Standard name
Human Ortholog
Description Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0.05 0 0.06 0.12 0 0 0
Bud 0 0 0 0 0 0 0 0 0.05 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.78 0.67 0.83 0.85 0.89 0.7 0.51 0.42 0.3 0.26 0.22 0.17 0.85 0.8 0.76 0.16 0.26 0.22 0.25 0.46 0.2 0.61 0.63 0.55
Endoplasmic Reticulum 0 0.23 0 0 0 0 0 0 0 0 0 0 0.11 0.07 0.11 0 0.1 0.05 0.32 0.2 0.3 0.12 0.1 0.1
Endosome 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.51 0.41 0.5 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.25 0.12 0 0.13 0.12 0.37 0.57 0.61 0.74 0.78 0.85 0.88 0 0 0 0.08 0.11 0.16 0.24 0.14 0.19 0.12 0.09 0.12
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.2 0.15 0.15 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.05 0.06 0.06 0.08 0.07 0.08 0 0 0 0.12 0.09 0.1 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 5 2 1 0 0 0 0 0 0 0 0 4 12 1 4 2 6 10 10 40 5 11 23
Bud 5 2 3 12 6 13 23 18 27 31 20 20 1 1 0 1 2 2 3 0 4 2 5 10
Bud Neck 0 1 3 0 0 1 1 0 1 0 0 0 5 7 2 0 2 0 5 3 6 6 5 13
Bud Site 1 0 0 1 0 0 1 3 5 16 2 8 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 4 4 3 2 2 1 0 1 0 0 0 4 3 0 1 0 3 0 5 9 12 17
Cytoplasm 158 101 226 236 376 299 333 272 162 166 84 80 247 321 288 8 21 24 62 81 65 198 273 294
Endoplasmic Reticulum 1 34 4 1 1 7 3 2 3 1 1 6 32 27 40 1 8 6 79 35 101 38 42 50
Endosome 3 1 20 10 11 16 23 19 14 6 2 4 5 19 28 25 34 55 5 6 14 3 10 18
Golgi 0 0 1 0 0 1 0 0 0 0 0 0 0 1 1 1 1 3 1 1 6 0 1 0
Mitochondria 51 18 7 36 52 159 369 397 402 500 318 413 1 1 0 4 9 18 60 24 64 38 40 62
Nucleus 1 0 0 0 2 4 4 4 2 4 5 8 3 0 1 1 0 0 0 0 0 0 0 0
Nuclear Periphery 0 1 0 0 0 3 3 2 1 1 2 5 0 0 0 0 0 0 0 0 1 0 0 1
Nucleolus 3 0 0 0 0 1 4 2 1 2 3 3 0 0 0 0 1 2 0 0 0 0 0 0
Peroxisomes 0 0 9 11 4 2 1 0 3 3 0 3 0 4 0 0 0 0 0 1 4 0 1 0
SpindlePole 0 1 10 7 4 5 8 21 6 16 5 11 4 13 29 10 12 17 2 2 2 3 5 7
Vac/Vac Membrane 4 0 6 4 4 12 30 40 30 51 28 37 1 11 5 6 7 11 10 6 9 12 14 22
Unique Cell Count 203 150 271 279 424 428 649 647 540 641 374 471 290 401 380 49 82 110 251 179 335 328 431 533
Labelled Cell Count 228 165 295 323 463 525 805 781 657 798 470 598 303 421 398 61 100 144 251 179 335 328 431 533


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 4.6 4.8 4.4 4.3 3.9 3.6 3.9 3.6 3.6 3.4 3.5 5.7 5.7 5.6 6.9 6.5 6.4 5.8 5.9 6.2
Std Deviation (1e-4) 0.6 0.7 1.4 2.0 1.6 1.7 1.4 1.6 1.2 0.9 1.3 1.3 0.9 1.1 1.0 1.4 1.3 1.2 1.1 1.2 1.3
Intensity Change (Log2) – – – -0.11 -0.15 -0.31 -0.4 -0.3 -0.42 -0.43 -0.51 -0.45 0.25 0.26 0.22 0.52 0.44 0.42 0.29 0.3 0.37


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.3478 2.7268 2.4717 2.5252 1.9419 2.7515 -0.1352 0.0177 -0.0088 -0.6801 -0.83 -0.3719 -1.2679 -0.8568 -1.1226 -1.1347 -0.7471 -1.15
Actin 0.0171 0.0027 0.0143 0.0012 0.0042 0.003 0.05 0.0026 0.0065 0.0012 0.0136 0.0122 0.0352 0.0005 0.0063 0.0057 0.0529 0.0059
Bud 0.0003 0.0003 0.0019 0.0004 0.0004 0.0001 0.0068 0.0028 0.001 0.0001 0.0006 0.0008 0.0011 0.0003 0.0002 0.0004 0.0005 0.0002
Bud Neck 0.002 0.0003 0.0092 0.0007 0.0003 0.0011 0.0066 0.0006 0.0048 0.0004 0.004 0.0026 0.0075 0.0004 0.0031 0.0056 0.0032 0.0084
Bud Periphery 0.0012 0.0006 0.0048 0.001 0.0009 0.0003 0.0056 0.0013 0.0009 0.0001 0.0016 0.0017 0.0012 0.0004 0.0002 0.0006 0.0011 0.0003
Bud Site 0.0044 0.0035 0.0086 0.0016 0.0006 0.0005 0.0124 0.0162 0.0079 0.0003 0.0008 0.0018 0.0089 0.0038 0.0015 0.0025 0.0014 0.0002
Cell Periphery 0.0034 0.0018 0.0048 0.0009 0.0004 0.0007 0.0016 0.001 0.0005 0.0002 0.0002 0.0003 0.0011 0.0005 0.0007 0.0002 0.0004 0.0009
Cytoplasm 0.1263 0.2195 0.2232 0.1758 0.1673 0.2037 0.1661 0.4049 0.3729 0.4613 0.379 0.4669 0.1644 0.2275 0.2915 0.3423 0.1949 0.283
Cytoplasmic Foci 0.0545 0.0415 0.0447 0.0738 0.0324 0.0412 0.0693 0.069 0.0623 0.0346 0.0907 0.0541 0.1181 0.0793 0.0702 0.0973 0.1205 0.0662
Eisosomes 0.0041 0.0007 0.001 0.0004 0.0003 0.0003 0.0005 0.0002 0.0001 0.0001 0.0003 0.0002 0.0007 0.0003 0.0003 0.0002 0.0004 0.0001
Endoplasmic Reticulum 0.0094 0.0096 0.0153 0.005 0.0032 0.0083 0.0149 0.0287 0.0203 0.0164 0.0081 0.0139 0.0127 0.0132 0.0183 0.0211 0.0095 0.0131
Endosome 0.0251 0.0479 0.0325 0.0256 0.0128 0.0218 0.0559 0.055 0.0572 0.039 0.099 0.0336 0.0455 0.064 0.0533 0.0177 0.0905 0.0337
Golgi 0.0044 0.0033 0.0032 0.0031 0.0028 0.0017 0.0157 0.0027 0.0086 0.0027 0.009 0.0027 0.007 0.0029 0.0034 0.0031 0.0222 0.003
Lipid Particles 0.0278 0.0308 0.0267 0.0149 0.0104 0.0217 0.0337 0.0228 0.0196 0.017 0.0259 0.0161 0.0274 0.0294 0.0135 0.0123 0.028 0.0157
Mitochondria 0.0064 0.0016 0.0022 0.0009 0.0074 0.0007 0.0196 0.001 0.0058 0.0032 0.0367 0.0021 0.0097 0.0003 0.0008 0.0017 0.0041 0.0081
None 0.6885 0.6227 0.5903 0.679 0.7318 0.6775 0.491 0.3697 0.3936 0.3756 0.3156 0.3744 0.5263 0.5654 0.5151 0.4665 0.4464 0.5472
Nuclear Periphery 0.0035 0.0019 0.0027 0.0016 0.0006 0.0015 0.0052 0.0043 0.006 0.0081 0.0027 0.0025 0.0058 0.0017 0.0037 0.0032 0.0049 0.0023
Nucleolus 0.002 0.0009 0.0009 0.0006 0.0002 0.0004 0.0026 0.0013 0.0013 0.0002 0.0002 0.0005 0.0011 0.0003 0.0004 0.0004 0.0006 0.0003
Nucleus 0.0024 0.0012 0.0015 0.0011 0.0008 0.001 0.0026 0.0024 0.0051 0.0019 0.0011 0.003 0.0034 0.001 0.0016 0.0014 0.0018 0.0012
Peroxisomes 0.0043 0.0009 0.0037 0.0041 0.0202 0.0053 0.0171 0.0015 0.0136 0.0258 0.0018 0.0021 0.0076 0.0012 0.0057 0.0133 0.0035 0.0023
Punctate Nuclear 0.0039 0.003 0.0028 0.0045 0.0011 0.0065 0.0053 0.0034 0.0056 0.0026 0.0047 0.0047 0.0099 0.0026 0.0047 0.0028 0.007 0.004
Vacuole 0.0081 0.0048 0.0054 0.0035 0.0016 0.0025 0.0129 0.0082 0.005 0.0067 0.0029 0.0031 0.0047 0.0046 0.005 0.0016 0.0051 0.0034
Vacuole Periphery 0.0008 0.0005 0.0006 0.0003 0.0002 0.0002 0.0046 0.0005 0.0012 0.0025 0.0016 0.0006 0.0008 0.0003 0.0005 0.0003 0.0011 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.1925 4.6418 4.0185 8.4359 5.0492 7.7844 5.4755 7.1272 9.3698 9.524
Translational Efficiency 1.4771 1.3564 1.6893 0.7607 0.9935 1.0384 0.9038 0.8388 0.7188 0.6598

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1592 1127 1628 178 2307 2273 202 1166 3899 3400 1830 1344

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 648.29 736.13 912.50 926.31 706.88 745.48 1010.34 817.29 682.96 742.38 923.30 831.73
Standard Deviation 75.48 90.15 111.49 107.47 78.69 100.09 111.76 111.78 82.58 97.01 115.65 117.20
Intensity Change Log 2 — 0.183321 0.493185 0.514856 — 0.076704 0.515304 0.209383 — 0.128692 0.504765 0.363595

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001218 0.002257 0.000792 0.013660 0.000973 0.000571 0.012756 0.010372 0.001073 0.001130 0.002113 0.010807
Bud Neck 0.026778 0.025197 0.006197 0.005816 0.020329 0.027462 0.004572 0.018980 0.022962 0.026711 0.006018 0.017237
Bud Site 0.007779 0.010638 0.008283 0.018682 0.009989 0.010871 0.012296 0.036471 0.009087 0.010794 0.008726 0.034115
Cell Periphery 0.000510 0.000333 0.000603 0.000868 0.000762 0.000255 0.000834 0.000309 0.000659 0.000281 0.000628 0.000383
Cytoplasm 0.307245* 0.200151* 0.449662* 0.218471* 0.352069* 0.280946* 0.190441* 0.313780* 0.333767* 0.254164* 0.421048* 0.301157*
Cytoplasmic Foci 0.334681* 0.380297* 0.051478 0.112698 0.220255* 0.266465* 0.152076 0.151031 0.266976* 0.304197* 0.062582 0.145955
Eisosomes 0.001728 0.000590 0.000153 0.000498 0.001873 0.000346 0.000510 0.000227 0.001813 0.000427 0.000192 0.000263
Endoplasmic Reticulum 0.013298 0.011601 0.029173 0.028033 0.025344 0.006190 0.040472 0.005295 0.020426 0.007983 0.030420 0.008307
Endosome 0.029032 0.069839 0.008885 0.029485 0.024134 0.062599 0.043837 0.047526 0.026134 0.064999 0.012743 0.045136
Golgi 0.026050 0.041417 0.000438 0.003191 0.022364 0.014591 0.005309 0.009289 0.023869 0.023483 0.000976 0.008481
Lipid Particles 0.087765 0.086538 0.014062 0.056458 0.132850* 0.088727 0.078900 0.021004 0.114442* 0.088001 0.021219 0.025700
Mitochondria 0.016273 0.016724 0.000566 0.000236 0.011550 0.015942 0.000305 0.002516 0.013479 0.016201 0.000537 0.002214
Mitotic Spindle 0.000685 0.004839 0.002801 0.003013 0.001809 0.012370 0.010212 0.035584 0.001350 0.009874 0.003619 0.031271
None 0.002011 0.001354 0.001385 0.001642 0.002911 0.002324 0.000669 0.001792 0.002544 0.002002 0.001306 0.001772
Nuclear Periphery 0.000912 0.000856 0.004734 0.003209 0.001230 0.002589 0.003159 0.001357 0.001100 0.002014 0.004560 0.001602
Nuclear Periphery Foci 0.001402 0.003308 0.023959 0.029834 0.001969 0.002319 0.048186 0.007079 0.001737 0.002647 0.026633 0.010093
Nucleolus 0.001008 0.001721 0.000316 0.001155 0.001071 0.003005 0.001109 0.001486 0.001045 0.002579 0.000403 0.001442
Nucleus 0.079133 0.039658 0.281838* 0.109543 0.118140 0.096526 0.168276* 0.119884 0.102213 0.077676 0.269303* 0.118514
Peroxisomes 0.017194 0.035953 0.000999 0.023644 0.012660 0.017381 0.021541 0.043270 0.014511 0.023537 0.003267 0.040671
Vacuole 0.042849 0.062600 0.113451 0.338481* 0.036359 0.084391 0.204206* 0.171281 0.039008 0.077168 0.123469 0.193425
Vacuole Periphery 0.002450 0.004130 0.000226 0.001384 0.001359 0.004133 0.000334 0.001468 0.001804 0.004132 0.000238 0.001457

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.91 2.00 -2.92 -2.51 -3.07 1.96 -3.30 -4.18 -4.51 1.17 -0.28 -2.33 -4.79 -4.75 -4.00
Bud Neck 0.70 11.27 11.23 9.65 1.10 -3.61 11.12 1.96 5.10 -6.60 -2.35 14.39 4.58 6.41 -5.46
Bud Site -2.40 -0.74 -3.28 -2.08 -2.88 -0.46 -0.95 -6.26 -6.24 -4.87 -1.46 0.07 -7.15 -6.59 -7.19
Cell Periphery 2.49 -1.93 -2.13 -3.53 -1.34 7.39 -0.24 7.27 -0.40 7.90 7.82 0.80 7.01 -1.51 9.53
Cytoplasm 12.16 -13.64 6.65 0.86 12.92 9.72 10.93 5.75 -1.78 -6.89 13.95 -8.85 6.14 -3.33 11.95
Cytoplasmic Foci -5.56 51.13 24.26 27.12 -3.99 -7.99 7.26 16.05 22.38 1.75 -7.62 52.77 27.74 32.89 -11.66
Eisosomes 6.51 9.36 7.64 2.69 -4.87 12.50 10.79 13.86 6.08 5.39 13.72 16.36 15.99 7.92 -2.03
Endoplasmic Reticulum 0.89 -7.77 -2.81 -3.20 1.50 11.19 -1.47 11.88 0.79 4.65 9.83 -4.86 10.06 -0.06 13.05
Endosome -11.97 12.29 2.39 11.91 -4.64 -15.07 -3.72 -2.87 8.51 1.54 -18.95 12.01 -1.95 11.33 -7.61
Golgi -4.99 18.76 16.47 14.50 -2.58 5.49 9.90 11.27 6.05 -0.79 0.49 27.18 15.04 12.41 -4.38
Lipid Particles 0.30 19.56 5.99 5.52 -3.17 8.49 7.48 27.15 19.85 6.27 6.88 30.34 29.24 21.93 0.20
Mitochondria -0.16 13.52 13.85 11.05 2.60 -3.14 11.14 8.91 13.80 -3.55 -2.38 16.87 14.04 16.65 -2.88
Mitotic Spindle -4.25 -3.26 -2.71 0.18 -0.78 -6.62 -2.35 -7.58 -4.08 -3.41 -7.70 -3.20 -7.88 -4.67 -6.77
None 1.79 2.94 1.04 -0.09 -0.25 1.11 4.95 2.61 2.08 -3.87 1.54 4.61 2.74 1.46 -1.81
Nuclear Periphery 0.29 -12.76 -3.23 -3.29 2.23 -4.06 -4.99 -4.23 1.92 3.24 -3.99 -13.16 -6.09 -0.29 8.66
Nuclear Periphery Foci -3.23 -14.03 -4.99 -4.60 -0.92 -1.27 -7.35 -7.58 -6.75 6.30 -3.27 -15.62 -8.87 -7.71 8.20
Nucleolus -1.99 6.24 -0.77 -0.48 -1.04 -6.66 -0.64 -1.65 4.42 -0.53 -6.75 7.57 -1.55 2.19 -3.11
Nucleus 10.80 -31.78 -2.77 -5.92 12.66 5.16 -3.01 -4.39 -7.86 1.37 8.06 -28.36 -7.20 -11.61 17.50
Peroxisomes -7.49 17.35 0.52 4.07 -2.96 -4.25 -1.22 -5.21 -3.48 -1.82 -7.97 15.54 -4.47 -0.99 -8.86
Vacuole -5.77 -19.90 -17.35 -16.39 -13.17 -16.09 -12.16 -27.76 -20.67 -0.13 -16.51 -24.44 -31.40 -25.69 -15.00
Vacuole Periphery -3.40 8.53 2.66 4.73 -1.03 -7.35 10.56 1.59 7.20 -2.53 -7.60 12.84 3.44 8.86 -3.04
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER
Localization
Cell Percentages ER (33%), cytoplasm (8%), mixed (45%)
Cell Cycle Regulation Yes
cytoplasm - MA (0.00027)
Subcompartmental Group N/A

Say1

Say1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Say1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available