | 0.3467 | 0.2025 |
Nuclear Periphery | 0.0222 | 0.008 | 0.0162 | 0.0207 | 0.0164 | 0.0049 | 0.0306 | 0.0187 | 0.0145 | 0.0271 | 0.0093 | 0.0143 | 0.0149 | 0.0079 | 0.0148 | 0.0107 | 0.0083 | 0.0061 |
Nucleolus | 0.0038 | 0.0017 | 0.0034 | 0.0024 | 0.0125 | 0.0051 | 0.0043 | 0.002 | 0.0034 | 0.0027 | 0.002 | 0.0052 | 0.0033 | 0.0035 | 0.0018 | 0.0017 | 0.0062 | 0.0029 |
Nucleus | 0.3355 | 0.3876 | 0.5597 | 0.439 | 0.4011 | 0.6572 | 0.5969 | 0.6901 | 0.7171 | 0.7254 | 0.5607 | 0.8071 | 0.2209 | 0.5179 | 0.4337 | 0.3333 | 0.4711 | 0.5495 |
Peroxisomes | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0007 | 0 | 0.0141 | 0.0002 | 0.0099 | 0.0061 | 0.0097 | 0.0005 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0001 |
Punctate Nuclear | 0.0117 | 0.0048 | 0.0094 | 0.0144 | 0.0315 | 0.0111 | 0.017 | 0.008 | 0.0148 | 0.0116 | 0.0106 | 0.0223 | 0.0225 | 0.0058 | 0.0102 | 0.0089 | 0.0161 | 0.0259 |
Vacuole | 0.0066 | 0.003 | 0.003 | 0.0064 | 0.0062 | 0.0016 | 0.0062 | 0.0027 | 0.006 | 0.0012 | 0.0027 | 0.0021 | 0.0069 | 0.0057 | 0.0026 | 0.0016 | 0.0029 | 0.0022 |
Vacuole Periphery | 0.0005 | 0.0001 | 0.0003 | 0.0004 | 0.0006 | 0.0001 | 0.0019 | 0.0016 | 0.0008 | 0.0006 | 0.0012 | 0.0007 | 0.0004 | 0.0006 | 0.0003 | 0.0002 | 0.0003 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 31.976 | 30.6761 | 31.2474 | 50.3643 | 33.571 | 24.6312 | 39.4052 | 41.9634 | 43.9581 | 55.0303 |
Translational Efficiency | 0.6131 | 0.5252 | 0.7765 | 0.4831 | 0.5315 | 0.6805 | 0.6275 | 0.4967 | 0.5614 | 0.499 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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